Gene - combatTB X

Rv3921c

Type: protein_coding
Name: Rv3921c
Locus Name: Rv3921c
Product: Probable conserved transmembrane protein
Functional Category: None
Location: 4408969..4410069 (- strand)
Gene Length: 1100 bp
Nucleotides: GTGAGTCTTTTGTTTGATTTCTTCAGTCTCGACTTCATCTACTACCCGGTGTCGTGGATCATGTGGGTTTGGTACCGGCTGTTCGCGTTTGTGCTAGGACCATCCAACTTCTTCGCCTGGGCGTTGTCGGTGATGTTCCTGGTCTTCACGCTGCGTGCGCTGCTGTACAAGCCGTTCGTGCGCCAGATTCGCACCACCAGGCAGATGCAGGAACTGCAACCACAGATCAAGGCCTTGCAAAAGAAATACGGCAAGGATCGTCAGCGGATGGCGCTCGAAATGCAAAAGCTGCAACGCGAGCACGGCTTCAACCCCATTCTCGGATGTTTGCCGATGCTGGCGCAGATTCCGGTGTTTCTTGGGCTCTATCATGTGTTGCGCTCGTTTAACCGTACGACCGGGGGCTTTGGTCAACCACACTTGTCGGTGATCGAGAACCGACTGACTGGGAACTACGTCTTTAGCCCGGTCGACGTCGGCCACTTCCTAGATGCCAACTTGTTCGGCGCTCCGATCGGGGCGTACATGACGCAACGGTCCGGGTTGGATGCGTTCGTCGATTTCAGTCGCCCTGCGTTGATCGCGGTGGGTGTGCCGGTGATGATCTTGGCCGGCATCGCGACGTACTTCAACAGTCGCGCGTCTATCGCGCGGCAGAGCGCCGAGGCGGCTGCGAATCCACAGACCGCGATGATGAACAAGCTGGCGCTGTACGTATTTCCGCTCGGCGTAGTCGTCGGCGGACCGTTCCTGCCACTGGCGATCATCTTGTATTGGTTCTCGAACAATATCTGGACGTTCGGGCAGCAGCATTACGTCTTCGGCATGATCGAAAAGGAGGAGGAGGCCAAAAAGCAGGAGGCGGTCCGGCGCCGGGCGGCCAACGCGCCGGCCCCGGGAGCTAAGCCCAAGCGGAGCCCGAAGACCGCTCCAGCGACCAATGCGGCAGCCCCAACAGAAGCCGGGGACACCGATGACGGGGCAGAGTCGGACGCCAGCACTGAGCGACCAGCCGACACGTCCAATCCGGCCAGACGCAACAGCGGCCCGAGCGCCCGTACGCCGCGGCCCGGGGTGCGACCGAAAAAACGCAAACGTTG
Drug Resistance: Check for drug resistance association at TBDREAMDB
Mutations: Check for mutants available at TARGET

Function

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity). {ECO:0000250}.

Family

OXA1/ALB3/YidC family, Type 1 subfamily

GO

protein insertion into membrane GO:0051205 biological_process
integral component of plasma membrane GO:0005887 cellular_component
protein transport GO:0015031 biological_process
membrane insertase activity GO:0032977 molecular_function

InterPro

UniProt: P9WIT5
GenBank: Rv3921c
EnsemblBacteria: Rv3921c
Mycobrowser: Rv3921c

Summary

Name: Membrane protein insertase YidC (Foldase YidC) (Membrane integrase YidC) (Membrane protein YidC)
Family: OXA1/ALB3/YidC family, Type 1 subfamily
Protein Sequence: MSLLFDFFSLDFIYYPVSWIMWVWYRLFAFVLGPSNFFAWALSVMFLVFTLRALLYKPFVRQIRTTRQMQELQPQIKALQKKYGKDRQRMALEMQKLQREHGFNPILGCLPMLAQIPVFLGLYHVLRSFNRTTGGFGQPHLSVIENRLTGNYVFSPVDVGHFLDANLFGAPIGAYMTQRSGLDAFVDFSRPALIAVGVPVMILAGIATYFNSRASIARQSAEAAANPQTAMMNKLALYVFPLGVVVGGPFLPLAIILYWFSNNIWTFGQQHYVFGMIEKEEEAKKQEAVRRRAANAPAPGAKPKRSPKTAPATNAAAPTEAGDTDDGAESDASTERPADTSNPARRNSGPSARTPRPGVRPKKRKR
Mass: 40,916 Da
Length: 366 Aa

Rv3921c doesn't seem to be a targeted by any drug.

Bacterial secretion system mtu03070
mtu03070
Environmental Information Processing; Membrane transport

Protein export mtu03060
mtu03060
Genetic Information Processing; Folding, sorting and degradation

Quorum sensing mtu02024
mtu02024
Cellular Processes; Cellular community - prokaryotes

Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.: Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.: Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159.