Gene - combatTB X

eccD1

Type: protein_coding
Name: eccD1
Locus Name: Rv3877
Product: ESX conserved component EccD1. ESX-1 type VII secretion system protein. Probable transmembrane protein.
Functional Category: None
Location: 4355007..4356542 (+ strand)
Gene Length: 1535 bp
Nucleotides: TGAGCGCACCTGCTGTTGCTGCTGGTCCTACCGCCGCGGGGGCAACCGCTGCGCGGCCTGCCACCACCCGGGTGACGATCCTGACCGGCAGACGGATGACCGATTTGGTACTGCCAGCGGCGGTGCCGATGGAAACTTATATTGACGACACCGTCGCGGTGCTTTCCGAGGTGTTGGAAGACACGCCGGCTGATGTACTCGGCGGCTTCGACTTTACCGCGCAAGGCGTGTGGGCGTTCGCTCGTCCCGGATCGCCGCCGCTGAAGCTCGACCAGTCACTCGATGACGCCGGGGTGGTCGACGGGTCACTGCTGACTCTGGTGTCAGTCAGTCGCACCGAGCGCTACCGACCGTTGGTCGAGGATGTCATCGACGCGATCGCCGTGCTTGACGAGTCACCTGAGTTCGACCGCACGGCATTGAATCGCTTTGTGGGGGCGGCGATCCCGCTTTTGACCGCGCCCGTCATCGGGATGGCGATGCGGGCGTGGTGGGAAACTGGGCGTAGCTTGTGGTGGCCGTTGGCGATTGGCATCCTGGGGATCGCTGTGCTGGTAGGCAGCTTCGTCGCGAACAGGTTCTACCAGAGCGGCCACCTGGCCGAGTGCCTACTGGTCACGACGTATCTGCTGATCGCAACCGCCGCAGCGCTGGCCGTGCCGTTGCCGCGCGGGGTCAACTCGTTGGGGGCGCCACAAGTTGCCGGCGCCGCTACGGCCGTGCTGTTTTTGACCTTGATGACGCGGGGCGGCCCTCGGAAGCGTCATGAGTTGGCGTCGTTTGCCGTGATCACCGCTATCGCGGTCATCGCGGCCGCCGCTGCCTTCGGCTATGGATACCAGGACTGGGTCCCCGCGGGGGGGATCGCATTCGGGCTGTTCATTGTGACGAATGCGGCCAAGCTGACCGTCGCGGTCGCGCGGATCGCGCTGCCGCCGATTCCGGTACCCGGCGAAACCGTGGACAACGAGGAGTTGCTCGATCCCGTCGCGACCCCGGAGGCTACCAGCGAAGAAACCCCGACCTGGCAGGCCATCATCGCGTCGGTGCCCGCGTCCGCGGTCCGGCTCACCGAGCGCAGCAAACTGGCCAAGCAACTTCTGATCGGATACGTCACGTCGGGCACCCTGATTCTGGCTGCCGGTGCCATCGCGGTCGTGGTGCGCGGGCACTTCTTTGTACACAGCCTGGTGGTCGCGGGTTTGATCACGACCGTCTGCGGATTTCGCTCGCGGCTTTACGCCGAGCGCTGGTGTGCGTGGGCGTTGCTGGCGGCGACGGTCGCGATTCCGACGGGTCTGACGGCCAAACTCATCATCTGGTACCCGCACTATGCCTGGCTGTTGTTGAGCGTCTACCTCACGGTAGCCCTGGTTGCGCTCGTGGTGGTCGGGTCGATGGCTCACGTCCGGCGCGTTTCACCGGTCGTAAAACGAACTCTGGAATTGATCGACGGCGCCATGATCGCTGCCATCATTCCCATGCTGCTGTGGATCACCGGGGTGTACGACACGGTCCGCAATATCCGGTTCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). {ECO:0000269|PubMed:14557536, ECO:0000269|PubMed:16368961, ECO:0000305|PubMed:14557547}.

Family

EccD/Snm4 family

GO

integral component of membrane GO:0016021 cellular_component
active evasion of host immune response GO:0042783 biological_process
plasma membrane GO:0005886 cellular_component
cell wall GO:0005618 cellular_component
growth of symbiont in host GO:0044117 biological_process

InterPro

UniProt: P9WNQ7
GenBank: Rv3877
EnsemblBacteria: Rv3877
Mycobrowser: Rv3877

Summary

Name: ESX-1 secretion system protein EccD1 (ESX conserved component D1) (Snm4 secretory protein) (Type VII secretion system protein EccD1) (T7SS protein EccD1)
Family: EccD/Snm4 family
Protein Sequence: MSAPAVAAGPTAAGATAARPATTRVTILTGRRMTDLVLPAAVPMETYIDDTVAVLSEVLEDTPADVLGGFDFTAQGVWAFARPGSPPLKLDQSLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRTALNRFVGAAIPLLTAPVIGMAMRAWWETGRSLWWPLAIGILGIAVLVGSFVANRFYQSGHLAECLLVTTYLLIATAAALAVPLPRGVNSLGAPQVAGAATAVLFLTLMTRGGPRKRHELASFAVITAIAVIAAAAAFGYGYQDWVPAGGIAFGLFIVTNAAKLTVAVARIALPPIPVPGETVDNEELLDPVATPEATSEETPTWQAIIASVPASAVRLTERSKLAKQLLIGYVTSGTLILAAGAIAVVVRGHFFVHSLVVAGLITTVCGFRSRLYAERWCAWALLAATVAIPTGLTAKLIIWYPHYAWLLLSVYLTVALVALVVVGSMAHVRRVSPVVKRTLELIDGAMIAAIIPMLLWITGVYDTVRNIRF
Mass: 53,999 Da
Length: 511 Aa

Rv3877 doesn't seem to be a targeted by any drug.

Rv3877 doesn't seem to be involved in any pathway.

Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.: BMC Struct Biol. 2016 Feb 27;16:5. doi: 10.1186/s12900-016-0056-6.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue.: Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12420-5. doi: 10.1073/pnas.1635213100. Epub 2003 Oct 13.
Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system.: Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13001-6. doi: 10.1073/pnas.2235593100. Epub 2003 Oct 13.
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.: Infect Immun. 2006 Jan;74(1):88-98. doi: 10.1128/IAI.74.1.88-98.2006.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis.: Cell Host Microbe. 2015 Jun 10;17(6):820-8. doi: 10.1016/j.chom.2015.05.005. Epub 2015 Jun 2.