Function

Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression. {ECO:0000269|PubMed:18685700, ECO:0000269|PubMed:21883526, ECO:0000269|PubMed:22389481, ECO:0000269|PubMed:22479184, ECO:0000269|PubMed:23743602}.

Family

Unknown

GO

• pathogenesis GO:0009405 biological_process
• nucleoid GO:0009295 cellular_component
• cell wall GO:0005618 cellular_component
• extracellular region GO:0005576 cellular_component
• cytosol GO:0005829 cellular_component
• identical protein binding GO:0042802 molecular_function
• DNA binding GO:0003677 molecular_function
• response to host immune response GO:0052572 biological_process
• regulation of transcription, DNA-templated GO:0006355 biological_process
• plasma membrane GO:0005886 cellular_component
• regulation of protein secretion GO:0050708 biological_process

InterPro

• Unknown

UniProt

P9WJB7

GenBank

Rv3849

EnsemblBacteria

Rv3849

Mycobrowser

Rv3849

Rv3849 doesn't seem to be a targeted by any drug.

Rv3849 doesn't seem to be involved in any pathway.