Gene - combatTB X

Type: protein_coding
Name: espH
Locus Name: Rv3867
Product: ESX-1 secretion-associated protein EspH
Functional Category: None
Location: 4342770..4343321 (+ strand)
Gene Length: 551 bp
Nucleotides: TGGTGGACCCGCCGGGCAACGACGACGACCACGGTGATCTCGACGCCCTCGATTTCTCCGCCGCCCACACCAACGAGGCGTCGCCGCTGGACGCCTTAGACGACTATGCGCCGGTGCAGACCGATGACGCCGAAGGCGACCTGGACGCCCTCCATGCGCTCACCGAACGCGACGAGGAGCCGGAGCTGGAGTTGTTCACGGTGACCAACCCTCAAGGGTCGGTGTCGGTCTCAACCCTGATGGACGGCAGAATCCAGCACGTCGAGCTGACGGACAAGGCGACCAGCATGTCCGAAGCGCAGCTGGCCGACGAGATCTTCGTTATTGCCGATCTGGCCCGCCAAAAGGCGCGGGCGTCGCAGTACACGTTCATGGTGGAGAACATCGGTGAACTGACCGACGAAGACGCAGAAGGCAGCGCCCTGCTGCGGGAATTCGTGGGGATGACCCTGAATCTGCCGACGCCGGAAGAGGCTGCCGCAGCCGAAGCCGAAGTGTTCGCCACCCGCTACGATGTCGACTACACCTCCCGGTACAAGGCCGATGACTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

response to antibiotic GO:0046677 biological_process
negative regulation by symbiont of host immune response GO:0052562 biological_process
plasma membrane GO:0005886 cellular_component

InterPro

Summary

Name: ESX-1 secretion-associated protein EspH
Family: Unknown
Protein Sequence: MVDPPGNDDDHGDLDALDFSAAHTNEASPLDALDDYAPVQTDDAEGDLDALHALTERDEEPELELFTVTNPQGSVSVSTLMDGRIQHVELTDKATSMSEAQLADEIFVIADLARQKARASQYTFMVENIGELTDEDAEGSALLREFVGMTLNLPTPEEAAAAEAEVFATRYDVDYTSRYKADD
Mass: 19,946 Da
Length: 183 Aa

Rv3867 doesn't seem to be a targeted by any drug.

Rv3867 doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.: Infect Immun. 2006 Jan;74(1):88-98. doi: 10.1128/IAI.74.1.88-98.2006.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.