Gene - combatTB X

Type: protein_coding
Name: espF
Locus Name: Rv3865
Product: ESX-1 secretion-associated protein EspF
Functional Category: None
Location: 4341566..4341877 (+ strand)
Gene Length: 311 bp
Nucleotides: TGACCGGATTTCTCGGTGTCGTGCCTTCGTTCCTGAAGGTGCTGGCGGGCATGCACAACGAGATCGTGGGTGATATCAAAAGGGCGACCGATACGGTCGCCGGGATTAGCGGACGAGTTCAGCTTACCCATGGTTCGTTCACGTCGAAATTCAATGACACGCTGCAAGAGTTTGAGACCACCCGTAGCAGCACGGGCACGGGTTTGCAGGGAGTCACCAGCGGACTGGCCAATAATCTGCTCGCAGCCGCCGGCGCCTACCTCAAGGCCGACGATGGCCTAGCCGGTGTTATCGACAAGATTTTCGGTTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

EspC family

GO

InterPro

Summary

Name: ESX-1 secretion-associated protein EspF
Family: EspC family
Protein Sequence: MTGFLGVVPSFLKVLAGMHNEIVGDIKRATDTVAGISGRVQLTHGSFTSKFNDTLQEFETTRSSTGTGLQGVTSGLANNLLAAAGAYLKADDGLAGVIDKIFG
Mass: 10,618 Da
Length: 103 Aa

Rv3865 doesn't seem to be a targeted by any drug.

Rv3865 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis.: J Infect Dis. 2011 Apr 15;203(8):1155-64. doi: 10.1093/infdis/jiq089. Epub 2010 Dec 31.
ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria.: Mol Microbiol. 2009 Sep;73(5):950-62. doi: 10.1111/j.1365-2958.2009.06821.x. Epub 2009 Aug 4.
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.: Infect Immun. 2006 Jan;74(1):88-98. doi: 10.1128/IAI.74.1.88-98.2006.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.