pknA

Gene

Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A).

Rv0015c

ptbB

Gene

Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase).

Rv0153c

mce1R

Gene

Probable transcriptional regulatory protein Mce1R (probably GntR-family).

Rv0165c

Rv0196

Gene

Possible transcriptional regulatory protein.

Rv0196

nadR

Gene

Possible transcriptional regulatory protein NadR (probably AsnC-family).

Rv0212c

Rv0348

Gene

Possible transcriptional regulatory protein.

Rv0348

Rv0653c

Gene

Possible transcriptional regulatory protein (probably TetR-family).

Rv0653c

prrB

Gene

Two component sensor histidine kinase PrrB.

Rv0902c

csoR

Gene

Copper-sensitive operon repressor CsoR.

Rv0967

Rv1019

Gene

Probable transcriptional regulatory protein (probably TetR-family).

Rv1019

kdpD

Gene

Probable sensor protein KdpD.

Rv1028c

Rv1353c

Gene

Probable transcriptional regulatory protein.

Rv1353c

Rv1474c

Gene

Probable transcriptional regulatory protein.

Rv1474c

Rv1460

Gene

Probable transcriptional regulatory protein.

Rv1460

Rv1534

Gene

Probable transcriptional regulator.

Rv1534

Rv1776c

Gene

Possible transcriptional regulatory protein.

Rv1776c

dosT

Gene

Two component sensor histidine kinase DosT.

Rv2027c

Rv2021c

Gene

Transcriptional regulatory protein.

Rv2021c

Rv2017

Gene

Transcriptional regulatory protein.

Rv2017

Rv2034

Gene

ArsR repressor protein.

Rv2034

Rv2258c

Gene

Possible transcriptional regulatory protein.

Rv2258c

Rv2642

Gene

Possible transcriptional regulatory protein (probably ArsR-family).

Rv2642

lexA

Gene

Repressor LexA.

Rv2720

moaR1

Gene

Transcriptional regulatory protein MoaR1.

Rv3124

moxR3

Gene

Probable methanol dehydrogenase transcriptional regulatory protein MoxR3.

Rv3164c

lrpA

Gene

Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family).

Rv3291c

mtrA

Gene

Two component sensory transduction transcriptional regulatory protein MtrA.

Rv3246c

Rv3575c

Gene

Transcriptional regulatory protein (probably LacI-family).

Rv3575c

Rv0042c

Gene

Possible transcriptional regulatory protein (probably MarR-family).

Rv0042c

fhaB

Gene

Conserved protein with FHA domain, FhaB.

Rv0019c

Rv0273c

Gene

Possible transcriptional regulatory protein.

Rv0273c

Rv0081

Gene

Probable transcriptional regulatory protein.

Rv0081

Rv0144

Gene

Probable transcriptional regulatory protein (possibly TetR-family).

Rv0144

Rv0260c

Gene

Possible transcriptional regulatory protein.

Rv0260c

Rv0485

Gene

Possible transcriptional regulatory protein.

Rv0485

Rv1473A

Gene

Possible transcriptional regulatory protein.

Rv1473A

Rv0691c

Gene

Probable transcriptional regulatory protein.

Rv0691c

Rv0737

Gene

Possible transcriptional regulatory protein.

Rv0737

narL

Gene

Possible nitrate/nitrite response transcriptional regulatory protein NarL.

Rv0844c

kmtR

Gene

Metal sensor transcriptional regulator KmtR (ArsR-SmtB family).

Rv0827c

Rv1255c

Gene

Probable transcriptional regulatory protein.

Rv1255c

Rv0845

Gene

Possible two component sensor kinase.

Rv0845

Rv0890c

Gene

Probable transcriptional regulatory protein (probably LuxR-family).

Rv0890c

kdpE

Gene

Probable transcriptional regulatory protein KdpE.

Rv1027c

Rv1167c

Gene

Probable transcriptional regulatory protein.

Rv1167c

Rv1358

Gene

Probable transcriptional regulatory protein.

Rv1358

cmr

Gene

Probable transcriptional regulatory protein Cmr.

Rv1675c

Rv1816

Gene

Possible transcriptional regulatory protein.

Rv1816

blaI

Gene

Transcriptional repressor BlaI.

Rv1846c

Rv1985c

Gene

Probable transcriptional regulatory protein (probably LysR-family).

Rv1985c

pknJ

Gene

Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J).

Rv2088

ptkA

Gene

Protein tyrosine kinase transcriptional regulatory protein PtkA.

Rv2232

Rv2282c

Gene

Probable transcription regulator (LysR family).

Rv2282c

ideR

Gene

Iron-dependent repressor and activator IdeR.

Rv2711

pknI

Gene

Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydroxyalkyl-protein kinase).

Rv2914c

Rv2989

Gene

Probable transcriptional regulatory protein.

Rv2989

Rv3183

Gene

Possible transcriptional regulatory protein.

Rv3183

pknK

Gene

Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K).

Rv3080c

Rv3173c

Gene

Probable transcriptional regulatory protein (probably TetR/AcrR-family).

Rv3173c

Rv3066

Gene

Probable transcriptional regulatory protein (probably DeoR-family).

Rv3066

whiB2

Gene

Probable transcriptional regulatory protein WhiB-like WhiB2.

Rv3260c

Rv3295

Gene

Probable transcriptional regulatory protein (probably TetR-family).

Rv3295

kstR

Gene

Transcriptional regulatory protein KstR (probably TetR-family).

Rv3574

fhaA

Gene

Conserved protein with FHA domain, FhaA.

Rv0020c

pstP

Gene

Phosphoserine/threonine phosphatase PstP.

Rv0018c

oxyS

Gene

Oxidative stress response regulatory protein OxyS.

Rv0117

Rv0324

Gene

Possible transcriptional regulatory protein (possibly ArsR-family).

Rv0324

pknG

Gene

Serine/threonine-protein kinase PknG (protein kinase G) (STPK G).

Rv0410c

senX3

Gene

Putative two component sensor histidine kinase SenX3.

Rv0490

phoP

Gene

Possible two component system response transcriptional positive regulator PhoP.

Rv0757

Rv2011c

Gene

Conserved hypothetical protein, probable transcription repressor..

Rv2011c

Rv0818

Gene

Transcriptional regulatory protein.

Rv0818

Rv0792c

Gene

Probable transcriptional regulatory protein (probably GntR-family).

Rv0792c

Rv0891c

Gene

Possible transcriptional regulatory protein.

Rv0891c

Rv0880

Gene

Possible transcriptional regulatory protein (possibly MarR-family).

Rv0880

pknD

Gene

Transmembrane serine/threonine-protein kinase D PknD (protein kinase D) (STPK D).

Rv0931c

mprB

Gene

Two component sensor kinase MprB.

Rv0982

Rv1152

Gene

Probable transcriptional regulatory protein.

Rv1152

Rv1151c

Gene

Transcriptional regulatory protein.

Rv1151c

Rv1332

Gene

Probable transcriptional regulatory protein.

Rv1332

pyrR

Gene

Probable pyrimidine operon regulatory protein PyrR.

Rv1379

Rv1395

Gene

Transcriptional regulatory protein.

Rv1395

moxR1

Gene

Probable transcriptional regulatory protein MoxR1.

Rv1479

Rv1453

Gene

Possible transcriptional activator protein.

Rv1453

Rv1626

Gene

Probable two-component system transcriptional regulator.

Rv1626

cmtR

Gene

Metal sensor transcriptional regulator CmtR (ArsR-SmtB family).

Rv1994c

Rv2175c

Gene

Conserved regulatory protein.

Rv2175c

pknL

Gene

Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L).

Rv2176

Rv2488c

Gene

Probable transcriptional regulatory protein (LuxR-family).

Rv2488c

Rv2640c

Gene

Possible transcriptional regulatory protein (probably ArsR-family).

Rv2640c

Rv2779c

Gene

Possible transcriptional regulatory protein (probably Lrp/AsnC-family).

Rv2779c

Rv2884

Gene

Probable transcriptional regulatory protein.

Rv2884

Rv3058c

Gene

Possible transcriptional regulatory protein (probably TetR-family).

Rv3058c

Rv3055

Gene

Possible transcriptional regulatory protein (probably TetR-family).

Rv3055

Rv3095

Gene

Hypothetical transcriptional regulatory protein.

Rv3095

devS

Gene

Two component sensor histidine kinase DevS.

Rv3132c

whiB1

Gene

Transcriptional regulatory protein WhiB-like WhiB1. Contains [4FE-4S]2+ cluster..

Rv3219

Rv3405c

Gene

Possible transcriptional regulatory protein.

Rv3405c

DNA-binding protein HU homolog (21 kDa laminin-2-binding protein) (28 kDa iron-regulated protein) (Irep-28) (Histone-like protein) (Hlp)

Protein

Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Binds DNA non-specifically. Induces lymphoproliferation, particularly in health tuberculin reactors, and is immunogenic. Maybe involved in pathogenesis of inflammatory bowel disease (IBD) in patients with ulcerative colitis and Crohn disease (CD). Bound by anti-neutrophil cytoplasmic antibodies (pANCA), which are a hallmark of IBD. The binding is due to pANCA directed against HIST1H1D cross-reacting with DBH epitopes. In CD, target of a strong IgA response. {ECO:0000269|PubMed:10569769, ECO:0000269|PubMed:10645441}..

P9WMK7

50S ribosomal protein L21

Protein

This protein binds to 23S rRNA in the presence of protein L20. {ECO:0000255|HAMAP-Rule:MF_01363}..

P9WHC3

Rv0067c

Gene

Possible transcriptional regulatory protein (possibly TetR-family).

Rv0067c

Rv0078

Gene

Probable transcriptional regulatory protein.

Rv0078

Rv0238

Gene

Possible transcriptional regulatory protein (probably TetR-family).

Rv0238

Rv0302

Gene

Probable transcriptional regulatory protein (probably TetR/AcrR-family).

Rv0302

Rv0328

Gene

Possible transcriptional regulatory protein (possibly TetR/AcrR-family).

Rv0328

Rv0339c

Gene

Possible transcriptional regulatory protein.

Rv0339c

Rv0386

Gene

Probable transcriptional regulatory protein (probably LuxR/UhpA-family).

Rv0386

Rv0377

Gene

Probable transcriptional regulatory protein (probably LysR-family).

Rv0377

Rv0474

Gene

Probable transcriptional regulatory protein.

Rv0474

Rv0452

Gene

Possible transcriptional regulatory protein.

Rv0452

regX3

Gene

Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family).

Rv0491

Rv1359

Gene

Probable transcriptional regulatory protein.

Rv1359

Rv0600c

Gene

Two component sensor kinase [second part].

Rv0600c

Rv0601c

Gene

Two component sensor kinase [first part].

Rv0601c

phoR

Gene

Possible two component system response sensor kinase membrane associated PhoR.

Rv0758

Rv0744c

Gene

Possible transcriptional regulatory protein.

Rv0744c

Rv0823c

Gene

Possible transcriptional regulatory protein.

Rv0823c

Rv0894

Gene

Possible transcriptional regulatory protein (possibly LuxR-family).

Rv0894

Rv1219c

Gene

Probable transcriptional regulatory protein.

Rv1219c

Rv1556

Gene

Possible regulatory protein.

Rv1556

Rv1674c

Gene

Probable transcriptional regulatory protein.

Rv1674c

pknF

Gene

Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F).

Rv1746

Rv1773c

Gene

Probable transcriptional regulatory protein.

Rv1773c

furA

Gene

Ferric uptake regulation protein FurA (fur).

Rv1909c

mce3R

Gene

Probable transcriptional repressor (probably TetR-family) Mce3R.

Rv1963c

ptpA

Gene

Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase).

Rv2234

Rv2250c

Gene

Possible transcriptional regulatory protein.

Rv2250c

smtB

Gene

Probable transcriptional regulatory protein SmtB (probably ArsR-family).

Rv2358

zur

Gene

Probable zinc uptake regulation protein Zur.

Rv2359

Rv2324

Gene

Probable transcriptional regulatory protein (probably AsnC-family).

Rv2324

Rv2506

Gene

Probable transcriptional regulatory protein (probably TetR-family).

Rv2506

nrdR

Gene

Probable transcriptional regulatory protein NrdR.

Rv2718c

clgR

Gene

Transcriptional regulatory protein ClgR.

Rv2745c

sirR

Gene

Probable transcriptional repressor SirR.

Rv2788

Rv2887

Gene

Probable transcriptional regulatory protein.

Rv2887

Rv2912c

Gene

Probable transcriptional regulatory protein (probably TetR-family).

Rv2912c

glnB

Gene

Probable nitrogen regulatory protein P-II GlnB.

Rv2919c

Rv3050c

Gene

Probable transcriptional regulatory protein (probably AsnC-family).

Rv3050c

whiB7

Gene

Probable transcriptional regulatory protein WhiB-like WhiB7.

Rv3197A

Rv3220c

Gene

Probable two component sensor kinase.

Rv3220c

Rv3334

Gene

Probable transcriptional regulatory protein (probably MerR-family).

Rv3334

Rv3583c

Gene

Possible transcription factor.

Rv3583c

crp

Gene

Transcriptional regulatory protein Crp (Crp/Fnr-family).

Rv3676

pknB

Gene

Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B).

Rv0014c

Rv0023

Gene

Possible transcriptional regulatory protein.

Rv0023

whiB5

Gene

Probable transcriptional regulatory protein WhiB-like WhiB5.

Rv0022c

Rv0135c

Gene

Possible transcriptional regulatory protein.

Rv0135c

Rv0043c

Gene

Probable transcriptional regulatory protein (probably GntR-family).

Rv0043c

Rv0158

Gene

Probable transcriptional regulatory protein (possibly TetR-family).

Rv0158

Rv0195

Gene

Possible two component transcriptional regulatory protein (probably LuxR-family).

Rv0195

Rv0232

Gene

Probable transcriptional regulatory protein (probably TetR/AcrR-family).

Rv0232

Rv0275c

Gene

Possible transcriptional regulatory protein (possibly TetR-family).

Rv0275c

Rv0472c

Gene

Probable transcriptional regulatory protein (possibly TetR-family).

Rv0472c

Rv0465c

Gene

Probable transcriptional regulatory protein.

Rv0465c

Rv0494

Gene

Probable transcriptional regulatory protein (probably GntR-family).

Rv0494

mce2R

Gene

Probable transcriptional regulatory protein Mce2R (GntR-family).

Rv0586

tcrA

Gene

Two component DNA binding transcriptional regulatory protein TcrA.

Rv0602c

Rv0576

Gene

Probable transcriptional regulatory protein (possibly ArsR-family).

Rv0576

Rv0681

Gene

Probable transcriptional regulatory protein (possibly TetR-family).

Rv0681

prrA

Gene

Two component response transcriptional regulatory protein PrrA.

Rv0903c

mprA

Gene

Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein).

Rv0981

trcS

Gene

Two component sensor histidine kinase TrcS.

Rv1032c

trcR

Gene

Two component transcriptional regulator TrcR.

Rv1033c

Rv1049

Gene

Probable transcriptional repressor protein.

Rv1049

Rv1129c

Gene

Probable transcriptional regulator protein.

Rv1129c

pknH

Gene

Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H).

Rv1266c

embR

Gene

Probable transcriptional regulatory protein EmbR.

Rv1267c

whiA

Gene

Probable transcriptional regulatory protein WhiA.

Rv1423

Rv1404

Gene

Probable transcriptional regulatory protein.

Rv1404

argR

Gene

Probable arginine repressor ArgR (AHRC).

Rv1657

Rv1719

Gene

Probable transcriptional regulatory protein.

Rv1719

pknE

Gene

Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E).

Rv1743

Rv1931c

Gene

Probable transcriptional regulatory protein.

Rv1931c

Rv1990c

Gene

Probable transcriptional regulatory protein.

Rv1990c

Rv2160A

Gene

Conserved hypothetical protein.

Rv2160A

Rv2160c

Gene

Conserved hypothetical protein.

Rv2160c

Rv2621c

Gene

Possible transcriptional regulatory protein.

Rv2621c

Rv3060c

Gene

Probable transcriptional regulatory protein (probably GntR-family).

Rv3060c

devR

Gene

Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family).

Rv3133c

Rv3143

Gene

Probable response regulator.

Rv3143

Rv3160c

Gene

Possible transcriptional regulatory protein (probably TetR-family).

Rv3160c

Rv3167c

Gene

Probable transcriptional regulatory protein (probably TetR-family).

Rv3167c

Rv3208

Gene

Probable transcriptional regulatory protein (probably TetR-family).

Rv3208

mtrB

Gene

Two component sensory transduction histidine kinase MtrB.

Rv3245c

Rv3249c

Gene

Possible transcriptional regulatory protein (probably TetR-family).

Rv3249c

whiB3

Gene

Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster..

Rv3416

Rv3557c

Gene

Transcriptional regulatory protein (probably TetR-family).

Rv3557c

moxR2

Gene

Probable methanol dehydrogenase transcriptional regulatory protein MoxR2.

Rv3692

whiB4

Gene

Probable transcriptional regulatory protein WhiB-like WhiB4.

Rv3681c

30S ribosomal protein S1

Protein

Binds mRNA, facilitating recognition of most mRNAs by the 30S ribosomal subunit during translation initiation (By similarity). Probably plays a role in trans-translation; binds tmRNA (the product of the ssrA gene) (PubMed:21835980). In trans-translation Ala-aminoacylated transfer-messenger RNA (tmRNA, product of the ssrA gene; the 2 termini fold to resemble tRNA(Ala) while it encodes a short internal open reading frame (the tag peptide)) acts like a tRNA, entering the A-site of the ribosome and displacing the stalled mRNA (which is subsequently degraded). The ribosome then switches to translate the ORF on the tmRNA, the nascent peptide is terminated with the "tag peptide" encoded by the tmRNA and thus targeted for degradation (By similarity). {ECO:0000250|UniProtKB:P0AG67, ECO:0000269|PubMed:21835980}.; FUNCTION: Binds pyrazinoic acid (POA), the active form of the prodrug pyrazinamide (PZA); POA disrupts tmRNA binding (at 50 ug/ml in vitro) and also trans-translation (at 25 ug/ml in vitro using purified H37Ra ribosomes). {ECO:0000269|PubMed:21835980}..

P9WH43

50S ribosomal protein L1

Protein

Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. {ECO:0000255|HAMAP-Rule:MF_01318}.; FUNCTION: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. {ECO:0000255|HAMAP-Rule:MF_01318}..

P9WHC7

Putative Rieske 2Fe-2S iron-sulfur protein Rv3818 (EC 1.-.-.-)

Protein

Unknown.

P9WH21

SL659 acyltransferase papA1 (EC 2.3.1.283) (Polyketide synthase-associated protein A1)

Protein

Catalyzes the acylation of trehalose-2-sulfate-2'-palmitate (SL659) by adding the (hydroxy)phthioceranoyl group at the 3'-position to yield the diacylated intermediate 2-palmitoyl-3-(C43)-phthioceranyl-alpha, alpha'-D-trehalose-2'-sulfate (SL1278) during the cell wall sulfolipid-1 (SL-1) biosynthesis. {ECO:0000269|PubMed:17259623, ECO:0000269|PubMed:17592143}..

P9WIK9

Aconitate hydratase A (ACN) (Aconitase) (EC 4.2.1.3) ((2R,3S)-2-methylisocitrate dehydratase) ((2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase) (Iron-responsive protein-like) (IRP-like) (Probable 2-methyl-cis-aconitate hydratase) (EC 4.2.1.99) (RNA-binding protein)

Protein

Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. The apo form of AcnA functions as a RNA-binding regulatory protein which binds to selected IRE-like sequences present within the UTRs (untranslated regions) of 3' trxC and 5' IdeR mRNA (PubMed:17384188). Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate (By similarity). {ECO:0000250|UniProtKB:Q8ZP52, ECO:0000269|PubMed:17384188}..

O53166

29 kDa antigen CFP29

Protein

Unknown.

I6WZG6

Cytokinin riboside 5'-monophosphate phosphoribohydrolase (EC 3.2.2.n1) (Protein LONELY GUY homolog) (LOG homolog)

Protein

Catalyzes the hydrolytic removal of ribose 5'-monophosphate from nitrogen N6-modified adenosines, the final step of bioactive cytokinin synthesis. Is involved in the synthesis of isopentenyladenine (iP) and 2-methylthio-iP (2MeS-iP), the most abundant cytokinins detected in M.tuberculosis lysates and supernatants. Is also able to convert trans-zeatin-riboside monophosphate (tZRMP) to trans-zeatin (tZ) in vitro; however, it may not be involved in the biosynthesis of this minor cytokinin in vivo. Accumulation of Rv1205 sensitizes M.tuberculosis to nitric oxide since cytokinin breakdown products synergize with NO to kill M.tuberculosis. Shows a slow AMP hydrolase activity, but is not able to hydrolyze ATP. Displays no lysine decarboxylase (LDC) activity (L-lysine conversion to cadaverine). {ECO:0000269|PubMed:25728768}..

O05306

ESX-1 secretion system protein EccA1 (ESX conserved component A1) (Type VII secretion system protein EccA1) (T7SS protein EccA1)

Protein

Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10) (PubMed:18974091, PubMed:16368961). EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (PubMed:18974091). {ECO:0000269|PubMed:16368961, ECO:0000269|PubMed:18974091}..

P9WPH9

CRISPR-associated endoribonuclease Cas6 (EC 3.1.-.-)

Protein

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements (spacers) and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions (PubMed:29979631). {ECO:0000269|PubMed:29979631, ECO:0000305|PubMed:29979631}.; FUNCTION: Processes pre-crRNA into individual crRNA units; accurate cleavage of pre-crRNA depends on a 3' stem-loop and the sequence of the bases in the stem. The mature crRNA is unusual for type III-A systems as it doe snot undergo 3' processing after Cas6 cleavage. Mature crRNA is about 71 nucleotides (nt long) with an 8 nt 5' handle and 28 nt repeat with a 10 nt stem-loop at the 3' end. {ECO:0000269|PubMed:29979631}..

P9WPJ1

ESX-1 secretion system protein EccE1 (ESX conserved component E1) (Type VII secretion system protein EccE1) (T7SS protein EccE1)

Protein

Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). {ECO:0000305|PubMed:19876390}..

P9WJE9

Lipoarabinomannan carrier protein LprG (27 kDa lipoprotein) (Antigen P27) (Lipoprotein LprG) (Triacylated glycolipid carrier LprG) (Triacylglyceride transfer protein LprG)

Protein

Probably helps membrane protein Rv1410c (P55) transport triacylglycerides (TAG) across the inner cell membrane into the periplasm; TAG probably regulates lipid metabolism and growth regulation (PubMed:26751071). Binds TAG and transfers it between lipid bilayers, probably to the outer membrane in vivo (PubMed:26751071). Binds di- and triacylated phosphatidyl-myo-inositol mannosides (PIMs), and glycolipid lipoglycan modulins lipoarabinomannan (LAM) and lipomannan (LM), facilitating their recognition by TLR2 (PubMed:20694006, PubMed:25356793). Binds LM > PIM6 > ManLAM > PI-LAM > PIM2 (mannose-capped LAM and phospho-myo-inositol-capped LAM, E.coli expressed without acyl-groups); deacylated LM and LAM also bind to this protein via their mannose moieties, showing LprG has at least 2 different ways to bind glycolipids (PubMed:25356793). Binds triacylglycerides (TAG) in the same cavity, is able to transfer TAG between lipid bilayers (PubMed:26751071). Overexpression of LprG and Rv1410c leads to increased levels of TAG in the culture medium (PubMed:26751071). Required for Rv1410c-mediated export of drugs (PubMed:18156250, PubMed:21762531). Required, probably with Rv1410c, for normal surface localization of LAM (PubMed:25232742). {ECO:0000269|PubMed:18156250, ECO:0000269|PubMed:20694006, ECO:0000269|PubMed:21762531, ECO:0000269|PubMed:25232742, ECO:0000269|PubMed:25356793, ECO:0000269|PubMed:26751071}.; FUNCTION: A host TLR2 agonist (toll-like receptor), shown experimentally for human and mouse (PubMed:19362712). Inhibits primary human macrophage MHC-II Ag processing via TLR2 (PubMed:15294983). Both lipidated and nonlipidated protein act as TLR2 agonists in antigen-presenting cells, although lipidated protein is more efficient (PubMed:20694006). In resting human CD4+ T-cells lipidated but not nonlipidated protein is a costimulatory ligand (with anti-CD3 and anti-CD28) for T-cell proliferation and IFN-gamma and IL-2 production, leading to increased expression of early T-cell activation markers, TLR2 and NFKB3 phosphorylation (PubMed:21078852). Human CD4+ T-cells use TLR1/TLR2 heterodimers to respond to this and probably other mycobacterial lipoproteins (PubMed:21078852). Able to stimulate proliferation of CD4+ T-cells derived from a human leprosy patient following protein processing/presentation by MHC class II molecules in peripheral blood mononuclear cells (PubMed:18424702). Requires both host TLR1 and TLR2 as coreceptors to elicit host response in mouse, although TLR6 may play a redundant role, has a partial requirement for CD14 as an accessory receptor (PubMed:19362712). {ECO:0000269|PubMed:15294983, ECO:0000269|PubMed:18424702, ECO:0000269|PubMed:19362712, ECO:0000269|PubMed:20694006, ECO:0000269|PubMed:21078852}..

