Gene - combatTB X

eccB1

Type: protein_coding
Name: eccB1
Locus Name: Rv3869
Product: ESX conserved component EccB1. ESX-1 type VII secretion system protein. Possible membrane protein.
Functional Category: None
Location: 4345039..4346481 (+ strand)
Gene Length: 1442 bp
Nucleotides: TGGGGCTTCGCCTCACCACCAAGGTTCAGGTTAGCGGCTGGCGTTTTCTGCTGCGCCGGCTCGAACACGCCATCGTGCGCCGGGACACCCGGATGTTTGACGACCCGCTGCAGTTCTACAGCCGCTCGATCGCTCTTGGCATCGTCGTCGCGGTCCTGATTCTGGCGGGTGCCGCGCTGCTGGCGTACTTCAAACCACAAGGCAAACTCGGCGGCACCAGCCTGTTCACCGACCGCGCGACCAACCAGCTTTACGTGCTGCTGTCCGGACAGTTGCATCCGGTCTACAACCTGACTTCGGCGCGGCTGGTGCTGGGCAATCCGGCCAACCCGGCCACCGTGAAGTCCTCCGAACTGAGCAAGCTGCCGATGGGCCAGACCGTTGGAATCCCCGGCGCCCCCTACGCCACGCCTGTTTCGGCGGGCAGCACCTCGATCTGGACCCTATGCGACACCGTCGCCCGAGCCGACTCCACTTCCCCGGTAGTGCAGACCGCGGTCATCGCGATGCCGTTGGAGATCGATGCTTCGATCGATCCGCTCCAGTCACACGAAGCGGTGCTGGTGTCCTACCAGGGCGAAACCTGGATCGTCACAACTAAGGGACGCCACGCCATAGATCTGACCGACCGCGCCCTCACCTCGTCGATGGGGATACCGGTGACGGCCAGGCCAACCCCGATCTCGGAGGGCATGTTCAACGCGCTGCCTGATATGGGGCCCTGGCAGCTGCCGCCGATACCGGCGGCGGGCGCGCCCAATTCGCTTGGCCTACCTGATGATCTAGTGATCGGATCGGTCTTCCAGATCCACACCGACAAGGGCCCGCAATACTATGTGGTGCTGCCCGACGGCATCGCGCAGGTCAACGCGACAACCGCTGCGGCGCTGCGCGCCACCCAGGCGCACGGGCTGGTCGCGCCACCGGCAATGGTGCCCAGTCTGGTCGTCAGAATCGCCGAACGGGTATACCCCTCACCGCTACCCGATGAACCGCTCAAGATCGTGTCCCGGCCGCAGGATCCCGCGCTGTGCTGGTCATGGCAACGCAGCGCCGGCGACCAGTCGCCGCAGTCAACGGTGCTGTCCGGCCGGCATCTGCCGATATCGCCCTCAGCGATGAACATGGGGATCAAGCAGATCCACGGGACGGCGACCGTTTACCTCGACGGCGGAAAATTCGTGGCACTGCAATCCCCCGATCCTCGATACACCGAATCGATGTACTACATCGATCCACAGGGCGTGCGTTATGGGGTGCCTAACGCGGAGACAGCCAAGTCGCTGGGCCTGAGTTCACCCCAAAACGCGCCCTGGGAGATCGTTCGTCTCCTGGTCGACGGTCCGGTGCTGTCGAAAGATGCCGCACTGCTCGAGCACGACACGCTGCCCGCTGACCCTAGCCCCCGAAAAGTTCCCGCCGGAGCCTCCGGAGCCCCCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

An ATPase (PubMed:26396239). Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10) (PubMed:16368961). {ECO:0000269|PubMed:16368961, ECO:0000269|PubMed:26396239}.

Family

EccB family

GO

cell wall GO:0005618 cellular_component
extracellular region GO:0005576 cellular_component
ATP binding GO:0005524 molecular_function
modulation by symbiont of host immune response GO:0052553 biological_process
plasma membrane GO:0005886 cellular_component
hydrolase activity GO:0016787 molecular_function
integral component of membrane GO:0016021 cellular_component

InterPro

IPR007795

UniProt: P9WNR7
GenBank: Rv3869
EnsemblBacteria: Rv3869
Mycobrowser: Rv3869

Summary

Name: ESX-1 secretion system ATPase EccB1 (EC 3.6.-.-) (ESX conserved component B1) (Type VII secretion system protein EccB1) (T7SS protein EccB1)
Family: EccB family
Protein Sequence: MGLRLTTKVQVSGWRFLLRRLEHAIVRRDTRMFDDPLQFYSRSIALGIVVAVLILAGAALLAYFKPQGKLGGTSLFTDRATNQLYVLLSGQLHPVYNLTSARLVLGNPANPATVKSSELSKLPMGQTVGIPGAPYATPVSAGSTSIWTLCDTVARADSTSPVVQTAVIAMPLEIDASIDPLQSHEAVLVSYQGETWIVTTKGRHAIDLTDRALTSSMGIPVTARPTPISEGMFNALPDMGPWQLPPIPAAGAPNSLGLPDDLVIGSVFQIHTDKGPQYYVVLPDGIAQVNATTAAALRATQAHGLVAPPAMVPSLVVRIAERVYPSPLPDEPLKIVSRPQDPALCWSWQRSAGDQSPQSTVLSGRHLPISPSAMNMGIKQIHGTATVYLDGGKFVALQSPDPRYTESMYYIDPQGVRYGVPNAETAKSLGLSSPQNAPWEIVRLLVDGPVLSKDAALLEHDTLPADPSPRKVPAGASGAP
Mass: 51,093 Da
Length: 480 Aa

Rv3869 doesn't seem to be a targeted by any drug.

Rv3869 doesn't seem to be involved in any pathway.

Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.: BMC Struct Biol. 2016 Feb 27;16:5. doi: 10.1186/s12900-016-0056-6.
Crystallographic observation of the movement of the membrane-distal domain of the T7SS core component EccB1 from Mycobacterium tuberculosis.: Acta Crystallogr F Struct Biol Commun. 2016 Feb;72(Pt 2):139-44. doi: 10.1107/S2053230X16000212. Epub 2016 Jan 22.
Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase.: FASEB J. 2015 Dec;29(12):4804-14. doi: 10.1096/fj.15-270843. Epub 2015 Sep 22.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA.: J Bacteriol. 2010 Jan;192(1):326-35. doi: 10.1128/JB.01032-09.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.: Infect Immun. 2006 Jan;74(1):88-98. doi: 10.1128/IAI.74.1.88-98.2006.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.