Gene - combatTB X

eccCb1

Type: protein_coding
Name: eccCb1
Locus Name: Rv3871
Product: ESX conserved component EccCb1. ESX-1 type VII secretion system protein.
Functional Category: None
Location: 4348827..4350602 (+ strand)
Gene Length: 1775 bp
Nucleotides: TGACTGCTGAACCGGAAGTACGGACGCTGCGCGAGGTTGTGCTGGACCAGCTCGGCACTGCTGAATCGCGTGCGTACAAGATGTGGCTGCCGCCGTTGACCAATCCGGTCCCGCTCAACGAGCTCATCGCCCGTGATCGGCGACAACCCCTGCGATTTGCCCTGGGGATCATGGATGAACCGCGCCGCCATCTACAGGATGTGTGGGGCGTAGACGTTTCCGGGGCCGGCGGCAACATCGGTATTGGGGGCGCACCTCAAACCGGGAAGTCGACGCTACTGCAGACGATGGTGATGTCGGCCGCCGCCACACACTCACCGCGCAACGTTCAGTTCTATTGCATCGACCTAGGTGGCGGCGGGCTGATCTATCTCGAAAACCTTCCACACGTCGGTGGGGTAGCCAATCGGTCCGAGCCCGACAAGGTCAACCGGGTGGTCGCAGAGATGCAAGCCGTCATGCGGCAACGGGAAACCACCTTCAAGGAACACCGAGTGGGCTCGATCGGGATGTACCGGCAGCTGCGTGACGATCCAAGTCAACCCGTTGCGTCCGATCCATACGGCGACGTCTTTCTGATCATCGACGGATGGCCCGGTTTTGTCGGCGAGTTCCCCGACCTTGAGGGGCAGGTTCAAGATCTGGCCGCCCAGGGGCTGGCGTTCGGCGTCCACGTCATCATCTCCACGCCACGCTGGACAGAGCTGAAGTCGCGTGTTCGCGACTACCTCGGCACCAAGATCGAGTTCCGGCTTGGTGACGTCAATGAAACCCAGATCGACCGGATTACCCGCGAGATCCCGGCGAATCGTCCGGGTCGGGCAGTGTCGATGGAAAAGCACCATCTGATGATCGGCGTGCCCAGGTTCGACGGCGTGCACAGCGCCGATAACCTGGTGGAGGCGATCACCGCGGGGGTGACGCAGATCGCTTCCCAGCACACCGAACAGGCACCTCCGGTGCGGGTCCTGCCGGAGCGTATCCACCTGCACGAACTCGACCCGAACCCGCCGGGACCAGAGTCCGACTACCGCACTCGCTGGGAGATTCCGATCGGCTTGCGCGAGACGGACCTGACGCCGGCTCACTGCCACATGCACACGAACCCGCACCTACTGATCTTCGGTGCGGCCAAATCGGGCAAGACGACCATTGCCCACGCGATCGCGCGCGCCATTTGTGCCCGAAACAGTCCCCAGCAGGTGCGGTTCATGCTCGCGGACTACCGCTCGGGCCTGCTGGACGCGGTGCCGGACACCCATCTGCTGGGCGCCGGCGCGATCAACCGCAACAGCGCGTCGCTAGACGAGGCCGTTCAAGCACTGGCGGTCAACCTGAAGAAGCGGTTGCCGCCGACCGACCTGACGACGGCGCAGCTACGCTCGCGTTCGTGGTGGAGCGGATTTGACGTCGTGCTTCTGGTCGACGATTGGCACATGATCGTGGGTGCCGCCGGGGGGATGCCGCCGATGGCACCGCTGGCCCCGTTATTGCCGGCGGCGGCAGATATCGGGTTGCACATCATTGTCACCTGTCAGATGAGCCAGGCTTACAAGGCAACCATGGACAAGTTCGTCGGCGCCGCATTCGGGTCGGGCGCTCCGACAATGTTCCTTTCGGGCGAGAAGCAGGAATTCCCATCCAGTGAGTTCAAGGTCAAGCGGCGCCCCCCTGGCCAGGCATTTCTCGTCTCGCCAGACGGCAAAGAGGTCATCCAGGCCCCCTACATCGAGCCTCCAGAAGAAGTGTTCGCAGCACCCCCAAGCGCCGGTTAA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10) (PubMed:14557547, PubMed:14557536, PubMed:16368961, PubMed:16973880). EccCb1 may link the cytosolic components of the system with the membrane components (PubMed:16973880). {ECO:0000269|PubMed:14557536, ECO:0000269|PubMed:16368961, ECO:0000269|PubMed:16973880, ECO:0000305|PubMed:14557547}.

