Showing 50 results for "P9WNL5"

Probable arabinosyltransferase C (EC 2.4.2.-)

Protein
Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan..
P9WNL5

ESAT-6-like protein EsxL

Protein
Induces apoptosis of host cells. {ECO:0000269|PubMed:25242740}..
P9WNJ5

UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase)

Protein
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). {ECO:0000250}..
P9WJL5

DNA ligase B (LigB) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])

Protein
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. {ECO:0000255|HAMAP-Rule:MF_00407, ECO:0000269|PubMed:14985346}..
P9WNV5

Error-prone DNA polymerase (EC 2.7.7.7)

Protein
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. Does not appear to be essential for chromosomal replication. May be involved in generating antibiotic resistance. {ECO:0000269|PubMed:12705867}..
P9WNT5

Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehyde dehydrogenase)

Protein
Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate (PubMed:15752328). Is essential for the growth and pathogenicity of M.tuberculosis, and for the generation of the bacterial cell wall (PubMed:26437401). {ECO:0000269|PubMed:15752328, ECO:0000269|PubMed:26437401}..
P9WNX5

Ferritin BfrB (EC 1.16.3.1) (Non-heme ferritin Ftn) (Nox19)

Protein
Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe(2+) ions into Fe(3+) ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex. {ECO:0000269|PubMed:21494619}..
P9WNE5

4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase (EC 3.7.1.17) (2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase) (HOPDA hydrolase) (EC 3.7.1.8) (Meta-cleavage product hydrolase) (MCP hydrolase)

Protein
Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid (HOPODA). {ECO:0000269|PubMed:19875455}..
P9WNH5

Pantothenate synthetase (PS) (EC 6.3.2.1) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme)

Protein
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. {ECO:0000269|PubMed:11669627}..
P9WIL5

UPF0182 protein Rv0064

Protein
Unknown.
P9WFL5

Probable glycerol-3-phosphate dehydrogenase 2 [NAD(P)+] (EC 1.1.1.94) (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 2)

Protein
Unknown.
P9WN75

Probable ribonucleotide transport ATP-binding protein mkl

Protein
Not known, could be involved in the transport of ribonucleotides..
P9WQL5

1,4-dihydroxy-2-naphthoyl-CoA synthase (DHNA-CoA synthase) (EC 4.1.3.36)

Protein
Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA). {ECO:0000255|HAMAP-Rule:MF_01934, ECO:0000269|PubMed:12909628}..
P9WNP5

Glycine cleavage system H protein

Protein
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. {ECO:0000255|HAMAP-Rule:MF_00272}..
P9WN55

Malonyl CoA-acyl carrier protein transacylase (MCT) (EC 2.3.1.39)

Protein
Unknown.
P9WNG5

Probable sensor histidine kinase pdtaS (EC 2.7.13.3)

Protein
Member of the two-component regulatory system pdtaR/pdtaS. Autophosphorylates, probably on a histidine residue, and transfers its phosphate group to pdtaR. {ECO:0000269|PubMed:16026786}..
P9WGL5

ESX-2 secretion system ATPase EccB2 (EC 3.6.-.-) (ESX conserved component B2) (Type VII secretion system protein EccB2) (T7SS protein EccB2)

Protein
An ATPase (By similarity). {ECO:0000250|UniProtKB:P9WNR7}..
P9WNR5

Putative acyl-[acyl-carrier-protein] desaturase DesA2 (Putative acyl-ACP desaturase DesA2) (EC 1.14.19.-)

Protein
May be a desaturase involved in mycobacterial fatty acid biosynthesis. {ECO:0000305|PubMed:14559907}..
P9WNZ5

Bifunctional enzyme CysN/CysC [Includes: Sulfate adenylyltransferase subunit 1 (EC 2.7.7.4) (ATP-sulfurylase large subunit) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (APS kinase) (ATP adenosine-5'-phosphosulfate 3'-phosphotransferase)]

Protein
ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity. {ECO:0000250}.; FUNCTION: APS kinase catalyzes the synthesis of activated sulfate. {ECO:0000250}..
P9WNM5

Cell division protein FtsZ

Protein
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. {ECO:0000255|HAMAP-Rule:MF_00909}..
P9WN95

