Gene - combatTB X

accD4

Type: protein_coding
Name: accD4
Locus Name: Rv3799c
Product: Probable propionyl-CoA carboxylase beta chain 4 AccD4 (pccase) (propanoyl-CoA:carbon dioxide ligase)
Functional Category: None
Location: 4254380..4255948 (- strand)
Gene Length: 1568 bp
Nucleotides: GTGACCGTCACCGAGCCGGTTCTGCATACCACCGCCGAGAAGCTGGCGGAGCTGCGCGAACGCCTGGAGTTGGCCAAGGAACCCGGCGGTGAGAAGGCCGCCGCCAAGCGCGACAAGAAGGGCATCCCGAGTGCCCGCGCCCGCATCTACGAGCTGGTCGATCCGGGTAGCTTCATGGAGATCGGAGCGCTGTGCCGCACCCCCGGTGACCCCAACGCGCTCTACGGGGACGGCGTGGTCACCGGACATGGCCTCATCAACGGCCGGCCGGTCGGCGTGTTCTCGCACGACCAAACCGTGTTCGGCGGCACCGTCGGGGAGATGTTTGGCCGCAAGGTGGCCCGGCTGATGGAGTGGTGCGCGATGGTCGGCTGCCCGATCGTCGGCATCAACGACTCCGGCGGCGCCCGCATCCAAGACGCCGTCACCTCGCTGGCCTGGTACGCCGAGCTGGGGCGCCGCCACGAACTGCTCAGTGGGCTGGTGCCGCAGATCTCCATCATTTTGGGCAAATGCGCTGGGGGAGCGGTGTATTCGCCGATCCAGACCGATCTGGTGGTGGCGGTGCGCGACCAGGGTTACATGTTCGTCACCGGCCCCGACGTCATCAAGGACGTCACCGGTGAGGACGTCAGCCTCGACGAGCTGGGGGGCGCCGACCACCAGGCGAGCTACGGCAACATCCATCAGGTGGTGGAGTCCGAGGCCGCCGCATACCAGTACGTGCGGGACTTTCTGTCGTTTCTGCCGTCCAACTGCTTCGACAAACCGCCGGTCGTCAACCCCGGGCTGGAACCCGAAATCACCGGCCACGATCTGGAACTCGACTCGATCGTGCCGGACTCGGACAACATGGCCTACGACATGCACGAGGTCCTGCTGCGGATCTTCGACGACGGCGACTTCCTCGACGTCGCTGCCCAGGCCGGGCAGGCGATCATCACCGGCTACGCGCGGGTGGACGGGCGGACCGTTGGTGTGGTGGCCAACCAGCCCATGCACATGTCGGGGGCGATCGACAACGAGGCGTCCGACAAGGCCGCACGGTTCATCCGGTTTAGCGACGCGTTCGACATCCCGCTGGTGTTCGTCGTGGACACACCGGGGTTTTTGCCCGGGGTGGAACAGGAAAAGAACGGGATCATCAAGCGCGGTGGGAGGTTCTTGTACGCGGTGGTCGAGGCTGATGTGCCGAAGGTGACGATCACCATCCGCAAGTCCTACGGCGGTGCCTACGCGGTGATGGGGTCCAAGCAGCTGACCGCCGACCTGAACTTCGCCTGGCCCACCGCGCGCATCGCGGTGATCGGCGCCGACGGGGCCGCGCAGTTGCTGATGAAGCGTTTCCCGGACCCGAATGCGCCGGAGGCGCAAGCGATCCGGAAGAGCTTCGTCGAGAATTACAACCTCAACATGGCGATCCCGTGGATCGCCGCCGAGCGCGGGTTCATCGATGCCGTCATCGACCCGCATGAGACCCGGCTGCTGTTGCGCAAGTCGATGCACCTGCTGCGGGACAAGCAGCTGTGGTGGCGGGTGGGCCGCAAGCACGGCCTGATCCCGGTCTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

mycolate cell wall layer assembly GO:0071769 biological_process
acetyl-CoA carboxylase complex GO:0009317 cellular_component
carbon fixation GO:0015977 biological_process
acetyl-CoA carboxylase activity GO:0003989 molecular_function
cell wall GO:0005618 cellular_component
plasma membrane GO:0005886 cellular_component
propionyl-CoA carboxylase activity GO:0004658 molecular_function

InterPro

UniProt: O53578
GenBank: Rv3799c
EnsemblBacteria: Rv3799c
Mycobrowser: Rv3799c

Summary

Name: Probable propionyl-CoA carboxylase beta chain 4 AccD4 (Pccase) (Propanoyl-CoA:carbon dioxide ligase)
Family: Unknown
Protein Sequence: MTVTEPVLHTTAEKLAELRERLELAKEPGGEKAAAKRDKKGIPSARARIYELVDPGSFMEIGALCRTPGDPNALYGDGVVTGHGLINGRPVGVFSHDQTVFGGTVGEMFGRKVARLMEWCAMVGCPIVGINDSGGARIQDAVTSLAWYAELGRRHELLSGLVPQISIILGKCAGGAVYSPIQTDLVVAVRDQGYMFVTGPDVIKDVTGEDVSLDELGGADHQASYGNIHQVVESEAAAYQYVRDFLSFLPSNCFDKPPVVNPGLEPEITGHDLELDSIVPDSDNMAYDMHEVLLRIFDDGDFLDVAAQAGQAIITGYARVDGRTVGVVANQPMHMSGAIDNEASDKAARFIRFSDAFDIPLVFVVDTPGFLPGVEQEKNGIIKRGGRFLYAVVEADVPKVTITIRKSYGGAYAVMGSKQLTADLNFAWPTARIAVIGADGAAQLLMKRFPDPNAPEAQAIRKSFVENYNLNMAIPWIAAERGFIDAVIDPHETRLLLRKSMHLLRDKQLWWRVGRKHGLIPV
Mass: 56,680 Da
Length: 522 Aa

Rv3799c doesn't seem to be a targeted by any drug.

Rv3799c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.