Gene - combatTB X

Type: protein_coding
Name: espJ
Locus Name: Rv3878
Product: ESX-1 secretion-associated protein EspJ. Conserved alanine rich protein.
Functional Category: None
Location: 4356693..4357535 (+ strand)
Gene Length: 842 bp
Nucleotides: TGGCTGAACCGTTGGCCGTCGATCCCACCGGCTTGAGCGCAGCGGCCGCGAAATTGGCCGGCCTCGTTTTTCCGCAGCCTCCGGCGCCGATCGCGGTCAGCGGAACGGATTCGGTGGTAGCAGCAATCAACGAGACCATGCCAAGCATCGAATCGCTGGTCAGTGACGGGCTGCCCGGCGTGAAAGCCGCCCTGACTCGAACAGCATCCAACATGAACGCGGCGGCGGACGTCTATGCGAAGACCGATCAGTCACTGGGAACCAGTTTGAGCCAGTATGCATTCGGCTCGTCGGGCGAAGGCCTGGCTGGCGTCGCCTCGGTCGGTGGTCAGCCAAGTCAGGCTACCCAGCTGCTGAGCACACCCGTGTCACAGGTCACGACCCAGCTCGGCGAGACGGCCGCTGAGCTGGCACCCCGTGTTGTTGCGACGGTGCCGCAACTCGTTCAGCTGGCTCCGCACGCCGTTCAGATGTCGCAAAACGCATCCCCCATCGCTCAGACGATCAGTCAAACCGCCCAACAGGCCGCCCAGAGCGCGCAGGGCGGCAGCGGCCCAATGCCCGCACAGCTTGCCAGCGCTGAAAAACCGGCCACCGAGCAAGCGGAGCCGGTCCACGAAGTGACAAACGACGATCAGGGCGACCAGGGCGACGTGCAGCCGGCCGAGGTCGTTGCCGCGGCACGTGACGAAGGCGCCGGCGCATCACCGGGCCAGCAGCCCGGCGGGGGCGTTCCCGCGCAAGCCATGGATACCGGAGCCGGTGCCCGCCCAGCGGCGAGTCCGCTGGCGGCCCCCGTCGATCCGTCGACTCCGGCACCCTCAACAACCACAACGTTGTAG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Could be involved in regulation of growth and intracellular survival. {ECO:0000269|PubMed:26228622}.

Family

Unknown

GO

InterPro

Summary

Name: ESX-1 secretion-associated protein EspJ (TB27.4)
Family: Unknown
Protein Sequence: MAEPLAVDPTGLSAAAAKLAGLVFPQPPAPIAVSGTDSVVAAINETMPSIESLVSDGLPGVKAALTRTASNMNAAADVYAKTDQSLGTSLSQYAFGSSGEGLAGVASVGGQPSQATQLLSTPVSQVTTQLGETAAELAPRVVATVPQLVQLAPHAVQMSQNASPIAQTISQTAQQAAQSAQGGSGPMPAQLASAEKPATEQAEPVHEVTNDDQGDQGDVQPAEVVAAARDEGAGASPGQQPGGGVPAQAMDTGAGARPAASPLAAPVDPSTPAPSTTTTL
Mass: 27,395 Da
Length: 280 Aa

Rv3878 doesn't seem to be a targeted by any drug.

Rv3878 doesn't seem to be involved in any pathway.

RD-1 encoded EspJ protein gets phosphorylated prior to affect the growth and intracellular survival of mycobacteria.: Sci Rep. 2015 Jul 31;5:12717. doi: 10.1038/srep12717.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA.: J Bacteriol. 2010 Jan;192(1):326-35. doi: 10.1128/JB.01032-09.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.: Infect Immun. 2006 Jan;74(1):88-98. doi: 10.1128/IAI.74.1.88-98.2006.
Human T-cell responses to the RD1-encoded protein TB27.4 (Rv3878) from Mycobacterium tuberculosis.: Immunology. 2003 Dec;110(4):507-12. doi: 10.1111/j.1365-2567.2003.01763.x.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.