Gene - combatTB X

eccC2

Type: protein_coding
Name: eccC2
Locus Name: Rv3894c
Product: ESX conserved component EccC2. ESX-2 type VII secretion system protein. Possible membrane protein.
Functional Category: None
Location: 4376262..4380452 (- strand)
Gene Length: 4190 bp
Nucleotides: ATGTCCAAGAAAGCGTTTCCCATCAACCGCGTCAACATCGACCCGCCGAAACCCGTTCGGGTGGCTCCGAATCCGCCGATAGCTCTGCCGGAGCGCGAGCCGCGCAACATCTGGGTGATGATCGGCGTTCCCGCGTTGATCGTGGCGCTGATCGGCACCATCGTCATGCTGTACGTGTCGGGCGTGCGCAGCTTGGCCACGGGGTTCTTCCCGCTGATGGGCATCGGCGCGTTCAGCATGCTGGCGTTCTCCGGACGATTCGGTCGAGCCCGCAAGATCACCTGGGGTGAGTTGGAGAAGGGGCGTCGTCGATATCTTCGTGACCTGGACACCAACCGCGACGAAATCCAGACGGCGGTGTGTGCGCAACGTGAATGGCAGAACGCCGTGCATTCGGACCCACCCGGACTGGGCGCCATCATTGGCGGTCCGCGGATGTGGGAGCGTGGCCGCGGCGACGTCGACTTCTTAGAGGTGCGGGTGGGCACGGGTGTGCAGCACGCACCAGATTCGGTGTTGTCGGTGACCTGGCCGGACATTTCCTCCGATGAGGAGCTAGAGCCCGTGACCGGGCAGGCGCTGCGCGATTTCATCTTGGAGCAGCGCAAGATTCGCGATATCGCCAAGGTGGTGAACCTACGGTCGGCACCAGGCTTCAGCTTCGTGAGCGAGGACCTGGACCGGGTGCGGTCGCTGATGCGGTCGGTGTTGTGCTCGCTGGCGGTGTTTCACAACCCGCGTGACGTCAAGCTGATGGTGGTGACGCGCAACCGCGAGGTGTGGGCGTGGATGGTGTGGCTCCCCCACAACCTGCACGACGAGCTGTTCGATGCCTGCGGCTGGCGGCGGCTGATCTTTGCCACACCCGAGGAACTGGAGGCGGCGCTGGGAGCCGAGCTGCATATGAAGGGCAAGCGAGGCGCATGGACCCCGCCGACGGTGGCCAGCCCAACCGCGATGGGCTCGGCGCTGGAAACCGGGCAGGTCGGCGTGGATTTGGGGCCGCACCTGGTGATCGTCGACGACAACACCGGCAGCCCGGATGCGTGGGAGAGCGTGGTCGGGCAGGTCGGCAAGGCCGGGCTTACGGTGCTGCGCATCGCGTCCCGGGTGGGCACCGGTGTGGGGTTCGCCGAGGACCAGGTCTTCGAGATGGCCCAACGACATGGGGCGGCAACCGCGGTCAAGGCCGGTCGCGATGGCGCAGACGCCGATGACGACCAGCGCCCGGCGCCGCTGTTGCGGGCGCGCGGCACGTTCTTCGCGCATGCCGACCAGCTGTCCATCCACCGGGCCTACCGATATGCGCGGGCGATGGCGCGGTGGTCACCGACCAGTCGCAGCGAGGTCACCGATTCCACCAGCGGCGCGGCCGAGCTGCTGCGTTCGCTCGGCATTAGCGACCCCCGGGAATTGGATGTCGATCGGTTGTGGGCCGAGCGGCGCGGTCGCGGCGACGATCGGTGGTGTGAGATTCCGGTGGGCGCCAAACCGAACGGCGAGCTGCAGAACATCATCCTGCGCGCCAAGGACTTTGGCGGCTTCGGGTTTCACTCAGTGGTCATCGGAACCAGCGGCTCGGGCAAGTCGGAGCTCTTCTTGTCGTTGGTCTATGGGATCGCGCTGACGCACTCACCGGAAACATTCAACGTCATCTTCGTCGACATGAAATTCGAATCGGCTGCCCAGGACATCCTGGGCATCCCGCACGTGGTGGCCGCGCTATCCAACCTCGGCAAAGACGAGCGGCATCTGGCCGAGCGGATGCGCAGAGTTATCGACGGCGAGATCAAACAGCGCTACGAACTGTTCAAATCGGTAGGTGCGCGCGACGCCAACGACTACGAAGAGATTCGCCTCGCCGGACGCGATCTGCCGCCGGTGCCGGTGCTGCTGGTGATCGTCGACGAATACCTGGAGCTGTTCGCCAACCACAAAAAGTGGATTGATCTGATCATCCACATCGGTCAGGAGGGTCGCGGCGCCAACGTCTTCTTCATGCTAGGCGGTCAACGGCTGGACCTGTCGTCGCTGCAAAAGGTCAAGTCCAACATCGCGTTTCGGATTGCGCTGCGCGCTGAATCCGGTGATGACAGCCGCGAAGTGATCGGCAGCGACGCCGCCTACCATCTGCCGTCGAAGGAGAACGGTTTCGCGCTGCTCAAGGTGGGGCCGCGGGATCTGGAACCGTTCCGCTGCTTTTACCTCTCTGCGCCGTTTGTGGTGCCGAAGAAGAAAGAGGTGGCCCGAACCATCGACATGACGTTGACCCAACCCCGGCTGTACGACTGGCAGTACCAACCGCTGGATGCCGCCGACGCCGAGGCATTGGCGACCGCCGCGGCCGCCGATGCGGAACCCGACGAATTCCTCTATTACGACGACGGTTTCAAGAAGAAGAAGATCGTCGACGTGCTGCGGGAGTCGCTATACAACGTGCCGCACCGATCGCCGCGCCGGCCGTGGTTGGCGCCGCTGGAAGACCCCGAGCCGGTCGATAGGCTGGTGGCTGCGTATCGTGGCAAACCCTGGCATGTCGACTACGGTCAAAACCCGGGACTGATGTTCCCGGTGGGAGTGATGGACATCCCCGAAGAATCCCAGCAAGTGGTACACGCCGTCGACGCGCTACGCAGCAACATCATCGTGGTGGGCGCCAAGCAGCGCGGCAAGACCACAACCTTGATGGCGCTGATGTGTTCGGCGGCAACGATGTACACCCCGGAGCGAGTGACGTTCTTTTGCATCGGCGGGGCGACCATGGCCCAGATTGGGTCGCTTCCACACGTTACCGATATCGTGTCGCCCAAGGATGCCGAGGGCATCGAACGCATCTTGAGCACCATGGATGCGCTGATCGATGCGCGGGAAGAGGCGTTTCGGCGAGCCAAGATCGACATGGACGGGTTCCGCGAGCGCCGGTTCGGGATCGGCGGCGACGGGGTGGGTGGCACCGATCCCACCGACGCGTTCGGCGATGTCTTTGTGGTGCTCGACGACTACGACGACCTGTACGCCAAGGACACCCTGTTGGGGGACCGCATCATCTCGTTGAGCAGCCGCGGTCCCGAATACGGGGTGCACCTGATGTGCAGTGCCGGCGGCTGGATTCATGGGCAGCGGCAGAGCCTGCTGCAGAATGTCACGGCGCGAATTCAGTTGCGGCTGGCCGATCCCGGTGAGAGCCAGATGGGGCATTTGTCGATCGAATCGCGGGAGGCGGCGCGGCGGACGTTGAACCGCCCAGGATTTGGTTTGACGGAAAGCCTGCACGAGCTGCGAATCGGTGTTCCGGCCCTGGCCGACCCCGGTACCGGCGAGCTGGTGGGCATCACCGATGTCGGGGCGCGAATCGCCGACGTGGCCGGGGTGACCAAGCACGCAAGTCTGCAGCGGCTGCCACAGCGGGTGGAACTGTCCGCGATTGTCGAGCACGAGGCCGTCCACCAGGGCGGTGACGATCTGTCGATCGCGTTTGCGATCGGAGAGCGCCACGAGCTGGGTCCGGTGCCGATCAAGCTGCGCGAGAGCCCAGGGTTGATGATCTTAGGTCGGCAAGGCTGCGGCAAGACCACGGCGCTGGTGGCCATCGGCGAGGCGGTGATGAACCGGTTCAGCCCGCAGCAGGCGCAGCTCACGCTGATCGACCCTAAAACGGCTCCGCACGGTCTGCGAGATCTGCACGCCCCTGGGTATGTGCGCGCGTATGCCTACGACCAAGATGAAATCGACGAGGTGATCACCGAGTTGGCCCAGCAGATCTTGCTGCCGCGGTTGCCGCCCAAGGGTTTGAGCCAGGAGGAGTTGCGCGCACTCAAGCCGTGGGAAGGACCGCGGCACTTTGTGCTCATCGACGACGTGCAGGACCTGCGGCCGGCTCAGAGCTACCCACAGAAGCCGCCGGTGGGTGCGGCGCTGTGGAAGTTGATGGAACGCGCCCGCCAGGTCGGTTTGCACGTATTCAGCACGCGCAACAGCGCGAACTGGGCCACGATGCCGATGGACCCCTGGGTGAAATCCCAGACCTCGGCGAAAGTGGCCCAGTTGTATATGGATAACGATCCGCAAAACCGAATCAATCGATCGGTGCGAGCCCAAACGTTGCCGCCTGGACGAGGTCTGTTGGTCGGTGCCGACGGCGACGTCGAGGGGATTTTGGTGGGGTATCCGTCGGTGCCCGGCGAGCAGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Unknown