P9WK45

ESX-1 secretion system protein EccD1 (ESX conserved component D1) (Snm4 secretory protein) (Type VII secretion system protein EccD1) (T7SS protein EccD1)

Protein

Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). {ECO:0000269|PubMed:14557536, ECO:0000269|PubMed:16368961, ECO:0000305|PubMed:14557547}..

P9WNQ7

RNA-splicing ligase RtcB (EC 6.5.1.-)

Protein

RNA ligase that mediates the joining of broken tRNA-like stem-loop structures. {ECO:0000250}..

P9WGW5

L,D-transpeptidase 5 (LDT 5) (EC 2.3.2.-) (Ldt(Mt5))

Protein

Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. {ECO:0000269|PubMed:24041897}..

P9WKV3

ESX-1 secretion system ATPase EccB1 (EC 3.6.-.-) (ESX conserved component B1) (Type VII secretion system protein EccB1) (T7SS protein EccB1)

Protein

An ATPase (PubMed:26396239). Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10) (PubMed:16368961). {ECO:0000269|PubMed:16368961, ECO:0000269|PubMed:26396239}..

P9WNR7

Pyruvate dehydrogenase E1 component (PDH E1 component) (EC 1.2.4.1)

Protein

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). AceE has reductase activity with pyruvate but does not react with 2-oxoglutarate. {ECO:0000269|PubMed:16045627}..

P9WIS9

ECF RNA polymerase sigma factor SigL (ECF sigma factor SigL) (Alternative RNA polymerase sigma factor SigL) (RNA polymerase sigma-L factor) (Sigma-L factor)

Protein

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis. Over-expression of SigL induces 19-28 genes including polyketide synthases, secreted and membrane proteins. Might play a minor role in regulating SigB. {ECO:0000269|PubMed:16199577, ECO:0000269|PubMed:16552079}..

P9WGH5

Proline-rich 28 kDa antigen

Protein

Unknown.

P9WIM9

Putative glyoxylase CFP32 (27 kDa antigen Cfp30B)

Protein

May function as a glyoxylase involved in the methylglyoxal detoxification pathway (PubMed:20975714). Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and proinflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL-12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses (PubMed:22415304). {ECO:0000269|PubMed:20975714, ECO:0000269|PubMed:22415304}..

P9WIR3

L,D-transpeptidase 4 (LDT 4) (EC 2.3.2.-) (Ldt(Mt4))

Protein

Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. {ECO:0000269|PubMed:24041897}..

O07436

3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase (EC 1.1.1.53)

Protein

Unknown.

P9WGT1

Acyl-CoA dehydrogenase FadE29 (ACAD) (EC 1.3.99.-) (3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA dehydrogenase beta subunit) (3-oxo-4-pregnene-20-carboxyl-CoA dehydrogenase beta subunit)

Protein

Involved in the third cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism (PubMed:26161441). Contributes partly to the virulence by increasing the efficiency of beta-oxidation (PubMed:22045806, PubMed:23560677). Catalyzes the dehydrogenation of 2'-propanoyl-CoA ester side chains of 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) to yield 3-oxo-4,17-pregnadiene-20-carboxyl-CoA (3-OPDC-CoA). Also able to dehydrogenate steroyl-CoA such as 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA), 1beta-(2'-propanoyl-CoA)-3a-alpha-H- 7a-beta-methylhexahydro-4-indanone (indanone-CoA ester), hexahydroindanone and pregenenone (PubMed:22045806, PubMed:23560677). {ECO:0000269|PubMed:22045806, ECO:0000269|PubMed:23560677, ECO:0000269|PubMed:26161441}..

P71858

RNA polymerase sigma factor SigF (Sigma factor SigF) (Alternative RNA polymerase sigma factor SigF) (RNA polymerase sigma-F factor) (Sigma-F factor) (Stress response/stationary phase sigma factor SigF)

Protein

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an inactive form by a cognate anti-sigma factor RsbW (UsfX) until released. Increased expression decreases growth rate, and after 3 days increases the expression of 51 loci encoding 33 protein-coding genes as well as some non-coding RNA (PubMed:22307756). {ECO:0000269|PubMed:12354223, ECO:0000269|PubMed:20729364, ECO:0000269|PubMed:22307756, ECO:0000269|PubMed:22570422}..

P9WGI3

Lipoprotein LpqH (19 kDa lipoprotein antigen) (Putative transporter LpqH) (p19)

Protein

Based on its structure might be involved in ligand transport (Ref.25) (By similarity). {ECO:0000250|UniProtKB:P65307, ECO:0000305|Ref.25}.; FUNCTION: A host TLR2 agonist (PubMed:10426995, PubMed:11441098, PubMed:12874328). Plays a complicated role in bacterial interactions with the host immune system; some effects favor the host (induces interleukin 1-beta and IL-12 p40 (IL12B), both increase the host's immune response) while others favor the bacteria (increases growth in monocyte-derived macrophages and decreases host MHC class II (MHC-II) expression and antigen processing) (PubMed:16177361). Induces host (human and mouse) IL-12 p40 (IL12B, a proinflammatory cytokine) release by monocyte cell lines via TLR2 and CD14 (PubMed:10426995). Induces host (human) monocytes to produce TNF-alpha, IL-6 and IL-12 p40; LpqH is a more potent inducer than PstS1 (PubMed:16622205). Inhibits MHC-II expression and antigen processing in host (mouse) macrophages via TLR2 (independently of TLR4) probably via the lipid modification (PubMed:11441098). Stimulates host (human) dendritic cell maturation to become MHC-II-positive antigen presenting cells via TLR2, which depends on lipidation; nonlipidated protein does not stimulate maturation (PubMed:11160304). Inhibits host (human and mouse) IFN-gamma signaling in macrophages via TLR2; decreases IFN-gamma stimulated MHC-II antigen processing as well as decreasing IFN-gamma-mediated up-regulation of immunoglobulin gamma Fc receptor (FCGR1A), enabling the bacteria to evade the immune system (PubMed:12874328). In resting human CD4+ T-cells lipidated (but probably not nonlipidated protein) is a costimulatory ligand (with anti-CD3 and anti-CD28) for T-cell proliferation and IFN-gamma and IL-2 production (PubMed:21078852). Human CD4+ T-cells probably use TLR1/TLR2 heterodimers to respond to mycobacterial lipoproteins (PubMed:21078852). Acting via TLR2 enhances expression of host peroxisome proliferator-activated receptor gamma (PPARG), a regulator of inflammation and immunoregulation, and increases p38 MAPK phosphorylation, IL-6 and TNF-alpha expression (PubMed:25504154). Native or nonlipidated recombinant protein missing the first 4 residues have been shown to induce apoptosis in the human macrophage cell line THP-1 and human monocyte-derived macrophages in a TLR2, caspase-3 and caspase-8-dependent manner (PubMed:12594264). Protein overexpressed in M.smegmatis (lipidated and probably glycosylated) induces apoptosis in human macrophages via TLR2 in a caspase-3/caspase-8-mediated manner, but also in a caspase-independent manner where mitochondrial apoptosis-inducing factor (AIFM1) translocates to the nucleus (PubMed:23316255). Another study found mature, native (lipidated) protein did not induce apoptosis in THP-1 macrophage cell line (PubMed:12874328). Functions as an adhesin, binds to human and mouse macrophages (PubMed:25359607). {ECO:0000269|PubMed:10426995, ECO:0000269|PubMed:11160304, ECO:0000269|PubMed:11441098, ECO:0000269|PubMed:12594264, ECO:0000269|PubMed:12874328, ECO:0000269|PubMed:16177361, ECO:0000269|PubMed:16622205, ECO:0000269|PubMed:21078852, ECO:0000269|PubMed:23316255, ECO:0000269|PubMed:25359607, ECO:0000269|PubMed:25504154}..

P9WK61

Cobalamin biosynthesis protein CobIJ [Includes: Precorrin-2 C(20)-methyltransferase (EC 2.1.1.130) (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT); Precorrin-3B C17-methyltransferase (EC 2.1.1.131) (S-adenosyl-L-methionine--precorrin-3B methyltransferase)]

Protein

Methylates precorrin-2 at the C-20 position to produce precorrin-3A. {ECO:0000250}..

P9WGB3

Mycocyclosin synthase (EC 1.14.19.70) (Cytochrome P450 121) (Cytochrome P450 MT2)

Protein

Catalyzes C-C bond formation between the carbons ortho to the phenolic hydroxyl of cyclo(L-tyr-L-tyr) (cYY) producing mycocyclosin. Can also use cyclo(L-Tyr-L-Phe) (cYF), cyclo(L-Tyr-L-Trp) (cYW) and cyclo(L-Tyr-L-3,4-dihydroxyphenylalanine) (cY-DOPA) as substrate. {ECO:0000269|PubMed:12237220, ECO:0000269|PubMed:19416919, ECO:0000269|Ref.2}..

P9WPP7

Precorrin-4 C(11)-methyltransferase (EC 2.1.1.133) (Precorrin-3 methylase)

Protein

Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. {ECO:0000250}..

P9WGB1

Acyl-CoA dehydrogenase FadE28 (ACAD) (EC 1.3.99.-) (3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA dehydrogenase alpha subunit) (3-oxo-4-pregnene-20-carboxyl-CoA dehydrogenase alpha subunit)

Protein

Involved in the third cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism (PubMed:26161441). May play an important role for the initial macrophage invasion, possibly in response to the acidification of phagosome (PubMed:18486437). It contributes partly to the virulence by increasing the efficiency of beta-oxidation (PubMed:18486437, PubMed:22045806). Catalyzes the dehydrogenation of 2'-propanoyl-CoA ester side chains of 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) to yield 3-oxo-4,17-pregnadiene-20-carboxyl-CoA (3-OPDC-CoA). Also able to dehydrogenate steroyl-CoA such as 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA), 1beta-(2'-propanoyl-CoA)-3a-alpha-H-7a-beta-methylhexahydro-4-indanone (indanone-CoA ester), hexahydroindanone and pregenenone (PubMed:22045806, PubMed:23560677, PubMed:26161441). {ECO:0000269|PubMed:18486437, ECO:0000269|PubMed:22045806, ECO:0000269|PubMed:23560677, ECO:0000269|PubMed:26161441}..

P71857

ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit) (F-ATPase epsilon subunit)

Protein

Produces ATP from ADP in the presence of a proton gradient across the membrane. {ECO:0000250}..

P9WPV1

Elongation factor 4 (EF-4) (EC 3.6.5.n1) (Ribosomal back-translocase LepA)

Protein

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. {ECO:0000255|HAMAP-Rule:MF_00071, ECO:0000269|PubMed:22578863}..

P9WK97

Acyl-CoA dehydrogenase FadE34 (ACAD) (EC 1.3.99.-) (3-oxochol-4-en-24-oyl-CoA dehydrogenase)

Protein

Involved in the second cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. It contributes partly to the virulence by increasing the efficiency of beta-oxidation. Catalyzes the highly specific dehydrogenation of acyl-CoA ester side chains of 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA) to yield 3-oxochol-4,22-dien-24-oyl-CoA. {ECO:0000269|PubMed:26161441}..

P96855

ESAT-6-like protein EsxV (Antigen Mtb9.9B)

Protein

Probable virulence factor. In mice, elicits increased levels of IFN-gamma, IL-12 and IgG(2a), indicating a dominant Th1 host immune response. {ECO:0000269|PubMed:21134129}..

P0DOA7

L,D-transpeptidase 1 (LDT 1) (EC 2.3.2.-) (Ldt(Mt1))

Protein

Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is thought to play a role in adaptation to the nonreplicative state of M.tuberculosis. {ECO:0000269|PubMed:18408028, ECO:0000269|PubMed:24041897}..

O53638

tRNA pseudouridine synthase A (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I)

Protein

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. {ECO:0000255|HAMAP-Rule:MF_00171}..

P9WHP9

L,D-transpeptidase 2 (LDT 2) (EC 2.3.2.-) (Ldt(Mt2))

Protein

Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. {ECO:0000269|PubMed:24041897}..

I6Y9J2

Protein translocase subunit SecY

Protein

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. {ECO:0000255|HAMAP-Rule:MF_01465}..

P9WGN3

ATP synthase gamma chain (ATP synthase F1 sector gamma subunit) (F-ATPase gamma subunit)

Protein

Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. {ECO:0000255|HAMAP-Rule:MF_00815}..

P9WPU9

Ribonucleoside-diphosphate reductase subunit alpha (EC 1.17.4.1) (Ribonucleotide reductase R1 subunit)

Protein

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. When coexpressed in E.coli with nrdF2 the 2 proteins complement a temperature-sensitive E.coli mutant, however coexpression with nrdF1 does not complement. {ECO:0000269|PubMed:9335290}..

P9WH75

Acetyl-/propionyl-coenzyme A carboxylase alpha chain [Includes: Biotin carboxylase (EC 6.3.4.14); Biotin carboxyl carrier protein (BCCP)]

Protein

This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. {ECO:0000250}..

P9WPQ3

AP-4-A phosphorylase (EC 2.7.7.53) (ATP adenylyltransferase) (Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase) (AP,A phosphorylase)

Protein

Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues. {ECO:0000269|PubMed:19778616, ECO:0000269|PubMed:21565198}..

P9WMK9

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) (4-diphosphocytidyl-2C-methyl-D-erythritol synthase) (MEP cytidylyltransferase) (MCT)

Protein

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). {ECO:0000255|HAMAP-Rule:MF_00108}..

P9WKG9

6 kDa early secretory antigenic target (ESAT-6)

Protein

A secreted protein that plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacterial escape into the host cytoplasm. Acts as a strong host (human) T-cell antigen (PubMed:7729876, PubMed:11940590). Inhibits IL-12 p40 (IL12B) and TNF-alpha expression by infected host (mouse) macrophages, reduces the nitric oxide response by about 75% (PubMed:14557536). In mice previously exposed to the bacterium, elicits high level of IFN-gamma production by T-cells upon subsequent challenge by M.tuberculosis, in the first phase of a protective immune response (PubMed:7897219, PubMed:7729876). Higher levels (1.6-3.3 uM) of recombinant protein inhibit IFN-gamma production by host (human) T-cells and also IL-17 and TNF-alpha production but not IL-2; decreases expression of host ATF-2 and JUN transcription factors by affecting T-cell receptors signaling downstream of ZAP70, without cytotoxicity or apoptosis (PubMed:19265145). EsxA inhibits IFN-gamma production in human T-cells by activating p38 MAPK (MAPK14), p38 MAPK is not responsible for IL-17 decrease (PubMed:21586573). Binds host (mouse) Toll-like receptor 2 (TLR2) and decreases host MYD88-dependent signaling; binding to TLR2 activates host kinase AKT and subsequently inhibits downstream activation of NF-kappa-B; the C-terminal 20 residues (76-95) are necessary and sufficient for the TLR2 inhibitory effect (PubMed:17486091). Required for induction of host (human) IL-1B maturation and release by activating the host NLRP3/ASC inflammasome; may also promote access of other tuberculosis proteins to the host cells cytoplasm (PubMed:20148899). Induces IL-8 (CXCL8) expression in host (human) lung epithelial cells (PubMed:23867456). Exogenously applied protein, or protein expressed in host (human and mouse), binds beta-2-microglobulin (B2M) and decreases its export to the cell surface, probably leading to defects in class I antigen presentation by the host cell (PubMed:25356553). Responsible for mitochondrial fragmention, redistribution around the cell nucleus and decreased mitochondrial mass; this effect is not seen until 48 hours post-infection (PubMed:26092385). Able to disrupt artificial planar bilayers in the absence of EsxB (CFP-10) (PubMed:14557547). Native protein binds artificial liposomes in the absence but not presence of EsxB and is able to rigidify and lyse them; the EsxA-EsxB complex dissociates at acidic pH, EsxB might serve as a chaperone to prevent membrane lysis (PubMed:17557817). Recombinant protein induces leakage of phosphocholine liposomes at acidic pH in the absence of ExsB, undergoes conformational change, becoming more alpha-helical at acidic pH (PubMed:23150662, PubMed:25645924). The study using recombinant protein did not find dissociation of EsxA-EsxB complex at acidic pH (PubMed:23150662). Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm (PubMed:17604718, PubMed:22319448). Translocation into host cytoplasm is visible 3 days post-infection using cultured human cells and precedes host cell death (PubMed:22319448). Recombinant protein induces apoptosis in host (human) differentiated cell lines, which is cell-line dependent; bacteria missing the ESX-1 locus do not induce apoptosis (PubMed:17298391). Host (human) cells treated with EsxA become permeable to extracellular dye (PubMed:17298391). EsxA and EsxA-EsxB are cytotoxic to pneumocytes (PubMed:19906174). ESX-1 secretion system-induced host (mouse) cell apoptosis, which is probably responsible for infection of new host cells, might be due to EsxA (PubMed:23848406). EsxA induces necrosis in aged neutrophils (PubMed:25321481). May help regulate assembly and function of the type VII secretion system (T7SS) (By similarity). EsxA disassembles pre-formed EccC-EsxB multimers, possibly by making EccC-EsxA-EsxB trimers instead of EccC-EsxB-EsxB-EccC tetramers (By similarity). {ECO:0000250|UniProtKB:D1A4H1, ECO:0000269|PubMed:11940590, ECO:0000269|PubMed:14557536, ECO:0000269|PubMed:14557547, ECO:0000269|PubMed:17298391, ECO:0000269|PubMed:17486091, ECO:0000269|PubMed:17557817, ECO:0000269|PubMed:17604718, ECO:0000269|PubMed:19265145, ECO:0000269|PubMed:19906174, ECO:0000269|PubMed:20148899, ECO:0000269|PubMed:21586573, ECO:0000269|PubMed:22319448, ECO:0000269|PubMed:23867456, ECO:0000269|PubMed:25321481, ECO:0000269|PubMed:25356553, ECO:0000269|PubMed:26092385, ECO:0000269|PubMed:26260636, ECO:0000269|PubMed:7729876, ECO:0000269|PubMed:7897219, ECO:0000305|PubMed:23848406}.; FUNCTION: May be critical in pro-bacteria versus pro-host interactions; ESX-1 mediates DNA mediated export (maybe via EsxA). The DNA interacts with host (human) cGAS, leading to cGAMP production and activation of the host STING-TBK-1-IRF-3 signaling pathway that leads to IFN-beta which is thought to be "pro-bacteria". Mycobacterial dsDNA also interacts with AIM2-NLRP3-ASC to activate an inflammasome, leading to the "pro-host" IL-1-beta (PubMed:26048138, PubMed:26048136). {ECO:0000269|PubMed:26048136, ECO:0000269|PubMed:26048138}..

P9WNK7

Exported repetitive protein (Cell surface protein PirG) (EXP53)

Protein

Surface-exposed protein required for multiplication and intracellular growth..

P9WIQ7

Sec translocon accessory complex subunit YajC

Protein

The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. {ECO:0000250|UniProtKB:P0ADZ7}..

P9WL75

Phosphate-binding protein PstS 1 (PBP 1) (PhoS1) (PstS-1) (38-kDa glycolipoprotein) (38-kDa lipoprotein) (P38) (Antigen Ag78) (Protein antigen B) (Pab)

Protein

Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation (PubMed:15731097, PubMed:20933472). Binds phosphate; probably able to bind both H(2)PO(4)(-) and HPO(4)(2-) (PubMed:8294447, PubMed:12842040). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). {ECO:0000269|PubMed:12842040, ECO:0000269|PubMed:15731097, ECO:0000269|PubMed:20933472, ECO:0000269|PubMed:8294447, ECO:0000305}.; FUNCTION: A host TLR2 agonist (toll-like receptor), shown experimentally for human and mouse (PubMed:1906192, PubMed:19362712). Requires both host TLR1 and TLR2 as coreceptors to elicit host response in mouse (TLR6 may also play a role) neither CD14 or CD36 function as accessory receptors (PubMed:19362712). Protein purified from culture filtrate induces host (human) monocytes to produce TNF-alpha, IL-6 and IL-12 p40 (IL12B) via ERK1/2 (MAPK3 and MAPK1) and p38 MAPK pathways; MEK inhibitors U0126 and PD98059 and p38 inhibitor SB203580 block most cytokine production (PubMed:16622205). Host ERK1/2 and p38 MAPK activation is mediated mainly by TLR2, but also partially by TLR4, and unlike the case for lipoprotein LpqH the protein moiety of PstS1 seems to be the antigenic agent (PubMed:16622205). Greater activation of ERK1/2 and p38 MAPK is seen in patients with active pulmonary tuberculosis than in tuberculin-negative patients (PubMed:16622205). Induces apoptosis when incubated with human monocyte-derived macrophages via TLR2 (PubMed:19140873). Protein purified from culture filtrate acts via TLR2 and TLR4 to induce host macrophage (shown for mouse) endoplasmic reticulum stress-mediated apoptosis via MAPK (at least JNK), C-C motif chemokine 2 (MCP-1, Ccl2) and ZC3H12 endoribonucleases (MCPIP, Zc3h12) (PubMed:25544271). Functions as an adhesin, binds to human and mouse macrophages via mannose residues, binds to the mouse macrophage mannose receptor (possibly Mrc1) and mediates bacterial phagocytosis (PubMed:25359607). {ECO:0000269|PubMed:16622205, ECO:0000269|PubMed:1906192, ECO:0000269|PubMed:19140873, ECO:0000269|PubMed:19362712, ECO:0000269|PubMed:25359607, ECO:0000269|PubMed:25544271}..

P9WGU1

Group 1 truncated hemoglobin GlbN (Truncated hemoglobin) (trHbN) (Hemoglobin-like protein HbN)

Protein

Binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20 degrees Celsius) because of a fast combination (25 microM(-1).s(-1)) and a slow dissociation (0.2 s(-1)) rate..

P9WN25

ATP synthase subunit alpha (EC 7.1.2.2) (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha)

Protein

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. {ECO:0000255|HAMAP-Rule:MF_01346}..

P9WPU7

Methyl-branched lipid omega-hydroxylase (EC 1.14.15.14) (Cholest-4-en-3-one C26-monooxygenase) (Cholest-4-en-3-one C26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]) (Cholesterol C26-monooxygenase) (Cholesterol C26-monooxygenase [(25R)-3beta-hydroxycholest-5-en-26-oate forming]) (Cytochrome P450 124) (Steroid C26-monooxygenase) (EC 1.14.15.28) (Steroid C27-monooxygenase)

Protein

Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate (PubMed:19933331). Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate (PubMed:20843794). Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer (PubMed:20843794). Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one (PubMed:20843794). {ECO:0000269|PubMed:19933331, ECO:0000269|PubMed:20843794}..

P9WPP3

50S ribosomal protein L13

Protein

This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. {ECO:0000255|HAMAP-Rule:MF_01366}..

P9WHE1

Uncharacterized transporter Rv1999c

Protein

Probable amino-acid or metabolite transport protein. {ECO:0000250}..

P9WQM3

Meromycolate extension acyl carrier protein (ACP)

Protein

Acyl carrier protein involved in meromycolate extension. {ECO:0000250}..

P9WQF3

Probable diacyglycerol O-acyltransferase tgs1 (TGS1) (EC 2.3.1.20) (Probable triacylglycerol synthase tgs1)

Protein

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis (Probable). {ECO:0000305|PubMed:15262939}.; FUNCTION: Upon expression in E.coli functions as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Prefers C(26:0)-CoA over C(18:1)-CoA. TG synthesis activity increases in M.tuberculosis upon oxygen depletion and NO treatment, with concomitant accumulation of TG in inclusion bodies. As disruption of the gene encoding this protein obviates TG synthesis this seems to be the major enzyme involved in production of TG. Has no wax synthase activity to produce wax esters. {ECO:0000269|PubMed:15262939}..

P9WKC9

Lanosterol 14-alpha demethylase (EC 1.14.14.154) (CYPLI) (Cytochrome P450 51) (Cytochrome P450-14DM) (Cytochrome P450-LIA1) (Sterol 14-alpha demethylase)

Protein

Its precise biological substrate is not known. Catalyzes C14-demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. {ECO:0000269|PubMed:10430874, ECO:0000269|PubMed:9756611}..

P9WPP9

Multifunctional 2-oxoglutarate metabolism enzyme (2-hydroxy-3-oxoadipate synthase) (HOA synthase) (HOAS) (EC 2.2.1.5) (2-oxoglutarate carboxy-lyase) (2-oxoglutarate decarboxylase) (Alpha-ketoglutarate decarboxylase) (KG decarboxylase) (KGD) (EC 4.1.1.71) (Alpha-ketoglutarate-glyoxylate carboligase) [Includes: 2-oxoglutarate dehydrogenase E1 component (ODH E1 component) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase E1 component) (KDH E1 component); Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex E2 component) (ODH E2 component) (OGDC-E2) (Dihydrolipoamide succinyltransferase)]

Protein

Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha-ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy-3-oxoadipate (HOA), which spontaneously decarboxylates to form 5-hydroxylevulinate (HLA). And is also a component of the 2-oxoglutarate dehydrogenase (ODH) complex, that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The KG decarboxylase and KG dehydrogenase reactions provide two alternative, tightly regulated, pathways connecting the oxidative and reductive branches of the TCA cycle, which can endow M.tuberculosis with the metabolic plasticity required for growth on diverse host-derived carbon sources. Appears to play a predominant role in growth on carbohydrates as the sole carbon source, and only a minimal role during growth on fatty acids. {ECO:0000269|PubMed:16027371, ECO:0000269|PubMed:19936047, ECO:0000269|PubMed:20416504, ECO:0000269|PubMed:21867916}..

