Gene - combatTB X

eccA1

Type: protein_coding
Name: eccA1
Locus Name: Rv3868
Product: ESX conserved component EccA1. ESX-1 type VII secretion system protein.
Functional Category: None
Location: 4343314..4345035 (+ strand)
Gene Length: 1721 bp
Nucleotides: TGACTGATCGCTTGGCCAGTCTGTTCGAAAGCGCCGTCAGCATGTTGCCGATGTCGGAGGCGCGGTCGCTAGATCTGTTCACCGAGATCACCAACTACGACGAATCCGCTTGCGACGCATGGATCGGCCGGATCCGGTGTGGGGACACCGACCGGGTGACGCTGTTTCGCGCCTGGTATTCGCGCCGCAATTTCGGACAGTTGTCGGGATCGGTCCAGATCTCGATGAGCACGTTAAACGCCAGGATTGCCATCGGGGGGCTGTACGGCGATATCACCTACCCGGTCACCTCGCCGCTAGCGATCACCATGGGCTTTGCCGCATGCGAGGCAGCGCAAGGCAATTACGCCGACGCCATGGAGGCCTTAGAGGCCGCCCCGGTCGCGGGTTCCGAGCACCTGGTGGCGTGGATGAAGGCGGTTGTCTACGGCGCGGCCGAACGCTGGACCGACGTGATCGACCAGGTCAAGAGTGCTGGGAAATGGCCGGACAAGTTTTTGGCCGGCGCGGCCGGTGTGGCGCACGGGGTTGCCGCGGCAAACCTGGCCTTGTTCACCGAAGCCGAACGCCGACTCACCGAGGCCAACGACTCGCCCGCCGGTGAGGCGTGTGCGCGCGCCATCGCCTGGTATCTGGCGATGGCACGGCGCAGCCAGGGCAACGAAAGCGCCGCGGTGGCGCTGCTGGAATGGTTACAGACCACTCACCCCGAGCCCAAAGTGGCTGCGGCGCTGAAGGATCCCTCCTACCGGCTGAAGACGACCACCGCCGAACAGATCGCATCCCGCGCCGATCCCTGGGATCCGGGCAGTGTCGTGACCGACAACTCCGGCCGGGAGCGGCTGCTCGCCGAGGCCCAAGCCGAACTCGACCGCCAAATTGGGCTCACCCGGGTTAAAAATCAGATTGAACGCTACCGCGCGGCGACGCTGATGGCCCGGGTCCGCGCCGCCAAGGGTATGAAGGTCGCCCAGCCCAGCAAGCACATGATCTTCACCGGACCGCCCGGTACCGGCAAGACCACGATCGCGCGGGTGGTGGCCAATATCCTGGCCGGCTTAGGCGTCATTGCCGAACCCAAACTCGTCGAGACGTCGCGCAAGGACTTCGTCGCCGAGTACGAGGGGCAATCGGCGGTCAAGACCGCTAAGACGATCGATCAGGCGCTGGGCGGGGTGCTTTTCATCGACGAGGCTTATGCGCTGGTGCAGGAAAGAGACGGCCGCACCGATCCGTTCGGTCAAGAGGCGCTGGACACGCTGCTGGCGCGGATGGAGAACGACCGGGACCGGCTGGTGGTGATCATCGCCGGGTACAGCTCCGACATAGATCGGCTGCTGGAAACCAACGAGGGTCTGCGGTCGCGGTTCGCCACTCGCATCGAGTTCGACACCTATTCCCCCGAGGAACTCCTCGAGATCGCCAACGTCATTGCCGCTGCTGATGATTCGGCGTTGACCGCAGAGGCGGCCGAGAACTTTCTTCAGGCCGCCAAGCAGTTGGAGCAGCGCATGTTGCGCGGCCGGCGCGCCCTGGACGTCGCCGGCAACGGTCGGTATGCGCGCCAGCTGGTGGAGGCCAGCGAGCAATGCCGGGACATGCGTCTAGCCCAGGTCCTCGATATCGACACCCTCGACGAAGACCGGCTTCGCGAGATCAACGGCTCAGATATGGCGGAGGCTATCGCCGCGGTGCACGCACACCTCAACATGAGAGAATGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10) (PubMed:18974091, PubMed:16368961). EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (PubMed:18974091). {ECO:0000269|PubMed:16368961, ECO:0000269|PubMed:18974091}.

Family

CbxX/CfxQ family

GO

ATPase activity GO:0016887 molecular_function
cytoplasm GO:0005737 cellular_component
plasma membrane GO:0005886 cellular_component
ATP binding GO:0005524 molecular_function
growth of symbiont in host GO:0044117 biological_process

InterPro

UniProt: P9WPH9
GenBank: Rv3868
EnsemblBacteria: Rv3868
Mycobrowser: Rv3868

Summary

Name: ESX-1 secretion system protein EccA1 (ESX conserved component A1) (Type VII secretion system protein EccA1) (T7SS protein EccA1)
Family: CbxX/CfxQ family
Protein Sequence: MTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAGKWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPKVAAALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVKNQIERYRAATLMARVRAAKGMKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEPKLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAYALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAAADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVLDIDTLDEDRLREINGSDMAEAIAAVHAHLNMRE
Mass: 62,426 Da
Length: 573 Aa

Rv3868 doesn't seem to be a targeted by any drug.

Rv3868 doesn't seem to be involved in any pathway.

Crystal structure of the N-terminal domain of EccA(1) ATPase from the ESX-1 secretion system of Mycobacterium tuberculosis.: Proteins. 2014 Jan;82(1):159-63. doi: 10.1002/prot.24351. Epub 2013 Aug 31.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
Characterization of Rv3868, an essential hypothetical protein of the ESX-1 secretion system in Mycobacterium tuberculosis.: J Biol Chem. 2008 Dec 26;283(52):36532-41. doi: 10.1074/jbc.M807144200. Epub 2008 Oct 30.
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.: Infect Immun. 2006 Jan;74(1):88-98. doi: 10.1128/IAI.74.1.88-98.2006.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
A protein linkage map of the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis.: Microbiol Res. 2009;164(3):253-9. doi: 10.1016/j.micres.2006.11.016. Epub 2007 Apr 12.
ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria.: Mol Microbiol. 2009 Sep;73(5):950-62. doi: 10.1111/j.1365-2958.2009.06821.x. Epub 2009 Aug 4.