Gene - combatTB X

espE

Type: protein_coding
Name: espE
Locus Name: Rv3864
Product: ESX-1 secretion-associated protein EspE
Functional Category: None
Location: 4340270..4341478 (+ strand)
Gene Length: 1208 bp
Nucleotides: TGGCATCGGGTAGCGGTCTTTGCAAGACGACGAGTAACTTTATTTGGGGCCAGTTACTCTTGCTTGGAGAGGGAATCCCCGACCCAGGCGACATTTTCAACACCGGTTCGTCGCTGTTCAAACAAATCAGCGACAAAATGGGACTCGCCATTCCGGGCACCAACTGGATCGGCCAAGCGGCGGAAGCTTACCTAAACCAGAACATCGCGCAACAACTTCGCGCACAGGTGATGGGCGATCTCGACAAATTAACCGGCAACATGATCTCGAATCAGGCCAAATACGTCTCCGATACGCGCGACGTCCTGCGGGCCATGAAGAAGATGATTGACGGTGTCTACAAGGTTTGTAAGGGCCTCGAAAAGATTCCGCTGCTCGGCCACTTGTGGTCGTGGGAGCTCGCAATCCCTATGTCCGGCATCGCGATGGCCGTTGTCGGCGGCGCATTGCTCTATCTAACGATTATGACGCTGATGAATGCGACCAACCTGAGGGGAATTCTCGGCAGGCTGATCGAGATGTTGACGACCTTGCCAAAGTTCCCCGGCCTGCCCGGGTTGCCCAGCCTGCCCGACATCATCGACGGCCTCTGGCCGCCGAAGTTGCCCGACATTCCGATCCCCGGCCTGCCCGACATCCCGGGCCTACCCGACTTCAAATGGCCGCCCACCCCCGGCAGCCCGTTGTTCCCCGACCTCCCGTCGTTCCCAGGGTTCCCCGGGTTCCCGGAGTTCCCCGCCATCCCCGGGTTCCCCGCACTGCCCGGGTTGCCCAGCATTCCCAACTTGTTCCCCGGCTTGCCGGGTCTGGGCGACCTGCTGCCCGGCGTAGGCGATTTGGGCAAGTTACCCACCTGGACTGAGCTGGCCGCTTTGCCTGACTTCTTGGGCGGCTTCGCCGGCCTGCCCAGCTTGGGTTTTGGCAATCTGCTCAGCTTTGCCAGTTTGCCCACCGTGGGTCAGGTGACCGCCACCATGGGTCAGCTGCAACAGCTCGTGGCGGCCGGCGGTGGCCCCAGCCAACTGGCCAGCATGGGCAGCCAACAAGCGCAACTGATCTCGTCGCAGGCCCAGCAAGGAGGCCAGCAGCACGCCACCCTCGTGAGCGACAAGAAGGAAGACGAGGAAGGCGTGGCCGAGGCGGAGCGTGCACCCATCGACGCTGGCACCGCGGCCAGCCAACGGGGGCAGGAGGGGACCGTCCTTTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

growth of symbiont in host GO:0044117 biological_process
plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

Unknown

UniProt: P9WJD3
GenBank: Rv3864
EnsemblBacteria: Rv3864
Mycobrowser: Rv3864

Summary

Name: ESX-1 secretion-associated protein EspE
Family: Unknown
Protein Sequence: MASGSGLCKTTSNFIWGQLLLLGEGIPDPGDIFNTGSSLFKQISDKMGLAIPGTNWIGQAAEAYLNQNIAQQLRAQVMGDLDKLTGNMISNQAKYVSDTRDVLRAMKKMIDGVYKVCKGLEKIPLLGHLWSWELAIPMSGIAMAVVGGALLYLTIMTLMNATNLRGILGRLIEMLTTLPKFPGLPGLPSLPDIIDGLWPPKLPDIPIPGLPDIPGLPDFKWPPTPGSPLFPDLPSFPGFPGFPEFPAIPGFPALPGLPSIPNLFPGLPGLGDLLPGVGDLGKLPTWTELAALPDFLGGFAGLPSLGFGNLLSFASLPTVGQVTATMGQLQQLVAAGGGPSQLASMGSQQAQLISSQAQQGGQQHATLVSDKKEDEEGVAEAERAPIDAGTAASQRGQEGTVL
Mass: 42,069 Da
Length: 402 Aa

Rv3864 doesn't seem to be a targeted by any drug.

Rv3864 doesn't seem to be involved in any pathway.

Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria.: Mol Microbiol. 2012 Feb;83(3):654-64. doi: 10.1111/j.1365-2958.2011.07958.x. Epub 2012 Jan 11.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.: Infect Immun. 2006 Jan;74(1):88-98. doi: 10.1128/IAI.74.1.88-98.2006.
Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis.: Mol Microbiol. 2004 Jan;51(2):359-70. doi: 10.1046/j.1365-2958.2003.03844.x.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.