P9WIS5

3-methyl-2-oxobutanoate dehydrogenase subunit beta (EC 1.2.4.4) (Branched-chain alpha-ketoacid dehydrogenase E1 component subunit beta) (BCKADH E1-beta)

Protein

Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2). {ECO:0000269|PubMed:21238944}..

P9WIS1

3-methyl-2-oxobutanoate dehydrogenase subunit alpha (EC 1.2.4.4) (Branched-chain alpha-ketoacid dehydrogenase E1 component subunit alpha) (BCKADH E1-alpha)

Protein

Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched-chain alpha-ketoacids to acyl-CoA and CO(2). {ECO:0000269|PubMed:21238944}..

P9WIS3

Probable protein-export membrane protein SecG

Protein

Involved in protein export. Participates in an early event of protein translocation (By similarity). {ECO:0000250}..

P9WGN5

Acyl-CoA dehydrogenase FadE26 (ACAD) (EC 1.3.99.-) (3-oxocholest-4-en-26-oyl-CoA dehydrogenase alpha subunit)

Protein

Involved in the first cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism (PubMed:26161441). It contributes partly to the virulence by increasing the efficiency of beta-oxidation. Catalyzes the dehydrogenation of acyl-CoA ester side chains of (25S)-3-oxo-cholest-4-en-26-oyl-CoA (3-OCS-CoA) to yield (24E)-3-oxo-cholest-4,24-dien-26-oyl-CoA (PubMed:26348625, PubMed:26161441). Also able to dehydrogenate steroyl-CoA such as 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA) as well as 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) (PubMed:26161441). It dehydrogenates only (25S)-OCS-CoA diastereomer (Probable). {ECO:0000269|PubMed:26161441, ECO:0000269|PubMed:26348625}..

I6YCA3

Uncharacterized transporter Rv1979c

Protein

Probable amino-acid or metabolite transport protein. {ECO:0000250}..

P9WQM5

Cell division protein FtsQ

Protein

Essential cell division protein. {ECO:0000255|HAMAP-Rule:MF_00911}..

P9WNA1

Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (EC 5.4.3.8) (Glutamate-1-semialdehyde aminotransferase) (GSA-AT)

Protein

Unknown.

P9WMN9

ATP synthase subunit beta (EC 7.1.2.2) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta)

Protein

Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. {ECO:0000255|HAMAP-Rule:MF_01347}..

P9WPU5

(2E,6E)-farnesyl diphosphate synthase (E,E-FPP synthase) (FPP synthase) (EC 2.5.1.10)

Protein

Catalyzes the condensation of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP). May be used for squalene and possibly sterol biosynthesis. {ECO:0000269|PubMed:15060088}..

P9WKH1

Glycine cleavage system H protein

Protein

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. {ECO:0000255|HAMAP-Rule:MF_00272}..

P9WN55

Acyl-CoA dehydrogenase FadE27 (ACAD) (EC 1.3.99.-) (3-oxocholest-4-en-26-oyl-CoA dehydrogenase beta subunit)

Protein

Involved in the first cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism (PubMed:26161441). It contributes partly to the virulence by increasing the efficiency of beta-oxidation. Catalyzes the dehydrogenation of acyl-CoA ester side chains of (25S)-3-oxo-cholest-4-en-26-oyl-CoA (3-OCS-CoA) to yield (24E)-3-oxo-cholest-4,24-dien-26-oyl-CoA (PubMed:26348625, PubMed:26161441). Also able to dehydrogenate steroyl-CoA such as 3-oxo-chol-4-en-24-oyl-CoA (3-OCO-CoA) as well as 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) (PubMed:26161441). It dehydrogenates only (25S)-OCS-CoA diastereomer (PubMed:26348625, PubMed:26161441). {ECO:0000269|PubMed:26161441, ECO:0000269|PubMed:26348625}..

I6Y3Q0

Long-chain-fatty-acid--CoA/3-oxocholest-4-en-26-oate--CoA ligase (FACL) (EC 6.2.1.3) (EC 6.2.1.42) (Acyl-CoA synthetase) (Steroid-CoA ligase) (Steroid-coenzyme A ligase)

Protein

Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. Also involved in the degradation of cholesterol via the degradation of the side chains of C-24 branched-chain sterols. Catalyzes the ATP-dependent CoA thioesterification of the sterol 3-oxocholest-4-en-26-oate to yield 3-oxocholest-4-en-26-oyl-CoA. It can also use 3beta-hydroxy-5-cholesten-26-oate. {ECO:0000269|PubMed:15042094, ECO:0000269|PubMed:24244004}..

P9WQ51

ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-)

Protein

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. {ECO:0000255|HAMAP-Rule:MF_01458}.; FUNCTION: Complements an E.coli null mutation. Upon overexpression in E.coli has been shown to degrade endogenous sigma-32, SecY and phage lambda cII protein..

P9WQN3

Prokaryotic ubiquitin-like protein Pup (Bacterial ubiquitin-like modifier)

Protein

Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. Among the identified substrates are the FabD, PanB and Mpa proteins. {ECO:0000269|PubMed:18832610, ECO:0000269|PubMed:19448618, ECO:0000269|PubMed:20233925}..

P9WHN5

NADPH-ferredoxin reductase FprA (NFR) (EC 1.18.1.2)

Protein

May serve as electron transfer protein and supply electrons to P450 systems..

P9WIQ3

Protein LppM (Putative lipoprotein LppM)

Protein

A putative lipoprotein that seems to be specialized for the initial steps of macrophage infection (PubMed:27220037). A non-acylated fragment (residues 26-185) binds phosphatidyl-myo-inositol mannosides (PIMs) (PubMed:27568926). Limits, in a TLR2-dependent fashion, bacterial uptake by host (mouse); this effect may be mediated by nonacylated fragment 26-185 (PubMed:27220037). Plays a TLR2-dependent role in host phagosome maturation arrest (PubMed:20844580, PubMed:27220037). Plays a TLR2-independent role in chemokine production during the first 24 hours of mouse infection (PubMed:27220037). {ECO:0000269|PubMed:27568926, ECO:0000305|PubMed:20844580, ECO:0000305|PubMed:27220037}..

O53505

Decaprenyl diphosphate synthase (DecaPP) (EC 2.5.1.86) (EC 2.5.1.87) (Decaprenyl pyrophosphate synthase) (Long-chain isoprenyl diphosphate synthase) (Trans,polycis-decaprenyl diphosphate synthase)

Protein

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP) generating the 50 carbon product trans,polycis-decaprenyl diphosphate. When (2E,6E)-farnesyl diphosphate (E-FPP or EE-FPP) is used in vitro, both primary products decaprenyl diphosphate and (2E,6E,10E)-geranylgeranyl diphosphate (EEE-GGPP) are synthesized. M.tuberculosis does not synthesize (2E,6E,10Z)-geranylgeranyl diphosphate (EEZ-GGPP) and heptaprenyl diphosphate. Can also accept many different allylic substrates, including E-geranyl diphosphate (E-GPP), neryl diphosphate (NPP), and all-trans-geranyl-geranyl diphosphate. {ECO:0000269|PubMed:10816587, ECO:0000269|PubMed:11004176, ECO:0000269|PubMed:15516568}..

P9WFF7

Chaperone protein DnaJ 1

Protein

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins. {ECO:0000255|HAMAP-Rule:MF_01152}..

P9WNV9

Chaperone protein DnaJ 2

Protein

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity). Inhibits the beta-lactamase and RNase activity of RNase J. {ECO:0000255|HAMAP-Rule:MF_01152, ECO:0000269|PubMed:21568871}..

P9WNV7

Pup deamidase/depupylase (EC 3.4.-.-) (EC 3.5.1.119) (Deamidase of protein Pup)

Protein

Specifically catalyzes the deamidation of the C-terminal glutamine of the prokaryotic ubiquitin-like protein Pup to glutamate, thereby rendering Pup competent for conjugation. Also displays depupylase (DPUP) activity, removing conjugated Pup from target proteins; is thus involved in the recycling of Pup and may function similarly to deubiquitinases (DUBs) in eukaryotes to prevent or promote proteasomal degradation of certain proteins. {ECO:0000269|PubMed:19448618, ECO:0000269|PubMed:20636328, ECO:0000269|PubMed:20705495}..

P9WNU9

Steroid C26-monooxygenase (EC 1.14.15.29) (Cholest-4-en-3-one 26-monooxygenase) (Cholest-4-en-3-one C26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]) (Cholesterol C26-monooxygenase) (Cholesterol C26-monooxygenase [(25S)-3beta-hydroxycholest-5-en-26-oate forming]) (Cytochrome P450 125) (Steroid C27-monooxygenase)

Protein

Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection (PubMed:20843794, PubMed:20545858). Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate (PubMed:19846551, PubMed:20843794, PubMed:20545858). Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one (PubMed:19846551, PubMed:20843794, PubMed:20545858). {ECO:0000269|PubMed:19846551, ECO:0000269|PubMed:20545858, ECO:0000269|PubMed:20843794}..

P9WPP1

Transcriptional regulatory protein TcrA

Protein

Member of the three-protein two-component system HK1/HK2/TcrA. {ECO:0000269|PubMed:17434492}..

O07776

50S ribosomal protein L4

Protein

One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. {ECO:0000255|HAMAP-Rule:MF_01328}.; FUNCTION: Forms part of the polypeptide exit tunnel. {ECO:0000255|HAMAP-Rule:MF_01328}..

P9WH85

Sec-independent protein translocase protein TatA

Protein

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. {ECO:0000255|HAMAP-Rule:MF_00236}..

P9WGA1

Putative 8-amino-7-oxononanoate synthase 2 (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (KAPA synthase) (8-amino-7-ketopelargonate synthase)

Protein

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. {ECO:0000250}..

P9WQ85

Elongation factor Tu (EF-Tu)

Protein

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00118}..

P9WNN1

Protein GrpE (HSP-70 cofactor)

Protein

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. {ECO:0000255|HAMAP-Rule:MF_01151}..

P9WMT5

50S ribosomal protein L5

Protein

This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. {ECO:0000255|HAMAP-Rule:MF_01333}..

P9WH83

Pyridoxal phosphate homeostasis protein (PLP homeostasis protein)

Protein

Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. {ECO:0000255|HAMAP-Rule:MF_02087}..

P9WFQ7

Bacterioferritin (BFR) (EC 1.16.3.1)

Protein

Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. {ECO:0000250}..

P9WPQ9

FHA domain-containing protein FhaB (FtsZ-interacting protein A)

Protein

Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress. {ECO:0000269|PubMed:20066037}..

P9WJB5

Uncharacterized protein Rv2004c

Protein

Some isolated peptides of this protein are able to bind to human U937 monocytoblastic and A549 epithelial cell lines..

P9WLN3

Holo-[acyl-carrier-protein] synthase (Holo-ACP synthase) (EC 2.7.8.7) (4'-phosphopantetheinyl transferase AcpS)

Protein

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. {ECO:0000255|HAMAP-Rule:MF_00101}..

P9WQD3

Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II)

Protein

This protein specifically catalyzes the removal of signal peptides from prolipoproteins. {ECO:0000250}..

P9WK99

Putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase 1 (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase) (PGP synthase)

Protein

This protein catalyzes the committed step to the synthesis of the acidic phospholipids. {ECO:0000250}..

P9WPG5

(2Z,6E)-farnesyl diphosphate synthase (EC 2.5.1.68) (Short-chain Z-isoprenyl diphosphate synthase) (Z-FPP synthase) (Z-FPPS) (Z-Polyprenyl diphosphate synthase) (Z-isoprenyl diphosphate synthase)

Protein

Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall. {ECO:0000269|PubMed:10816587, ECO:0000269|PubMed:11004176, ECO:0000269|PubMed:11152452}..

P9WFF5

Probable low molecular weight protein-tyrosine-phosphatase (PTPase) (EC 3.1.3.48)

Protein

Mediates host-pathogen interaction and interferes with vesicular trafficking in the infected macrophage. Inhibits host phagolysosomal fusion in M.tuberculosis-infected macrophages to promote bacteria survival. Dephosphorylates host VPS33B protein, which induces a block of the host phagosome maturation within macrophage cells. Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. {ECO:0000269|PubMed:18474358}..

P9WIA1

Iron-dependent repressor IdeR

Protein

Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism. Acts as a repressor of siderophore biosynthesis and as a positive modulator of iron storage. Also regulates expression of transporters, proteins involved in siderophore synthesis, iron storage and transcriptional regulators. {ECO:0000269|PubMed:11722747, ECO:0000269|PubMed:12065475}..

P9WMH1

60 kDa chaperonin 1 (GroEL protein 1) (Protein Cpn60-1)

Protein

Prevents aggregation of substrate proteins and promotes their refolding (PubMed:15327959). Functions in the absence of co-chaperone CH10 and ATP. {ECO:0000269|PubMed:15327959, ECO:0000305|PubMed:21094166}.; FUNCTION: May mediate association of bacteria with macrophages; recombinant protein competitively inhibits the association of M.tuberculosis with mouse bone marrow-derived macrophages (PubMed:19470749). {ECO:0000269|PubMed:19470749}..

P9WPE9

Protein translocase subunit SecA 2

Protein

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. {ECO:0000255|HAMAP-Rule:MF_01382}..

P9WGP3

Ribonucleoside-diphosphate reductase subunit beta nrdF1 (EC 1.17.4.1) (Ribonucleotide reductase R2-1 small subunit) (Ribonucleotide reductase small subunit 1)

Protein

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Two genes for this protein are present in M.tuberculosis; this is thought to not be the active form. When coexpressed in E.coli with nrdE the 2 proteins do not complement a temperature-sensitive E.coli mutant, whereas the other gene (nrdF2) does complement. {ECO:0000250}..

P9WH73

Ribonucleoside-diphosphate reductase subunit beta nrdF2 (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase nrdF2) (Ribonucleotide reductase R2-2 small subunit)

Protein

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Two genes for this protein are present in M.tuberculosis; this is the active form. When coexpressed in E.coli with nrdE the 2 proteins complement a temperature-sensitive E.coli mutant. {ECO:0000269|PubMed:9335290}..

P9WH71

Hypoxic response protein 1 (HRP1)

Protein

Unlike some other CBS-domain containing proteins does not seem to bind AMP..

P9WJA3

Thiamine-monophosphate kinase (TMP kinase) (Thiamine-phosphate kinase) (EC 2.7.4.16)

Protein

Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1. {ECO:0000255|HAMAP-Rule:MF_02128}..

P9WG71

Cell division protein FtsZ

Protein

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. {ECO:0000255|HAMAP-Rule:MF_00909}..

P9WN95

Zinc metalloprotease Rip1 (EC 3.4.24.-) (Regulator of sigma KLM proteases) (S2P endopeptidase) (Site-2 protease Rip1) (S2P protease Rip1) (Site-2-type intramembrane protease)

Protein

A probable intramembrane site-2 protease (S2P) that cleaves type-2 transmembrane proteins within their membrane-spanning domains. Cleaves PbpB (PBP3, FtsI) near 'Ala-102' and 'Ala-103' in response to oxidative stress; cleavage is inhibited by Wag31-PbpB interaction. Probably also cleaves anti-sigma factors RskA, RslA and RsmA but not RsdA. {ECO:0000269|PubMed:19496931}.; FUNCTION: Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal (possibly oxidative stress) triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein (includes anti-sigma factors RskA, RslA, RsmA, and PbpB in M.tuberculosis) is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this entry), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein (ECF sigma factors SigK, SigL and SigM). {ECO:0000269|PubMed:19496931}..

P9WHS3

Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (ACCase beta chain) (EC 6.4.1.2)

Protein

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. {ECO:0000250}..

P9WQH9

Protein translocase subunit SecD

Protein

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. {ECO:0000255|HAMAP-Rule:MF_01463}..

P9WGP1

Protein translocase subunit SecF

Protein

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. {ECO:0000255|HAMAP-Rule:MF_01464}..

P9WGN9

Steroid C26-monooxygenase (EC 1.14.15.28) (Cholest-4-en-3-one C26-monooxygenase) (Cholest-4-en-3-one C26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]) (Cholesterol C26-monooxygenase) (Cholesterol C26-monooxygenase [(25R)-3beta-hydroxycholest-5-en-26-oate forming]) (Cytochrome P450 142) (Steroid C27-monooxygenase)

Protein

Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection (PubMed:20843794). Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate (PubMed:20843794, PubMed:20889498). In vitro, Cyp142 catalyzes with equal preference the oxidation of both (25R)- and (25S)-26-hydroxycholest-4-en-3-one diastereomers to the corresponding carboxylic acid which is a prerequisite for entry into the beta-oxidation pathway (PubMed:20843794). Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one (PubMed:20843794). {ECO:0000269|PubMed:20843794, ECO:0000269|PubMed:20889498, ECO:0000269|PubMed:25210044}..

P9WPL5

30S ribosomal protein S19

Protein

Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. {ECO:0000250}..

P9WH45

Universal stress protein Rv2623 (USP Rv2623)

Protein

May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not show this retardation, suggesting growth may be regulated through an ATP-dependent function..

P9WFD7

Protein translocase subunit SecA 1 (tbSecA)

Protein

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of precursor proteins, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity). {ECO:0000250}..

P9WGP5

PP2C-family Ser/Thr phosphatase (EC 3.1.3.16) (Mycobacterial Ser/Thr phosphatase) (Mstp) (Possible serine/threonine phosphatase Ppp)

Protein

The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (PknA, PknB, PknD, PknE and PknF) and the penicillin-binding protein PBPA. {ECO:0000269|PubMed:12950916, ECO:0000269|PubMed:14575702, ECO:0000269|PubMed:15967413, ECO:0000269|PubMed:16436437}..

P9WHW5

50S ribosomal protein L22

Protein

This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). {ECO:0000255|HAMAP-Rule:MF_01331}.; FUNCTION: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. {ECO:0000255|HAMAP-Rule:MF_01331}..

P9WHC1

Protein translocase subunit SecE

Protein

Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. {ECO:0000255|HAMAP-Rule:MF_00422}..

P9WGN7

GTPase HflX (GTP-binding protein HflX)

Protein

GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. {ECO:0000256|HAMAP-Rule:MF_00900}..

O33230

Trigger factor (TF) (EC 5.2.1.8) (PPIase)

Protein

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). {ECO:0000250}..

P9WG55

Phthiocerol synthesis polyketide synthase type I PpsC (Beta-ketoacyl-acyl-carrier-protein synthase I) (EC 2.3.1.41)

Protein

Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. {ECO:0000250}..

P96202

Phthiocerol synthesis polyketide synthase type I PpsD (Beta-ketoacyl-acyl-carrier-protein synthase I) (EC 2.3.1.41)

Protein

Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. {ECO:0000250}..

P9WQE3

Phthiocerol synthesis polyketide synthase type I PpsA (Beta-ketoacyl-acyl-carrier-protein synthase I) (EC 2.3.1.41)

Protein

Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. {ECO:0000250}..

P9WQE7

Chaperone protein ClpB

Protein

Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). {ECO:0000250}..

P9WPD1

ATP-dependent Clp protease adapter protein ClpS

Protein

Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. {ECO:0000255|HAMAP-Rule:MF_00302}..

P9WPC1

Lipoprotein LprI (Glycolipoprotein LprI) (Lysozyme inhibitor LprI)

Protein

Strongly binds and inhibits lysozyme, may help bacteria survive in lysozyme-producing host cells. When overexpressed in M.tuberculosis or M.smegmatis increases resistance to hen egg white lysozyme. M.smegmatis overexpressing LprI survive better during intracellular infection of peritoneal and monocyte-derived macrophages, both of which produce lysozyme during infection; M.smegmatis does not encode this protein. Somewhat better survival is seen in human cell lines when M.smegmatis cells express both proteins from this operon, i.e. GlbN (HbN) and LprI. {ECO:0000269|PubMed:26589796}..

P9WK41

60 kDa chaperonin 2 (65 kDa antigen) (Antigen A) (Cell wall protein A) (GroEL protein 2) (Heat shock protein 65) (Protein Cpn60-2)

Protein

Prevents aggregation of substrate proteins and promotes their refolding (PubMed:15327959). {ECO:0000269|PubMed:15327959}.; FUNCTION: Recombinant extracellular protein activates expression of NF-kappa-B in immortalized human dermal endothelial cells in a TLR4-dependent, TLR2-independent manner. Activation occurs via MYD88-dependent and -independent pathways and requires TIRAP, TRIF, TRAM and MD-2 (some experiments done in mouse cells, mice do not usually catch tuberculosis) (PubMed:15809303). {ECO:0000269|PubMed:15809303}..

P9WPE7

Molybdenum transport system permease protein ModB

Protein

Part of the binding-protein-dependent transport system ModABCD for molybdenum; probably responsible for the translocation of the substrate across the membrane. {ECO:0000250}..

P9WG13

MPT51/MPB51 antigen

Protein

May have a role in host tissue attachment, whereby ligands may include the serum protein fibronectin and small sugars. {ECO:0000269|PubMed:14672660}..

P9WQN7

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (EC 2.7.1.148) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase)

Protein

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. {ECO:0000255|HAMAP-Rule:MF_00061}..

P9WKG7

Steroid 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acetyltransferase FadA5) (Beta-ketoacyl-CoA thiolase)

Protein

Involved in the beta-oxidation of the cholesterol side chain (PubMed:19822655). It is important for utilization of cholesterol as a sole carbon source in vitro and for full virulence in the chronic stage of mouse lung infection (PubMed:19822655). Catalyzes the thiolysis of 3,22-dioxochol-4-en-24-oyl-CoA to yield 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) and acetyl-CoA (PubMed:25482540). Also able to use acetoacetyl-CoA (AcAcCoA) as substrate (PubMed:19822655). {ECO:0000269|PubMed:19822655, ECO:0000269|PubMed:25482540}..

I6XHI4

Membrane protein insertase YidC (Foldase YidC) (Membrane integrase YidC) (Membrane protein YidC)

Protein

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity). {ECO:0000250}..

P9WIT5

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (EC 1.17.7.3) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)

Protein

Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. {ECO:0000255|HAMAP-Rule:MF_00159}..

P9WKG3

Phthiocerol synthesis polyketide synthase type I PpsB (Beta-ketoacyl-acyl-carrier-protein synthase I) (EC 2.3.1.41)

Protein

Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. {ECO:0000250}..

P9WQE5

Proteasome subunit beta (EC 3.4.25.1) (20S proteasome beta subunit) (Proteasome core protein PrcB)

Protein

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave oligopeptides not only after hydrophobic but also after basic, acidic and small neutral residues (PubMed:16468985). In complex with the ATPase Mpa, degrades protein targets conjugated to a prokaryotic ubiquitin-like protein (Pup). Among the identified substrates of the M.tuberculosis proteasome are the pupylated FabD, PanB and Mpa proteins (PubMed:17082771). One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic phase of infection in mice (PubMed:18059281). Likely functions to recycle amino acids under nutrient starvation, thereby enabling the cell to maintain basal metabolic activities (PubMed:20711362) (By similarity). The mechanism of protection against bactericidal chemistries of the host's immune response probably involves the degradation of proteins that are irreversibly oxidized, nitrated, or nitrosated. A proteolysis-independent activity of the proteasome core is required for optimal growth of M.tuberculosis in mouse lungs and for RNI resistance; in contrast, long-term survival of M.tuberculosis in stationary phase and during starvation in vitro and in the chronic phase of mouse infection required a proteolytically active proteasome (PubMed:20711362). {ECO:0000250|UniProtKB:A0QZ47, ECO:0000255|HAMAP-Rule:MF_02113, ECO:0000269|PubMed:16468985, ECO:0000269|PubMed:17082771, ECO:0000269|PubMed:18059281, ECO:0000269|PubMed:20711362}..

P9WHT9

8-amino-7-oxononanoate synthase 1 (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (KAPA synthase) (8-amino-7-ketopelargonate synthase)

Protein

Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide (By similarity). Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate. To a lesser extent, can also utilize D-alanine instead of L-alanine as substrate. {ECO:0000250, ECO:0000269|PubMed:16769720}..

P9WQ87

Antitoxin RelJ (Antitoxin YefM)

Protein

Antitoxin component of a type II toxin-antitoxin (TA) system. A probable antitoxin for the putative mRNA interferase RelK. Upon expression in E.coli but not in M.smegmatis this protein neutralizes E.coli YoeB.; FUNCTION: Binds to and represses its own promoter, in combination with RelK repression is somewhat lessened. Several DNA-protein complexes are formed in vitro depending on the RelJ:RelK ratio..

P9WF25

Apoptosis inhibitor Rv3654c

Protein

Effector protein that participates in the suppression of macrophage apoptosis by blocking the extrinsic pathway. Recognizes the host polypyrimidine tract binding protein-associated splicing factor (PSF), which probably leads to its cleavage, diminishing the level of caspase-8 in macrophages. {ECO:0000269|PubMed:20454556}..

O69622

Peptide methionine sulfoxide reductase MsrA (Protein-methionine-S-oxide reductase) (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase)

Protein

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. {ECO:0000255|HAMAP-Rule:MF_01401}..

