papA1
- Type
- protein_coding
- Name
- papA1
- Locus Name
-
Rv3824c
- Product
-
Conserved polyketide synthase associated protein PapA1
- Functional Category
-
None
- Location
- 4291639..4293174 (- strand)
- Gene Length
- 1535 bp
- Nucleotides
-
GTGCGAATAGGACCAGTAGAGTTGTCAGCGGTCAAAGACTGGGACCCAGCGCCCGGCGTGTTAGTTTCGTGGCACCCAACACCTGCCTCGTGCGCGAAAGCCCTTGCAGCGCCGGTGAGTGCTGTGCCTCCCAGTTATGTACAAGCCAGACAAATTCGGAGCTTTTCTGAGCAGGCTGCCCGGGGGCTCGATCACTCGCGGCTGCTCATTGCGTCCGTTGAGGTGTTTGGTCACTGCGATCTGCGCGCCATGACCTATGTCATCAATGCGCACCTTCGTCGGCACGATACATACCGCAGCTGGTTCGAGCTTCGAGATACCGACCACATCGTTCGGCACAGCATCGCCGATCCGGCGGATATCGAATTTGTTCCGACCACACATGGCGAGATGACGAGCGCGGACCTGCGACAGCACATCGTGGCGACACCGGATTCGCTTCATTGGGACTGCTTCAGCTTCGGAGTCATTCAGCGAGCAGACTCCTTCACGTTCTATGCCAGCATCGATCATCTGCATGCGGACGGTCAGTTCGTAGGAGTCGGACTCATGGAGTTCCAGTCGATGTACACCGCGCTGATAATGGGTGAGCCACCGATTGGGTTATCGGAGGCTGGCAGCTATGTGGACTTCTGCGTCAGGCAGCACGAGTACACCTCGGCGTTGACCGTCGATTCCCCGGAGGTGCGCGCGTGGATCGACTTCGCCGAAATCAATAACGGAACTTTCCCGGAATTTCCGCTGCCCCTCGGAGATCCGTCTGTACGCTGCGGCGGCGACCTGCTCAGCATGATGCTAATGGACGAGCAGCAAACACAGCGATTCGAATCCGCCTGCATGGCGGCGAACGCTCGTTTCATTGGTGGCATGCTGGCTTGCATCGCCATCGCGATACACGAGTTGACCGGCGCCGATACCTATTTTGGAATTACTCCCAAAGATATCCGCACACCAGCCGACCTTATGACGCAGGGGTGGTTCACCGGGCAGATCCCGGTGACCGTTCCAGTCGCCGGATTGTCCTTTAACGAGATTGCACGAATCGCGCAGACCTCCTTCGATACTGGTGCGGATCTGGCGAAAGTGCCGTTCGAACGGGTCGTCGAATTGTCGCCGTCGCTGCGCAGGCCCCAACCGCTTTTTTCCCTGGTGAACTTTTTCGACGCACAAGTGGGACCGCTCTCGGCGGTGACGAAACTGTTCGAGGGCCTCAACGTTGGTACCTACAGCGACGGGAGGGTCACCTATCCGCTAAGTACGATGGTCGGTCGTTTCGACGAGACCGCGGCGAGCGTGCTATTCCCAGATAATCCGGTCGCTCGCGAATCCGTTACCGCATATCTGAGGGCAATTAGATCGGTGTGTATGCGCATTGCCAACGGTGGGACGGCGGAACGTGTAGGCAACGTCGTTGCGCTTTCCCCAGGCCGGCGAAATAACATCGAAAGGATGACATGGCGGTCTTGTCGCGCGGGTGATTTTATCGATATCTGCAATCTAAAGGTTGCGAATGTGACGGTAGATAGAGAAGCTTA
- Drug Resistance
- Mutations
- Function
- Catalyzes the acylation of trehalose-2-sulfate-2'-palmitate (SL659) by adding the (hydroxy)phthioceranoyl group at the 3'-position to yield the diacylated intermediate 2-palmitoyl-3-(C43)-phthioceranyl-alpha, alpha'-D-trehalose-2'-sulfate (SL1278) during the cell wall sulfolipid-1 (SL-1) biosynthesis. {ECO:0000269|PubMed:17259623, ECO:0000269|PubMed:17592143}.
- Family
-
PapA acyltransferase family
- GO
-
- sulfolipid biosynthetic process GO:0046506 biological_process
- transferase activity, transferring acyl groups other than amino-acyl groups GO:0016747 molecular_function
- InterPro
Summary
- Name
- SL659 acyltransferase papA1 (EC 2.3.1.283) (Polyketide synthase-associated protein A1)
- Family
- PapA acyltransferase family
- Protein Sequence
-
MRIGPVELSAVKDWDPAPGVLVSWHPTPASCAKALAAPVSAVPPSYVQARQIRSFSEQAARGLDHSRLLIASVEVFGHCDLRAMTYVINAHLRRHDTYRSWFELRDTDHIVRHSIADPADIEFVPTTHGEMTSADLRQHIVATPDSLHWDCFSFGVIQRADSFTFYASIDHLHADGQFVGVGLMEFQSMYTALIMGEPPIGLSEAGSYVDFCVRQHEYTSALTVDSPEVRAWIDFAEINNGTFPEFPLPLGDPSVRCGGDLLSMMLMDEQQTQRFESACMAANARFIGGMLACIAIAIHELTGADTYFGITPKDIRTPADLMTQGWFTGQIPVTVPVAGLSFNEIARIAQTSFDTGADLAKVPFERVVELSPSLRRPQPLFSLVNFFDAQVGPLSAVTKLFEGLNVGTYSDGRVTYPLSTMVGRFDETAASVLFPDNPVARESVTAYLRAIRSVCMRIANGGTAERVGNVVALSPGRRNNIERMTWRSCRAGDFIDICNLKVANVTVDREA
- Mass
- 56,128 Da
- Length
- 511 Aa
Rv3824c doesn't seem to be a targeted by any drug.
Rv3824c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1.
- Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11221-6. doi: 10.1073/pnas.0611649104. Epub 2007 Jun 25.
- Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.
- Microbiology. 2007 Feb;153(Pt 2):513-20. doi: 10.1099/mic.0.2006/003103-0.
- The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis.
- Mol Microbiol. 2006 Apr;60(2):312-30. doi: 10.1111/j.1365-2958.2006.05102.x.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.