Probable enoyl-CoA hydratase echA14 (EC 4.2.1.17)

Protein
Could possibly oxidize fatty acids using specific components. {ECO:0000250}..
P9WNN5

Zinc uptake regulation protein (Zinc uptake regulator)

Protein
Global transcriptional regulator involved in zinc homeostasis. Represses the transcription of at least 32 genes, including genes involved in zinc homeostasis, by binding to promoter sequences that contain a conserved 26 bp palindrome, in the presence of zinc. {ECO:0000269|PubMed:17098899}..
P9WN85

dTDP-glucose 4,6-dehydratase (EC 4.2.1.46)

Protein
Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction (By similarity). Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to peptidoglycan via a phosphodiester linkage (PubMed:16472764). {ECO:0000250|UniProtKB:P27830, ECO:0000269|PubMed:16472764}..
P9WN65

ESAT-6-like protein EsxB (10 kDa culture filtrate antigen CFP-10) (CFP-10) (Secreted antigenic protein MTSA-10)

Protein
A secreted protein. Acts as a strong host (human) T-cell antigen (PubMed:11940590). Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm (PubMed:17604718). Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA; native protein binds poorly to artificial liposomes in the absence or presence of EsxA (PubMed:17557817, PubMed:26260636). EsxA and EsxA-EsxB are cytotoxic to pneumocytes (PubMed:19906174). EsxB (and EsxA-EsxB but not EsxA alone) activates human neutrophils; EsxB transiently induces host (human) intracellular Ca(2+) mobility in a dose-dependent manner, monocytes and lymphocytes do not respond (PubMed:25332123). Neutrophils respond to EsxB by chemotaxis and primed neutrophils treated with EsxB produce reactive oxygen species (ROS); Ca(2+) release and the ROS burst via are induced by an unidentified G-protein coupled receptor (PubMed:25332123). May help regulate assembly and function of the type VII secretion system (T7SS) (PubMed:25865481). {ECO:0000269|PubMed:11940590, ECO:0000269|PubMed:17557817, ECO:0000269|PubMed:17604718, ECO:0000269|PubMed:19906174, ECO:0000269|PubMed:25332123, ECO:0000269|PubMed:25865481, ECO:0000305|PubMed:26260636}..
P9WNK5

Dihydroneopterin aldolase (DHNA) (EC 4.1.2.25) (7,8-dihydroneopterin 2'-epimerase) (7,8-dihydroneopterin aldolase) (7,8-dihydroneopterin epimerase) (EC 5.1.99.8) (7,8-dihydroneopterin hydroxylase) (EC 1.13.11.81) (Dihydroneopterin epimerase) (Dihydroneopterin hydroxylase)

Protein
Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8-dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin. {ECO:0000269|PubMed:23150985}..
P9WNC5

Putative phenylalanine aminotransferase (EC 2.6.1.-)

Protein
May catalyze the transamination reaction in phenylalanine biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01513}..
P9WML5

Probable dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109)

Protein
Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins (Probable). Mannosylates an artificial substrate, probably on a Thr residue, upon expression in M.smegmatis. Glycosylation probably requires the Sec-translocation system. {ECO:0000269|PubMed:16081738, ECO:0000305}..
P9WN05

Phosphoribosylformylglycinamidine synthase subunit PurQ (FGAM synthase) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase subunit I) (FGAR amidotransferase I) (FGAR-AT I) (Glutaminase PurQ) (EC 3.5.1.2) (Phosphoribosylformylglycinamidine synthase subunit I)

Protein
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. {ECO:0000255|HAMAP-Rule:MF_00421}..
P9WHL5

Fumarate reductase subunit D

Protein
Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. {ECO:0000255|HAMAP-Rule:MF_00709}..
P9WNB5

1,4-alpha-glucan branching enzyme GlgB (EC 2.4.1.18) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase) (Alpha-(1->4)-glucan branching enzyme) (Glycogen-branching enzyme) (BE)

Protein
Essential enzyme that catalyzes the formation of the alpha-1,6-glucosidic linkages in glucan chains by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. Is involved in the biosynthesis of both glycogen and capsular alpha-D-glucan. {ECO:0000269|PubMed:17005418, ECO:0000269|PubMed:18808383}..
P9WN45

