Gene - combatTB X

Type: protein_coding
Name: espG2
Locus Name: Rv3889c
Product: ESX-2 secretion-associated protein EspG2
Functional Category: None
Location: 4372800..4373630 (- strand)
Gene Length: 830 bp
Nucleotides: ATGCTGACGACGACGGTCGATGGCCTGTGGGTACTACAAGCGGTAACCGGGGTGGAACAAACCTGTCCGGAACTGGGATTACGGCCATTGTTGCCGCGGTTGGACACCGCCGAGCGGGCACTTCGCCACCCGGTGGCCGCCGAGTTGATGGCGGTGGGGGCTCTGGACCAGGCCGGTAATGCCGACCCCATGGTCCGTGAATGGCTGACCGTGCTGTTGCGACGCGACCTGGGGTTACTGGTAACGATCGGGGTGCCGGGCGGCGAACCGACGCGCGCGGCCATTTGCCGATTTGCCACCTGGTGGGTGGTCTTGGAACGCCACGGCAACCTGGTGCGGCTCTACCCGGCCGGCACCGCCAGTGACGAGGCCGGGGCCGGCGAACTCGTGGTGGGTCAGGTCGAGCGGTTGTGCGGTGTCGCTGAGGCCGCCCCGCTACGGCCGGTCACCGTCGACGCCGACGAACTACTACACGCCGTACGCGACGCCGGCACCTTGCGGTCGTATCTGCTCAGTCAGCGCCTGGACGTCGACCAGCTACAGATGGTAACCATGGCCGCCGATCCCACACGCTCCGCGCACGCCACCCTGGTGGCGCTGCAGGCAGGCGTCGGGCCGGAAAAGTCGGCGCGCATCCTGGTCGGCGATTCAACGGTGGCCATCGTGGACACTGCCGCCGGGCGCATCTGCGTCGAAAGCGTGACCTCGGGACAGCGACGTTACCAGGTCCTCTCGCCTGGATCGCGCTCTGATATCGGTGGGGCGGTGCAACGGCTCATCCGCCGCTTGCCCGCTGGTGACGAATGGTACTCATACCGGCGTGTGGTGTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. {ECO:0000250|UniProtKB:O53943}.

Family

EspG family

GO

InterPro

Summary

Name: ESX-2 secretion-associated protein EspG2
Family: EspG family
Protein Sequence: MLTTTVDGLWVLQAVTGVEQTCPELGLRPLLPRLDTAERALRHPVAAELMAVGALDQAGNADPMVREWLTVLLRRDLGLLVTIGVPGGEPTRAAICRFATWWVVLERHGNLVRLYPAGTASDEAGAGELVVGQVERLCGVAEAAPLRPVTVDADELLHAVRDAGTLRSYLLSQRLDVDQLQMVTMAADPTRSAHATLVALQAGVGPEKSARILVGDSTVAIVDTAAGRICVESVTSGQRRYQVLSPGSRSDIGGAVQRLIRRLPAGDEWYSYRRVV
Mass: 29,596 Da
Length: 276 Aa

Rv3889c doesn't seem to be a targeted by any drug.

Rv3889c doesn't seem to be involved in any pathway.

Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.