Rv3915
- Type
- protein_coding
- Name
- Rv3915
- Locus Name
-
Rv3915
- Product
-
Probable peptidoglycan hydrolase
- Functional Category
-
None
- Location
- 4403192..4404412 (+ strand)
- Gene Length
- 1220 bp
- Nucleotides
-
TGCCGAGTCCGCGCCGCGAAGACGGCGATGCGCTGCGCTGTGGCGACCGCAGTGCGGCCGTCACCGAGATCCGGGCTGCGCTGACCGCGTTAGGGATGCTGGATCATCAGGAAGAAGACCTGACGACGGGCCGTAACGTCGCCCTTGAGTTGTTCGACGCGCAGCTCGACCAGGCGGTCCGTGCCTTCCAACAGCATCGCGGCCTGCTGGTGGACGGCATCGTCGGTGAGGCCACCTACCGCGCGTTGAAAGAAGCCTCCTACCGGCTCGGGGCCCGCACGCTGTACCACCAATTCGGCGCCCCGCTCTACGGGGACGACGTCGCTACACTGCAGGCCCGGCTGCAGGATCTTGGTTTCTACACCGGGCTGGTCGACGGTCATTTCGGGTTGCAGACCCACAATGCGTTGATGTCCTATCAGCGTGAGTACGGACTTGCCGCAGACGGTATCTGCGGCCCAGAAACGTTGCGCTCCTTGTACTTTCTAAGTTCGCGAGTCAGCGGTGGCTCGCCACATGCGATTCGCGAAGAAGAGCTGGTCCGCAGCTCGGGGCCGAAGCTGTCTGGCAAACGGATCATCATTGATCCCGGTCGCGGCGGCGTGGACCACGGACTTATCGCGCAAGGTCCGGCTGGGCCCATCAGCGAAGCAGACTTGTTGTGGGACTTGGCAAGTCGGCTCGAAGGACGGATGGCAGCTATCGGTATGGAGACCCACCTGTCCCGTCCGACCAACCGTAGTCCGTCCGACGCAGAGCGTGCCGCCACCGCCAACGCCGTTGGCGCAGACCTGATGATCAGCCTGCGCTGCGAGACCCAGACCAGTCTCGCGGCCAACGGCGTGGCTTCCTTTCACTTCGGCAACTCGCACGGCTCGGTGTCTACCATCGGCCGCAATCTTGCCGATTTCATTCAACGAGAAGTGGTGGCGCGCACCGGTTTACGGGATTGCCGTGTGCATGGTCGAACGTGGGATCTGTTGCGGCTGACCAGGATGCCGACCGTTCAGGTCGATATCGGCTACATCACCAACCCCCACGATCGTGGGATGCTGGTCTCAACGCAGACGCGCGATGCCATCGCCGAAGGCATTCTCGCCGCGGTCAAACGGCTGTATCTGTTAGGCAAGAACGATCGGCCCACCGGCACATTCACTTTCGCCGAGTTGCTGGCCCACGAACTGTCTGTCGAGCGAGCGGGTAGACTCGGCGGTTCTTAA
- Drug Resistance
- Mutations
- Function
- Cell-wall hydrolase that hydrolyzes the amide bond between N-acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to lyse whole mycobacteria, release peptidoglycan from the cell wall of M.luteus and M.smegmatis, and cleave N-acetylmuramoyl-L-alanyl-D-isoglutamine, releasing free N-acetylmuramic acid and dipeptide. {ECO:0000269|PubMed:15680239}.
- Family
-
N-acetylmuramoyl-L-alanine amidase 3 family
- GO
-
- cell wall macromolecule catabolic process GO:0016998 biological_process
- periplasmic space GO:0042597 cellular_component
- N-acetylmuramoyl-L-alanine amidase activity GO:0008745 molecular_function
- peptidoglycan catabolic process GO:0009253 biological_process
- cell wall organization GO:0071555 biological_process
- InterPro
Summary
- Name
- N-acetylmuramoyl-L-alanine amidase CwlM (EC 3.5.1.28) (Peptidoglycan hydrolase CwlM)
- Family
- N-acetylmuramoyl-L-alanine amidase 3 family
- Protein Sequence
-
MPSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTGRNVALELFDAQLDQAVRAFQQHRGLLVDGIVGEATYRALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGFYTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSLYFLSSRVSGGSPHAIREEELVRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEADLLWDLASRLEGRMAAIGMETHLSRPTNRSPSDAERAATANAVGADLMISLRCETQTSLAANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRVHGRTWDLLRLTRMPTVQVDIGYITNPHDRGMLVSTQTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERAGRLGGS
- Mass
- 43,912 Da
- Length
- 406 Aa
Rv3915 doesn't seem to be a targeted by any drug.
Rv3915 doesn't seem to be involved in any pathway.
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
- Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
- Identification of a novel peptidoglycan hydrolase CwlM in Mycobacterium tuberculosis.
- Biochim Biophys Acta. 2005 Feb 14;1747(1):57-66. doi: 10.1016/j.bbapap.2004.09.021. Epub 2004 Nov 11.
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
- Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.