Function

Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. It is not able to add an Araf residue to a terminal Galf. {ECO:0000269|PubMed:16595677, ECO:0000305|PubMed:18556798}.

Family

Glycosyltransferase 85 family

GO

• cell wall organization GO:0071555 biological_process
• integral component of membrane GO:0016021 cellular_component
• transferase activity, transferring glycosyl groups GO:0016757 molecular_function
• capsule polysaccharide biosynthetic process GO:0045227 biological_process
• UDP-galactosyltransferase activity GO:0035250 molecular_function
• plasma membrane GO:0005886 cellular_component
• cell wall GO:0005618 cellular_component
• cell wall macromolecule biosynthetic process GO:0044038 biological_process
• mycolate cell wall layer assembly GO:0071769 biological_process

InterPro

• IPR020959
• IPR020963

UniProt

P9WN03

GenBank

Rv3792

EnsemblBacteria

Rv3792

Mycobrowser

Rv3792

Rv3792 doesn't seem to be a targeted by any drug.

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  Arabinogalactan biosynthesis - Mycobacterium mtu00572

  mtu00572

  Metabolism; Glycan biosynthesis and metabolism