Gene - combatTB X

eccB2

Type: protein_coding
Name: eccB2
Locus Name: Rv3895c
Product: ESX conserved component EccB2. ESX-2 type VII secretion system protein. Probable membrane protein.
Functional Category: None
Location: 4380453..4381940 (- strand)
Gene Length: 1487 bp
Nucleotides: ATGCCGCTGAGTTTGTCCAACCGCGACCAAAATTCCGGTCATCTGTTCTACAACCGGCGGCTGCGGGCGGCGACCACCCGGTTCTCGGTGCGCATGAAACACGACGACCGCAAGCAGACCGCCGCGCTGGCGTTGTCGATGGTGTTGGTGGCCATTGCCGCCGGATGGATGATGCTGCTCAACGTGCTCAAGCCCACCGGCATTGTGGGTGACTCGGCGATCATCGGGGACCGCGACTCCGGGGCACTCTACGCGCGCATCGACGGCCGGTTGTATCCGGCGCTGAACTTGACGTCCGCGCGGCTGGCCACCGGCACGGCGGGGCAGCCGACATGGGTCAAGCCCGCCGAGATCGCCAAGTATCCGACCGGGCCGCTGGTCGGCATCCCGGGCGCACCCGCGGCCATGCCGGTGAACCGGGGCGCGGTCTCGGCGTGGGCGGTGTGCGACACGGCGGGACGCCCGCGCAGCGCGGACAAGCCGGTGGTCACCTCGATCGCGGGCCCGATCACCGGCGGTGGCCGCGCCACACACCTGCGCGACGACGCCGGGCTGCTGGTGACTTTCGACGGCAGCACCTACGTGATCTGGGGTGGCAAACGCTCACAGATCGATCCGACCAACAGGGCGGTCACCTTGAGCTTGGGGCTCGACCCCGGCGTGACATCACCAATACAGATCTCACGGGCGCTCTTCGACGGGCTGCCCGCGACCGAGCCGCTGCGGGTGCCAGCGGTGCCCGAGGCGGGCACCCCGTCGACGTGGGTGCCGGGCGCTCGGGTGGGATCGGTGTTGCAGGCCCAAACCGCCGGCGGGGGCAGCCAGTTCTATGTGCTGCTGCCCGACGGGGTGCAAAAGATCAGCAGCTTCGTGGCCGATCTGCTGCGCAGCGCGAACTCCTACGGGGCGGCGGCGCCGCGGGTGGTGACCCCCGATGTGCTGGTCCACACACCGCAGGTGACCTCGCTGCCGGTGGAGTACTACCCGGCCGGGCGGCTGAATTTCGTTGACACCGCGGCGGATCCGACCACCTGCGTGTCGTGGGAGAAGGCGTCGACGGATCCACAGGCCCGGGTCGCGGTCTACAACGGGCGGGGGCTTCCGGTGCCCCCGTCGATGGACAGCCGGATCGTGCGGCTGGTACGCGATGACCGCGCCCCGGCGTCGGTGGTGGCCACCCAGGTGCTGGTGTTGCCCGGCGCGGCCAACTTCGTGACATCGACCAGCGGTGTGATCACCGCCGAGTCGCGCGAATCGTTGTTCTGGGTGTCCGGCAATGGGGTGCGATTCGGGATCGCCAACGACGAGGCGACGCTGCGGGCGCTGGGCCTGGATCCGGGTGCGGCCGTGCAGGCGCCGTGGCCGTTGCTGCGGACTTTTGCTGCGGGACCGGCTCTGTCGCGGGATGCGGCACTCTTGGCTCGCGATACTGTGCCCACCCTCGGCCAGGTGGCCATTGTGACGACAACGGCGAAGGCGGGCGCCTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

An ATPase (By similarity). {ECO:0000250|UniProtKB:P9WNR7}.

Family

EccB family

GO

ATP binding GO:0005524 molecular_function
plasma membrane GO:0005886 cellular_component
hydrolase activity GO:0016787 molecular_function
integral component of membrane GO:0016021 cellular_component

InterPro

IPR007795

UniProt: P9WNR5
GenBank: Rv3895c
EnsemblBacteria: Rv3895c
Mycobrowser: Rv3895c

Summary

Name: ESX-2 secretion system ATPase EccB2 (EC 3.6.-.-) (ESX conserved component B2) (Type VII secretion system protein EccB2) (T7SS protein EccB2)
Family: EccB family
Protein Sequence: MPLSLSNRDQNSGHLFYNRRLRAATTRFSVRMKHDDRKQTAALALSMVLVAIAAGWMMLLNVLKPTGIVGDSAIIGDRDSGALYARIDGRLYPALNLTSARLATGTAGQPTWVKPAEIAKYPTGPLVGIPGAPAAMPVNRGAVSAWAVCDTAGRPRSADKPVVTSIAGPITGGGRATHLRDDAGLLVTFDGSTYVIWGGKRSQIDPTNRAVTLSLGLDPGVTSPIQISRALFDGLPATEPLRVPAVPEAGTPSTWVPGARVGSVLQAQTAGGGSQFYVLLPDGVQKISSFVADLLRSANSYGAAAPRVVTPDVLVHTPQVTSLPVEYYPAGRLNFVDTAADPTTCVSWEKASTDPQARVAVYNGRGLPVPPSMDSRIVRLVRDDRAPASVVATQVLVLPGAANFVTSTSGVITAESRESLFWVSGNGVRFGIANDEATLRALGLDPGAAVQAPWPLLRTFAAGPALSRDAALLARDTVPTLGQVAIVTTTAKAGA
Mass: 51,587 Da
Length: 495 Aa

Rv3895c doesn't seem to be a targeted by any drug.

Rv3895c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Systematic genetic nomenclature for type VII secretion systems.: PLoS Pathog. 2009 Oct;5(10):e1000507. doi: 10.1371/journal.ppat.1000507. Epub 2009 Oct 30.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.