P9WJM5

Phthiocerol synthesis polyketide synthase type I PpsE (Beta-ketoacyl-acyl-carrier-protein synthase I) (EC 2.3.1.41)

Protein

Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives. {ECO:0000269|PubMed:19197369}..

P9WQE1

Sensor histidine kinase component HK2 (EC 2.7.13.3)

Protein

Member of the three-protein two-component system HK1/HK2/TcrA. HK2 transfers its phosphoryl group to TcrA. {ECO:0000269|PubMed:17434492}..

O07777

Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)

Protein

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation..

P9WFU5

Molybdate-binding protein ModA (Molybdate/tungstate-binding protein ModA)

Protein

Involved in the transport of molybdenum into the cell. Part of the binding-protein-dependent transport system ModABCD (By similarity). {ECO:0000250}..

P9WGU3

Phosphate transport system permease protein PstA 2

Protein

Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. {ECO:0000305|PubMed:20933472}..

P9WG09

Peptidyl-tRNA hydrolase (PTH) (EC 3.1.1.29)

Protein

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. {ECO:0000255|HAMAP-Rule:MF_00083}..

P9WHN7

Ferritin BfrB (EC 1.16.3.1) (Non-heme ferritin Ftn) (Nox19)

Protein

Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe(2+) ions into Fe(3+) ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex. {ECO:0000269|PubMed:21494619}..

P9WNE5

Phosphate transport system permease protein PstA 1

Protein

Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. {ECO:0000305|PubMed:20933472}..

P9WG11

Ferredoxin

Protein

Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. {ECO:0000256|RuleBase:RU365098}..

O50433

Putative lipoprotein LprJ

Protein

Overexpression induces expression of sensor protein kdpD gene at low K(+) concentrations (0 and 250 uM, tested in M.smegatis). {ECO:0000269|PubMed:12581360}..

O33192

Serine/threonine-protein kinase PknL (EC 2.7.11.1)

Protein

Phosphorylates the DNA-binding protein Rv2175c. May be involved in the regulation of cell division and cell envelope biosynthesis. {ECO:0000269|PubMed:18175374, ECO:0000269|PubMed:19457863}..

P9WI63

Ferredoxin

Protein

Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. {ECO:0000250}..

P9WNE7

Putative membrane protein insertion efficiency factor

Protein

Could be involved in insertion of integral membrane proteins into the membrane. {ECO:0000255|HAMAP-Rule:MF_00386}..

P9WFL9

Pup--protein ligase (EC 6.3.1.19) (Proteasome accessory factor A) (Pup-conjugating enzyme)

Protein

Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine. PafA is required to confer resistance against the lethal effects of reactive nitrogen intermediates (RNI), antimicrobial molecules produced by activated macrophages and other cell types. {ECO:0000269|PubMed:14671303, ECO:0000269|PubMed:17082771, ECO:0000269|PubMed:19448618, ECO:0000269|PubMed:20355727}..

P9WNU7

30S ribosomal protein S18 2

Protein

Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. {ECO:0000255|HAMAP-Rule:MF_00270}..

P9WH47

Alkyl hydroperoxide reductase AhpD (EC 1.11.1.15)

Protein

Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. {ECO:0000256|SAAS:SAAS00088543}..

O06218

Probable transcriptional regulator WhiB6

Protein

Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA (By similarity). The apo-form has been shown to act as a protein disulfide reductase. {ECO:0000250, ECO:0000269|PubMed:19016840}..

P9WF37

ESX-3 secretion-associated protein EspG3

Protein

Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. {ECO:0000250|UniProtKB:O53943}..

P9WJC7

ESX-5 secretion-associated protein EspG5

Protein

Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. {ECO:0000269|PubMed:25155747}..

O53943

ESX-2 secretion-associated protein EspG2

Protein

Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. {ECO:0000250|UniProtKB:O53943}..

P9WJC9

ESX-1 secretion-associated protein EspG1

Protein

Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. {ECO:0000250|UniProtKB:O53943}..

P96210

Proteasome subunit alpha (EC 3.4.25.1) (20S proteasome alpha subunit) (Proteasome core protein PrcA)

Protein

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave oligopeptides not only after hydrophobic but also after basic, acidic and small neutral residues (PubMed:16468985). In complex with the ATPase Mpa, degrades protein targets conjugated to a prokaryotic ubiquitin-like protein (Pup). Among the identified substrates of the M.tuberculosis proteasome are the pupylated FabD, PanB and Mpa proteins (PubMed:17082771). One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic phase of infection in mice (PubMed:18059281). Likely functions to recycle amino acids under nutrient starvation, thereby enabling the cell to maintain basal metabolic activities (PubMed:20711362) (By similarity). The mechanism of protection against bactericidal chemistries of the host's immune response probably involves the degradation of proteins that are irreversibly oxidized, nitrated, or nitrosated. A proteolysis-independent activity of the proteasome core is required for optimal growth of M.tuberculosis in mouse lungs and for RNI resistance; in contrast, long-term survival of M.tuberculosis in stationary phase and during starvation in vitro and in the chronic phase of mouse infection required a proteolytically active proteasome (PubMed:20711362). {ECO:0000250|UniProtKB:A0QZ46, ECO:0000255|HAMAP-Rule:MF_00289, ECO:0000269|PubMed:16468985, ECO:0000269|PubMed:17082771, ECO:0000269|PubMed:18059281, ECO:0000269|PubMed:20711362}..

P9WHU1

3-ketosteroid-9-alpha-monooxygenase, ferredoxin reductase component (3-ketosteroid-9-alpha-hydroxylase, ferredoxin reductase component) (KSH) (Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase) (EC 1.14.15.30) (Rieske-type oxygenase) (RO)

Protein

Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. KSH is also able to use 4-androstene-3,17-dione (AD), 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4-BNC), 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oate (1,4-BNC), 3-oxo-23,24-bisnorcholesta-4-en-22-oyl-coenzyme A thioester (4-BNC-CoA) and 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA) as substrates. {ECO:0000269|PubMed:19234303, ECO:0000269|PubMed:21987574}..

P9WJ93

3-ketosteroid-9-alpha-monooxygenase, oxygenase component (3-ketosteroid-9-alpha-hydroxylase, oxygenase component) (KSH) (Androsta-1,4-diene-3,17-dione 9-alpha-hydroxylase) (EC 1.14.15.30) (Rieske-type oxygenase) (RO)

Protein

Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (ADD) to yield the 9alpha-hydroxy-1,4-androstadiene-3,17-dione (9OHADD) intermediate which spontaneously form 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (HSA) via the meta-cleavage of ring B with concomitant aromatization of ring A. KSH is also able to use 4-androstene-3,17-dione (AD), 3-oxo-23,24-bisnorcholesta-4-en-22-oate (4-BNC), 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oate (1,4-BNC), 3-oxo-23,24-bisnorcholesta-4-en-22-oyl-coenzyme A thioester (4-BNC-CoA) and 3-oxo-23,24-bisnorcholesta-1,4-dien-22-oyl-coenzyme A thioester (1,4-BNC-CoA) as substrates. {ECO:0000269|PubMed:19234303, ECO:0000269|PubMed:21987574}..

P71875

Sensor histidine kinase component HK1 (EC 2.7.13.3)

Protein

Member of the three-protein two-component system HK1/HK2/TcrA. Kinase that binds ATP and catalyzes the transfer of a phosphoryl group from ATP to HK2. {ECO:0000269|PubMed:17434492}..

O07778

PE family immunomodulator PE15

Protein

May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways. {ECO:0000269|PubMed:23284742}..

P9WIH1

Acyl carrier protein MbtL (ACP) (Mycobactin synthase protein L)

Protein

Acyl carrier protein involved in the formation of acyl-S-ACP intermediates within the mycobactin biosynthesis process. The aliphatic chains carried by ACP are subsequently transferred on to the mycobactin core by MbtK. {ECO:0000269|PubMed:16461464}..

P9WQF1

Copper transporter MctB (Mycobacterial copper transport protein B)

Protein

Pore-forming protein, which is involved in efflux of copper across the outer membrane. Essential for copper resistance and maintenance of a low intracellular copper concentration. Required for virulence. {ECO:0000269|PubMed:18434314, ECO:0000269|PubMed:21205886}..

P9WJ83

Sulfur carrier protein FdhD

Protein

Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. {ECO:0000255|HAMAP-Rule:MF_00187}..

P9WNF1

Uncharacterized protein

Protein

One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. {ECO:0000256|SAAS:SAAS00828801}..

O05873

Probable glycine dehydrogenase (decarboxylating) (EC 1.4.4.2) (Glycine cleavage system P-protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring))

Protein

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity). {ECO:0000250}..

P9WN53

Apoptosis inhibitor Rv3655c

Protein

Effector protein that participates in the suppression of macrophage apoptosis by blocking the extrinsic pathway. Interferes with caspase-8 activation and binds to the host E3 ubiquitin-protein ligase RNF213, whose fusion partners have anti-apoptotic function. {ECO:0000269|PubMed:20454556}..

O69623

ATP-dependent Clp protease proteolytic subunit 1 (EC 3.4.21.92) (Endopeptidase Clp 1)

Protein

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). Degrades anti-sigma-D factor (rsdA) when present in a complex with ClpP2 and ClpX. Does not seem to act on anti-sigma-L factor (rslA). {ECO:0000255|HAMAP-Rule:MF_00444, ECO:0000269|PubMed:23314154}..

P9WPC5

Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin) (Rotamase A)

Protein

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000269|PubMed:15479239, ECO:0000269|PubMed:17141764}..

P9WHW3

Probable cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase) (LAP) (EC 3.4.11.10) (Leucyl aminopeptidase)

Protein

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity). {ECO:0000250}..

P9WHT3

Probable peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Rotamase B)

Protein

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}..

P9WHW1

30S ribosomal protein S17

Protein

One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. {ECO:0000255|HAMAP-Rule:MF_01345}..

P9WH51

50S ribosomal protein L19

Protein

This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. {ECO:0000250}..

P9WHC9

30S ribosomal protein S18 1

Protein

Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. {ECO:0000255|HAMAP-Rule:MF_00270}..

P9WH49

Sensor protein KdpD (EC 2.7.13.3)

Protein

Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals (By similarity). {ECO:0000250}..

P9WGL3

Long-chain-fatty-acid--[acyl-carrier-protein] ligase MbtM (EC 6.2.1.20) (Fatty acyl-[acyl-carrier-protein] synthetase) (Fatty acyl-ACP synthetase) (Mycobactin synthetase protein M)

Protein

Activates lipidic moieties required for mycobactin biosynthesis. Converts medium- to long-chain aliphatic fatty acids into acyl adenylate, which is further transferred on to the phosphopantetheine arm of the carrier protein MbtL. {ECO:0000269|PubMed:16461464}..

P9WQ41

50S ribosomal protein L20

Protein

Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity). {ECO:0000250}..

P9WHC5

Arabinogalactan biosynthesis recruiting protein Rv3789

Protein

Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis. {ECO:0000269|PubMed:26369580}..

P9WMS9

Bifunctional uridylyltransferase/uridylyl-removing enzyme (UTase/UR) (Bifunctional [protein-PII] modification enzyme) (Bifunctional nitrogen sensor protein) [Includes: [Protein-PII] uridylyltransferase (PII uridylyltransferase) (UTase) (EC 2.7.7.59); [Protein-PII]-UMP uridylyl-removing enzyme (UR) (EC 3.1.4.-)]

Protein

Modifies, by uridylylation and deuridylylation, the PII regulatory protein (GlnB), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII protein and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII protein, and plays an important role in the regulation of nitrogen assimilation and metabolism (Probable). {ECO:0000305|PubMed:17303474}..

P9WN29

50S ribosomal protein L23

Protein

One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome. {ECO:0000255|HAMAP-Rule:MF_01369}..

P9WHB9

50S ribosomal protein L24

Protein

One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. {ECO:0000255|HAMAP-Rule:MF_01326}.; FUNCTION: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. {ECO:0000255|HAMAP-Rule:MF_01326}..

P9WHB7

Zinc uptake regulation protein (Zinc uptake regulator)

Protein

Global transcriptional regulator involved in zinc homeostasis. Represses the transcription of at least 32 genes, including genes involved in zinc homeostasis, by binding to promoter sequences that contain a conserved 26 bp palindrome, in the presence of zinc. {ECO:0000269|PubMed:17098899}..

P9WN85

Bifunctional oligoribonuclease and PAP phosphatase NrnA (EC 3.1.-.-) (3'(2'),5'-bisphosphate nucleotidase) (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (nanoRNase)

Protein

Bifunctional enzyme which has both oligoribonuclease and pAp-phosphatase activities. Degrades RNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for 2-mers. Also degrades 24-mers. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. {ECO:0000269|PubMed:22114320}..

P71615

50S ribosomal protein L25 (General stress protein CTC)

Protein

This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. {ECO:0000255|HAMAP-Rule:MF_01334}..

P9WHB5

Putative mycofactocin system creatinine amidohydrolase family protein MftE (EC 3.5.-.-)

Protein

May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster..

P9WP59

Putative mycofactocin system heme/flavin oxidoreductase MftD (EC 1.-.-.-)

Protein

May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster..

P9WND7

Putative electron carrier mycofactocin

Protein

A putative polypeptide that may function as an electron carrier; the C-terminal 8 residues are highly conserved. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster..

P9WJ81

ESX-5 secretion system protein EccD5 (ESX conserved component D5) (Type VII secretion system protein EccD5) (T7SS protein EccD5)

Protein

Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. {ECO:0000269|PubMed:22340629, ECO:0000269|PubMed:22925462}..

P9WNP9

Signal recognition particle receptor FtsY (SRP receptor)

Protein

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). {ECO:0000255|HAMAP-Rule:MF_00920}..

P9WGD9

Anti-sigma-K factor RskA (Regulator of SigK) (Sigma-K anti-sigma factor RskA)

Protein

An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor. {ECO:0000269|PubMed:17064366}..

P9WGX5

D-aminoacyl-tRNA deacylase (DTD) (EC 3.1.1.96) (Gly-tRNA(Ala) deacylase) (EC 3.1.1.-)

Protein

An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality. {ECO:0000255|HAMAP-Rule:MF_00518}..

P9WNS9

Anti-sigma-M factor RsmA (Regulator of SigM) (Sigma-M anti-sigma factor RsmA)

Protein

An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigM. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor (By similarity). {ECO:0000250}..

P9WJ65

DNA replication and repair protein RecF

Protein

The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). {ECO:0000250}..

P9WHI9

Lysine N-acyltransferase MbtK (N-acyltransferase MbtK) (EC 2.3.1.-) (Mycobactin synthase protein K)

Protein

Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core. {ECO:0000269|PubMed:16461464}..

P9WK15

Alkyl hydroperoxide reductase AhpD (EC 1.11.1.15)

Protein

Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. {ECO:0000256|SAAS:SAAS00088543}..

O06800

Ribosome-recycling factor (RRF) (Ribosome-releasing factor)

Protein

Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. {ECO:0000255|HAMAP-Rule:MF_00040}..

P9WGY1

50S ribosomal protein L3

Protein

One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. {ECO:0000255|HAMAP-Rule:MF_01325}..

P9WH87

Anti-sigma-L factor RslA (Regulator of SigL) (Sigma-L anti-sigma factor RslA)

Protein

An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigL. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor. {ECO:0000269|PubMed:16552079}..

P9WJ67

Sec-independent protein translocase protein TatB

Protein

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. {ECO:0000255|HAMAP-Rule:MF_00237}..

P9WG99

Putative diacylated glycolipid transporter LprF (Lipoprotein LprF)

Protein

Might be involved in transporting short diacylated glycolipids to the cell outer membrane (By similarity). Overexpression induces expression of sensor protein kdpD gene at low K(+) concentrations (0 and 250 uM, tested in M.smegatis). {ECO:0000250|UniProtKB:P65315, ECO:0000269|PubMed:12581360}..

P9WK47

Serine/threonine-protein kinase PknF (EC 2.7.11.1)

Protein

Phosphorylates the FHA domains of the ABC transporter Rv1747, the heat-shock protein GroEL 1, and Rv0020c. May play a role in the regulation of glucose transport, cell growth and septum formation. {ECO:0000269|PubMed:15135525, ECO:0000269|PubMed:15866927, ECO:0000269|PubMed:15987910, ECO:0000269|PubMed:19201798, ECO:0000269|PubMed:21622570}..

P9WI75

Translation initiation factor IF-3

Protein

IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. {ECO:0000255|HAMAP-Rule:MF_00080}..

P9WKJ9

Probable sulfate transporter Rv1739c

Protein

Expression in E.coli induces sulfate uptake during early-to mid-log phase growth. Uptake is maximal at pH 6.0, is sulfate-specific, requires E.coli CysA and the transmembrane segment but not the STAS domain of the protein. {ECO:0000269|PubMed:18255326}..

P9WGF7

Ribosomal silencing factor RsfS

Protein

Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. {ECO:0000256|HAMAP-Rule:MF_01477}..

O86327

SsrA-binding protein (Small protein B)

Protein

Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. {ECO:0000255|HAMAP-Rule:MF_00023}..

P9WGD3

Endoribonuclease MazF4 (EC 3.1.-.-) (Toxin MazF4) (mRNA interferase MazF-mt7)

Protein

Toxic component of a type II toxin-antitoxin (TA) system. Acts as an endoribonuclease (mRNA interferase) on single-strand mRNA, cleaving between the first and second bases in the sequence UCGCU. Overexpression in M.smegmatis but not E.coli inhibits growth, this effect is neutralized by coexpression with cognate toxin MazE4. {ECO:0000269|PubMed:18485066}.; FUNCTION: Residues 29-56 inhibit ssDNA cleavage by DNA topoisomerase. This fragment does not have mRNA cleavage activity but it inhibits growth upon overexpression in M.smegmatis. {ECO:0000269|PubMed:20724443}..

P9WII5

Galactofuranosyltransferase GlfT2 (GalTr 2) (EC 2.4.1.288) (Arabinogalactan galactosyltransferase 2) (Galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase) (Polymerizing galactofuranosyltransferase GlfT2)

Protein

Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacteria cell wall. Thus, successively transfers approximately 28 galactofuranosyl (Galf) residues from UDP-galactofuranose (UDP-Galf) onto the galactofuranosyl-galactofuranosyl-rhamnosyl-GlcNAc-diphospho-decaprenol (Galf-Galf-Rha-GlcNAc-PP-C50) acceptor produced by GlfT1, with alternating 1->5 and 1->6 links, forming a galactan domain with approximately 30 galactofuranosyl residues. {ECO:0000269|PubMed:18055597, ECO:0000269|PubMed:19571009, ECO:0000305|PubMed:10934214, ECO:0000305|PubMed:11304545, ECO:0000305|PubMed:16704275, ECO:0000305|PubMed:18423586}..

O53585

ESX-5 secretion system protein EccC5 (ESX conserved component C5) (Type VII secretion system protein EccC5) (T7SS protein EccC5)

Protein

Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. {ECO:0000269|PubMed:22340629, ECO:0000269|PubMed:22925462, ECO:0000269|PubMed:23284869}..

P9WNA5

50S ribosomal protein L18

Protein

This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. {ECO:0000255|HAMAP-Rule:MF_01337}..

P9WHD1

Putative mycofactocin system protein MftB

Protein

May function to bind or modify mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster..

P95038

ESX-5 secretion system protein EccE5 (ESX conserved component E5) (Type VII secretion system protein EccE5) (T7SS protein EccE5)

Protein

Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. {ECO:0000269|PubMed:22340629, ECO:0000269|PubMed:22925462}..

P9WJE3

Soluble secreted antigen MPT53

Protein

Disulfide oxidoreductase that catalyzes the oxidation of reduced, unfolded secreted proteins to form disulfide bonds. Despite a weak homology to thioredoxin this cannot serve as a substrate for thioredoxin reductase. {ECO:0000269|PubMed:14597624}..

P9WG65

Heme uptake protein MmpL11

Protein

Part of a heme-iron acquisition system. Receives heme from the heme-binding protein Rv0203 and transports it into the mycobacterial cell. Contributes to virulence. {ECO:0000269|PubMed:15908378, ECO:0000269|PubMed:21383189, ECO:0000269|PubMed:23760277}.; FUNCTION: Could also transport the mycolic acid-containing lipids monomeromycolyl diacylglycerol (MMDAG) and mycolate ester wax (WE) to the bacterial surface. {ECO:0000303|PubMed:23836904}..

P9WJT9

50S ribosomal protein L6

Protein

This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. {ECO:0000255|HAMAP-Rule:MF_01365}..

P9WH81

Cell division protein SepF

Protein

Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. {ECO:0000255|HAMAP-Rule:MF_01197}..

P9WGJ5

Ribonuclease P protein component (RNase P protein) (RNaseP protein) (EC 3.1.26.5) (Protein C5)

Protein

RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. {ECO:0000255|HAMAP-Rule:MF_00227}..

P9WGZ3

4-hydroxyphenylalkanoate adenylyltransferase (EC 6.2.1.51) (Acyl-AMP synthase) (Long-chain-fatty-acid--AMP ligase FadD29) (FAAL)

Protein

Catalyzes the activation of the long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension. Involved in the biosynthesis of phenolphthiocerol, which is an important intermediate in the biosynthesis of phenolic glycolipid (mycosid B). {ECO:0000269|PubMed:15042094, ECO:0000269|PubMed:20553505}..

P95141

Anti-sigma-D factor RsdA (Regulator of SigD) (Sigma-D anti-sigma factor RsdA)

Protein

An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigD. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor. Neither S1P nor S2P proteases have been so far identified for this anti-sigma factor..

P9WJ71

Long-chain-fatty-acid--AMP ligase FadD26 (FAAL) (EC 6.2.1.-) (Acyl-AMP synthetase)

Protein

Catalyzes the activation of long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase PpsA for further chain extension. Involved in the biosynthesis of phthiocerol dimycocerosate (DIM A) and phthiodiolone dimycocerosate (DIM B). {ECO:0000269|PubMed:11279114, ECO:0000269|PubMed:15042094}..

P9WQ43

2-phospho-L-lactate guanylyltransferase (LP guanylyltransferase) (EC 2.7.7.68)

Protein

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. {ECO:0000255|HAMAP-Rule:MF_02114}..

P9WP83

30S ribosomal protein S8

Protein

One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit. {ECO:0000255|HAMAP-Rule:MF_01302}..

P9WH27

Putative mycofactocin radical SAM maturase MftC (EC 2.-.-.-)

Protein

May function to modify mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster..

P9WJ79

Putative mycofactocin biosynthesis glycosyltransferase MftF (EC 2.-.-.-)

Protein

May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster..

P9WMX1

Thiazole synthase (EC 2.8.1.10)

Protein

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. {ECO:0000255|HAMAP-Rule:MF_00443}..

P9WG73

Translation initiation factor IF-2

Protein

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity). {ECO:0000250}..

P9WKK1

N-alpha-acetyltransferase RimI (EC 2.3.1.255) (EC 2.3.1.258)

Protein

N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues. Able to mediate acetylation of a wide variety of N-terminal residues, with preference for hydrophobic N-termini. Acetylates GroS/GroES and GroEL1. Able to acetylate the ribosomal protein S18, but it is unclear whether it acetylates its N-terminal alanine residue. {ECO:0000269|PubMed:27353550}..

I6YG32

Aspartate 1-decarboxylase (EC 4.1.1.11) (Aspartate alpha-decarboxylase) [Cleaved into: Aspartate 1-decarboxylase beta chain; Aspartate 1-decarboxylase alpha chain]

Protein

Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. {ECO:0000255|HAMAP-Rule:MF_00446, ECO:0000305|PubMed:12182836}.; FUNCTION: Overexpression of wild-type protein confers resistance to pyrazinoic acid (POA), the active form of the anti-tuberculosis prodrug pyrazinamide (PZA). {ECO:0000269|PubMed:26038753}..

P9WIL3

PE family immunomodulator PE5

Protein

Important for the siderophore-mediated iron-acquisition function of ESX-3 (PubMed:26729876). May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling pathways (PubMed:23284742). {ECO:0000269|PubMed:23284742, ECO:0000269|PubMed:26729876}..

L7N695

Phosphate-binding protein PstS 2 (PBP 2) (PstS-2)

Protein

Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation (PubMed:15731097, PubMed:20933472). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). {ECO:0000269|PubMed:15731097, ECO:0000269|PubMed:20933472, ECO:0000305}..

P9WGT9

Octanoyltransferase (EC 2.3.1.181) (Lipoate-protein ligase B) (Lipoyl/octanoyl transferase) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase)

Protein

Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. {ECO:0000255|HAMAP-Rule:MF_00013, ECO:0000269|PubMed:16735476}..

P9WK83

Serine protease inhibitor Rv3364c

Protein

Effector protein that binds to the host serine protease cathepsin G on the macrophage cell membrane, inhibiting its enzymatic activity and the downstream activation of caspase-1-dependent apoptosis. Thus prevents macrophage pyroptosis and helps M.tuberculosis survival within host cells. {ECO:0000269|PubMed:22275911}..

O50393

30S ribosomal protein S13

Protein

Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. {ECO:0000255|HAMAP-Rule:MF_01315}..

