Showing 50 results for "P9WML5"

Putative phenylalanine aminotransferase (EC 2.6.1.-)

Protein
May catalyze the transamination reaction in phenylalanine biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01513}..
P9WML5

UPF0182 protein Rv0064

Protein
Unknown.
P9WFL5

Probable ribonucleotide transport ATP-binding protein mkl

Protein
Not known, could be involved in the transport of ribonucleotides..
P9WQL5

Protein Rv1269c

Protein
Unknown.
P9WM45

Phosphoribosyl isomerase A (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase) (EC 5.3.1.16) (N-(5'-phosphoribosyl)anthranilate isomerase) (PRAI) (EC 5.3.1.24) (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase)

Protein
Involved in both the histidine and tryptophan biosynthetic pathways..
P9WMM5

Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol-phosphate transaminase)

Protein
Unknown.
P9WML7

Probable sensor histidine kinase pdtaS (EC 2.7.13.3)

Protein
Member of the two-component regulatory system pdtaR/pdtaS. Autophosphorylates, probably on a histidine residue, and transfers its phosphate group to pdtaR. {ECO:0000269|PubMed:16026786}..
P9WGL5

4-hydroxy-2-oxovalerate aldolase (HOA) (EC 4.1.3.39) (4-hydroxy-2-keto-pentanoic acid aldolase) (4-hydroxy-2-oxopentanoate aldolase)

Protein
Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds. {ECO:0000255|HAMAP-Rule:MF_01656}..
P9WMK5

Uncharacterized protein Rv0080

Protein
Unknown.
P9WMA5

Uncharacterized HIT-like protein Rv0759c

Protein
Unknown.
P9WML3

Delta-aminolevulinic acid dehydratase (ALAD) (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase)

Protein
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). {ECO:0000250}..
P9WMP5

HTH-type transcriptional regulator Mce2R

Protein
Negatively regulates the expression of its operon as well as expression of end (endonuclease 4). {ECO:0000269|PubMed:19027363}..
P9WMG5

Putative glycosyltransferases (EC 2.4.-.-)

Protein
May play only a redundant role in maintaining cell wall viability and bacterial virulence. {ECO:0000269|PubMed:18585090}..
P9WMX5

Uncharacterized HTH-type transcriptional regulator Rv1255c

Protein
Unknown.
P9WMD5

Uncharacterized HIT-like protein Rv1262c

Protein
Unknown.
P9WML1

Protein Rv2204c

Protein
Unknown.
P9WMN5

Uncharacterized protein Rv0085

Protein
Unknown.
P9WM75

Uncharacterized protein Rv0049

Protein
Unknown.
P9WM85

Uncharacterized protein Rv0560c

Protein
Unknown.
P9WKL5

GDP-mannose-dependent alpha-mannosyltransferase (EC 2.4.1.-) (Guanosine diphosphomannose-dependent alpha-mannosyltransferase)

Protein
Catalyzes the addition of a mannose residue from GDP-D-mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D-mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)-glycerol(ManGlcAGroAc2). {ECO:0000269|PubMed:19395496}..
P9WMY5

Uncharacterized protein Rv1148c

Protein
Unknown.
P9WM55

Transcription-repair-coupling factor (TRCF) (EC 3.6.4.-)

Protein
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site. {ECO:0000255|HAMAP-Rule:MF_00969}..
P9WMQ5

Uncharacterized protein Rv1352

Protein
Unknown.
P9WM15

Uncharacterized GMC-type oxidoreductase Rv1279 (EC 1.1.-.-)

Protein
Unknown.
P9WMV5

Transcriptional regulator BlaI

Protein
Transcription regulator that binds to an inverted DNA repeat with the consensus sequence 5'-TAC[GT]AC-NNNNN-GT[AC]GTA-3' and regulates genes involved in antibiotic transport, detoxification and cell wall function. Also regulates its own transcription. Binds DNA as a dimer. {ECO:0000269|PubMed:19154333}..
P9WMJ5

Phosphatidyl-myo-inositol mannosyltransferase (EC 2.4.1.345) (Alpha-mannosyltransferase) (GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase) (Guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase) (Phosphatidylinositol alpha-mannosyltransferase) (PI alpha-mannosyltransferase)

Protein
Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1) (PubMed:15939292). PimA plays an essential role for growth in macrophages and during both the acute and chronic phases of infection (PubMed:25049093). {ECO:0000269|PubMed:15939292, ECO:0000269|PubMed:25049093}..
P9WMZ5

Steroid C26-monooxygenase (EC 1.14.15.28) (Cholest-4-en-3-one C26-monooxygenase) (Cholest-4-en-3-one C26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]) (Cholesterol C26-monooxygenase) (Cholesterol C26-monooxygenase [(25R)-3beta-hydroxycholest-5-en-26-oate forming]) (Cytochrome P450 142) (Steroid C27-monooxygenase)

