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Function

A secreted protein. Acts as a strong host (human) T-cell antigen (PubMed:11940590). Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm (PubMed:17604718). Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA; native protein binds poorly to artificial liposomes in the absence or presence of EsxA (PubMed:17557817, PubMed:26260636). EsxA and EsxA-EsxB are cytotoxic to pneumocytes (PubMed:19906174). EsxB (and EsxA-EsxB but not EsxA alone) activates human neutrophils; EsxB transiently induces host (human) intracellular Ca(2+) mobility in a dose-dependent manner, monocytes and lymphocytes do not respond (PubMed:25332123). Neutrophils respond to EsxB by chemotaxis and primed neutrophils treated with EsxB produce reactive oxygen species (ROS); Ca(2+) release and the ROS burst via are induced by an unidentified G-protein coupled receptor (PubMed:25332123). May help regulate assembly and function of the type VII secretion system (T7SS) (PubMed:25865481). {ECO:0000269|PubMed:11940590, ECO:0000269|PubMed:17557817, ECO:0000269|PubMed:17604718, ECO:0000269|PubMed:19906174, ECO:0000269|PubMed:25332123, ECO:0000269|PubMed:25865481, ECO:0000305|PubMed:26260636}.

Family

WXG100 family, CFP-10 subfamily

GO

• protein secretion by the type VII secretion system GO:0044315 biological_process
• host cell surface binding GO:0046812 molecular_function
• host cell surface GO:0044228 cellular_component
• host cell endoplasmic reticulum GO:0044165 cellular_component
• pathogenesis GO:0009405 biological_process
• cell wall GO:0005618 cellular_component
• extracellular region GO:0005576 cellular_component
• plasma membrane GO:0005886 cellular_component

InterPro

• IPR036689
• IPR010310

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UniProt

P9WNK5

GenBank

Rv3874

EnsemblBacteria

Rv3874

Mycobrowser

Rv3874

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Rv3874 doesn't seem to be a targeted by any drug.

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Rv3874 doesn't seem to be involved in any pathway.