mutT4
- Type
- protein_coding
- Name
- mutT4
- Locus Name
-
Rv3908
- Product
-
Possible mutator protein MutT4
- Functional Category
-
None
- Location
- 4393449..4394195 (+ strand)
- Gene Length
- 746 bp
- Nucleotides
-
TGTCCGACGGCGAACAAGCCAAATCACGTCGACGCCGGGGGCGGCGCCGCGGGCGGCGCGCTGCGGCTACAGCCGAGAATCACATGGACGCCCAACCGGCCGGCGACGCCACCCCGACCCCGGCAACGGCGAAGCGGTCCCGGTCCCGCTCACCTCGTCGCGGGTCGACTCGGATGCGCACCGTGCACGAAACATCGGCTGGAGGGTTGGTCATTGACGGTATCGACGGTCCACGAGACGCGCAGGTCGCGGCTCTGATCGGCCGCGTCGACCGGCGCGGCCGGCTGCTGTGGTCGCTACCCAAGGGGCACATCGAGTTGGGCGAGACCGCCGAGCAGACCGCCATCCGCGAGGTCGCCGAGGAGACCGGCATCCGCGGCAGTGTGCTCGCCGCGCTGGGGCGCATCGACTACTGGTTCGTCACCGACGGCCGGCGGGTGCACAAGACCGTCCACCATTATTTGATGCGGTTTTTAGGCGGAGAGCTGTCCGACGAAGACCTCGAGGTAGCCGAGGTAGCCTGGGTGCCGATCCGGGAACTGCCGTCTCGACTGGCCTACGCCGACGAACGTCGACTAGCCGAGGTGGCCGACGAACTGATCGACAAGCTGCAGAGCGACGGCCCCGCCGCGCTTCCGCCGCTACCACCCAGCTCGCCTCGTCGACGGCCGCAAACGCATTCACGCGCTCGTCATGCCGATGACTCAGCACCGGGTCAGCACAACGGTCCCGGGCCGGGGCCGTGA
- Drug Resistance
- Mutations
- Function
- May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool (By similarity). In vitro has dATPase rather than 8-oxo-dGTPase activity. {ECO:0000250}.
- Family
-
Nudix hydrolase family
- GO
-
- metal ion binding GO:0046872 molecular_function
- hydrolase activity GO:0016787 molecular_function
- InterPro
Summary
- Name
- Putative mutator protein MutT4 (EC 3.6.1.-)
- Family
- Nudix hydrolase family
- Protein Sequence
-
MSDGEQAKSRRRRGRRRGRRAAATAENHMDAQPAGDATPTPATAKRSRSRSPRRGSTRMRTVHETSAGGLVIDGIDGPRDAQVAALIGRVDRRGRLLWSLPKGHIELGETAEQTAIREVAEETGIRGSVLAALGRIDYWFVTDGRRVHKTVHHYLMRFLGGELSDEDLEVAEVAWVPIRELPSRLAYADERRLAEVADELIDKLQSDGPAALPPLPPSSPRRRPQTHSRARHADDSAPGQHNGPGPGP
- Mass
- 27,171 Da
- Length
- 248 Aa
Rv3908 doesn't seem to be a targeted by any drug.
Rv3908 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Identification of Nudix hydrolase family members with an antimutator role in Mycobacterium tuberculosis and Mycobacterium smegmatis.
- J Bacteriol. 2006 Apr;188(8):3159-61. doi: 10.1128/JB.188.8.3159-3161.2006.
- Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin.
- Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7534-9. doi: 10.1073/pnas.121172498.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.