Family

Unknown

GO

cytoplasm GO:0005737 cellular_component
active evasion of host immune response GO:0042783 biological_process
plasma membrane GO:0005886 cellular_component
DNA binding GO:0003677 molecular_function
ATP binding GO:0005524 molecular_function
cell wall GO:0005618 cellular_component
pathogenesis GO:0009405 biological_process
growth of symbiont in host GO:0044117 biological_process
protein secretion by the type VII secretion system GO:0044315 biological_process

InterPro

UniProt: P9WNB1
GenBank: Rv3871
EnsemblBacteria: Rv3871
Mycobrowser: Rv3871

Summary

Name: ESX-1 secretion system protein EccCb1 (ESX conserved component Cb1) (Snm2 secretory protein) (Type VII secretion system protein EccCb1) (T7SS protein EccCb1)
Family: Unknown
Protein Sequence: MTAEPEVRTLREVVLDQLGTAESRAYKMWLPPLTNPVPLNELIARDRRQPLRFALGIMDEPRRHLQDVWGVDVSGAGGNIGIGGAPQTGKSTLLQTMVMSAAATHSPRNVQFYCIDLGGGGLIYLENLPHVGGVANRSEPDKVNRVVAEMQAVMRQRETTFKEHRVGSIGMYRQLRDDPSQPVASDPYGDVFLIIDGWPGFVGEFPDLEGQVQDLAAQGLAFGVHVIISTPRWTELKSRVRDYLGTKIEFRLGDVNETQIDRITREIPANRPGRAVSMEKHHLMIGVPRFDGVHSADNLVEAITAGVTQIASQHTEQAPPVRVLPERIHLHELDPNPPGPESDYRTRWEIPIGLRETDLTPAHCHMHTNPHLLIFGAAKSGKTTIAHAIARAICARNSPQQVRFMLADYRSGLLDAVPDTHLLGAGAINRNSASLDEAVQALAVNLKKRLPPTDLTTAQLRSRSWWSGFDVVLLVDDWHMIVGAAGGMPPMAPLAPLLPAAADIGLHIIVTCQMSQAYKATMDKFVGAAFGSGAPTMFLSGEKQEFPSSEFKVKRRPPGQAFLVSPDGKEVIQAPYIEPPEEVFAAPPSAG
Mass: 64,561 Da
Length: 591 Aa

Rv3871 doesn't seem to be a targeted by any drug.

Rv3871 doesn't seem to be involved in any pathway.

Polar assembly and scaffolding proteins of the virulence-associated ESX-1 secretory apparatus in mycobacteria.: Mol Microbiol. 2012 Feb;83(3):654-64. doi: 10.1111/j.1365-2958.2011.07958.x. Epub 2012 Jan 11.
Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion.: Cell. 2015 Apr 23;161(3):501-512. doi: 10.1016/j.cell.2015.03.040. Epub 2015 Apr 9.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA.: J Bacteriol. 2010 Jan;192(1):326-35. doi: 10.1128/JB.01032-09.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
A mycobacterium ESX-1-secreted virulence factor with unique requirements for export.: PLoS Pathog. 2007 Aug 3;3(8):e105. doi: 10.1371/journal.ppat.0030105.
C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis.: Science. 2006 Sep 15;313(5793):1632-6. doi: 10.1126/science.1131167.
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.: Infect Immun. 2006 Jan;74(1):88-98. doi: 10.1128/IAI.74.1.88-98.2006.
Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis.: Mol Microbiol. 2004 Jan;51(2):359-70. doi: 10.1046/j.1365-2958.2003.03844.x.
Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system.: Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13001-6. doi: 10.1073/pnas.2235593100. Epub 2003 Oct 13.
The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue.: Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12420-5. doi: 10.1073/pnas.1635213100. Epub 2003 Oct 13.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.