Gene - combatTB X

Rv3910

Type: protein_coding
Name: Rv3910
Locus Name: Rv3910
Product: Probable conserved transmembrane protein
Functional Category: None
Location: 4396597..4400151 (+ strand)
Gene Length: 3554 bp
Nucleotides: TGAGACCCTCCCCTGGAGAGGTGCCCACGGCATCGCAGAGGCAGCCCGAGCTGTCCGACGCGGCGCTGGTATCGCACTCCTGGGCAATGGCATTCGCGACGCTGATCAGCCGGATCACCGGCTTTGCCCGGATCGTGCTGCTGGCCGCGATCTTAGGTGCGGCGCTGGCCAGCTCGTTCTCGGTGGCCAACCAGCTGCCGAACCTGGTCGCCGCACTCGTGCTGGAGGCCACCTTCACCGCCATCTTCGTACCGGTGCTGGCCCGCGCCGAGCAGGACGACCCGGACGGCGGCGCGGCGTTCGTGCGCCGTTTGGTCACGTTGGCAACCACCCTGCTGCTGGGCGCCACCACGCTGTCGGTGCTGGCCGCGCCACTGCTTGTGCGGTTGATGCTGGGCACAAACCCACAGGTTAACGAGCCGCTGACCACGGCGTTCGCTTACCTGCTGCTACCGCAAGTCCTCGTCTACGGCCTCTCGTCGGTATTCATGGCGATCCTGAACACCCGCAATGTGTTCGGGCCGCCGGCCTGGGCGCCCGTCGTCAACAATGTCGTCGCCATCGCGACCCTAGCGGTGTATCTGGCGGTCCCCGGCGAGCTTTCAGTCGATCCGGTTCGGATGGGCAACGCCAAGCTGCTGGTGCTCGGCATCGGCACCACCGCAGGCGTGTTTGCACAGACCGCGGTGCTGCTGGTGGCCATCCGGCGCGAGCACATCAGCCTGCGCCCCCTGTGGGGAATCGATCAGCGGCTCAAGCGCTTTGGCGCGATGGCCGCCGCGATGGTGCTCTATGTGCTGATCAGCCAGCTCGGCCTGGTGGTCGGTAACCGGATCGCCAGCACGGCAGCGGCTTCCGGCCCCGCGATCTACAACTACACCTGGCTAGTGCTGATGTTGCCATTCGGCATGATCGGCGTGACGGTGCTGACCGTGGTGATGCCGCGGCTGAGCCGCAATGCCGCGGCCGACGATACCCCGGCCGTGCTCGCCGACCTGTCGCTAGCCACCAGGCTGACCATGATCACGCTGATCCCAACGGTGGCGTTCATGACGGTCGGCGGTCCGGCGATCGGTAGCGCGCTTTTTGCATACGGCAACTTCGGCGACGTTGATGCCGGGTACCTGGGGGCGGCGATCGCATTGTCGGCGTTCACGTTGATCCCCTATGCGTTAGTGCTGTTGCAGCTACGCGTGTTCTACGCCCGCGAGCAGCCGTGGACACCAATCACGATCATCGTGGTCATCACCGGCGTCAAGATCCTCGGCTCGCTGCTGGCGCCGCATATTACCGGTGATCCCCAGCTGGTCGCGGCCTATCTCGGGCTGGCTAACGGACTCGGATTTCTCGCCGGCACGATCGTCGGCTACTACATACTGCGTCGGGCCCTGCGGCCCGACGGCGGCCAGCTGATCGGCGTCGGCGAGGCGCGAACCGTCCTGGTGACCGTCGCCGCGTCGTTGCTTGCCGGACTGCTGGCACACGTGGCCGATCGGTTACTAGGGCTAAGCGAGCTGACGGCCCACGCGGGCAGCGTCGGTTCGCTGCTGCGGCTGTCGGTGCTGGCTCTCATCATGCTGCCAATTCTGGCTGCGGTCACCCTCTGCGCACGGGTGCCCGAGGCGCGGGCGGCGCTGGATGCCGTGCGAGCCCGAATCAGGAGCCGGCGCTTGAAGACCGGGCCTCAGACCCAGAATGTCTTGGATCAATCGTCTCGCCCCGGACCGGTCACGTACCCTGAGCGGAGGCGTTTGGCCCCGCCGCGGGGGAAAAGTGTGGTCCACGAGCCGATCCGGCGCAGGCCTCCGGAGCAGGTAGCCAGAGCCGGGAGAGCGAAAGGACCGGAGGTGATCGACCGCCCATCGGAGAACGCCTCGTTTGGTGCCGCGTCGGGTGCCGAGCTGCCGCGGCCCGTCGCCGACGAGCTTCAGCTCGACGCGCCAGCCGGCCGTGACCCCGGCCCCGTTTCCCGGCCGCACCCATCCGACCTGCAAAACGGCGATCTGCCCGCCGATGCGGCCCGTGGGCCGATTGCGTTCGACGCGCTCCGCGAACCGGACCGAGAATCGTCGGCCCCCCCAGATGATGTGCAGCTGGTTCCCGGCGCCCGCATCGCTAACGGCCGCTACCGCCTGCTGATCTTCCACGGGGGTGTACCACCCCTGCAGTTCTGGCAGGCGCTTGACACAGCGCTGGACCGCCAGGTGGCGCTGACCTTCGTCGACCCGCAGGGCGTCCTGCCCGACGACGTCCTCCAGGAGACCTTGTCCCGTACGTTGCGGCTCAGCCGGATCGACAAGCCCGGTGTCGCCCGAGTGCTTGACGTCGTGCACACCCGGGCCGGTGGTCTGGTAGTCGCGGAGTGGATCCGCGGCGGTTCGTTACAGGAAGTCGCCGACACCTCACCGTCGCCGGTTGGCGCCATCCGGGCGATGCAGTCCCTGGCCGCGGCCGCAGATGCTGCCCACCGCGCCGGTGTTGCGCTGTCGATCGACCATCCCAGCCGGGTGCGCGTGAGCATCGACGGCGACGTCGTGCTGGCCTACCCGGCGACCATGCCGGACGCCAACCCGCAAGACGACATCCGCGGCATCGGCGCCTCCCTGTACGCCCTGCTGGTCAACCGGTGGCCGCTGCCGGAGGCCGGCGTGCGCAGCGGGTTGGCACCCGCCGAGCGCGACACCGCTGGCCAGCCCATCGAACCCGCCGACATCGACCGTGACATCCCCTTCCAGATTTCCGCGGTGGCGGCCCGGTCGGTTCAAGGAGACGGCGGGATACGCAGCGCGTCAACGCTGTTGAATCTAATGCAGCAGGCGACCGCGGTGGCCGATCGCACCGAGGTGCTGGGACCGATCGACGAAGCACCGGTCTCCGCGGCCCCGCGCACATCCGCGCCCAACAGCGAAACCTACACCCGCCGCCGTCGCAACCTGCTGATCGGCATCGGCGCGGGTGCTGCCGTCCTCATGGTGGCCCTGCTGGTCTTGGCTTCGGTGTTGAGCCGGATATTCGGCGATGTCAGCGGCGGCCTCAACAAGGACGAACTGGGCCTCAACGCACCCACCGCGTCGACCTCGGCGGCCAGTTCGGCGCCGCCCGGCAGCGTCGTCAAACCCACCAAGGTCACGGTCTTCTCCCCCGACGGCGGCGCCGACAACCCCGGGGAGGCTGATTTGGCCATCGACGGCAATCCGGCCACTTCCTGGAAGACCGACATCTATACCGACCCCGTCCCGTTCCCTAGCTTCAAGAACGGAGTCGGTTTGATGTTGCAGCTGCCCCAGGCCACGGTGGTCGGCACCGTCGCCATCGACGTGGCCAGCACCGGCACCAAGGTGGAGATCCGCTCGGCATCCACGCCGACGCCGGCAACGCTGGAGGATACCGCCGTGTTGACTTCGGCCACCGCGCTGCGGCCCGGCCACAACACCATCTCGGTCGAGGCGGCCGCGCCCACCTCGAATCTGCTGGTGTGGATCTCTACCTTGGGAACCACCGACGGAAAGAGTCAAGCCGACATCTCGGAGATCACGATTTACGCCGCGTCCTGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Essential for cell growth and peptidoglycan synthesis. {ECO:0000269|PubMed:22275220}.