P9WH61

Probable adenylyltransferase/sulfurtransferase MoeZ [Includes: Sulfur carrier protein CysO adenylyltransferase (EC 2.7.7.-); Sulfur carrier protein CysO sulfurtransferase (EC 2.8.1.-)]

Protein

Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps: first, ATP-dependent activation of CysO as acyl-adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO-thiocarboxylate (CysO-COSH) (Probable). The sulfur source is unknown. {ECO:0000269|PubMed:16104727, ECO:0000305}..

P9WMN7

Lipid uptake coordinator A

Protein

Required for the import of both fatty acids and cholesterol during growth in macrophages and in axenic culture. Facilitates the uptake of these lipids by stabilizing protein subunits of the Mce1 and Mce4 multi-subunit transporters, which transport fatty acids and cholesterol, respectively. Required for full virulence in vivo. {ECO:0000269|PubMed:28708968}..

O69690

Serine/threonine-protein kinase PknB (EC 2.7.11.1)

Protein

Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host (PubMed:24706757). Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA (PubMed:15978616, PubMed:15985609, PubMed:15987910, PubMed:16436437, PubMed:16817899, PubMed:16980473, PubMed:19121323, PubMed:19826007, PubMed:20025669, PubMed:21423706, PubMed:22275220). Also catalyzes the phosphorylation of the core proteasome alpha-subunit (PrcA), and thereby regulates the proteolytic activity of the proteasome (PubMed:25224505). Is a major regulator of the oxygen-dependent replication switch since PknB activity is necessary for reactivation of cells from the hypoxic state (PubMed:24409094). Shows a strong preference for Thr versus Ser as the phosphoacceptor. Overexpression of PknB alters cell morphology and leads to cell death (PubMed:24706757) (PubMed:24409094). {ECO:0000269|PubMed:15978616, ECO:0000269|PubMed:15985609, ECO:0000269|PubMed:15987910, ECO:0000269|PubMed:16436437, ECO:0000269|PubMed:16817899, ECO:0000269|PubMed:16980473, ECO:0000269|PubMed:19121323, ECO:0000269|PubMed:19826007, ECO:0000269|PubMed:20025669, ECO:0000269|PubMed:21423706, ECO:0000269|PubMed:22275220, ECO:0000269|PubMed:24409094, ECO:0000269|PubMed:24706757, ECO:0000269|PubMed:25224505}..

P9WI81

ATP-dependent Clp protease proteolytic subunit 2 (EC 3.4.21.92) (Endopeptidase Clp 2)

Protein

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity). Degrades anti-sigma-D factor RsdA when present in a complex with ClpP1 and ClpX. Degrades anti-sigma-E factor RseA in the presence of ClpC1. Does not seem to act on anti-sigma-L factor RslA. {ECO:0000255|HAMAP-Rule:MF_00444, ECO:0000269|PubMed:20025669, ECO:0000269|PubMed:23314154}..

P9WPC3

Transcriptional regulator WhiB1

Protein

Acts as a transcriptional repressor, inhibiting expression in vitro. Probably redox-responsive. The apo- but not holo-form binds to its own promoter as well as that of groEL2. Oxidized apo-form and nitrosylated holo-form also bind DNA. The apo-form has been shown to act as a protein disulfide reductase (PubMed:17157031) (PubMed:19016840), but also not to act as a protein disulfide reductase (PubMed:20929442). {ECO:0000269|PubMed:17157031, ECO:0000269|PubMed:19016840, ECO:0000269|PubMed:20929442, ECO:0000269|PubMed:22464736}..

P9WF43

Alpha-crystallin (Acr) (14 kDa antigen) (16 kDa antigen) (HSP 16.3) (Nox16)

Protein

Acts as a chaperone, as it has a significant ability to suppress the thermal denaturation of alcohol dehydrogenase. Cells overexpressing this gene grow more slowly than wild-type cells, and are less susceptible to autolysis following saturation of the culture in vitro, suggesting this protein may slow down the growth rate of M.tuberculosis in culture and by extension during macrophage infection. {ECO:0000269|PubMed:8755875}..

P9WMK1

Cell surface glycolipoprotein MPT83 (Lipoprotein p23)

Protein

Recombinant, non-modified protein stimulates secretion of cytokines (TNF-alpha, IL-6 and IL-12p40) by mouse macrophage cell lines in a TLR2-dependent fashion, which leads to increased host innate immunity responses against the bacterium (PubMed:22174456). Serves as a strong human and mouse antigen T cell antigen during M.tuberculosis infection, inducing strong IFN-gamma expression (PubMed:22567094). {ECO:0000269|PubMed:22174456, ECO:0000269|PubMed:22567094}..

P9WNF3

Probable transcriptional regulator WhiB7

Protein

The apo- but not holo-form probably binds DNA (By similarity). Acts as a transcriptional regulator. Probably redox-responsive. Upon overproduction at least 10 other genes are up-regulated, among them are Rv1258c, Rv1988, Rv2301, Rv2416c, Rv2725c and whiB7 itself. Probably redox-responsive. The apo-form has been shown to act as a protein disulfide reductase. {ECO:0000250, ECO:0000269|PubMed:16103351, ECO:0000269|PubMed:19016840}..

Q6MX01

Sensor histidine kinase MtrB (EC 2.7.13.3)

Protein

Member of the two-component regulatory system MtrA/MtrB. Probably functions as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals. Autophosphorylates and transfers phosphate to MtrA in vitro. Overexpression of MtrA alone decreases bacterial virulence in mouse infection; co-expression of MtrA and MtrB restores normal bacterial growth, suggesting that bacterial growth in macrophages requires an optimal ratio of MtrB to MtrA. Probably plays a role in cell division. {ECO:0000269|PubMed:21295603, ECO:0000269|PubMed:22610443}..

P9WGK9

Lipoprotein LprN

Protein

Stimulates the host (mouse) immune response; lipidated protein produced in E.coli stimulates T-cell proliferation in mice previously sensitized with LprN. Spleenocytes from these mice produce increased amounts of TNF-alpha and IFN-gamma, as well as somewhat increased nitric oxide levels, upon subsequent challenge with LprN. Previously sensitized mice infected with M.tuberculosis have an exacerbated disease response, suggesting this lipoprotein may down-regulate the host's immune response. {ECO:0000269|PubMed:24989028}..

I6Y3P1

ESAT-6-like protein EsxB (10 kDa culture filtrate antigen CFP-10) (CFP-10) (Secreted antigenic protein MTSA-10)

Protein

A secreted protein. Acts as a strong host (human) T-cell antigen (PubMed:11940590). Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm (PubMed:17604718). Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA; native protein binds poorly to artificial liposomes in the absence or presence of EsxA (PubMed:17557817, PubMed:26260636). EsxA and EsxA-EsxB are cytotoxic to pneumocytes (PubMed:19906174). EsxB (and EsxA-EsxB but not EsxA alone) activates human neutrophils; EsxB transiently induces host (human) intracellular Ca(2+) mobility in a dose-dependent manner, monocytes and lymphocytes do not respond (PubMed:25332123). Neutrophils respond to EsxB by chemotaxis and primed neutrophils treated with EsxB produce reactive oxygen species (ROS); Ca(2+) release and the ROS burst via are induced by an unidentified G-protein coupled receptor (PubMed:25332123). May help regulate assembly and function of the type VII secretion system (T7SS) (PubMed:25865481). {ECO:0000269|PubMed:11940590, ECO:0000269|PubMed:17557817, ECO:0000269|PubMed:17604718, ECO:0000269|PubMed:19906174, ECO:0000269|PubMed:25332123, ECO:0000269|PubMed:25865481, ECO:0000305|PubMed:26260636}..

P9WNK5

Signal transduction histidine-protein kinase/phosphatase MprB (EC 2.7.13.3) (EC 3.1.3.-) (Mycobacterial persistence regulator B)

Protein

Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA. MprB/MprA is involved in regulation of numerous stress-responsive genes, including up-regulation of two sigma factors, sigE and sigB as well as pepD and mprA, and repression of multiple genes from regulons associated with hypoxia, starvation and iron metabolism. The majority of genes regulated by MprB/MprA under a particular stress condition are different from those induced during normal growth, but several genes are commonly regulated under more than one condition. {ECO:0000269|PubMed:11675502, ECO:0000269|PubMed:14638785, ECO:0000269|PubMed:15601704, ECO:0000269|PubMed:16513743, ECO:0000269|PubMed:17379732}..

P9WGL1

Peptide deformylase (PDF) (EC 3.5.1.88) (Polypeptide deformylase)

Protein

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). {ECO:0000250}..

P9WIJ3

Formylglycine-generating enzyme (FGE) (EC 1.8.3.7)

Protein

Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. {ECO:0000269|PubMed:18390551}..

I6Y8I5

ESX-5 secretion system protein EccA5 (ESX conserved component A5) (Type VII secretion system protein EccA5) (T7SS protein EccA5)

Protein

Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41 (PubMed:22340629, PubMed:22925462). EccA5 exhibits ATPase activity and may provide energy for the export of ESX-5 substrates (By similarity). {ECO:0000250|UniProtKB:P9WPH9, ECO:0000269|PubMed:22340629, ECO:0000269|PubMed:22925462}..

P9WPI1

ESX-5 secretion system ATPase EccB5 (EC 3.6.-.-) (ESX conserved component B5) (Type VII secretion system protein EccB5) (T7SS protein EccB5)

Protein

An ATPase (shown for residues 80-506) (PubMed:26396239). Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41. {ECO:0000269|PubMed:22340629, ECO:0000269|PubMed:22925462, ECO:0000269|PubMed:23284869}..

P9WNQ9

Sec-independent protein translocase protein TatC

Protein

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. {ECO:0000255|HAMAP-Rule:MF_00902}..

P9WG97

30S ribosomal protein S15

Protein

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. {ECO:0000255|HAMAP-Rule:MF_01343}.; FUNCTION: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. {ECO:0000255|HAMAP-Rule:MF_01343}..

P9WH55

Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Peptidase M)

Protein

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. {ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|PubMed:19688379, ECO:0000269|PubMed:20038112}..

P9WK19

Dormancy associated translation inhibitor (DATIN)

Protein

Involved in translation regulation (PubMed:19795912, PubMed:22719925). Inhibits protein synthesis and decreases bacterial growth when expressed in E.coli (PubMed:22719925). Can also stimulate macrophages and peripheral blood mononuclear cells (PBMC) to secrete important cytokines that may be significant in granuloma formation and its maintenance. Increases secretion of IFN-gamma, TNF-alpha, IL-1 beta and IL-8 through human Toll-like receptor 2 (TLR2) signaling pathway (PubMed:23819907). {ECO:0000269|PubMed:22719925, ECO:0000269|PubMed:23819907, ECO:0000305|PubMed:19795912}..

P9WMA9

PE-PGRS family protein PE25

Protein

The PE25/PPE41 dimer induces both a strong humoral and cellular immune response. PE25 protein alone induces low response (PubMed:18974870). The dimer induces necrosis, but not apoptosis, in mouse macrophage cells (PubMed:25379378). It also induces activation and maturation of mouse dendritic cells and drives Th2-biased immune responses (PubMed:26318856). {ECO:0000269|PubMed:18974870, ECO:0000269|PubMed:25379378, ECO:0000269|PubMed:26318856}..

I6X486

Chaperone protein DnaK (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70)

Protein

Acts as a chaperone. {ECO:0000255|HAMAP-Rule:MF_00332}.; FUNCTION: Recombinant extracellular protein activates expression of NF-kappa-B in immortalized human dermal endothelial cells in a TLR2- and TLR4-dependent manner. Activation occurs via MYD88-dependent and -independent pathways and requires TIRAP, TRIF and TRAM (some experiments done in mouse cells, mice do not usually catch tuberculosis) (PubMed:15809303). {ECO:0000269|PubMed:15809303}..

P9WMJ9

Probable ECF RNA polymerase sigma factor SigI (ECF sigma factor SigI) (Alternative RNA polymerase sigma factor SigI) (RNA polymerase sigma-I factor) (Sigma-I factor)

Protein

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein (By similarity). {ECO:0000250}..

P9WGH3

Acyltransferase papA3 (EC 2.3.1.-) (Polyketide synthase-associated protein A3)

Protein

Involved in the biosynthesis of polyacyltrehalose (PAT) which could have a role in anchoring the bacterial capsule. In vitro catalyzes the sequential transfer of two palmitoyl groups onto a single glucose residue of trehalose generating the diacylated product 2,3-diacyltrehalose (trehalose dipalmitate). Although palmitoyl-CoA (PCoA) seems to be the physiological acyl donor, PapA3 can also use docosanoyl (22-carbon saturated fatty acid) coenzyme A as acyl donor. {ECO:0000269|PubMed:19276083}..

P9WIK5

Long-chain-fatty-acid--AMP ligase FadD28 (FAAL) (EC 6.2.1.-) (Acyl-AMP synthetase)

Protein

Catalyzes the activation of long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase Mas for further chain extension. Involved in the biosynthesis of mycoserates. Probably plays a role in host phagosome maturation arrest (PubMed:20844580). {ECO:0000269|PubMed:10573420, ECO:0000269|PubMed:11279114, ECO:0000269|PubMed:15042094, ECO:0000305|PubMed:20844580}..

P9WQ59

Probable L,D-transpeptidase 3 (LDT 3) (EC 2.3.2.-) (Ldt(Mt3))

Protein

Probable L,D-transpeptidase that may perform as-yet-unknown cross-linking reactions in M.tuberculosis. Is not able to generate 3->3 cross-links in peptidoglycan, using tetrapeptide stems as acyl donor substrates. May function in the anchoring of proteins to peptidoglycan. {ECO:0000269|PubMed:24041897}..

O06825

30S ribosomal protein S12

Protein

With S4 and S5 plays an important role in translational accuracy. {ECO:0000250}.; FUNCTION: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). {ECO:0000250}..

P9WH63

NAD-dependent protein deacylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog)

Protein

NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form (By similarity). Reactivates acetylated acetyl-CoA synthetase (ACS) through an NAD-dependent deacetylation. Is able to ADP-ribosylate itself. {ECO:0000255|HAMAP-Rule:MF_01121, ECO:0000269|PubMed:21627103, ECO:0000269|PubMed:21896569}.; FUNCTION: Involved in non-homologous end joining (NHEJ) repair of blunt, 5' overhang and 3' overhang DNA double strand breaks (DSB). {ECO:0000305}..

P9WGG3

Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)

Protein

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. {ECO:0000269|PubMed:16239227, ECO:0000269|PubMed:26296329}.; FUNCTION: Antigen that activates dendritic cells (DCs), increasing their expression of cell surface molecules and augmenting their production of TNF-alpha, IL-1beta, IL-6, IL-23 and IL-12p70. Rv3628 mediates these effects by binding to TLR2 and activating downstream MyD88-, MAPK- and NF-kappaB-dependent signaling pathways. Rv3628-stimulated DCs induce the expansion of OVA-specific CD4+ and CD8+ T cells which secrete IFN-gamma and IL-2, and the generation of effector/memory T cells. Thus, Rv3628 polarizes DCs toward a Th1 immune response and promotes protective immunity against M.tuberculosis infection. Is not able to bind to TLR4 molecules on the cell surface. {ECO:0000269|PubMed:27097115}..

P9WI55

Lipoprotein LprA

Protein

Constitutes a host TLR2 agonist (toll-like receptor), shown experimentally for human and mouse (PubMed:19362712). In host cells full-length (acylated) protein acts as a TLR2 agonist, inducing human and murine macrophages to produce cytokines, inducing murine dendritic cell maturation and cytokine production and inhibiting antibody processing in murine macrophages (PubMed:16785538). Binds diacylated phosphatidyl-myo-inositol mannosides (PIMs) (PubMed:20694006). Does not induce murine macrophage apoptosis or necrosis (PubMed:16785538). Non-acylated protein does not act as a TLR2 agonist (PubMed:20694006). Requires only host TLR2 as receptors to elicit host response in mouse, although TLR6 may play a redundant role, also requires CD14 and CD16 as accessory receptors (PubMed:19362712). {ECO:0000269|PubMed:16785538, ECO:0000269|PubMed:19362712, ECO:0000269|PubMed:20694006}..

P9WK55

ECF RNA polymerase sigma factor SigJ (ECF sigma factor SigJ) (Alternative RNA polymerase sigma factor SigJ) (RNA polymerase sigma-J factor) (Sigma-J factor)

Protein

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by an anti-sigma factor until released, although no anti-sigma factor is known for this protein (By similarity). Regulates the promoter of SigI, may not be autoregulated. {ECO:0000250, ECO:0000269|PubMed:16483748, ECO:0000269|PubMed:18248429}..

L0TCG5

Ribosome maturation factor RimM

Protein

An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes. {ECO:0000255|HAMAP-Rule:MF_00014}..

P9WH19

Translation initiation factor IF-1

Protein

One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. {ECO:0000255|HAMAP-Rule:MF_00075}..

P9WKK3

Serine/threonine-protein kinase PknA (EC 2.7.11.1)

Protein

Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host (PubMed:25713147). Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422 (PubMed:15985609, PubMed:16817899, PubMed:19121323, PubMed:20066037, PubMed:21190553, PubMed:21423706). Also catalyzes the phosphorylation of the proteasome alpha-subunit (PrcA) and unprocessed proteasome beta-subunit (pre-PrcB), which results in the inhibition of processing of pre-PrcB and assembly of the proteasome complex, and thereby enhances the mycobacterial resistance to H(2)O(2); PknA thus plays an important role in the oxidative stress response by impeding the formation of holo-proteasome in M.tuberculosis under H(2)O(2) stress (PubMed:25224505). Shows a strong preference for Thr versus Ser as the phosphoacceptor. {ECO:0000269|PubMed:15985609, ECO:0000269|PubMed:16817899, ECO:0000269|PubMed:19121323, ECO:0000269|PubMed:20066037, ECO:0000269|PubMed:21190553, ECO:0000269|PubMed:21423706, ECO:0000269|PubMed:25224505, ECO:0000269|PubMed:25713147}..

P9WI83

Heme-binding protein Rv0203

Protein

Part of a heme-iron acquisition system. Acts by binding heme and delivering it to the membrane proteins MmpL3 and MmpL11. Can use free heme or heme from host hemoglobin. {ECO:0000269|PubMed:21383189, ECO:0000269|PubMed:22283334, ECO:0000269|PubMed:23760277}..

I6X8R5

30S ribosomal protein S7

Protein

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA. {ECO:0000255|HAMAP-Rule:MF_00480}..

P9WH29

Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M)

Protein

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. {ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|PubMed:19688379}..

P9WK21

Probable dolichyl-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.109)

Protein

Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins (Probable). Mannosylates an artificial substrate, probably on a Thr residue, upon expression in M.smegmatis. Glycosylation probably requires the Sec-translocation system. {ECO:0000269|PubMed:16081738, ECO:0000305}..

P9WN05

Ribosome-binding factor A

Protein

One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. {ECO:0000255|HAMAP-Rule:MF_00003}..

P9WHJ7

30S ribosomal protein S4

Protein

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. {ECO:0000255|HAMAP-Rule:MF_01306}.; FUNCTION: With S5 and S12 plays an important role in translational accuracy. {ECO:0000255|HAMAP-Rule:MF_01306}..

P9WH35

Metallothionein (MT) (Copper-binding metallothionein) (Cu(I)-binding metallothionein) (Mycobacterial metallothionein)

Protein

Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu(+), with a preference for four to six Cu(+) ions, in a solvent-shielded core. MymT protects M.tuberculosis from copper toxicity. {ECO:0000269|PubMed:18724363}..

P9WK09

50S ribosomal protein L2

Protein

One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. {ECO:0000255|HAMAP-Rule:MF_01320}..

P9WHA5

Signal recognition particle protein (Fifty-four homolog)

Protein

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity). Shows GTPase activity. {ECO:0000255|HAMAP-Rule:MF_00306, ECO:0000269|PubMed:22534010}..

P9WGD7

Uncharacterized protein

Protein

Unknown.

P96815

Uncharacterized protein

Protein

Unknown.

P71591

Conserved protein

Protein

Unknown.

P95198

Uncharacterized protein

Protein

Unknown.

O53711

Uncharacterized protein

Protein

Unknown.

P96392

Conserved protein

Protein

Unknown.

O33270

Uncharacterized protein

Protein

Unknown.

O06296

Conserved protein

Protein

Unknown.

O53697

Uncharacterized protein

Protein

Unknown.

O07251

Conserved protein

Protein

Unknown.

P71704

Uncharacterized protein

Protein

Unknown.

I6X8E6

Conserved protein

Protein

Unknown.

I6X8G2

Conserved protein

Protein

Unknown.

O06418

Uncharacterized protein

Protein

Unknown.

I6WZ39

Uncharacterized protein

Protein

Unknown.

I6Y897

Uncharacterized protein

Protein

Unknown.

O53813

Conserved protein

Protein

Unknown.

I6Y3N9

Conserved protein

Protein

Unknown.

O06412

Conserved protein

Protein

Unknown.

O53751

Uncharacterized protein

Protein

Unknown.

O53744

Uncharacterized protein

Protein

Unknown.

O53414

Uncharacterized protein

Protein

Unknown.

O06572

Uncharacterized protein

Protein

Unknown.

O05592

Uncharacterized protein

Protein

Unknown.

O86320

Uncharacterized protein

Protein

Unknown.

O05573

Uncharacterized protein

Protein

Unknown.

I6XWB9

Uncharacterized protein

Protein

Unknown.

P71840

Uncharacterized protein

Protein

Unknown.

P96356

Conserved protein

Protein

Unknown.

I6Y4U9

Uncharacterized protein

Protein

Unknown.

O53400

Uncharacterized protein

Protein

Unknown.

O53410

Uncharacterized protein

Protein

Unknown.

I6XWK6

Uncharacterized protein

Protein

Unknown.

I6WZS8

Uncharacterized protein

Protein

Unknown.

O06577

Uncharacterized protein

Protein

Unknown.

O53897

Conserved protein

Protein

Unknown.

P71839

Uncharacterized protein

Protein

Unknown.

O05580

Uncharacterized protein

Protein

Unknown.

L7N6A4

Uncharacterized protein

Protein

Unknown.

O53408

Uncharacterized protein

Protein

Unknown.

P96357

Conserved protein

Protein

Unknown.

O86315

Uncharacterized protein

Protein

Unknown.

P71780

Conserved protein

Protein

Unknown.

L7N6B1

Uncharacterized protein

Protein

Unknown.

O06815

Uncharacterized protein

Protein

Unknown.

O06816

Uncharacterized protein

Protein

Unknown.

O06830

Uncharacterized protein

Protein

Unknown.

O07742

Uncharacterized protein

Protein

Unknown.

O07756

Conserved protein

Protein

Unknown.

O07222

Uncharacterized protein

Protein

Unknown.

P95145

Uncharacterized protein

Protein

Unknown.

O07751

Conserved protein

Protein

Unknown.

P95144

Conserved protein

Protein

Unknown.

O53931

Uncharacterized protein

Protein

Unknown.

P95285

Uncharacterized protein

Protein

Unknown.

O53920

Uncharacterized protein

Protein

Unknown.

P95284

Uncharacterized protein

Protein

Unknown.

L0TAY1

Uncharacterized protein

Protein

Unknown.

P71976

Uncharacterized protein

Protein

Unknown.

O07755

Conserved protein

Protein

Unknown.

O06597

Conserved protein

Protein

Unknown.

O06145

Conserved protein

Protein

Unknown.

O07754

Conserved protein

Protein

Unknown.

O06803

Uncharacterized protein

Protein

Unknown.

P95263

Protein Rv2204c

Protein

Unknown.

P9WMN5

Uncharacterized protein

Protein

Unknown.

O53487

Uncharacterized protein

Protein

Unknown.

O53479

Uncharacterized protein

Protein

Unknown.

O53534

Uncharacterized protein

Protein

Unknown.

O53462

Conserved protein

Protein

Unknown.

P71898

Uncharacterized protein

Protein

Unknown.

L7N666

Uncharacterized protein

Protein

Unknown.

O53523

Conserved protein

Protein

Unknown.

O53979

Uncharacterized protein

Protein

Unknown.

Q79FF7

Uncharacterized protein

Protein

Unknown.

O53518

Conserved protein

Protein

Unknown.

O53506

Uncharacterized protein

Protein

Unknown.

Q79FG9

Conserved protein

Protein

Unknown.

O53494

Protein MbtH

Protein

Could be involved in mycobactin synthesis. {ECO:0000250}..

P9WIP5

Uncharacterized protein

Protein

Unknown.

I6YE70

Uncharacterized protein

Protein

Unknown.

O06175

Uncharacterized protein

Protein

Unknown.

O06195

Uncharacterized protein

Protein

Unknown.

O05823

Uncharacterized protein

Protein

Unknown.

P71728

Uncharacterized protein

Protein

Unknown.

P71925

Uncharacterized protein

Protein

Unknown.

P95244

Uncharacterized protein

Protein

Unknown.

I6X520

Uncharacterized protein

Protein

Unknown.

I6XEF6

Uncharacterized protein

Protein

Unknown.

P71916

Uncharacterized protein

Protein

Unknown.

O53206

Uncharacterized protein

Protein

Unknown.

I6X562

Uncharacterized protein

Protein

Unknown.

I6YDI9

Uncharacterized protein

Protein

Unknown.

P95232

Protein DipZ

Protein

Unknown.

