Gene - combatTB X

parB

Type: protein_coding
Name: parB
Locus Name: Rv3917c
Product: Probable chromosome partitioning protein ParB
Functional Category: None
Location: 4405457..4406491 (- strand)
Gene Length: 1034 bp
Nucleotides: ATGACCCAGCCGTCACGCAGAAAGGGTGGCCTCGGCCGTGGCCTGGCTGCGCTGATCCCGACTGGCCCGGCAGACGGAGAATCGGGGCCACCGACCTTGGGTCCCCGGATGGGATCTGCCACGGCAGATGTCGTAATCGGCGGACCGGTCCCGGACACTTCCGTGATGGGCGCCATCTATCGGGAAATCCCACCGAGCGCCATCGAGGCTAATCCCCGTCAGCCGCGTCAGGTGTTCGACGAAGAGGCACTGGCCGAGTTGGTGCACTCCATCCGCGAATTCGGTCTCCTGCAGCCGATCGTGGTGCGGTCATTGGCTGGATCCCAAACCGGCGTGCGCTACCAGATAGTGATGGGGGAGCGGCGCTGGCGGGCTGCCCAAGAGGCGGGCTTGGCCACCATCCCGGCCATCGTGCGTGAGACCGGCGACGATAATCTGCTGCGCGACGCCCTCCTGGAAAATATTCATCGAGTACAGCTGAATCCGTTAGAAGAAGCGGCGGCATACCAGCAATTGCTCGACGAATTCGGGGTCACCCACGATGAACTGGCGGCGCGCATCGGCCGCTCGCGGCCCTTGATCACCAACATGATCCGATTGCTCAAACTCCCCATCCCGGTACAGCGGCGAGTGGCCGCCGGCGTGCTGTCGGCCGGGCATGCTCGCGCCCTGCTGTCGCTCGAGGCCGGACCGGAGGCGCAAGAGGAGCTGGCGAGCCGGATCGTCGCGGAGGGCCTGTCGGTGCGAGCCACCGAGGAGACGGTCACGCTGGCCAATCACGAGGCCAATCGCCAAGCCCATCACAGCGACGCGACTACACCCGCGCCGCCGCGGCGTAAGCCGATTCAGATGCCTGGCCTCCAAGATGTTGCTGAGCGTCTATCGACCACCTTTGACACGCGGGTGACCGTCAGTCTGGGCAAACGCAAGGGTAAGATTGTGGTGGAGTTCGGCTCGGTCGATGATTTAGCGCGCATAGTCGGTTTGATGACCACTGATGGCCGAGATAAAGGCCTGCACAGGGACGCTCTGTA
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity). {ECO:0000250}.

Family

ParB family

GO

chromosome segregation GO:0007059 biological_process
positive regulation of sporulation resulting in formation of a cellular spore GO:0045881 biological_process
chromosome GO:0005694 cellular_component
extracellular region GO:0005576 cellular_component
DNA binding GO:0003677 molecular_function
plasma membrane GO:0005886 cellular_component
cell pole GO:0060187 cellular_component

InterPro

UniProt: P9WIJ9
GenBank: Rv3917c
EnsemblBacteria: Rv3917c
Mycobrowser: Rv3917c

Summary

Name: Probable chromosome-partitioning protein ParB
Family: ParB family
Protein Sequence: MTQPSRRKGGLGRGLAALIPTGPADGESGPPTLGPRMGSATADVVIGGPVPDTSVMGAIYREIPPSAIEANPRQPRQVFDEEALAELVHSIREFGLLQPIVVRSLAGSQTGVRYQIVMGERRWRAAQEAGLATIPAIVRETGDDNLLRDALLENIHRVQLNPLEEAAAYQQLLDEFGVTHDELAARIGRSRPLITNMIRLLKLPIPVQRRVAAGVLSAGHARALLSLEAGPEAQEELASRIVAEGLSVRATEETVTLANHEANRQAHHSDATTPAPPRRKPIQMPGLQDVAERLSTTFDTRVTVSLGKRKGKIVVEFGSVDDLARIVGLMTTDGRDKGLHRDAL
Mass: 37,018 Da
Length: 344 Aa

Rv3917c doesn't seem to be a targeted by any drug.

Rv3917c doesn't seem to be involved in any pathway.

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.: BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.