Family

MurJ/MviN family

GO

lipid translocation GO:0034204 biological_process
peptidoglycan biosynthetic process GO:0009252 biological_process
lipid-linked peptidoglycan transport GO:0015836 biological_process
extracellular region GO:0005576 cellular_component
integral component of plasma membrane GO:0005887 cellular_component
regulation of cell shape GO:0008360 biological_process
lipid-linked peptidoglycan transporter activity GO:0015648 molecular_function
plasma membrane GO:0005886 cellular_component

InterPro

UniProt: P9WJK3
GenBank: Rv3910
EnsemblBacteria: Rv3910
Mycobrowser: Rv3910

Summary

Name: Probable peptidoglycan biosynthesis protein MviN
Family: MurJ/MviN family
Protein Sequence: MRPSPGEVPTASQRQPELSDAALVSHSWAMAFATLISRITGFARIVLLAAILGAALASSFSVANQLPNLVAALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLATTLLLGATTLSVLAAPLLVRLMLGTNPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRNVFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGNAKLLVLGIGTTAGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQLGLVVGNRIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNAAADDTPAVLADLSLATRLTMITLIPTVAFMTVGGPAIGSALFAYGNFGDVDAGYLGAAIALSAFTLIPYALVLLQLRVFYAREQPWTPITIIVVITGVKILGSLLAPHITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRPDGGQLIGVGEARTVLVTVAASLLAGLLAHVADRLLGLSELTAHAGSVGSLLRLSVLALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKTGPQTQNVLDQSSRPGPVTYPERRRLAPPRGKSVVHEPIRRRPPEQVARAGRAKGPEVIDRPSENASFGAASGAELPRPVADELQLDAPAGRDPGPVSRPHPSDLQNGDLPADAARGPIAFDALREPDRESSAPPDDVQLVPGARIANGRYRLLIFHGGVPPLQFWQALDTALDRQVALTFVDPQGVLPDDVLQETLSRTLRLSRIDKPGVARVLDVVHTRAGGLVVAEWIRGGSLQEVADTSPSPVGAIRAMQSLAAAADAAHRAGVALSIDHPSRVRVSIDGDVVLAYPATMPDANPQDDIRGIGASLYALLVNRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIPFQISAVAARSVQGDGGIRSASTLLNLMQQATAVADRTEVLGPIDEAPVSAAPRTSAPNSETYTRRRRNLLIGIGAGAAVLMVALLVLASVLSRIFGDVSGGLNKDELGLNAPTASTSAASSAPPGSVVKPTKVTVFSPDGGADNPGEADLAIDGNPATSWKTDIYTDPVPFPSFKNGVGLMLQLPQATVVGTVAIDVASTGTKVEIRSASTPTPATLEDTAVLTSATALRPGHNTISVEAAAPTSNLLVWISTLGTTDGKSQADISEITIYAAS
Mass: 123,564 Da
Length: 1184 Aa

Rv3910 doesn't seem to be a targeted by any drug.

Rv3910 doesn't seem to be involved in any pathway.

A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.: Sci Signal. 2012 Jan 24;5(208):ra7. doi: 10.1126/scisignal.2002525.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.