P9WG63

Conserved protein

Protein

Unknown.

O33291

Uncharacterized protein

Protein

Unknown.

Q6MX20

Uncharacterized protein

Protein

Unknown.

P71627

Conserved protein

Protein

Unknown.

I6YF16

Conserved protein

Protein

Unknown.

O53240

Uncharacterized protein

Protein

Unknown.

O33316

Uncharacterized protein

Protein

Unknown.

P71653

Conserved protein

Protein

Unknown.

I6Y1P2

Uncharacterized protein

Protein

Unknown.

I6YAC9

Conserved protein

Protein

Unknown.

P95137

Uncharacterized protein

Protein

Unknown.

Q50655

Conserved protein

Protein

Unknown.

I6Y2Q7

Conserved protein

Protein

Unknown.

O05876

Uncharacterized protein

Protein

Unknown.

O53351

Uncharacterized protein

Protein

Unknown.

I6XHD1

Conserved protein

Protein

Unknown.

I6X7D4

Uncharacterized protein

Protein

Unknown.

I6YG27

Conserved protein

Protein

Unknown.

I6X7B3

Uncharacterized protein

Protein

Unknown.

O07033

Uncharacterized protein

Protein

Unknown.

P96221

Uncharacterized protein

Protein

Unknown.

I6YGU1

Uncharacterized protein

Protein

Unknown.

P96247

Conserved protein

Protein

Unknown.

O69667

Uncharacterized protein

Protein

Unknown.

O06364

Uncharacterized protein

Protein

Unknown.

P96230

Uncharacterized protein

Protein

Unknown.

P96216

Conserved protein

Protein

Unknown.

O69720

Conserved protein

Protein

Unknown.

I6X827

Uncharacterized protein

Protein

Unknown.

O69700

Conserved protein

Protein

Unknown.

I6YGW9

Conserved protein

Protein

Unknown.

P96837

Conserved protein

Protein

Unknown.

P72062

Uncharacterized protein

Protein

Unknown.

I6Y469

Uncharacterized protein

Protein

Unknown.

O69654

Uncharacterized protein

Protein

Unknown.

O06270

Uncharacterized protein

Protein

Unknown.

O06381

Conserved protein

Protein

Unknown.

I6Y6S3

Uncharacterized protein

Protein

Unknown.

O07437

Uncharacterized protein

Protein

Unknown.

P95220

Uncharacterized protein

Protein

Unknown.

P71599

Uncharacterized protein

Protein

Unknown.

P95215

Uncharacterized protein

Protein

Unknown.

O07254

Conserved protein

Protein

Unknown.

O07237

Conserved protein

Protein

Unknown.

O07408

Conserved protein

Protein

Unknown.

O53619

Uncharacterized protein

Protein

Unknown.

O06300

Uncharacterized protein

Protein

Unknown.

O53682

Uncharacterized protein

Protein

Unknown.

L7N694

Uncharacterized protein

Protein

Unknown.

O86364

Uncharacterized protein

Protein

Unknown.

P95203

Uncharacterized protein

Protein

Unknown.

P71830

Uncharacterized protein

Protein

Unknown.

O07771

Conserved protein

Protein

Unknown.

V5QPR5

Uncharacterized protein

Protein

Unknown.

O53733

Uncharacterized protein

Protein

Unknown.

I6X9E8

Conserved protein

Protein

Unknown.

O53728

Uncharacterized protein

Protein

Unknown.

I6X9N8

Conserved protein

Protein

Unknown.

O06396

Uncharacterized protein

Protein

Unknown.

L7N6A9

Conserved protein

Protein

Unknown.

I6X9Y7

Uncharacterized protein

Protein

Unknown.

P96358

Uncharacterized protein

Protein

Unknown.

I6Y4V2

Conserved protein

Protein

Unknown.

O06554

Uncharacterized protein

Protein

Unknown.

I6Y4Z9

Conserved protein

Protein

Unknown.

I6X9T8

Conserved protein

Protein

Unknown.

O05910

Uncharacterized protein

Protein

Unknown.

O53399

Uncharacterized protein

Protein

Unknown.

P71560

Uncharacterized protein

Protein

Unknown.

P71568

Uncharacterized protein

Protein

Unknown.

O86351

Conserved protein

Protein

Unknown.

O53407

Protein Rv1269c

Protein

Unknown.

P9WM45

Uncharacterized protein

Protein

Unknown.

P71804

Conserved protein

Protein

Unknown.

O05316

Conserved protein

Protein

Unknown.

O50442

Conserved protein

Protein

Unknown.

P71792

Uncharacterized protein

Protein

Unknown.

P71784

Uncharacterized protein

Protein

Unknown.

O05294

Conserved protein

Protein

Unknown.

O05310

Uncharacterized protein

Protein

Unknown.

O06824

Uncharacterized protein

Protein

Unknown.

Q79FJ0

Uncharacterized protein

Protein

Unknown.

O33271

Uncharacterized protein

Protein

Unknown.

P95287

Uncharacterized protein

Protein

Unknown.

O33181

Conserved protein

Protein

Unknown.

O53961

Conserved protein

Protein

Unknown.

O07726

Conserved protein

Protein

Unknown.

P95148

Uncharacterized protein

Protein

Unknown.

O53923

Uncharacterized protein

Protein

Unknown.

O07720

Uncharacterized protein

Protein

Unknown.

O33178

Uncharacterized protein

Protein

Unknown.

P71983

Uncharacterized protein

Protein

Unknown.

O06797

Uncharacterized protein

Protein

Unknown.

O86371

Conserved protein

Protein

Unknown.

O06790

Conserved protein

Protein

Unknown.

O06154

Conserved protein

Protein

Unknown.

P71897

Conserved protein

Protein

Unknown.

O53978

Uncharacterized protein

Protein

Unknown.

I6XDW5

Uncharacterized protein

Protein

Unknown.

O53466

Uncharacterized protein

Protein

Unknown.

L7N6B8

Uncharacterized protein

Protein

Unknown.

O53527

Conserved protein

Protein

Unknown.

I6XDU8

Conserved protein

Protein

Unknown.

O53517

Conserved protein

Protein

Unknown.

O86353

Uncharacterized protein

Protein

Unknown.

P95256

Uncharacterized protein

Protein

Unknown.

O53976

Uncharacterized protein

Protein

Unknown.

O06243

Uncharacterized protein

Protein

Unknown.

L0TBP1

Conserved protein

Protein

Unknown.

O53531

Uncharacterized protein

Protein

Unknown.

Q79FD9

Uncharacterized protein

Protein

Unknown.

P95011

Conserved protein

Protein

Unknown.

P71734

Uncharacterized protein

Protein

Unknown.

P95021

Uncharacterized protein

Protein

Unknown.

I6YDM0

Uncharacterized protein

Protein

Unknown.

O07207

Conserved protein

Protein

Unknown.

P71733

Uncharacterized protein

Protein

Unknown.

I6YA17

Uncharacterized protein

Protein

Unknown.

P71958

Uncharacterized protein

Protein

Unknown.

I6YDZ2

Protein NrdI

Protein

Probably involved in ribonucleotide reductase function. {ECO:0000250}..

P9WIZ3

Uncharacterized protein

Protein

Unknown.

I6YEF3

Uncharacterized protein

Protein

Unknown.

I6X5B0

Uncharacterized protein

Protein

Unknown.

P71625

Uncharacterized protein

Protein

Unknown.

I6Y1W7

Uncharacterized protein

Protein

Unknown.

P95086

Uncharacterized protein

Protein

Unknown.

I6YAY5

Conserved protein

Protein

Unknown.

I6X630

Uncharacterized protein

Protein

Unknown.

P95133

Uncharacterized protein

Protein

Unknown.

I6YEW1

Conserved protein

Protein

Unknown.

O53287

Uncharacterized protein

Protein

Unknown.

I6Y1K4

Uncharacterized protein

Protein

Unknown.

I6YAW3

Uncharacterized protein

Protein

Unknown.

P71644

Uncharacterized protein

Protein

Unknown.

O05785

Uncharacterized protein

Protein

Unknown.

O53245

Protein Rv3402c

Protein

Unknown.

P9WGJ7

Conserved protein

Protein

Unknown.

O05882

Conserved protein

Protein

Unknown.

I6XGJ1

Uncharacterized protein

Protein

Unknown.

O50380

Uncharacterized protein

Protein

Unknown.

O07034

Conserved protein

Protein

Unknown.

O53362

Conserved protein

Protein

Unknown.

P96874

Uncharacterized protein

Protein

Unknown.

O50389

Uncharacterized protein

Protein

Unknown.

Q6MWZ5

Uncharacterized protein

Protein

Unknown.

O53315

Uncharacterized protein

Protein

Unknown.

O53342

Conserved protein

Protein

Unknown.

O05899

Uncharacterized protein

Protein

Unknown.

O07804

Conserved protein

Protein

Unknown.

P96227

Uncharacterized protein

Protein

Unknown.

I6YGI1

Uncharacterized protein

Protein

Unknown.

O69712

Uncharacterized protein

Protein

Unknown.

I6YCP0

Uncharacterized protein

Protein

Unknown.

O53566

Uncharacterized protein

Protein

Unknown.

I6YGX2

Uncharacterized protein

Protein

Unknown.

O69624

Conserved protein

Protein

Unknown.

P72040

Conserved protein

Protein

Unknown.

P96246

Uncharacterized protein

Protein

Unknown.

O07036

Bacterial proteasome activator

Protein

Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome. {ECO:0000269|PubMed:25469515}..

P9WKX3

Transcriptional regulator WhiB2 (Probable chaperone WhiB2)

Protein

Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA (By similarity). {ECO:0000250}.; FUNCTION: The apo-form functions as a chaperone, preventing aggregation or helping in correct refolding of a number of substrates; this activity does not require ATP or the ability to bind a Fe-S cluster. Chaperone activity is insensitive to the redox state of its cysteine residues. The apo-form has no protein disulfide reductase activity. The apo-form binds to its own promoter. {ECO:0000269|PubMed:19016840, ECO:0000269|PubMed:22686939}..

O53353

Transcriptional regulator WhiB5

Protein

A transcription factor that is probably redox-responsive. Probably plays a role in immunomodulation and reactivation after chronic infection. Its induction results in transcription of a number of genes including sigM, and the genes for 2 type VII secretion systems ESX-2 and ESX-4. Seems to negatively regulate its own expression. The apo-form has been shown to act as a protein disulfide reductase. The apo- but not holo-form probably binds DNA. {ECO:0000269|PubMed:19016840, ECO:0000269|PubMed:22733573}..

P71592

Alkyl hydroperoxide reductase AhpD (EC 1.11.1.15) (Alkylhydroperoxidase AhpD)

Protein

Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.; FUNCTION: Together with AhpC, DlaT and Lpd, constitutes an NADH-dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative stress generated by the host immune system..

P9WQB5

Salicyl-AMP ligase / salicyl-S-ArCP synthetase (EC 6.2.1.-) (Mycobactin biosynthesis protein MbtA) (Salicyl-AMP ligase) (Sal-AMP ligase) (EC 2.7.7.-) (Salicyl-S-ArCP synthetase)

Protein

Involved in the initial steps of the mycobactin biosynthetic pathway. Catalyzes the salicylation of the aryl carrier protein (ArCP) domain of MbtB through a two-step reaction. The first step is the ATP-dependent adenylation of salicylate to generate a salicyl-AMP intermediate. The second step is the transfer of this activated salicylate to MbtB to form a salicyl-ArCP domain thioester. {ECO:0000269|PubMed:9831524}..

P71716

DNA translocase FtsK

Protein

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). {ECO:0000250}..

P9WNA3

Uncharacterized protein

Protein

Unknown.

P95226

Uncharacterized protein

Protein

Unknown.

P95229

Uncharacterized protein

Protein

Unknown.

P96818

Conserved protein

Protein

Unknown.

O06308

Conserved protein

Protein

Unknown.

O07171

Uncharacterized protein

Protein

Unknown.

O53702

Uncharacterized protein

Protein

Unknown.

O33273

Uncharacterized protein

Protein

Unknown.

P95221

Uncharacterized protein

Protein

Unknown.

O07172

Uncharacterized protein

Protein

Unknown.

P96389

Uncharacterized protein

Protein

Unknown.

O53703

Uncharacterized protein

Protein

Unknown.

L7N651

Uncharacterized protein

Protein

Unknown.

I6WZ83

Uncharacterized protein

Protein

Unknown.

P96276

Conserved protein

Protein

Unknown.

O06409

Conserved protein

Protein

Unknown.

O53777

Uncharacterized protein

Protein

Unknown.

P96280

Conserved protein

Protein

Unknown.

O06389

Uncharacterized protein

Protein

Unknown.

O53756

Uncharacterized protein

Protein

Unknown.

P95044

Conserved protein

Protein

Unknown.

I6WZD7

Conserved protein

Protein

Unknown.

O53740

Uncharacterized protein

Protein

Unknown.

O07763

Uncharacterized protein

Protein

Unknown.

Q6MX36

Uncharacterized protein

Protein

Unknown.

O53848

Uncharacterized protein

Protein

Unknown.

O06534

Conserved protein

Protein

Unknown.

I6XA34

Uncharacterized protein

Protein

Unknown.

O53892

Conserved protein

Protein

Unknown.

O06633

Uncharacterized protein

Protein

Unknown.

I6Y8U3

Conserved protein

Protein

Unknown.

O06578

Conserved protein

Protein

Unknown.

O53432

Uncharacterized protein

Protein

Unknown.

O06537

Uncharacterized protein

Protein

Unknown.

L7N654

Uncharacterized protein

Protein

Unknown.

I6XWA9

Uncharacterized protein

Protein

Unknown.

O05304

Uncharacterized protein

Protein

Unknown.

L0T6V0

Uncharacterized protein

Protein

Unknown.

O06820

Conserved protein

Protein

Unknown.

V5QQR7

Conserved protein

Protein

Unknown.

L7N692

Uncharacterized protein

Protein

Unknown.

P71802

Conserved protein

Protein

Unknown.

O06829

Uncharacterized protein

Protein

Unknown.

Q50699

Uncharacterized protein

Protein

Unknown.

Q79FL4

Conserved protein

Protein

Unknown.

O06802

Conserved protein

Protein

Unknown.

O06799

Uncharacterized protein

Protein

Unknown.

O07739

Uncharacterized protein

Protein

Unknown.

P71982

Uncharacterized protein

Protein

Unknown.

O07719

Uncharacterized protein

Protein

Unknown.

P71985

Conserved protein

Protein

Unknown.

O07741

Uncharacterized protein

Protein

Unknown.

O06798

Uncharacterized protein

Protein

Unknown.

P72005

Uncharacterized protein

Protein

Unknown.

O07745

Uncharacterized protein

Protein

Unknown.

P95267

Uncharacterized protein

Protein

Unknown.

O33252

Uncharacterized protein

Protein

Unknown.

O53470

Uncharacterized protein

Protein

Unknown.

O53520

Uncharacterized protein

Protein

Unknown.

O53529

Uncharacterized protein

Protein

Unknown.

O06232

Uncharacterized protein

Protein

Unknown.

P95253

Conserved protein

Protein

Unknown.

P71885

Uncharacterized protein

Protein

Unknown.

L7N683

Uncharacterized protein

Protein

Unknown.

O07257

Conserved protein

Protein

Unknown.

O86340

Uncharacterized protein

Protein

Unknown.

O33254

Conserved protein

Protein

Unknown.

O33249

Uncharacterized protein

Protein

Unknown.

O05833

Uncharacterized protein

Protein

Unknown.

P71923

Uncharacterized protein

Protein

Unknown.

O05828

Uncharacterized protein

Protein

Unknown.

I6YDJ7

Uncharacterized protein

Protein

Unknown.

I6Y9Z5

Uncharacterized protein

Protein

Unknown.

P95024

Uncharacterized protein

Protein

Unknown.

I6X4D6

Uncharacterized protein

Protein

Unknown.

I6Y1G8

Uncharacterized protein

Protein

Unknown.

O33227

Uncharacterized protein

Protein

Unknown.

P95233

Uncharacterized protein

Protein

Unknown.

P71917

Uncharacterized protein

Protein

Unknown.

P71959

Conserved protein

Protein

Unknown.

I6X540

Uncharacterized protein

Protein

Unknown.

O53222

Uncharacterized protein

Protein

Unknown.

P95238

Conserved protein

Protein

Unknown.

I6YDH3

Uncharacterized protein

Protein

Unknown.

I6YEE1

Uncharacterized protein

Protein

Unknown.

I6YEE9

Uncharacterized protein

Protein

Unknown.

P95120

Uncharacterized protein

Protein

Unknown.

O05773

Conserved protein

Protein

Unknown.

O05777

Conserved protein

Protein

Unknown.

O53260

Uncharacterized protein

Protein

Unknown.

I6XFT2

Uncharacterized protein

Protein

Unknown.

I6X666

Uncharacterized protein

Protein

Unknown.

I6YB54

Uncharacterized protein

Protein

Unknown.

O33319

Uncharacterized protein

Protein

Unknown.

I6YAV3

Uncharacterized protein

Protein

Unknown.

I6XFD1

Uncharacterized protein

Protein

Unknown.

O05805

Uncharacterized protein

Protein

Unknown.

O53298

Uncharacterized protein

Protein

Unknown.

P95105

Conserved protein

Protein

Unknown.

I6YB49

Uncharacterized protein

Protein

Unknown.

O06257

Uncharacterized protein

Protein

Unknown.

O05791

Uncharacterized protein

Protein

Unknown.

O53363

Uncharacterized protein

Protein

Unknown.

O50419

Uncharacterized protein

Protein

Unknown.

O53335

Conserved protein

Protein

Unknown.

O53319

Uncharacterized protein

Protein

Unknown.

O05844

Uncharacterized protein

Protein

Unknown.

O53388

Uncharacterized protein

Protein

Unknown.

O50382

Uncharacterized protein

Protein

Unknown.

L7N658

Uncharacterized protein

Protein

Unknown.

L7N685

Conserved protein

Protein

Unknown.

I6YG83

Conserved protein

Protein

Unknown.

O05848

Uncharacterized protein

Protein

Unknown.

L7N668

Uncharacterized protein

Protein

Unknown.

O05887

Uncharacterized protein

Protein

Unknown.

O69681

Uncharacterized protein

Protein

Unknown.

I6YGR2

Uncharacterized protein

Protein

Unknown.

O53564

Uncharacterized protein

Protein

Unknown.

O69715

Conserved protein

Protein

Unknown.

I6XI16

Conserved protein

Protein

Unknown.

O69686

Conserved protein

Protein

Unknown.

O69689

Uncharacterized protein

Protein

Unknown.

Q79F96

Conserved protein

Protein

Unknown.

I6X831

Conserved protein

Protein

Unknown.

I6XHI0

Uncharacterized protein

Protein

Unknown.

P96239

Conserved protein

Protein

Unknown.

O07810

Uncharacterized protein

Protein

Unknown.

I6XHX8

Uncharacterized protein

Protein

Unknown.

P96859

Uncharacterized protein

Protein

Unknown.

I6XHG6

Conserved protein

Protein

Unknown.

I6YCS6

Uncharacterized protein

Protein

Unknown.

O05448

Uncharacterized protein

Protein

Unknown.

I6Y3Z2

Uncharacterized protein

Protein

Unknown.

O53594

O-phosphoserine sulfhydrylase (OPS sulfhydrylase) (EC 2.5.1.113) (CysO-thiocarboxylate-dependent cysteine synthase) (Cysteine synthase B) (CSase B) (O-phosphoserine-specific cysteine synthase) ([CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase)

Protein

Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O-phospho-L-serine (OPS) as sulfur acceptor. Can also use sodium sulfide as sulfur donor in vitro, albeit with less efficiency, but not thiosulfate or thio-nitro-benzoate. O-acetylserine (OAS) is a very poor substrate in comparison with OPS. May be of particular importance for cysteine biosynthesis in the persistent phase of M.tuberculosis. {ECO:0000269|PubMed:18799456, ECO:0000269|PubMed:18842002}..

P9WP53

Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme (ATP:glutamine synthetase adenylyltransferase) (ATase) [Includes: Glutamine synthetase adenylyl-L-tyrosine phosphorylase (EC 2.7.7.89) (Adenylyl removase) (AR) (AT-N); Glutamine synthetase adenylyl transferase (EC 2.7.7.42) (Adenylyl transferase) (AT) (AT-C)]

Protein

Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell. {ECO:0000255|HAMAP-Rule:MF_00802}..

P9WN27

Toxin RelK (EC 3.1.-.-) (Endoribonuclease YoeB) (Putative mRNA interferase RelE3) (Putative mRNA interferase YoeB) (Toxin YoeB)

Protein

Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides (By similarity). Overexpression in M.tuberculosis or M.smegmatis inhibits colony formation in a bacteriostatic rather than bacteriocidal fashion. Its toxic effect is neutralized by coexpression with antitoxin RelJ (shown only for M.smegmatis). Overexpression also increases the number of rifampcin-tolerant persister cells. {ECO:0000250, ECO:0000269|PubMed:19114484, ECO:0000269|PubMed:20011113, ECO:0000269|PubMed:20061486, ECO:0000269|PubMed:20498855}.; FUNCTION: In combination with RelJ represses its own promoter. Several DNA-protein complexes are formed in vitro depending on the RelJ:RelK ratio..

P9WF09

CRP-like cAMP-activated global transcriptional regulator (cAMP receptor protein) (CRP) (cAMP regulatory protein)

Protein

Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. The CRP regulon is predicted to contain about 115 genes. Some genes are activated by CRP (rpfA, whiB1) while others are repressed (fadD10). There are 2 CRP-binding sites in the promoter of whiB1, at low concentrations of CRP with or without cAMP transcription of whiB1 is enhanced via site CRP1, then repressed as site CRP2 is filled. {ECO:0000269|PubMed:15882420, ECO:0000269|PubMed:20028978}..

P9WMH3

Uncharacterized protein

Protein

Unknown.

P96391

Uncharacterized protein

Protein

Unknown.

O53605

Uncharacterized protein

Protein

Unknown.

O07429

Conserved protein

Protein

Unknown.

O53652

Uncharacterized protein

Protein

Unknown.

L0T643

Conserved protein

Protein

Unknown.

O06310

Conserved protein

Protein

Unknown.

P96817

Uncharacterized protein

Protein

Unknown.

O07428

Uncharacterized protein

Protein

Unknown.

P96827

Uncharacterized protein

Protein

Unknown.

O07173

Conserved protein

Protein

Unknown.

O06315

Conserved protein

Protein

Unknown.

O53680

Uncharacterized protein

Protein

Unknown.

L0T6I4

Uncharacterized protein

Protein

Unknown.

I6WZ26

Uncharacterized protein

Protein

Unknown.

O53776

Uncharacterized protein

Protein

Unknown.

P96267

Uncharacterized protein

Protein

Unknown.

I6WYU2

Uncharacterized protein

Protein

Unknown.

I6XVR9

Uncharacterized protein

Protein

Unknown.

O06406

Uncharacterized protein

Protein

Unknown.

P95204

Uncharacterized protein

Protein

Unknown.

P95046

Conserved protein

Protein

Unknown.

O53749

Uncharacterized protein

Protein

Unknown.

I6XW93

Uncharacterized protein

Protein

Unknown.

P96353

Conserved protein

Protein

Unknown.

O53874

Conserved protein

Protein

Unknown.

I6Y946

Conserved protein

Protein

Unknown.

O06570

Conserved protein

Protein

Unknown.

O53404

Uncharacterized protein

Protein

Unknown.

O53421

Conserved protein

Protein

Unknown.

O53836

Uncharacterized protein

Protein

Unknown.

L0T8G6

Conserved protein

Protein

Unknown.

O53842

Uncharacterized protein

Protein

Unknown.

I6Y4U0

Uncharacterized protein

Protein

Unknown.

O06571

Conserved protein

Protein

Unknown.

O05900

Uncharacterized protein

Protein

Unknown.

O53868

Uncharacterized protein

Protein

Unknown.

O53837

Uncharacterized protein

Protein

Unknown.

O53413

Uncharacterized protein

Protein

Unknown.

O53405

Conserved protein

Protein

Unknown.

O53417

Uncharacterized protein

Protein

Unknown.

P71794

Uncharacterized protein

Protein

Unknown.

O50435

Conserved protein

Protein

Unknown.

O53147

Uncharacterized protein

Protein

Unknown.

O50432

Uncharacterized protein

Protein

Unknown.

O06178

Uncharacterized protein

Protein

Unknown.

O50466

Conserved protein

Protein

Unknown.

I6XY36

Uncharacterized protein

Protein

Unknown.

Q79FQ6

Uncharacterized protein

Protein

Unknown.

P71806

Uncharacterized protein

Protein

Unknown.

O07738

Conserved protein

Protein

Unknown.

P95151

Uncharacterized protein

Protein

Unknown.

O53954

Uncharacterized protein

Protein

Unknown.

O07743

Uncharacterized protein

Protein

Unknown.

P71986

Uncharacterized protein

Protein

Unknown.

O33193

Conserved protein

Protein

Unknown.

O53953

Uncharacterized protein

Protein

Unknown.

L7N673

Uncharacterized protein

Protein

Unknown.

P95264

Uncharacterized protein

Protein

Unknown.

O33182

Uncharacterized protein

Protein

Unknown.

