Gene - combatTB X

Type: protein_coding
Name: espG1
Locus Name: Rv3866
Product: ESX-1 secretion-associated protein EspG1
Functional Category: None
Location: 4341880..4342731 (+ strand)
Gene Length: 851 bp
Nucleotides: TGACGGGTCCGTCCGCTGCAGGCCGCGCGGGCACCGCCGACAACGTGGTCGGCGTCGAGGTAACCATCGACGGCATGTTGGTGATCGCCGATCGGTTACACCTGGTTGATTTCCCTGTCACGCTTGGGATTCGGCCGAATATCCCGCAAGAGGATCTGCGAGACATCGTCTGGGAACAGGTGCAGCGTGACCTCACAGCGCAAGGGGTGCTCGACCTCCACGGGGAGCCCCAACCGACGGTCGCGGAGATGGTCGAAACCCTGGGCAGGCCAGATCGGACCTTGGAGGGTCGCTGGTGGCGGCGCGACATTGGCGGCGTCATGGTGCGCTTCGTCGTGTGCCGCAGGGGCGACCGCCATGTGATCGCGGCGCGCGACGGCGACATGCTGGTGCTGCAGTTGGTGGCGCCGCAGGTCGGCTTGGCGGGCATGGTGACAGCGGTGCTGGGGCCCGCCGAACCCGCCAACGTCGAACCCCTGACGGGTGTGGCAACCGAGCTAGCCGAATGCACAACCGCGTCCCAATTGACGCAATACGGTATCGCACCGGCCTCGGCCCGCGTCTATGCCGAGATCGTGGGTAACCCGACCGGCTGGGTGGAGATCGTTGCCAGCCAACGCCACCCCGGCGGCACCACGACGCAGACCGACGCCGCCGCTGGCGTCCTGGACTCCAAGCTCGGTAGGCTGGTGTCGCTTCCCCGCCGTGTTGGAGGCGACCTGTACGGAAGCTTCCTGCCCGGCACTCAGCAGAACTTGGAGCGTGCGCTGGACGGCTTGCTAGAGCTGCTCCCTGCGGGCGCTTGGCTAGATCACACCTCAGATCACGCACAAGCCTCCTCCCGAGGCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. {ECO:0000250|UniProtKB:O53943}.

Family

EspG family

GO

InterPro

Summary

Name: ESX-1 secretion-associated protein EspG1
Family: EspG family
Protein Sequence: MTGPSAAGRAGTADNVVGVEVTIDGMLVIADRLHLVDFPVTLGIRPNIPQEDLRDIVWEQVQRDLTAQGVLDLHGEPQPTVAEMVETLGRPDRTLEGRWWRRDIGGVMVRFVVCRRGDRHVIAARDGDMLVLQLVAPQVGLAGMVTAVLGPAEPANVEPLTGVATELAECTTASQLTQYGIAPASARVYAEIVGNPTGWVEIVASQRHPGGTTTQTDAAAGVLDSKLGRLVSLPRRVGGDLYGSFLPGTQQNLERALDGLLELLPAGAWLDHTSDHAQASSRG
Mass: 30,064 Da
Length: 283 Aa

Rv3866 doesn't seem to be a targeted by any drug.

Rv3866 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis.: J Infect Dis. 2011 Apr 15;203(8):1155-64. doi: 10.1093/infdis/jiq089. Epub 2010 Dec 31.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
A protein linkage map of the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis.: Microbiol Res. 2009;164(3):253-9. doi: 10.1016/j.micres.2006.11.016. Epub 2007 Apr 12.
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.: Infect Immun. 2006 Jan;74(1):88-98. doi: 10.1128/IAI.74.1.88-98.2006.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.