Gene - combatTB X

eccE1

Type: protein_coding
Name: eccE1
Locus Name: Rv3882c
Product: ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein.
Functional Category: None
Location: 4362032..4363420 (- strand)
Gene Length: 1388 bp
Nucleotides: ATGAGAAATCCTTTAGGGCTGCGGTTCAGCACCGGGCACGCCTTGCTTGCCTCCGCGTTGGCCCCGCCATGCATCATCGCATTCTTGGAGACGCGCTACTGGTGGGCGGGGATTGCGCTGGCCTCGTTGGGCGTCATCGTGGCCACGGTCACTTTCTACGGCCGCCGGATCACCGGCTGGGTGGCGGCGGTGTACGCGTGGTTGCGGCGGCGCCGACGGCCCCCGGATTCCTCGTCAGAACCTGTGGTCGGGGCCACCGTGAAGCCAGGAGATCACGTTGCGGTGCGCTGGCAAGGCGAGTTTCTGGTCGCCGTAATCGAGCTCATTCCCCGACCATTCACGCCGACGGTCATCGTCGACGGGCAAGCCCACACCGACGACATGCTGGACACCGGACTGGTGGAGGAGCTCCTGTCGGTGCACTGTCCCGACTTGGAGGCCGATATCGTCTCAGCCGGCTACCGCGTCGGCAATACCGCAGCGCCGGACGTGGTGAGTCTGTATCAGCAGGTGATCGGGACAGACCCGGCGCCGGCGAACCGCCGGACCTGGATCGTGCTGCGCGCCGACCCGGAACGCACCCGCAAATCGGCGCAGCGCCGCGATGAAGGCGTCGCAGGACTGGCCCGGTATTTGGTGGCGTCCGCGACGCGCATTGCCGATCGACTGGCTAGCCATGGTGTCGACGCGGTGTGTGGCCGCAGCTTCGATGACTACGACCACGCCACCGACATCGGCTTTGTGCGGGAGAAATGGTCGATGATCAAGGGGCGCGATGCCTACACTGCCGCCTACGCGGCGCCCGGAGGTCCGGATGTATGGTGGTCGGCGCGCGCGGACCACACCATCACCAGAGTCCGGGTCGCGCCGGGGATGGCCCCGCAGTCCACGGTGTTGCTGACCACGGCGGACAAGCCCAAGACACCCAGGGGCTTCGCCCGCCTATTTGGCGGGCAGCGGCCCGCGCTGCAAGGCCAGCATCTGGTGGCCAACCGCCACTGCCAGCTGCCGATCGGGTCAGCTGGGGTACTGGTCGGCGAGACGGTGAACCGATGCCCGGTCTACATGCCCTTCGACGATGTCGACATCGCCCTCAACCTGGGTGACGCTCAGACATTCACCCAGTTCGTGGTGCGTGCGGCGGCGGCAGGTGCGATGGTCACAGTCGGGCCACAGTTCGAGGAATTTGCCCGGTTGATCGGCGCACACATCGGGCAGGAGGTAAAGGTGGCGTGGCCGAATGCGACGACCTATCTCGGCCCGCATCCCGGTATTGACCGGGTGATTCTGCGGCACAATGTGATCGGTACCCCGCGGCATCGGCAGCTGCCGATTCGCCGGGTTTCCCCACCCGAGGAAAGCCGCTACCAGATGGCGCTGCCGAAGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). {ECO:0000305|PubMed:19876390}.

Family

EccE family

GO

plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

IPR021368

UniProt: P9WJE9
GenBank: Rv3882c
EnsemblBacteria: Rv3882c
Mycobrowser: Rv3882c

Summary

Name: ESX-1 secretion system protein EccE1 (ESX conserved component E1) (Type VII secretion system protein EccE1) (T7SS protein EccE1)
Family: EccE family
Protein Sequence: MRNPLGLRFSTGHALLASALAPPCIIAFLETRYWWAGIALASLGVIVATVTFYGRRITGWVAAVYAWLRRRRRPPDSSSEPVVGATVKPGDHVAVRWQGEFLVAVIELIPRPFTPTVIVDGQAHTDDMLDTGLVEELLSVHCPDLEADIVSAGYRVGNTAAPDVVSLYQQVIGTDPAPANRRTWIVLRADPERTRKSAQRRDEGVAGLARYLVASATRIADRLASHGVDAVCGRSFDDYDHATDIGFVREKWSMIKGRDAYTAAYAAPGGPDVWWSARADHTITRVRVAPGMAPQSTVLLTTADKPKTPRGFARLFGGQRPALQGQHLVANRHCQLPIGSAGVLVGETVNRCPVYMPFDDVDIALNLGDAQTFTQFVVRAAAAGAMVTVGPQFEEFARLIGAHIGQEVKVAWPNATTYLGPHPGIDRVILRHNVIGTPRHRQLPIRRVSPPEESRYQMALPK
Mass: 50,397 Da
Length: 462 Aa

Rv3882c doesn't seem to be a targeted by any drug.

Rv3882c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis.: Mol Microbiol. 2005 Sep;57(6):1653-63. doi: 10.1111/j.1365-2958.2005.04800.x.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.