O86372

Conserved protein

Protein

Unknown.

O06592

Uncharacterized protein

Protein

Unknown.

O06618

Uncharacterized protein

Protein

Unknown.

P95147

Uncharacterized protein

Protein

Unknown.

O06805

Uncharacterized protein

Protein

Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. {ECO:0000256|SAAS:SAAS01145534}..

O53536

Uncharacterized protein

Protein

Unknown.

O53977

Uncharacterized protein

Protein

Unknown.

O06242

Conserved protein

Protein

Unknown.

O53486

Conserved protein

Protein

Unknown.

O06240

Uncharacterized protein

Protein

Unknown.

O53196

Uncharacterized protein

Protein

Unknown.

O53199

Conserved protein

Protein

Unknown.

O06198

Uncharacterized protein

Protein

Unknown.

O05838

Uncharacterized protein

Protein

Unknown.

I6Y1G3

Uncharacterized protein

Protein

Unknown.

O53179

Conserved protein

Protein

Unknown.

I6Y0X6

Conserved protein

Protein

Unknown.

I6Y9E8

Uncharacterized protein

Protein

Unknown.

P71729

Uncharacterized protein

Protein

Unknown.

P71926

Conserved protein

Protein

Unknown.

O07196

Conserved protein

Protein

Unknown.

I6YA21

Uncharacterized protein

Protein

Unknown.

P71754

Uncharacterized protein

Protein

Unknown.

O53205

Conserved protein

Protein

Unknown.

O86317

Conserved protein

Protein

Unknown.

I6Y242

Uncharacterized protein

Protein

Unknown.

O05769

Uncharacterized protein

Protein

Unknown.

I6XFC2

Uncharacterized protein

Protein

Unknown.

I6YA42

Uncharacterized protein

Protein

Unknown.

I6YEY1

Uncharacterized protein

Protein

Unknown.

I6YA47

Uncharacterized protein

Protein

Unknown.

I6X642

Uncharacterized protein

Protein

Unknown.

I6XFY8

Conserved protein

Protein

Unknown.

I6YF40

Uncharacterized protein

Protein

Unknown.

P71646

Uncharacterized protein

Protein

Unknown.

O05796

Uncharacterized protein

Protein

Unknown.

O50383

Conserved protein

Protein

Unknown.

O05856

Uncharacterized protein

Protein

Unknown.

P95184

Uncharacterized protein

Protein

Unknown.

O50392

Uncharacterized protein

Protein

Unknown.

O53322

Uncharacterized protein

Protein

Unknown.

O53316

Conserved protein

Protein

Unknown.

O50398

Uncharacterized protein

Protein

Unknown.

O53341

Conserved protein

Protein

Unknown.

O05859

Uncharacterized protein

Protein

Unknown.

O53352

Uncharacterized protein

Protein

Unknown.

I6YGF8

Conserved protein

Protein

Unknown.

I6Y3Q7

Uncharacterized protein

Protein

Unknown.

O69697

Uncharacterized protein

Protein

Unknown.

O69702

Conserved protein

Protein

Unknown.

P96217

Uncharacterized protein

Protein

Unknown.

I6X7P2

Conserved protein

Protein

Unknown.

I6XI06

Conserved protein

Protein

Unknown.

O86358

Uncharacterized protein

Protein

Unknown.

P72038

Uncharacterized protein

Protein

Unknown.

I6XHH2

Conserved protein

Protein

Unknown.

O69699

Uncharacterized protein

Protein

Unknown.

P72035

Uncharacterized protein

Protein

Unknown.

I6YCP7

Uncharacterized protein

Protein

Unknown.

P72036

Uncharacterized protein

Protein

Unknown.

P96242

Uncharacterized protein

Protein

Unknown.

P96214

Uncharacterized protein

Protein

Unknown.

P96233

Uncharacterized protein

Protein

Unknown.

O05439

Conserved protein

Protein

Unknown.

O05436

Conserved protein (CPSA-related protein)

Protein

Unknown.

P96872

Nucleoid-associated protein Lsr2

Protein

DNA-bridging protein that has both architectural and regulatory roles (PubMed:18187505). Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments (PubMed:20133735). Binds in the minor groove of AT-rich DNA (PubMed:21673140). Represses expression of multiple genes involved in a broad range of cellular processes, including major virulence factors or antibiotic-induced genes, such as iniBAC or efpA (PubMed:17590082), and genes important for adaptation of changing O(2) levels (PubMed:24895305). May also activate expression of some gene (PubMed:24895305). May coordinate global gene regulation and virulence (PubMed:20133735). Also protects mycobacteria against reactive oxygen intermediates during macrophage infection by acting as a physical barrier to DNA degradation (PubMed:19237572); the physical protection has been questioned (PubMed:24895305). A strain overexpressing this protein consumes O(2) more slowly than wild-type (PubMed:24895305). {ECO:0000269|PubMed:17590082, ECO:0000269|PubMed:18187505, ECO:0000269|PubMed:19237572, ECO:0000269|PubMed:20133735, ECO:0000269|PubMed:21673140, ECO:0000269|PubMed:24895305}..

P9WIP7

ECF RNA polymerase sigma factor SigH (ECF sigma factor SigH) (Alternative RNA polymerase sigma factor SigH) (RNA polymerase sigma-H factor) (Sigma-H factor)

Protein

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (RshA) until released. This sigma factor is involved in heat shock and oxidative stress responses; it positively regulates the expression of itself, sigE, sigB and a number of transcriptional regulators as well as other effectors of heat and oxidative stress, leading to direct and indirect control of up to 25% of the bacterial genome. Modulates expression of host genes for intercrine beta (chemokine CC) and apoptosis, altering the host immune response. {ECO:0000269|PubMed:11567012, ECO:0000269|PubMed:12123450, ECO:0000269|PubMed:14617153, ECO:0000269|PubMed:16298337}..

P9WGH9

ECF RNA polymerase sigma factor SigG (ECF sigma factor SigG) (Alternative RNA polymerase sigma factor SigG) (RNA polymerase sigma-G factor) (Sigma-g factor)

Protein

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein. May be involved in host intracellular survival after infection (strains H37Rv and CDC 1551). A role in the SOS response is controversial; it has been seen in strain CDC 1551 (PubMed:18039768) but not in H37Rv (PubMed:21169493). {ECO:0000269|PubMed:16483748, ECO:0000269|PubMed:21169493}..

P9WGG5

Ribonuclease VapC4 (RNase VapC4) (EC 3.1.-.-) (Toxin VapC4) (VapC-mt4)

Protein

Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis. Upon expression in situ, in M.smegmatis or E.coli inhibits cell growth and colony formation; in at least E.coli also causes increased levels of cellular RNA. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4. {ECO:0000269|PubMed:19016878, ECO:0000269|PubMed:22354968, ECO:0000269|PubMed:25622615}..

O07783

Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)

Protein

Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity). {ECO:0000250}.; FUNCTION: Confers high-level resistance to the antibiotic mupirocin (pseudomonic acid A), an Ile-analog that competitively inhibits activation by Ile-tRNA synthetase, thus inhibiting protein biosynthesis..

P9WFV3

PPE family protein PPE26

Protein

Probably plays a key role in regulating innate and adaptive immune responses through human Toll-like receptor 2 (TLR2). Interacts with TLR2, leading to the subsequent activation of the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappa-B) signaling pathways. Stimulates macrophage activation by augmenting pro-inflammatory cytokine production (TNF-alpha, IL-6 and IL-12p40) and the expression of cell surface molecules (CD80, CD86, MHC class I and II). Also participates in adaptive immunity by directing Th1-polarised immune responses. {ECO:0000269|PubMed:26439698}..

Q79FK6

UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A)

Protein

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Alone it slightly inhibits RecA-mediated DNA strand exchange, in concert with UvrD1 greatly inhibits RecA-mediated DNA strand exchange. {ECO:0000255|HAMAP-Rule:MF_00205, ECO:0000269|PubMed:20455546, ECO:0000269|PubMed:22467787}..

P9WQK7

PPE family immunomodulator PPE68

Protein

Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M.tuberculosis infection. Together with PE35, stimulates the secretion of IL-10 and MCP-1 from human macrophages, via the interaction with human Toll-like receptor 2 (TLR2) (PubMed:24467650). Stimulates high levels of gamma interferon secretion in peripheral blood mononuclear cells isolated from tuberculosis patients, as well as from healthy tuberculin purified protein derivative-positive donors. Does not interfere with the secretion and immunogenicity of EsxA (ESAT-6) and EsxB (CFP-10) (PubMed:14573626, PubMed:15039340). {ECO:0000269|PubMed:14573626, ECO:0000269|PubMed:15039340, ECO:0000269|PubMed:24467650}..

P9WHW9

Putative secreted protein P60-related protein

Protein

Unknown.

P71594

50S ribosomal protein L36 (Ribosomal protein B)

Protein

Unknown.

P9WH89

Conserved protein similar to jag protein

Protein

Unknown.

O53598

ECF RNA polymerase sigma factor SigC (ECF sigma factor SigC) (Alternative RNA polymerase sigma factor SigC) (RNA polymerase sigma-C factor) (Sigma-C factor)

Protein

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are usually held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; this sigma factor does not seem to have a cognate anti-sigma factor however. It has been suggested that the sigma domains 2 and 4 may interact via polar residues in this protein to autoregulate. Positively regulates expression of a small regulon of genes..

P9WGH1

Diacylglycerol acyltransferase/mycolyltransferase Ag85C (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex C) (85C) (Ag85C) (Fibronectin-binding protein C) (Fbps C)

Protein

The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM. {ECO:0000269|PubMed:1830294, ECO:0000269|PubMed:9162010}..

P9WQN9

Diacylglycerol acyltransferase/mycolyltransferase Ag85B (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (30 kDa extracellular protein) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex B) (85B) (Ag85B) (Extracellular alpha-antigen) (Fibronectin-binding protein B) (Fbps B)

Protein

The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM. {ECO:0000269|PubMed:12010501, ECO:0000269|PubMed:3141278, ECO:0000269|PubMed:9162010}..

P9WQP1

Possible thioredoxin protein (Thiol-disulfide interchange protein)

Protein

Unknown.

O06392

PPE family protein PPE18

Protein

Could be a crucial virulence factor for intracellular survival of M.tuberculosis (PubMed:23300718). Favors development of Th2-type response, and downregulates the proinflammatory and Th1-type response (PubMed:19880448, PubMed:21451109). Specifically interacts with the human Toll-like receptor 2 (TLR2), leading to an early and sustained activation of p38 MAPK, which induces IL-10 production and activates Th2-type immune response (PubMed:19880448). Also inhibits proinflammatory cytokines IL-12p40 and TNF-alpha production. Acts by upregulating the expression as well as tyrosine phosphorylation of suppressor of cytokine signaling 3 (SOCS-3), leading to the inhibition of phosphorylation of I-kappa-B-alpha, thereby preventing nuclear translocation of the NF-kappa-B/REL subunits and expression of NF-kappa-B regulated genes like IL-12 and TNF-alpha. Induction of SOCS-3 probably depends on the activation of p38 MAPK (PubMed:21451109). {ECO:0000269|PubMed:19880448, ECO:0000269|PubMed:21451109, ECO:0000269|PubMed:23300718}..

L7N675

Oxygen sensor histidine kinase response regulator DevS/DosS (EC 2.7.13.3)

Protein

Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response (PubMed:12953092). Regulates an approximately 48-member regulon (PubMed:12953092, PubMed:11416222, PubMed:15033981, PubMed:18400743). Required for full induction of the DevR (DosR) regulon; acts later than DosT to positively regulate expression of the DevR regulon during adaptation to anaerobiosis (PubMed:19487478). Characterized as an oxygen sensor; O(2) acts as a switch, with O(2)-bound Fe(2+) protein inactive in autophosphorylation (PubMed:17371046, PubMed:17600145, PubMed:18975917, PubMed:19463006, PubMed:28977726). Has also been suggested to act as a redox sensor, or perhaps as a dual oxygen/redox sensor (PubMed:17609369). Autophosphorylates under anaerobic but not aerobic conditions, binding of NO or CO does not dramatically change the level of autophosphorylation of Fe(2+) protein, binding of O(2) inactivates kinase activity (PubMed:17600145, PubMed:18975917, PubMed:27235395). Binds O(2), NO, CO (PubMed:17371046, PubMed:17609369, PubMed:17600145, PubMed:18975917, PubMed:27235395). It is probably reduced by flavin nucleotides such as FMN and FAD (PubMed:19276084). May be the primary sensor for CO (PubMed:18400743). Donates a phosphate group to transcriptional regulator DevR (DosR) (PubMed:15033981, PubMed:15073296, PubMed:28977726). {ECO:0000269|PubMed:11416222, ECO:0000269|PubMed:12953092, ECO:0000269|PubMed:15033981, ECO:0000269|PubMed:15073296, ECO:0000269|PubMed:17371046, ECO:0000269|PubMed:17600145, ECO:0000269|PubMed:17609369, ECO:0000269|PubMed:18400743, ECO:0000269|PubMed:18474359, ECO:0000269|PubMed:18975917, ECO:0000269|PubMed:19463006, ECO:0000269|PubMed:19487478, ECO:0000269|PubMed:27235395, ECO:0000269|PubMed:28977726}..

P9WGK3

Uncharacterized protein

Protein

Unknown.

I6WY86

Uncharacterized protein

Protein

Unknown.

O53604

Uncharacterized protein

Protein

Unknown.

O53716

Uncharacterized protein

Protein

Unknown.

O53630

Uncharacterized protein

Protein

Unknown.

L7N686

Uncharacterized protein

Protein

Unknown.

O07250

Uncharacterized protein

Protein

Unknown.

O07253

Uncharacterized protein

Protein

Unknown.

O07234

Uncharacterized protein

Protein

Unknown.

O07238

Uncharacterized protein

Protein

Unknown.

P96819

Uncharacterized protein

Protein

Unknown.

P95216

Uncharacterized protein

Protein

Unknown.

O53701

Conserved protein

Protein

Unknown.

I6WXK8

Conserved protein

Protein

Unknown.

O06307

Conserved protein

Protein

Unknown.

O07256

Uncharacterized protein

Protein

Unknown.

O53707

Uncharacterized protein

Protein

Unknown.

I6X9Q1

Uncharacterized protein

Protein

Unknown.

I6Y4G1

Uncharacterized protein

Protein

Unknown.

P96270

Uncharacterized protein

Protein

Unknown.

Q79FY5

Uncharacterized protein

Protein

Unknown.

I6Y481

Uncharacterized protein

Protein

Unknown.

O53734

Uncharacterized protein

Protein

Unknown.

O07761

Uncharacterized protein

Protein

Unknown.

P71813

Uncharacterized protein

Protein

Unknown.

O06552

Uncharacterized protein

Protein

Unknown.

I6X9X6

Conserved protein

Protein

Unknown.

O06569

Conserved protein

Protein

Unknown.

O06547

Uncharacterized protein

Protein

Unknown.

O53431

Conserved protein

Protein

Unknown.

O53448

Uncharacterized protein

Protein

Unknown.

I6Y4Y1

Uncharacterized protein

Protein

Unknown.

O53401

Uncharacterized protein

Protein

Unknown.

O06568

Uncharacterized protein

Protein

Unknown.

I6XWF9

Conserved protein

Protein

Unknown.

I6X9V3

Uncharacterized protein

Protein

Unknown.

I6Y4S9

Uncharacterized protein

Protein

Unknown.

O05582

Conserved protein

Protein

Unknown.

P96375

Conserved protein

Protein

Unknown.

O53409

Uncharacterized protein

Protein

Unknown.

P71837

Conserved protein

Protein

Unknown.

I6WZI4

Uncharacterized protein

Protein

Unknown.

O05597

Uncharacterized protein

Protein

Unknown.

P71763

Uncharacterized protein

Protein

Unknown.

O50427

Conserved protein

Protein

Unknown.

O05296

Uncharacterized protein

Protein

Unknown.

O33221

Uncharacterized protein

Protein

Unknown.

O06180

Conserved protein

Protein

Unknown.

O05312

Conserved protein

Protein

Unknown.

O05293

Uncharacterized protein

Protein

Unknown.

O05305

Uncharacterized protein

Protein

Unknown.

L7N6B6

Conserved protein

Protein

Unknown.

O53157

Conserved protein

Protein

Unknown.

O53905

Uncharacterized protein

Protein

Unknown.

Q79FN0

Uncharacterized protein

Protein

Unknown.

O86348

Conserved protein

Protein

Unknown.

L7N6A8

Uncharacterized protein

Protein

Unknown.

P94979

Uncharacterized protein

Protein

Unknown.

O33195

Uncharacterized protein

Protein

Unknown.

P95289

Uncharacterized protein

Protein

Unknown.

O53929

Uncharacterized protein

Protein

Unknown.

O53917

Conserved protein

Protein

Unknown.

P95270

Conserved protein

Protein

Unknown.

O06619

Conserved protein

Protein

Unknown.

P71990

Uncharacterized protein

Protein

Unknown.

O06149

Uncharacterized protein

Protein

Unknown.

O33198

Uncharacterized protein

Protein

Unknown.

O07748

Uncharacterized protein

Protein

Unknown.

O06593

Uncharacterized protein

Protein

Unknown.

P95266

Uncharacterized protein

Protein

Unknown.

O33187

Uncharacterized protein

Protein

Unknown.

O06789

Uncharacterized protein

Protein

Unknown.

O53477

Uncharacterized protein

Protein

Unknown.

O33260

Uncharacterized protein

Protein

Unknown.

O53469

Uncharacterized protein

Protein

Unknown.

O53530

Uncharacterized protein

Protein

Unknown.

O53491

Conserved protein

Protein

Unknown.

O06241

Conserved protein

Protein

Unknown.

O06216

Uncharacterized protein

Protein

Unknown.

O06238

Uncharacterized protein

Protein

Unknown.

O53480

Uncharacterized protein

Protein

Unknown.

O53461

Conserved protein

Protein

Unknown.

L7N684

Uncharacterized protein

Protein

Unknown.

I6XEH5

Uncharacterized protein

Protein

Unknown.

I6X4J0

Uncharacterized protein

Protein

Unknown.

I6Y0Y0

Uncharacterized protein

Protein

Unknown.

L0TC46

Uncharacterized protein

Protein

Unknown.

P71730

Conserved protein

Protein

Unknown.

O06194

Conserved protein

Protein

Unknown.

I6XEK2

Conserved protein

Protein

Unknown.

P71757

Uncharacterized protein

Protein

Unknown.

O07206

Uncharacterized protein

Protein

Unknown.

I6Y1F5

Conserved protein

Protein

Unknown.

P71737

Conserved protein

Protein

Unknown.

P71738

Uncharacterized protein

Protein

Unknown.

Q79FC4

Uncharacterized protein

Protein

Unknown.

P71922

Uncharacterized protein

Protein

Unknown.

I6Y9M6

Uncharacterized protein

Protein

Unknown.

O86326

Uncharacterized protein

Protein

Unknown.

O33313

Uncharacterized protein

Protein

Unknown.

I6XG38

Conserved protein

Protein

Unknown.

I6YAZ1

Uncharacterized protein

Protein

Unknown.

O05776

Uncharacterized protein

Protein

Unknown.

P95087

Uncharacterized protein

Protein

Unknown.

P71643

Uncharacterized protein

Protein

Unknown.

I6X5U4

Uncharacterized protein

Protein

Unknown.

I6XFF7

Uncharacterized protein

Protein

Unknown.

P71640

Conserved protein

Protein

Unknown.

I6XG43

Uncharacterized protein

Protein

Unknown.

I6X5G8

Uncharacterized protein

Protein

Unknown.

P71654

Uncharacterized protein

Protein

Unknown.

I6Y1K7

Uncharacterized protein

Protein

Unknown.

P71626

Uncharacterized protein

Protein

Unknown.

O07166

Uncharacterized protein

Protein

Unknown.

O05888

Uncharacterized protein

Protein

Unknown.

Q6MWZ4

Conserved protein

Protein

Unknown.

O53329

Conserved protein

Protein

Unknown.

O53356

Uncharacterized protein

Protein

Unknown.

O06336

Conserved protein

Protein

Unknown.

O05861

Uncharacterized protein

Protein

Unknown.

O53336

Uncharacterized protein

Protein

Unknown.

P96873

Uncharacterized protein

Protein

Unknown.

O53387

Uncharacterized protein

Protein

Unknown.

I6YC91

Uncharacterized protein

Protein

Unknown.

O53334

Uncharacterized protein

Protein

Unknown.

I6Y4C4

Uncharacterized protein

Protein

Unknown.

I6Y464

Conserved protein

Protein

Unknown.

O06380

Uncharacterized protein

Protein

Unknown.

I6X824

Uncharacterized protein

Protein

Unknown.

I6YGE4

Uncharacterized protein

Protein

Unknown.

O53562

Conserved protein

Protein

Unknown.

O69714

Uncharacterized protein

Protein

Unknown.

I6YCC4

Uncharacterized protein

Protein

Unknown.

O05447

Uncharacterized protein

Protein

Unknown.

O05446

HTH-type transcriptional regulator PrpR (Propionate regulator) (PRPR)

Protein

Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degradation route) and the methylcitrate cycle (propionate degradation route) (PubMed:22916289, PubMed:24705740). Required for intracellular growth in macrophages and for the assimilation of cholesterol-derived propionate (PubMed:22365605). PrpR acts as a transcriptional activator of prpDC and icl genes when propionate is the main carbon source, and as a ramB repressor (PubMed:22916289). During growth on propionate, PrpR also acts as a transcriptional repressor of dnaA, which encodes the DnaA initiator protein responsible for initiating chromosomal replication (PubMed:24705740). It is possibly involved in the regulation of genes responsible for controlling cholesterol utilization (PubMed:22365605). {ECO:0000269|PubMed:22365605, ECO:0000269|PubMed:22916289, ECO:0000269|PubMed:24705740}..

O06581

Endoribonuclease MazF3 (EC 3.1.-.-) (23S rRNA endonuclease MazF3) (Toxin MazF3) (mRNA interferase MazF-mt6)

Protein

Toxic component of a type II toxin-antitoxin (TA) system. Acts as an mRNA and 23S rRNA interferase, cleaving predominantly after the first 2 Us in the sequence 5'-UUCCU-3'; in 23S rRNA only cleaves once in the ribosomal A site in dissociated but not intact ribosomes. Cleavage of 23S rRNA inhibits protein translation; the 23S rRNA region cleaved is involved in tRNA-binding in the A site, 30S and 50S subunit interaction and ribosome recycling factor association (PubMed:23650345). Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. It dramatically increases persister cell formation in M.smegmatis upon challenge with gentamicin or kanamycin. Overexpression leads to bacteriostasis rather than bacteriocide. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE3. {ECO:0000269|PubMed:16611633, ECO:0000269|PubMed:19016878, ECO:0000269|PubMed:20011113, ECO:0000269|PubMed:20705052, ECO:0000269|PubMed:23650345, ECO:0000269|PubMed:25608501}..

P9WIH9

Transcriptional regulator WhiB4

Protein

Redox-responsive transcriptional regulator that regulates a set of genes involved in protection against environmental stresses encountered during infection. The loss of the O(2) and NO-responsive 4Fe-4S cluster and subsequent redox modifications of Cys residue thiols (possibly by disulfide bond formation) may activate its role in gene regulation. The thiol-oxidized apo-form binds in a sequence non-specific manner to GC-rich DNA, probably in the minor groove. Represses transcription of a number of genes including itself. The reduced apo-form and holo-form do not bind DNA. The apo-form can act as protein disulfide reductase. {ECO:0000269|PubMed:17302817, ECO:0000269|PubMed:19016840, ECO:0000269|PubMed:22780904}..

P9WF39

Putative transport protein Rv0205

Protein

Unknown.

P9WFM5

Putative secreted protein Rv0236.1

Protein

Unknown.

P9WLB1

Uncharacterized protein Rv0313

Protein

Unknown.

P9WL03

Uncharacterized FtsW-like protein

Protein

Unknown.

P9WN99

UPF0232 protein Rv0004

Protein

Unknown.

P9WFL1

Uncharacterized protein Rv0026

Protein

Unknown.

P9WMB1

Uncharacterized protein Rv0102

Protein

Unknown.

P9WM63

Uncharacterized protein Rv0048c

Protein

Unknown.

P9WM87

Uncharacterized protein Rv0028A

Protein

Unknown.

P0DMM2

Uncharacterized protein Rv0093c

Protein

Unknown.

P9WM69

Uncharacterized protein Rv0039c

Protein

Unknown.

P9WM89

Uncharacterized protein Rv0080

Protein

Unknown.

P9WMA5

Possible transcriptional regulatory protein

Protein

Unknown.

O86342

Possible transcriptional regulatory protein

Protein

Unknown.

O33269

Probable conserved transmembrane protein

Protein

Unknown.

P96408

Probable conserved transmembrane protein

Protein

Unknown.

O07432

Probable conserved membrane protein

Protein

Unknown.

O53650

PE family protein PE4

Protein

Unknown.

L7N661

Probable conserved transmembrane protein

Protein

Unknown.

P71708

30S ribosomal protein S3

Protein

Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. {ECO:0000255|HAMAP-Rule:MF_01309}..

P9WH37

Uncharacterized protein Rv0628c

Protein

Unknown.