ESX-5 secretion system protein EccC5 (ESX conserved component C5) (Type VII secretion system protein EccC5) (T7SS protein EccC5)

Protein
Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. {ECO:0000269|PubMed:22340629, ECO:0000269|PubMed:22925462, ECO:0000269|PubMed:23284869}..
P9WNA5

GTPase Der (GTP-binding protein EngA)

Protein
GTPase that plays an essential role in the late steps of ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}..
P9WNL3

DNA polymerase I (POL I) (EC 2.7.7.7)

Protein
In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity..
P9WNU5

Putative L-lactate dehydrogenase (EC 1.1.-.-)

Protein
Unknown.
P9WND5

Uncharacterized protein Rv2075c

Protein
Unknown.
P9WLL5

Immunogenic protein MPT70

Protein
Unknown.
P9WNF5

Anthranilate synthase component 2 (AS) (ASII) (EC 4.1.3.27) (Anthranilate synthase, GATase component) (Anthranilate synthase, glutamine amidotransferase component)

Protein
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity). {ECO:0000250}..
P9WN35

Uncharacterized protein Rv0560c

Protein
Unknown.
P9WKL5

Probable 3-hydroxyisobutyrate dehydrogenase (HIBADH) (EC 1.1.1.31)

Protein
Unknown.
P9WNY5

Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase)

Protein
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. {ECO:0000255|HAMAP-Rule:MF_00318}..
P9WNL1

Group 1 truncated hemoglobin GlbN (Truncated hemoglobin) (trHbN) (Hemoglobin-like protein HbN)

Protein
Binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20 degrees Celsius) because of a fast combination (25 microM(-1).s(-1)) and a slow dissociation (0.2 s(-1)) rate..
P9WN25

Uncharacterized glycosyl hydrolase Rv2006 (EC 3.2.1.-)

Protein
Unknown.
P9WN15

Uncharacterized protein Rv2001

Protein
Unknown.
P9WLN5

ESAT-6-like protein EsxP

Protein
Unknown.
P9WNI5

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

Protein
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA..
P9WNS5

DNA integrity scanning protein DisA (Cyclic-di-AMP synthase) (c-di-AMP synthase) (Diadenylate cyclase) (EC 2.7.7.85)

Protein
Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions. {ECO:0000255|HAMAP-Rule:MF_01438}.; FUNCTION: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. To a lesser extent, can also use ADP as substrate to produce c-di-AMP. Does not convert GTP to c-di-GMP. Also exhibits residual ATPase and ADPase activities in vitro. {ECO:0000255|HAMAP-Rule:MF_01438, ECO:0000269|PubMed:22529992}..
P9WNW5

Probable arabinosyltransferase A (EC 2.4.2.-)

Protein
Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan..
P9WNL9

Steroid C26-monooxygenase (EC 1.14.15.28) (Cholest-4-en-3-one C26-monooxygenase) (Cholest-4-en-3-one C26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]) (Cholesterol C26-monooxygenase) (Cholesterol C26-monooxygenase [(25R)-3beta-hydroxycholest-5-en-26-oate forming]) (Cytochrome P450 142) (Steroid C27-monooxygenase)

Protein
Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection (PubMed:20843794). Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate (PubMed:20843794, PubMed:20889498). In vitro, Cyp142 catalyzes with equal preference the oxidation of both (25R)- and (25S)-26-hydroxycholest-4-en-3-one diastereomers to the corresponding carboxylic acid which is a prerequisite for entry into the beta-oxidation pathway (PubMed:20843794). Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one (PubMed:20843794). {ECO:0000269|PubMed:20843794, ECO:0000269|PubMed:20889498, ECO:0000269|PubMed:25210044}..
P9WPL5

Probable arabinosyltransferase B (EC 2.4.2.-)

Protein
Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan..
P9WNL7

ESX-2 secretion system protein eccD2 (ESX conserved component D2) (Type VII secretion system protein eccD2) (T7SS protein eccD2)

Protein
Unknown.
P9WNQ5