Protein
Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection (PubMed:20843794). Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate (PubMed:20843794, PubMed:20889498). In vitro, Cyp142 catalyzes with equal preference the oxidation of both (25R)- and (25S)-26-hydroxycholest-4-en-3-one diastereomers to the corresponding carboxylic acid which is a prerequisite for entry into the beta-oxidation pathway (PubMed:20843794). Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one (PubMed:20843794). {ECO:0000269|PubMed:20843794, ECO:0000269|PubMed:20889498, ECO:0000269|PubMed:25210044}..
P9WPL5

Protein GrpE (HSP-70 cofactor)

Protein
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. {ECO:0000255|HAMAP-Rule:MF_01151}..
P9WMT5

Uncharacterized protein Rv0100

Protein
Unknown.
P9WM65

Uncharacterized protein Rv1332

Protein
Unknown.
P9WM25

Uncharacterized protein Rv1290c

Protein
Unknown.
P9WM35

HTH-type transcriptional regulator Cmr

Protein
Positively regulates the expression of at least groEL2. Cyclic AMP does not affect transcription in vitro. {ECO:0000269|PubMed:22464736}..
P9WMH5

Uncharacterized HTH-type transcriptional regulator Rv1985c

Protein
Unknown.
P9WMF5

UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase)

Protein
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). {ECO:0000250}..
P9WJL5

Uncharacterized HTH-type transcriptional regulator Rv2250c

Protein
Unknown.
P9WMC5

Phosphatidylinositol mannoside acyltransferase (PIM acyltransferase) (EC 2.3.1.265)

Protein
Catalyzes the acylation to the position 6 of the alpha-1,2-linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1). {ECO:0000269|PubMed:12851411}..
P9WMB5

HTH-type transcriptional repressor SmtB

Protein
Transcriptional regulator involved in zinc homeostasis. Represses the expression of the smtB-zur operon in the absence of zinc. Could act as the metal sensor that controls the expression of zur in response to zinc availability. {ECO:0000269|PubMed:16077132}..
P9WMI5

Pantothenate synthetase (PS) (EC 6.3.2.1) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme)

Protein
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. {ECO:0000269|PubMed:11669627}..
P9WIL5

Uncharacterized protein Rv0030

Protein
Unknown.
P9WM95

Phosphoribosylformylglycinamidine synthase subunit PurQ (FGAM synthase) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase subunit I) (FGAR amidotransferase I) (FGAR-AT I) (Glutaminase PurQ) (EC 3.5.1.2) (Phosphoribosylformylglycinamidine synthase subunit I)

Protein
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. {ECO:0000255|HAMAP-Rule:MF_00421}..
P9WHL5

Probable ATP-dependent helicase DinG homolog (EC 3.6.4.12)

Protein
Probable helicase involved in DNA repair and perhaps also replication. {ECO:0000250}..
P9WMR5

Decaprenyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.35) (Decaprenyl-phosphate GlcNAc-1-phosphate transferase) (Decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase) (UDP-GlcNAc:decaprenyl-phosphate GlcNAc-1-phosphate transferase)

Protein
Involved in the biosynthesis of the disaccharide D-N-acetylglucosamine-L-rhamnose which plays an important role in the mycobacterial cell wall as a linker connecting arabinogalactan and peptidoglycan via a phosphodiester linkage. Catalyzes the transfer of the N-acetylglucosamine-1-phosphate (GlcNAc-1P) moiety from UDP-GlcNAc onto the carrier lipid decaprenyl phosphate (C50-P), yielding GlcNAc-pyrophosphoryl-decaprenyl (GlcNAc-PP-C50). {ECO:0000269|PubMed:20637039}..
P9WMW5

Uncharacterized protein Rv1359

Protein
Unknown.
P9WM05

Putative gluconeogenesis factor

Protein
Required for morphogenesis under gluconeogenic growth conditions. {ECO:0000255|HAMAP-Rule:MF_00973}..
P9WMU5

Uncharacterized HTH-type transcriptional regulator Rv1830

Protein
Unknown.
P9WME5

Imidazoleglycerol-phosphate dehydratase (IGPD) (EC 4.2.1.19)

Protein
Unknown.
P9WML9

Uncharacterized protein Rv2011c

Protein
Unknown.
P9WLM5

Uncharacterized protein Rv2075c

Protein
Unknown.
P9WLL5

Phosphatase Rv3376 (EC 3.1.-.-)

Protein
Able to hydrolyze geranyl diphosphate (GPP), farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) to respectively yield geraniol, farnesol and geranylgeraniol. {ECO:0000269|PubMed:21228491}..
P9WMS5

Probable arabinosyltransferase C (EC 2.4.2.-)

Protein
Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan..
P9WNL5