Gene - combatTB X

Rv3821

Type: protein_coding
Name: Rv3821
Locus Name: Rv3821
Product: Probable conserved integral membrane protein
Functional Category: None
Location: 4285973..4286686 (+ strand)
Gene Length: 713 bp
Nucleotides: TGTGGTCCACCGTGCTGGTCTTGGCGCTCTCGGTGATCTGCGAGCCGGTACGGATCGGTTTGGTGGTCCTCATGCTCAACAGGCGCCGCCCGCTGCTCCATTTGCTCACATTCTTGTGCGGTGGTTACACGATGGCTGGTGGCGTGGCCATGGTGACGCTTGTGGTCCTCGGGGCCACTCCGTTGGCCGGACATTTCAGTGTGGCCGAGGTACAGATCGGGACCGGGCTGATTGCCTTGCTTATCGCGTTTGCGCTGACCACAAATGTCATAGGCAAGCATGTCCGGCGAGCTACCCACGCCCGCGTCGGAGACGACGGTGGCAGGGTCCTACGGGAGTCGGTACCGCCAAGTGGTGCGCATAAGCTGGCTGTGCGTGCACGTTGTTTTCTGCAGGGCGATTCGCTGTATGTCGCCGGGGTGAGTGGCCTAGGAGCCGCACTGCCTTCGGCCAACTACATGGGCGCGATGGCCGCCATTCTTGCCTCCGGCGCTACGCCGGCAACACAGGCACTGGCTGTCGTTACGTTCAACGTGGTGGCATTCACAGTGGCCGAAGTCCCCCTCGTCAGCTACCTGGCAGCACCGCGTAAGACCCGCGCGTTCATGGCTGCGCTGCAATCATGGCTGCGGTCCCGTAGCCGCCGCGACGCCGCGTTGCTGGTGGCCGCCGGAGGTTGCCTGATGCTCACGCTAGGCCTGAGCAACCTGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Required for the transport across the inner membrane of sulfolipid-1 (SL-1), which is a major cell wall lipid of pathogenic mycobacteria. Could also transport SL1278 (2-palmitoyl-3-(C43)-phthioceranyl-alpha, alpha'-D-trehalose-2'-sulfate), which is the precursor of SL-1. May potentiate SL-1 levels and confer specificity for sulfolipids over structurally similar glycolipids. {ECO:0000269|PubMed:22194604}.

Family

Peptidoglycolipid addressing protein (GAP) (TC 2.A.116) family

GO

cell wall organization GO:0071555 biological_process
plasma membrane GO:0005886 cellular_component
lipid transport GO:0006869 biological_process
integral component of membrane GO:0016021 cellular_component

InterPro

IPR021315

UniProt: O07802
GenBank: Rv3821
EnsemblBacteria: Rv3821
Mycobrowser: Rv3821

Summary

Name: Sulfolipid-1 exporter Sap (Sulfolipid-1-addressing protein)
Family: Peptidoglycolipid addressing protein (GAP) (TC 2.A.116) family
Protein Sequence: MWSTVLVLALSVICEPVRIGLVVLMLNRRRPLLHLLTFLCGGYTMAGGVAMVTLVVLGATPLAGHFSVAEVQIGTGLIALLIAFALTTNVIGKHVRRATHARVGDDGGRVLRESVPPSGAHKLAVRARCFLQGDSLYVAGVSGLGAALPSANYMGAMAAILASGATPATQALAVVTFNVVAFTVAEVPLVSYLAAPRKTRAFMAALQSWLRSRSRRDAALLVAAGGCLMLTLGLSNL
Mass: 24,627 Da
Length: 237 Aa

Rv3821 doesn't seem to be a targeted by any drug.

Rv3821 doesn't seem to be involved in any pathway.

Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.: J Biol Chem. 2012 Mar 9;287(11):7990-8000. doi: 10.1074/jbc.M111.315473. Epub 2011 Dec 22.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.