Rv3822
- Type
- protein_coding
- Name
- Rv3822
- Locus Name
-
Rv3822
- Product
-
Conserved hypothetical protein
- Functional Category
-
None
- Location
- 4286721..4287935 (+ strand)
- Gene Length
- 1214 bp
- Nucleotides
-
TGAAATGTCCAGGCGTCTCCGACTGCGTTGCGACCGTAAGGCACGATAACGTGTTTGCTATTGCTGCTGGTTTGCGTTGGTCGGCCGCTGTACCGCCGCTACACAAAGGGGACGCTGTGACCAAACTGCTCGTCGGGGCCATCGCGGGCGGAATGCTAGCTTGCGCAGCTATATTGGGCGACGGAATCGCTTCGGCCGATACTGCGTTGATAGTACCCGGTACCGCACCGTCCCCGTACGGGCCACTCAGGTCGCTCTATCATTTCAATCCCGCGATGCAGCCTCAGATCGGCGCGAATTACTACAACCCCACCGCTACCCGCCACGTCGTTTCATATCCAGGCAGCTTTTGGCCTGTCACAGGCTTGAATTCGCCCACCGTCGGCAGTTCTGTCAGTGCCGGGACGAACAATCTCGATGCGGCGATCCGCAGCACTGACGGACCAATCTTCGTGGCCGGGTTATCACAGGGCACGCTCGTGCTTGACCGCGAGCAGGCACGGTTAGCGAATGACCCGACGGCTCCTCCCCCTGGGCAACTCACATTCATCAAGGCCGGCGACCCTAACAATCTTCTTTGGCGGGCGTTTAGGCCGGGAACCCACGTGCCGATCATCGACTACACCGTTCCGGCCCCAGCGGAAAGCCAGTACGACACAATCAATATCGTGGGCCAGTACGACATTTTTTCTGACCCGCCTAATCGTCCGGGCAACCTACTCGCTGACCTCAATGCGATTGCCGCGGGCGGATACTACGGCCACAGCGCCACCGCATTCTCGGACCCAGCTCGCGTTGCGCCTAGGGACATTACGACGACAACGAACAGTTTGGGTGCGACGACCACGACCTACTTCATCCGGACCGATCAGCTACCTCTGGTGCGGGCGCTGGTGGACATGGCGGGCCTGCCCCCGCAGGCGGCGGGAACAGTTGATGCCGCACTGCGGCCCATAATTGACAGGGCTTATCAGCCCGGACCAGCACCCGCTGTGAACCCGCGTGATTTGGTCCAGGGCATCCGCGGTATCCCCGCCATCGCCCCTGCCATCGCCATCCCTATCGGCAGCACCACCGGGGCCAGTGCCGCCACCAGCACCGCTGCCGCCACGGCAGCAGCAACAAATGCGCTCCGCGGGGCCAACGTGGGCCCGGGCGCCAACAAGGCGTTGTCGATGGTCCGGGGTTTGCTACCCAAAGGGAAGAAGCACTAG
- Drug Resistance
- Mutations
- Function
- Involved in the final steps of the cell wall sulfolipid-1 (SL-1) biosynthesis. Catalyzes two successive acylations of the precursor 2-palmitoyl-3-(C43)-phthioceranyl-alpha, alpha'-D-trehalose-2'-sulfate (SL1278) to yield the tetraacylated sulfolipid SL-1. {ECO:0000269|PubMed:22194604}.
- Family
-
Mycobacterial PPE family
- GO
-
- plasma membrane GO:0005886 cellular_component
- transferase activity, transferring acyl groups GO:0016746 molecular_function
- integral component of membrane GO:0016021 cellular_component
- lipid metabolic process GO:0006629 biological_process
- InterPro
Summary
- Name
- SL1278 acyltransferase Chp1 (EC 2.3.1.284) (Cutinase-like hydrolase protein)
- Family
- Mycobacterial PPE family
- Protein Sequence
-
MKCPGVSDCVATVRHDNVFAIAAGLRWSAAVPPLHKGDAVTKLLVGAIAGGMLACAAILGDGIASADTALIVPGTAPSPYGPLRSLYHFNPAMQPQIGANYYNPTATRHVVSYPGSFWPVTGLNSPTVGSSVSAGTNNLDAAIRSTDGPIFVAGLSQGTLVLDREQARLANDPTAPPPGQLTFIKAGDPNNLLWRAFRPGTHVPIIDYTVPAPAESQYDTINIVGQYDIFSDPPNRPGNLLADLNAIAAGGYYGHSATAFSDPARVAPRDITTTTNSLGATTTTYFIRTDQLPLVRALVDMAGLPPQAAGTVDAALRPIIDRAYQPGPAPAVNPRDLVQGIRGIPAIAPAIAIPIGSTTGASAATSTAAATAAATNALRGANVGPGANKALSMVRGLLPKGKKH
- Mass
- 41,408 Da
- Length
- 404 Aa
Rv3822 doesn't seem to be a targeted by any drug.
Rv3822 doesn't seem to be involved in any pathway.
- Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis.
- J Biol Chem. 2012 Mar 9;287(11):7990-8000. doi: 10.1074/jbc.M111.315473. Epub 2011 Dec 22.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.