mycP1
- Type
- protein_coding
- Name
- mycP1
- Locus Name
-
Rv3883c
- Product
-
Membrane-anchored mycosin MycP1 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-1)
- Functional Category
-
None
- Location
- 4363417..4364757 (- strand)
- Gene Length
- 1340 bp
- Nucleotides
-
GTGCACCGTATCTTTCTGATCACGGTGGCGCTGGCGTTGCTCACCGCGTCGCCCGCATCGGCCATCACGCCACCGCCGATCGATCCGGGCGCGTTGCCGCCCGACGTGACGGGCCCGGATCAGCCTACCGAACAGCGCGTTTTGTGCGCGTCGCCCACCACGCTGCCGGGGTCCGGGTTCCACGATCCGCCGTGGAGCAACACGTATCTGGGCGTGGCCGATGCCCACAAGTTCGCGACCGGGGCCGGGGTGACGGTGGCGGTGATCGACACCGGTGTCGACGCTTCGCCACGGGTCCCGGCGGAACCTGGCGGCGATTTCGTCGACCAGGCCGGTAACGGCCTGTCTGACTGTGATGCCCATGGGACTCTCACAGCATCCATCATCGCGGGCCGGCCCGCGCCCACCGACGGGTTCGTCGGCGTCGCGCCCGACGCTCGACTGCTCTCGCTACGTCAGACGTCTGAGGCCTTCGAACCGGTCGGCTCACAAGCCAACCCGAATGACCCCAACGCCACCCCGGCCGCCGGTTCCATCCGCAGTCTTGCCCGCGCCGTGGTGCACGCCGCCAACCTCGGCGTGGGTGTGATCAACATCAGTGAAGCCGCCTGCTACAAGGTGAGCAGGCCGATCGATGAAACCTCACTGGGTGCATCCATCGACTATGCGGTCAACGTCAAAGGCGTGGTGGTGGTGGTCGCGGCCGGCAACACCGGTGGCGATTGCGTACAGAATCCGGCGCCGGACCCGTCCACACCCGGCGACCCACGCGGCTGGAACAATGTGCAGACCGTTGTCACCCCGGCGTGGTACGCACCGCTGGTGTTAAGCGTCGGCGGTATCGGCCAGACCGGGATGCCCAGCTCGTTCTCGATGCACGGACCGTGGGTGGACGTGGCCGCGCCCGCAGAAAACATCGTCGCGCTCGGCGACACCGGTGAACCGGTGAATGCGCTGCAAGGCCGGGAGGGGCCGGTACCCATCGCCGGCACCTCGTTTGCCGCGGCATATGTGTCGGGTCTGGCGGCCCTGCTTCGGCAGCGGTTCCCCGACCTGACGCCGGCGCAGATCATCCACCGGATCACCGCCACCGCGAGACACCCCGGGGGCGGGGTCGACGACCTGGTCGGCGCCGGCGTCATCGATGCGGTGGCCGCGCTGACGTGGGACATTCCGCCCGGCCCTGCTTCGGCGCCATACAACGTCAGACGACTTCCACCCCCGGTGGTGGAGCCGGGTCCCGATCGTCGCCCGATTACGGCTGTGGCGTTGGTGGCCGTCGGCCTTACGTTGGCCCTGGGCCTGGGCGCGCTGGCTAGACGGGCGCTGAGCCGCCGATG
- Drug Resistance
- Mutations
- Function
- May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Essential for ESX-1 function, required for early replication in macrophages and full virulence in mice. {ECO:0000269|PubMed:20227664}.
- Family
-
Peptidase S8 family
- GO
-
- membrane GO:0016020 cellular_component
- integral component of membrane GO:0016021 cellular_component
- regulation of secretion GO:0051046 biological_process
- serine-type endopeptidase activity GO:0004252 molecular_function
- proteolysis GO:0006508 biological_process
- protein processing GO:0016485 biological_process
- plasma membrane GO:0005886 cellular_component
- pathogenesis GO:0009405 biological_process
- cell surface GO:0009986 cellular_component
- InterPro
Summary
- Name
- Mycosin-1 (EC 3.4.21.-) (MycP1 protease)
- Family
- Peptidase S8 family
- Protein Sequence
-
MHRIFLITVALALLTASPASAITPPPIDPGALPPDVTGPDQPTEQRVLCASPTTLPGSGFHDPPWSNTYLGVADAHKFATGAGVTVAVIDTGVDASPRVPAEPGGDFVDQAGNGLSDCDAHGTLTASIIAGRPAPTDGFVGVAPDARLLSLRQTSEAFEPVGSQANPNDPNATPAAGSIRSLARAVVHAANLGVGVINISEAACYKVSRPIDETSLGASIDYAVNVKGVVVVVAAGNTGGDCVQNPAPDPSTPGDPRGWNNVQTVVTPAWYAPLVLSVGGIGQTGMPSSFSMHGPWVDVAAPAENIVALGDTGEPVNALQGREGPVPIAGTSFAAAYVSGLAALLRQRFPDLTPAQIIHRITATARHPGGGVDDLVGAGVIDAVAALTWDIPPGPASAPYNVRRLPPPVVEPGPDRRPITAVALVAVGLTLALGLGALARRALSRR
- Mass
- 45,118 Da
- Length
- 446 Aa
Rv3883c doesn't seem to be a targeted by any drug.
Rv3883c doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence.
- Cell Host Microbe. 2010 Mar 18;7(3):210-20. doi: 10.1016/j.chom.2010.02.006.
- Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages.
- BMC Microbiol. 2002 Oct 7;2:30.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.
- The mycosins of Mycobacterium tuberculosis H37Rv: a family of subtilisin-like serine proteases.
- Gene. 2000 Aug 22;254(1-2):147-55.