Family

Unknown

GO

cell wall GO:0005618 cellular_component
ATP binding GO:0005524 molecular_function
DNA binding GO:0003677 molecular_function
plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

UniProt: O05450
GenBank: Rv3894c
EnsemblBacteria: Rv3894c
Mycobrowser: Rv3894c

Summary

Name: ESX conserved component EccC2. ESX-2 type VII secretion system protein. Possible membrane protein
Family: Unknown
Protein Sequence: MSKKAFPINRVNIDPPKPVRVAPNPPIALPEREPRNIWVMIGVPALIVALIGTIVMLYVSGVRSLATGFFPLMGIGAFSMLAFSGRFGRARKITWGELEKGRRRYLRDLDTNRDEIQTAVCAQREWQNAVHSDPPGLGAIIGGPRMWERGRGDVDFLEVRVGTGVQHAPDSVLSVTWPDISSDEELEPVTGQALRDFILEQRKIRDIAKVVNLRSAPGFSFVSEDLDRVRSLMRSVLCSLAVFHNPRDVKLMVVTRNREVWAWMVWLPHNLHDELFDACGWRRLIFATPEELEAALGAELHMKGKRGAWTPPTVASPTAMGSALETGQVGVDLGPHLVIVDDNTGSPDAWESVVGQVGKAGLTVLRIASRVGTGVGFAEDQVFEMAQRHGAATAVKAGRDGADADDDQRPAPLLRARGTFFAHADQLSIHRAYRYARAMARWSPTSRSEVTDSTSGAAELLRSLGISDPRELDVDRLWAERRGRGDDRWCEIPVGAKPNGELQNIILRAKDFGGFGFHSVVIGTSGSGKSELFLSLVYGIALTHSPETFNVIFVDMKFESAAQDILGIPHVVAALSNLGKDERHLAERMRRVIDGEIKQRYELFKSVGARDANDYEEIRLAGRDLPPVPVLLVIVDEYLELFANHKKWIDLIIHIGQEGRGANVFFMLGGQRLDLSSLQKVKSNIAFRIALRAESGDDSREVIGSDAAYHLPSKENGFALLKVGPRDLEPFRCFYLSAPFVVPKKKEVARTIDMTLTQPRLYDWQYQPLDAADAEALATAAAADAEPDEFLYYDDGFKKKKIVDVLRESLYNVPHRSPRRPWLAPLEDPEPVDRLVAAYRGKPWHVDYGQNPGLMFPVGVMDIPEESQQVVHAVDALRSNIIVVGAKQRGKTTTLMALMCSAATMYTPERVTFFCIGGATMAQIGSLPHVTDIVSPKDAEGIERILSTMDALIDAREEAFRRAKIDMDGFRERRFGIGGDGVGGTDPTDAFGDVFVVLDDYDDLYAKDTLLGDRIISLSSRGPEYGVHLMCSAGGWIHGQRQSLLQNVTARIQLRLADPGESQMGHLSIESREAARRTLNRPGFGLTESLHELRIGVPALADPGTGELVGITDVGARIADVAGVTKHASLQRLPQRVELSAIVEHEAVHQGGDDLSIAFAIGERHELGPVPIKLRESPGLMILGRQGCGKTTALVAIGEAVMNRFSPQQAQLTLIDPKTAPHGLRDLHAPGYVRAYAYDQDEIDEVITELAQQILLPRLPPKGLSQEELRALKPWEGPRHFVLIDDVQDLRPAQSYPQKPPVGAALWKLMERARQVGLHVFSTRNSANWATMPMDPWVKSQTSAKVAQLYMDNDPQNRINRSVRAQTLPPGRGLLVGADGDVEGILVGYPSVPGEQ
Mass: 153,701 Da
Length: 1396 Aa

Rv3894c doesn't seem to be a targeted by any drug.

Rv3894c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.