Gene - combatTB X

eccA2

Type: protein_coding
Name: eccA2
Locus Name: Rv3884c
Product: ESX conserved component EccA2. ESX-2 type VII secretion system protein. Probable CbxX/CfqX family protein.
Functional Category: None
Location: 4364979..4366838 (- strand)
Gene Length: 1859 bp
Nucleotides: ATGTCGAGAATGGTGGACACGATGGGTGATTTACTCACTGCGCGCCGGCATTTCGATCGGGCGATGACGATCAAGAATGGCCAGGGATGCGTGGCGGCGTTGCCTGAGTTTGTGGCTGCCACCGAGGCCGATCCGTCGATGGCCGACGCGTGGCTGGGTCGTATCGCCTGCGGTGACCGCGATCTGGCCTCGCTTAAGCAGCTCAACGCCCATAGCGAGTGGCTGCACCGCGAGACCACGCGGATCGGCCGGACGTTGGCCGCTGAGGTCCAGCTGGGACCATCCATCGGGATCACGGTGACCGACGCATCTCAGGTGGGGCTGGCGCTGTCGTCGGCGTTGACGATCGCGGGGGAGTATGCGAAGGCCGATGCCCTGTTAGCAAACCGCGAGCTATTGGATTCGTGGCGCAACTACCAGTGGCATCAGCTGGCTCGGGCGTTCCTGATGTACGTCACGCAGCGATGGCCCGACGTGTTGTCGACGGCCGCCGAGGATCTGCCGCCACAGGCGATCGTCATGCCGGCGGTGACCGCGTCGATTTGTGCGCTGGCAGCCCACGCCGCCGCCCATCTCGGGCAGGGGCGAGTGGCCCTGGACTGGCTGGACCGGGTGGACGTGATCGGACACAGCAGGTCATCGGAGCGGTTCGGCGCCGACGTGCTCACCGCGGCGATCGGACCGGCCGATATTCCGCTGCTGGTCGCCGACTTGGCGTATGTGCGGGGGATGGTGTACCGGCAACTGCATGAGGAGGACAAGGCCCAGATCTGGCTGTCGAAGGCCACCATCAACGGGGTGCTCACCGACGCCGCCAAAGAAGCCCTGGCGGACCCGAACCTGCGCTTGATTGTTACCGATGAACGAACCATCGCCAGCCGCTCCGACCGTTGGGATGCTTCGACGGCGAAAAGCCGCGACCAGCTCGATGACGACAATGCAGCGCAGCGGCGCGGCGAGCTGCTAGCCGAGGGCCGGGAACTGCTGGCCAAACAGGTGGGCCTGGCGGCGGTCAAGCAAGCGGTATCGGCGCTGGAAGACCAACTCGAGGTGCGCATGATGCGCCTAGAGCACGGCCTACCGGTGGAGGGGCAGACCAACCACATGTTGCTGGTGGGGCCACCAGGCACAGGTAAGACAACCACCGCTGAAGCGCTCGGCAAGATCTACGCCGGCATGGGGATCGTGCGTCACCCCGAAATTCGAGAAGTTCGCCGATCGGACTTCTGTGGGCACTACATCGGGGAGTCAGGACCCAAGACGAACGAGCTGATCGAAAAGTCACTCGGGCGAATCATTTTCATGGACGAGTTCTACTCGCTGATCGAACGTCATCAAGACGGAACACCGGACATGATCGGCATGGAGGCGGTCAATCAACTCCTGGTTCAATTGGAAACACACCGATTCGACTTCTGTTTCATCGGGGCCGGCTATGAGGATCAGGTGGATGAATTCCTCACCGTGAACCCGGGTTTGGCTGGCCGGTTCAACCGAAAGCTGCGGTTCGAGTCTTATTCGCCGGTGGAGATCGTCGAGATTGGACACCGCTACGCTACACCGCGCGCCAGCCAGCTCGATGACGCCGCACGGGAGGTATTCCTCGACGCGGTCACCACCATCCGTAACTACACCACCCCTAGTGGGCAGCACGGTATCGACGCTATGCAAAACGGTCGGTTCGCCCGCAACGTGATCGAACGCGCCGAAGGGTTCCGGGACACCCGGGTGGTTGCGCAAAAACGTGCGGGCCAACCGGTATCGGTTCAGGATCTGCAGATCATCACCGCCACCGACATCGATGCCGCGATACGCAGCGTGTGCTCAGACAACCGAGACATGGCCGCGATCGTTTGGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). {ECO:0000250}.

Family

CbxX/CfxQ family

GO

ATP binding GO:0005524 molecular_function
cytoplasm GO:0005737 cellular_component
ATPase activity GO:0016887 molecular_function

InterPro

UniProt: P9WPH7
GenBank: Rv3884c
EnsemblBacteria: Rv3884c
Mycobrowser: Rv3884c

Summary

Name: ESX-2 secretion system protein EccA2 (ESX conserved component A2) (Type VII secretion system protein EccA2) (T7SS protein EccA2)
Family: CbxX/CfxQ family
Protein Sequence: MSRMVDTMGDLLTARRHFDRAMTIKNGQGCVAALPEFVAATEADPSMADAWLGRIACGDRDLASLKQLNAHSEWLHRETTRIGRTLAAEVQLGPSIGITVTDASQVGLALSSALTIAGEYAKADALLANRELLDSWRNYQWHQLARAFLMYVTQRWPDVLSTAAEDLPPQAIVMPAVTASICALAAHAAAHLGQGRVALDWLDRVDVIGHSRSSERFGADVLTAAIGPADIPLLVADLAYVRGMVYRQLHEEDKAQIWLSKATINGVLTDAAKEALADPNLRLIVTDERTIASRSDRWDASTAKSRDQLDDDNAAQRRGELLAEGRELLAKQVGLAAVKQAVSALEDQLEVRMMRLEHGLPVEGQTNHMLLVGPPGTGKTTTAEALGKIYAGMGIVRHPEIREVRRSDFCGHYIGESGPKTNELIEKSLGRIIFMDEFYSLIERHQDGTPDMIGMEAVNQLLVQLETHRFDFCFIGAGYEDQVDEFLTVNPGLAGRFNRKLRFESYSPVEIVEIGHRYATPRASQLDDAAREVFLDAVTTIRNYTTPSGQHGIDAMQNGRFARNVIERAEGFRDTRVVAQKRAGQPVSVQDLQIITATDIDAAIRSVCSDNRDMAAIVW
Mass: 68,041 Da
Length: 619 Aa

Rv3884c doesn't seem to be a targeted by any drug.

Rv3884c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Conservation of structure and protein-protein interactions mediated by the secreted mycobacterial proteins EsxA, EsxB, and EspA.: J Bacteriol. 2010 Jan;192(1):326-35. doi: 10.1128/JB.01032-09.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.