Gene - combatTB X

Rv3912

Type: protein_coding
Name: Rv3912
Locus Name: Rv3912
Product: Hypothetical alanine rich protein
Functional Category: Conserved hypotheticals
Location: 4400870..4401634 (+ strand)
Gene Length: 764 bp
Nucleotides: TGAGTGCAGCCGACAAGGATCCAGACAAACATAGCGCCGATGCGGACCCGCCGCTGACCGTTGAGCTGCTGGCCGACCTGCAAGCAGGTCTGCTGGACGACGCAACCGCCGCCCGCATCCGCAGCCGGGTCCGCTCAGACCCGCAGGCTCAGCAAATCCTGCGCGCGTTGAACCGGGTACGCCGCGATGTCGCCGCGATGGGTGCCGACCCCGCTTGGGGGCCAGCTGCTCGCCCAGCGGTCGTCGACAGCATTTCGGCGGCCTTACGGTCGGCGCGCCCGAACAGCTCACCCGGCGCCGCTCACGCCGCCCGTCCGCACGTCCACCCCGTCCGAATGATCGCCGGCGCGGCCGGATTGTGCGCCGTGGCCACAGCGATCGGTGTCGGCGCCGTGGTCGATGCACCGCCACCCGCACCGAGTGCACCGACAACCGCGCAGCACATCACGGTGTCAAAACCTGCCCCGGTGATTCCGCTGTCTCGGCCGCAGGTTCTCGACCTGCTTCACCACACCCCGGACTATGGCCCACCCGGAGGCCCGCTGGGCGATCCGTCCCGGCGTACGTCCTGCCTGAGCGGCCTCGGCTATCCGGCGTCCACGCCGGTGCTGGGCGCGCAGCCGATCGATATCGACGCTCGGCCCGCCGTACTGCTGGTGATACCCGCGGACACGCCCGACAAACTGGCCGTTTTTGCGGTCGCGCCGCACTGCAGCGCCGCCGATACCGGGTTGTTGGCTAGCACCGTGGTCCCCCGCGCATGA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigM. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor (By similarity). {ECO:0000250}.

Family

Unknown

GO

plasma membrane GO:0005886 cellular_component
integral component of membrane GO:0016021 cellular_component

InterPro

Unknown

UniProt: P9WJ65
GenBank: Rv3912
EnsemblBacteria: Rv3912
Mycobrowser: Rv3912

Summary

Name: Anti-sigma-M factor RsmA (Regulator of SigM) (Sigma-M anti-sigma factor RsmA)
Family: Unknown
Protein Sequence: MSAADKDPDKHSADADPPLTVELLADLQAGLLDDATAARIRSRVRSDPQAQQILRALNRVRRDVAAMGADPAWGPAARPAVVDSISAALRSARPNSSPGAAHAARPHVHPVRMIAGAAGLCAVATAIGVGAVVDAPPPAPSAPTTAQHITVSKPAPVIPLSRPQVLDLLHHTPDYGPPGGPLGDPSRRTSCLSGLGYPASTPVLGAQPIDIDARPAVLLVIPADTPDKLAVFAVAPHCSAADTGLLASTVVPRA
Mass: 25,769 Da
Length: 254 Aa

Rv3912 doesn't seem to be a targeted by any drug.

Rv3912 doesn't seem to be involved in any pathway.

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.