espL
- Type
- protein_coding
- Name
- espL
- Locus Name
-
Rv3880c
- Product
-
ESX-1 secretion-associated protein EspL
- Functional Category
-
None
- Location
- 4360199..4360546 (- strand)
- Gene Length
- 347 bp
- Nucleotides
-
GTGAGCATGGACGAATTGGACCCGCATGTCGCCCGGGCGTTGACGCTGGCGGCGCGGTTTCAGTCGGCCCTAGACGGGACGCTCAATCAGATGAACAACGGATCCTTCCGCGCCACCGACGAAGCCGAGACCGTCGAAGTGACGATCAATGGGCACCAGTGGCTCACCGGCCTGCGCATCGAAGATGGTTTGCTGAAGAAGCTGGGTGCCGAGGCGGTGGCTCAGCGGGTCAACGAGGCGCTGCACAATGCGCAGGCCGCGGCGTCCGCGTATAACGACGCGGCGGGCGAGCAGCTGACCGCTGCGTTATCGGCCATGTCCCGCGCGATGAACGAAGGAATGGCCTA
- Drug Resistance
- Mutations
- Function
- Probably plays a role in host phagosome maturation arrest (PubMed:20844580). {ECO:0000305|PubMed:20844580}.
- Family
-
Unknown
- GO
-
- cell wall GO:0005618 cellular_component
- negative regulation by symbiont of host innate immune response GO:0052170 biological_process
- plasma membrane GO:0005886 cellular_component
- InterPro
Summary
- Name
- ESX-1 secretion-associated protein EspL
- Family
- Unknown
- Protein Sequence
-
MSMDELDPHVARALTLAARFQSALDGTLNQMNNGSFRATDEAETVEVTINGHQWLTGLRIEDGLLKKLGAEAVAQRVNEALHNAQAAASAYNDAAGEQLTAALSAMSRAMNEGMA
- Mass
- 12,200 Da
- Length
- 115 Aa
Rv3880c doesn't seem to be a targeted by any drug.
Rv3880c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling.
- PLoS Pathog. 2010 Sep 9;6(9):e1001100. doi: 10.1371/journal.ppat.1001100.
- Systematic genetic nomenclature for type VII secretion systems.
- PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.