Gene - combatTB X

Rv3818

Type: protein_coding
Name: Rv3818
Locus Name: Rv3818
Product: Unknown protein
Functional Category: None
Location: 4282449..4283999 (+ strand)
Gene Length: 1550 bp
Nucleotides: TGCAGGTCACAAGCGTTGGTCACGCCGGCTTTCTGATCCAGACCCAGGCCGGCAGCATCCTGTGCGACCCTTGGGTCAATCCGGCCTACTTTGCGTCTTGGTTTCCGTTCCCCGACAACAGCGGGCTGGACTGGGGCGCTTTGGGTGAGTGCGATTATCTGTATGTCTCGCACCTACATAAGGACCACTTCGACGCGGAAAATCTACGAGCGCACGTCAACAAGGACGCCGTCGTGCTGCTGCCCGACTTTCCGGTACCCGACCTGCGAAATGAGTTGCAGAAGTTAGGATTTCATCGGTTCTTCGAAACCACCGACTCGGTCAAACACCGCCTGAGGGGACCCAACGGCGATCTCGACGTGATGATCATCGCACTGCGGGCCCCCGCCGACGGTCCGATCGGCGACTCGGCGCTAGTCGTTGCCGACGGCGAAACAACGGCTTTCAACATGAACGACGCCCGCCCGGTCGATTTGGACGTGCTGGCATCGGAGTTCGGTCACATCGACGTGCATATGCTGCAGTACTCGGGCGCGATCTGGTACCCGATGGTCTACGACATGCCGGCGCGCGCGAAGGATGCGTTCGGCGCCCAAAAGCGGCAACGGCAGATGGACCGTGCTCGCCAGTACATCGCGCAGGTGGGAGCGACGTGGGTGGTGCCGTCGGCGGGGCCGCCATGCTTTTTAGCCCCCGAGCTGCGCCACCTCAACGACGACGGTAGCGATCCGGCCAATATCTTCCCCGACCAGATGGTGTTCCTGGATCAGATGCGGGCGCACGGCCAGGACGGCGGGCTGCTGATGATCCCCGGCTCGACTGCGGATTTCACTGGTACAACCCTGAATTCATTGCGCCATCCACTGCCCGCCGAACAGGTCGAGGCCATCTTTACCACCGACAAAGCCGCATACATCGCTGACTATGCCGACCGGATGGCGCCGGTGCTCGCCGCGCAAAAGGCTGGCTGGGCCGCCGCCGCCGGCGAGCCACTGCTGCAGCCGCTGCGCACCCTGTTCGAGCCGATCATGCTGCAAAGCAACGAGATCTGCGACGGCATCGGATACCCGGTCGAGCTCGCCATCGGTCCCGAAACCATTGTTTTGGACTTTCCGAAAAGAGCTGTACGAGAACCGATTCCCGACGAGAGGTTCCGCTACGGGTTCGCGATCGCGCCGGAGCTGGTGCGCACGGTGCTGCGCGACAACGAACCCGACTGGGTCAACACCATCTTCTTATCCACCCGATTTCGGGCATGGCGGGTTGGTGGCTACAACGAATACCTTTACACGTTCTTCAAGTGTCTGACCGACGAACGCATCGCCTACGCCGACGGCTGGTTCGCCGAGGCCCACGATGACTCCTCATCGATCACCCTGAACGGTTGGGAGATCCAGCGCCGCTGCCCCCATCTCAAAGCCGACCTATCGAAATTCGGTGTGGTGGAAGGCAACACGCTCACTTGTAACCTGCACGGCTGGCAGTGGCGTCTGGACGACGGTCGCTGCCTCACCGCCCGGGGCCATCAACTACGCAGTTCACGGCCATGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

metal ion binding GO:0046872 molecular_function
2 iron, 2 sulfur cluster binding GO:0051537 molecular_function
oxidoreductase activity GO:0016491 molecular_function

InterPro

UniProt: P9WH21
GenBank: Rv3818
EnsemblBacteria: Rv3818
Mycobrowser: Rv3818

Summary

Name: Putative Rieske 2Fe-2S iron-sulfur protein Rv3818 (EC 1.-.-.-)
Family: Unknown
Protein Sequence: MQVTSVGHAGFLIQTQAGSILCDPWVNPAYFASWFPFPDNSGLDWGALGECDYLYVSHLHKDHFDAENLRAHVNKDAVVLLPDFPVPDLRNELQKLGFHRFFETTDSVKHRLRGPNGDLDVMIIALRAPADGPIGDSALVVADGETTAFNMNDARPVDLDVLASEFGHIDVHMLQYSGAIWYPMVYDMPARAKDAFGAQKRQRQMDRARQYIAQVGATWVVPSAGPPCFLAPELRHLNDDGSDPANIFPDQMVFLDQMRAHGQDGGLLMIPGSTADFTGTTLNSLRHPLPAEQVEAIFTTDKAAYIADYADRMAPVLAAQKAGWAAAAGEPLLQPLRTLFEPIMLQSNEICDGIGYPVELAIGPETIVLDFPKRAVREPIPDERFRYGFAIAPELVRTVLRDNEPDWVNTIFLSTRFRAWRVGGYNEYLYTFFKCLTDERIAYADGWFAEAHDDSSSITLNGWEIQRRCPHLKADLSKFGVVEGNTLTCNLHGWQWRLDDGRCLTARGHQLRSSRP
Mass: 57,647 Da
Length: 516 Aa

Rv3818 doesn't seem to be a targeted by any drug.

Tuberculosis mtu05152
mtu05152
Human Diseases; Infectious disease: bacterial

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.