P9WKS7

Uncharacterized protein Rv0479c

Protein

Unknown.

P9WKV7

Uncharacterized protein Rv0559c

Protein

Unknown.

P9WKL3

UPF0336 protein Rv0637

Protein

Unknown.

P9WFJ9

Uncharacterized protein Rv0572c

Protein

Unknown.

P9WM81

Uncharacterized protein Rv0498

Protein

Unknown.

P9WKU1

Uncharacterized protein Rv0502

Protein

Unknown.

P9WKT1

Uncharacterized protein Rv0525

Protein

Unknown.

O06391

Probable conserved transmembrane protein

Protein

Unknown.

P95210

Probable conserved transmembrane protein

Protein

Unknown.

O06422

Possible conserved membrane protein

Protein

Unknown.

P96258

Possible secreted protein

Protein

Unknown.

P95202

Possible transcriptional regulatory protein

Protein

Unknown.

I6Y8K3

Possible conserved membrane protein

Protein

Unknown.

O06404

Possible exported protein

Protein

Unknown.

P96923

Probable conserved transmembrane protein

Protein

Unknown.

I6WZ58

Possible transmembrane protein

Protein

Unknown.

O33359

Uncharacterized protein Rv0898c

Protein

Unknown.

P9WKP5

Uncharacterized protein Rv0953c

Protein

Unknown.

P9WKN5

Uncharacterized protein Rv0887c

Protein

Unknown.

P9WKQ3

Uncharacterized protein Rv0894

Protein

Unknown.

P9WKP9

Putative transport protein Rv1101c

Protein

Unknown.

P9WFM3

Transcriptional regulatory protein PrrA

Protein

Member of the two-component regulatory system PrrB/PrrA. Involved specifically in early intracellular multiplication of Mycobacterium. {ECO:0000269|PubMed:11953357}..

P9WGM1

Probable conserved exported protein

Protein

Unknown.

I6WZH9

Probable conserved transmembrane protein

Protein

Unknown.

I6WZK3

Probable membrane protein

Protein

Unknown.

O05589

Probable transcriptional repressor protein

Protein

Unknown.

I6Y5H3

Probable conserved transmembrane protein

Protein

Unknown.

O05904

Possible exported protein

Protein

Unknown.

O06567

50S ribosomal protein L31

Protein

Binds the 23S rRNA. {ECO:0000255|HAMAP-Rule:MF_00501}..

P9WHA1

Uncharacterized protein Rv1303

Protein

Unknown.

P9WM31

Uncharacterized protein Rv1291c

Protein

Unknown.

P9WM33

Uncharacterized protein Rv1356c

Protein

Unknown.

P9WM09

Uncharacterized protein Rv1366

Protein

Unknown.

P9WLZ5

Uncharacterized protein Rv1501

Protein

Unknown.

P9WI91

Uncharacterized protein Rv1480

Protein

Unknown.

P9WLX5

Uncharacterized protein Rv1546

Protein

Unknown.

P9WLU7

Magnesium transport protein CorA

Protein

Mediates influx of magnesium ions. {ECO:0000256|RuleBase:RU362010}..

O50455

Uncharacterized protein (Fragment)

Protein

Unknown.

L0T8G4

Probable transmembrane protein

Protein

Unknown.

O33222

PE family protein PE14

Protein

Unknown.

L7N6A7

Possible membrane protein

Protein

Unknown.

O50464

UPF0098 protein Rv1910c

Protein

Unknown.

P9WFN5

Uncharacterized protein Rv1836c

Protein

Unknown.

P9WLQ9

CinA-like protein

Protein

Unknown.

P9WPE3

UPF0045 protein Rv1898

Protein

Unknown.

P9WFQ1

Uncharacterized protein Rv1588c

Protein

Unknown.

P9WLT9

PPE family protein PPE27

Protein

Unknown.

Q79FK5

Probable transcriptional regulatory protein

Protein

Unknown.

O06806

PE family protein PE20

Protein

Unknown.

L7N656

Probable transcriptional regulatory protein

Protein

Unknown.

O53921

Probable transcriptional regulatory protein

Protein

Unknown.

P71977

Probable PhiRv1 phage protein

Protein

Unknown.

O06617

Probable membrane protein

Protein

Unknown.

O06787

Probable PhiRv1 phage protein

Protein

Unknown.

O06612

Uncharacterized protein Rv2272

Protein

Unknown.

P9WLF5

Uncharacterized protein Rv2100

Protein

Unknown.

P9WLJ3

Possible exported protein

Protein

Unknown.

O06796

Uncharacterized protein Rv2008c

Protein

Unknown.

P9WLM9

Uncharacterized protein Rv2292c

Protein

Unknown.

P9WLE3

Uncharacterized protein Rv2307c

Protein

Unknown.

P9WLC7

Uncharacterized protein Rv2000

Protein

Unknown.

P9WLN7

Uncharacterized protein Rv1989c

Protein

Unknown.

P9WLP9

Uncharacterized protein Rv2003c

Protein

Unknown.

P9WJZ5

Uncharacterized protein Rv2304c

Protein

Unknown.

P9WLD3

Uncharacterized protein Rv2302

Protein

Unknown.

P9WLD5

Uncharacterized protein Rv2084

Protein

Unknown.

P9WLK1

Possible conserved membrane protein

Protein

Unknown.

Q79FG5

Probable integral membrane protein

Protein

Unknown.

O33248

Probable transmembrane protein FxsA

Protein

Unknown.

O53495

Hypothetical glycine rich protein

Protein

Unknown.

Q79FG2

Mce-family protein Mce3A

Protein

Unknown.

L7N698

Possible transcriptional regulatory protein

Protein

Unknown.

O53532

Cobalamin biosynthesis protein CobN

Protein

Unknown.

O53498

Possible conserved membrane protein

Protein

Unknown.

Q79FG4

UPF0060 membrane protein Rv2639c

Protein

Unknown.

P9WFN9

Uncharacterized protein Rv2667

Protein

Unknown.

P9WPC7

UPF0719 transmembrane protein Rv2600

Protein

Unknown.

P9WFG5

Uncharacterized protein Rv2645

Protein

Unknown.

P9WL51

Uncharacterized protein Rv2578c

Protein

Unknown.

P9WL79

PhoH-like protein

Protein

Unknown.

P9WIA3

Uncharacterized protein Rv2561/Rv2562

Protein

Unknown.

P9WL99

Uncharacterized protein Rv2576c

Protein

Unknown.

P9WL83

Uncharacterized protein Rv2568c

Protein

Unknown.

P9WL95

Long conserved protein

Protein

Unknown.

Q50732

Probable conserved transmembrane protein

Protein

Unknown.

P95017

Hypothetical alanine rich protein

Protein

Unknown.

O53214

Probable conserved transmembrane protein

Protein

Unknown.

I6Y9U6

Probable conserved membrane protein

Protein

Unknown.

I6YDV4

PPE family protein PPE39

Protein

Unknown.

Q79FF3

Uncharacterized protein Rv2923c

Protein

Unknown.

P9WL19

Uncharacterized protein Rv2901c

Protein

Unknown.

P9WL27

30S ribosomal protein S16

Protein

Unknown.

P9WH53

Chromosome partition protein Smc

Protein

Required for chromosome condensation and partitioning. {ECO:0000255|HAMAP-Rule:MF_01894}..

P9WGF3

Uncharacterized protein Rv2915c

Protein

Unknown.

P9WL23

Uncharacterized protein Rv2929

Protein

Unknown.

P9WL13

Uncharacterized protein Rv2917

Protein

Unknown.

P9WL21

Conserved alanine rich protein

Protein

Unknown.

I6X579

Probable transcriptional regulatory protein

Protein

Unknown.

O53238

Hypothetical proline-rich protein

Protein

Unknown.

O05780

Conserved alanine rich protein

Protein

Unknown.

I6Y1V1

Uncharacterized protein Rv3424c

Protein

Unknown.

P9WKY3

UPF0182 protein Rv3193c

Protein

Unknown.

P9WFL3

Uncharacterized protein Rv3403c

Protein

Unknown.

P9WKZ5

Uncharacterized protein Rv3421c

Protein

Unknown.

P9WKY7

Uncharacterized protein Rv3412

Protein

Unknown.

P9WKY9

Uncharacterized protein Rv3466

Protein

Unknown.

P9WKY1

Uncharacterized protein Rv3126c

Protein

Unknown.

P9WL09

Uncharacterized protein Rv3127

Protein

Unknown.

P9WL07

Probable conserved transmembrane protein

Protein

Unknown.

O06252

Probable conserved transmembrane protein

Protein

Unknown.

P96883

Possible integral membrane protein

Protein

Unknown.

O53312

Conserved transmembrane protein

Protein

Unknown.

O50377

Possible conserved transmembrane protein

Protein

Unknown.

I6YC44

Possible conserved protein CpsA

Protein

Unknown.

O06347

Hypothetical proline rich protein

Protein

Unknown.

O53383

Uncharacterized protein Rv3630

Protein

Unknown.

P9WKX9

PPE family protein PPE64

Protein

Unknown.

Q6MWW0

Possible transcriptional regulatory protein

Protein

Unknown.

P96238

Probable conserved secreted protein

Protein

Unknown.

O06277

Hypothetical leucine rich protein

Protein

Unknown.

P72037

Possible conserved membrane protein

Protein

Unknown.

O69663

PPE family protein PPE4

Protein

Important for the siderophore-mediated iron-acquisition function of ESX-3. {ECO:0000269|PubMed:26729876}..

P9WI43

30S ribosomal protein S6

Protein

Binds together with S18 to 16S ribosomal RNA. {ECO:0000250}..

P9WH31

Uncharacterized protein Rv0106

Protein

Unknown.

P9WPI5

Cell division protein CrgA

Protein

Involved in cell division. Plays an important role in septal peptidoglycan synthesis and cell shape morphogenesis. May facilitate the recruitment of the peptidoglycan synthesis machinery to poles and septal zones and coordinate peptidoglycan synthesis at these sites. {ECO:0000255|HAMAP-Rule:MF_00631, ECO:0000269|PubMed:21531798, ECO:0000269|PubMed:23002219}..

P9WP57

Isoniazid-induced protein IniA

Protein

Participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear to directly transport isoniazid from the cell. {ECO:0000269|PubMed:15752203}..

P9WJ99

Phosphotriesterase homology protein

Protein

Unknown.

P9WHN9

UPF0182 protein Rv0064

Protein

Unknown.

P9WFL5

Uncharacterized protein Rv0036c

Protein

Unknown.

P9WM91

Uncharacterized protein Rv0057

Protein

Unknown.

P9WM77

Isoniazid-induced protein IniB

Protein

Unknown.

P9WJ97

Possible transcriptional regulatory protein

Protein

Unknown.

O06299

Probable conserved transmembrane protein

Protein

Unknown.

P96418

Possible conserved membrane protein

Protein

Unknown.

O07241

Mce-family protein Mce1B

Protein

Unknown.

O07414

Probable conserved transmembrane protein

Protein

Unknown.

P96400

Possible transcriptional regulatory protein

Protein

Unknown.

P95217

Probable conserved transmembrane protein

Protein

Unknown.

O07424

Possible conserved exported protein

Protein

Unknown.

O07236

Probable conserved membrane protein

Protein

Unknown.

O06298

PPE family protein PPE5

Protein

Unknown.

Q6MX49

50S ribosomal protein L16

Protein

Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs. {ECO:0000255|HAMAP-Rule:MF_01342}..

P9WHD5

Uncharacterized protein Rv0441c

Protein

Unknown.

P9WKW3

50S ribosomal protein L11

Protein

Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. {ECO:0000255|HAMAP-Rule:MF_00736}..

P9WHE5

Uncharacterized protein Rv0495c

Protein

Unknown.

P9WKU5

Uncharacterized protein Rv0739

Protein

Unknown.

P9WKS1

Uncharacterized protein Rv0738

Protein

Unknown.

P9WKS3

Probable transport protein MmpL1

Protein

Unknown.

P9WJV9

Probable transport protein MmpL2

Protein

Unknown.

P9WJV7

Probable conserved exported protein

Protein

Unknown.

I6Y8R4

Possible exported protein

Protein

Unknown.

O07775

Possible exported protein

Protein

Unknown.

O33363

Possible transcriptional regulatory protein

Protein

Unknown.

O53737

Probable integral membrane protein

Protein

Unknown.

O07762

Possible secreted protein

Protein

Unknown.

P95206

Probable membrane protein

Protein

Unknown.

I6XVZ6

50S ribosomal protein L32

Protein

Unknown.

P9WH99

Probable integral membrane protein

Protein

Unknown.

O06403

Uncharacterized protein Rv0875c

Protein

Unknown.

P9WKR7

Uncharacterized protein Rv0876c

Protein

Unknown.

P9WKR5

UPF0073 membrane protein Rv1085c

Protein

Unknown.

P9WFN7

PE family protein PE9

Protein

Together with PE10, induces macrophage apoptosis through human Toll-like receptor 4 (TLR4) signaling pathway. Interaction with TLR4 leads to increased levels of phospho-IRF-3, increase in the transcript levels of IFN-beta and pro-apoptotic genes, up-regulation of IL-10, down-regulation of IL-1b and enhanced levels of macrophage apoptosis. {ECO:0000269|PubMed:26031846}..

Q79FS8

Uncharacterized protein Rv0963c

Protein

Unknown.

P9WKM7

Uncharacterized protein Rv0943c

Protein

Unknown.

P9WKN7

Uncharacterized protein Rv0906

Protein

Unknown.

P9WKP3

Probable conserved transmembrane protein

Protein

Unknown.

O05579

Probable integral membrane protein

Protein

Unknown.

O06540

Conserved exported protein

Protein

Unknown.

O53423

Uncharacterized protein Rv1490

Protein

Unknown.

P9WLX1

Uncharacterized protein Rv1362c

Protein

Unknown.

P9WM01

Uncharacterized membrane protein Rv1401

Protein

Unknown.

P9WG51

Uncharacterized protein Rv1363c

Protein

Unknown.

P9WLZ9

Uncharacterized protein Rv1510

Protein

Unknown.

P9WLW1

Uncharacterized protein Rv1319c

Protein

Unknown.

P9WQ31

Uncharacterized protein Rv1312

Protein

Unknown.

P9WM29

Uncharacterized protein Rv1414

Protein

Unknown.

P9WLY3

Uncharacterized protein Rv1509

Protein

Unknown.

P9WLW3

Conserved hypothetical transmembrane protein

Protein

Unknown.

P71796

Probable transcriptional regulatory protein

Protein

Unknown.

Q11028

Conserved membrane protein

Protein

Unknown.

P71767

Conserved hypothetical membrane protein

Protein

Unknown.

O86316

Probable membrane protein

Protein

Unknown.

O86314

Possible transcriptional activator protein

Protein

Unknown.

O06807

Uncharacterized protein Rv1841c

Protein

Unknown.

P9WLQ7

Uncharacterized protein Rv1899c

Protein

Unknown.

P9WK29

Uncharacterized protein Rv1815

Protein

Unknown.

P9WLR9

Probable membrane protein Rv1733c

Protein

Unknown.

P9WLS9

Uncharacterized protein Rv1583c

Protein

Unknown.

P9WLU1

Probable membrane protein

Protein

Unknown.

O07740

Probable conserved transmembrane protein

Protein

Unknown.

O33206

Probable conserved membrane protein

Protein

Unknown.

O07729

Probable PhiRv1 phage protein

Protein

Unknown.

O06613

UPF0434 protein Rv1684

Protein

Unknown.

O33186

Probable conserved membrane protein

Protein

Unknown.

O06141

Possible penicillin-binding protein

Protein

Unknown.

P71988

Probable integral membrane protein

Protein

Unknown.

O53925

PE family protein PE19

Protein

Unknown.

Q79FK4

Conserved membrane protein

Protein

Unknown.

O06133

Probable membrane protein

Protein

Unknown.

O53918

Possible conserved membrane protein

Protein

Unknown.

O06128

Uncharacterized protein (Fragment)

Protein

Unknown.

L0T9Q6

Uncharacterized protein Rv2239c

Protein

Unknown.

P9WLG9

Uncharacterized protein Rv2277c

Protein

Unknown.

P9WLF1

Uncharacterized protein Rv2265

Protein

Unknown.

P9WLG3

Cobalamin biosynthesis protein CobD

Protein

Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. {ECO:0000250}..

P9WP93

Uncharacterized protein Rv2237

Protein

Unknown.

P9WLH1

Uncharacterized protein Rv2325c

Protein

Unknown.

P9WPI7

Probable antibiotic-resistance protein

Protein

Unknown.

Q50662

Conserved transmembrane protein

Protein

Unknown.

O33262

UPF0047 protein Rv2556c

Protein

Unknown.

P9WFP9

Uncharacterized protein Rv2629

Protein

Unknown.

P9WL63

Uncharacterized protein Rv2567

Protein

Unknown.

P9WL97

PPE family protein PPE41

Protein

The PE25/PPE41 dimer induces both a strong humoral and cellular immune response (PubMed:18974870). The dimer induces necrosis, but not apoptosis, in mouse macrophage cells (PubMed:25379378). It also induces activation and maturation of mouse dendritic cells and drives Th2-biased immune responses (PubMed:26318856). {ECO:0000269|PubMed:18974870, ECO:0000269|PubMed:25379378, ECO:0000269|PubMed:26318856}..

Q79FE1

Uncharacterized membrane protein Rv2723

Protein

Unknown.

P9WG93

Putative uncharacterized protein Rv2628

Protein

Unknown.

P9WL65

Uncharacterized protein Rv2676c

Protein

Unknown.

P9WL45

Probable protein archease

Protein

Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). {ECO:0000250}..

P9WQ03

Uncharacterized protein Rv2560

Protein

Unknown.

P9WLA1

Uncharacterized protein Rv2632c

Protein

Unknown.

P9WL61

Uncharacterized protein Rv2633c

Protein

Unknown.

P9WL59

PE family protein PE26

Protein

Unknown.

Q79FD3

Regulatory protein RecX

Protein

Binds to RecA inhibiting ATP hydrolysis and the generation of heteroduplex DNA. It might act as an anti-recombinase to quell inappropriate recombinational repair during normal DNA metabolism. It is essential for cell survival. {ECO:0000269|PubMed:12218174}..

P9WHI1

Uncharacterized protein Rv2897c

Protein

Unknown.

P9WPR1

Possible PhiRv2 prophage protein

Protein

Unknown.

I6Y1F0

Uncharacterized protein Rv2886c

Protein

Unknown.

P9WL35

35 kDa protein

Protein

Unknown.

P9WHP5

Multidrug resistance protein Mmr

Protein

Multidrug efflux pump. Confers resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, pyronin Y and methyl viologen. {ECO:0000269|PubMed:11574548, ECO:0000269|PubMed:9811672}..

P9WGF1

Uncharacterized protein Rv3067

Protein

Unknown.

I6YB21

Probable conserved transmembrane protein

Protein

Unknown.

O33237

50S ribosomal protein L17

Protein

Unknown.

P9WHD3

Biotinylated protein TB7.3

Protein

Unknown.

P9WPQ1

Uncharacterized membrane protein Rv3486

Protein

Unknown.

O06349

PPE family protein PPE55

Protein

Unknown.

Q6MWX9

PPE family protein PPE52

Protein

Unknown.

I6X6H8

Probable transposase fusion protein

Protein

Unknown.

O53377

Probable integral membrane protein

Protein

Unknown.

I6XHC3

Possible transmembrane protein

Protein

Unknown.

P96894

Mce-family protein Mce4B

Protein

Unknown.

I6X7G8

PE family protein PPE60

Protein

Unknown.

Q6MWX1

Uncharacterized protein Rv3660c

Protein

May play a role in septum formation. {ECO:0000269|PubMed:16735741}..

P9WKX7

Possible exported protein

Protein

Unknown.

I6X7F2

Uncharacterized membrane protein Rv3835

Protein

May play a role in septum formation. {ECO:0000269|PubMed:16735741}..

P9WKW5

Uncharacterized protein Rv3776

Protein

Unknown.

P72042

Possible membrane protein

Protein

Unknown.

P96220

PE family protein PE33

Protein

Unknown.

I6X7Z8

Probable conserved membrane protein

Protein

Unknown.

O05456

Probable conserved transmembrane protein

Protein

Unknown.

P96235

Probable conserved membrane protein

Protein

Unknown.

O53572

Hypothetical short protein

Protein

Unknown.

O06283

Possible membrane protein

Protein

Unknown.

I6YCQ7

Probable conserved transmembrane protein

Protein

Unknown.

O69637

50S ribosomal protein L34

Protein

Unknown.

P9WH93

N-acetyltransferase Eis (EC 2.3.1.-) (Aminoglycoside N-acetyltransferase) (Enhanced intracellular survival protein) (Protein-lysine N-acetyltransferase)

Protein

Effector that is released into the host cell and affects host immune responses; it negatively modulates inflammation, macrophage autophagy, and cell death through redox-dependent signaling (PubMed:17259625, PubMed:21187903). Acts as an acetyltransferase. Acetylates 'Lys-55' of dual-specificity protein phosphatase 16 (DUSP16)/mitogen-activated protein kinase phosphatase-7 (MKP-7), a JNK-specific phosphatase; this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis (PubMed:22547814). Inhibits Con A-mediated T-cell proliferation in vitro (PubMed:17449476). Treatment of T-cells with Eis inhibits ERK1/2, JAK pathway, and subsequent production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-4 (IL-4); on the contrary, there is increased production of interferon-gamma (IFN-gamma) and interleukin-10 (IL-10), which indicates that immunity in response to Eis treatment is skewed away from a protective T(H)1 response and Eis disturbs the cross regulation of T-cells (PubMed:17449476). When expressed in M.smegmatis, enhances intracellular survival of the bacteria in host macrophages during infection (PubMed:10629183). {ECO:0000269|PubMed:10629183, ECO:0000269|PubMed:17259625, ECO:0000269|PubMed:17449476, ECO:0000269|PubMed:21187903, ECO:0000269|PubMed:22547814}.; FUNCTION: Can also acetylate multiple amine groups of many aminoglycoside (AG) antibiotics, leading to their inactivation, and thus contributes to drug resistance (PubMed:19906990, PubMed:21628583, PubMed:24106131). Is also able to acetylate and deactivate the cyclic peptide antibiotic capreomycin, but not the other anti-tuberculous drugs isoniazid and pyrazinamide (PubMed:23233486). Acetylates kanamycin (KAN) more efficiently than amikacin (AMK), even though Eis seems to bind AMK with higher affinity (PubMed:19906990). Does not acetylate and inactivate streptomycin, apramycin and spectinomycin (PubMed:19906990, PubMed:21628583). {ECO:0000269|PubMed:19906990, ECO:0000269|PubMed:21628583, ECO:0000269|PubMed:23233486, ECO:0000269|PubMed:24106131}..

P9WFK7

DNA repair protein RecO (Recombination protein O)

Protein

Involved in DNA repair and RecF pathway recombination. {ECO:0000250}..

P9WHI5

50S ribosomal protein L9

Protein

Binds to the 23S rRNA. {ECO:0000255|HAMAP-Rule:MF_00503}..

P9WH79

Uncharacterized protein Rv0025

Protein

Unknown.

P9WMA1

Putative uncharacterized protein Rv0095c

Protein

Unknown.

Q10891

Uncharacterized protein Rv0028

Protein

Unknown.

P9WM97

Uncharacterized protein Rv0034

Protein

Unknown.

P9WM93

Uncharacterized protein Rv0100

Protein

Unknown.

P9WM65

Uncharacterized protein Rv0007

Protein

Unknown.

P9WMA7

Uncharacterized protein Rv0090

Protein

Unknown.

P9WM71

Possible conserved protein

Protein

Unknown.

P96407

Probable transcriptional regulatory protein

Protein

Unknown.

O53623

Mce-family protein Mce1A

Protein

Unknown.

Q79FZ9

Probable membrane protein

Protein

Unknown.

O53621

PE family protein PE1

Protein

Unknown.

Q79G06

PPE family protein PPE9

Protein

Unknown.

L0T6B3

Mce-family protein Mce1D

Protein

Unknown.

O07416

PE family protein PE2

Protein

Unknown.

Q79G05

30S ribosomal protein S10

Protein

Involved in the binding of tRNA to the ribosomes. {ECO:0000255|HAMAP-Rule:MF_00508}..

P9WH67

50S ribosomal protein L29

Protein

Unknown.

P9WHA7

PPE family protein PPE6

Protein

Unknown.

Q6MX48

Uncharacterized protein Rv0481c

Protein

Unknown.

P9WKV5

Uncharacterized protein Rv0477

Protein

Unknown.

P9WKV9

Uncharacterized protein Rv0508

Protein

Unknown.

P9WKS9

Uncharacterized protein Rv0740

Protein

Unknown.

O53803

Uncharacterized protein Rv0609B

Protein

Unknown.

P0DN33

UPF0234 protein Rv0566c

Protein

Unknown.

P9WFK9

Uncharacterized protein Rv0500B

Protein

Unknown.

P9WKT5

Uncharacterized protein Rv0487

Protein

Unknown.

P9WKU9

Possible transmembrane protein

Protein

Unknown.

P96266

Probable conserved transmembrane protein

Protein

Unknown.

O06394

Possible conserved membrane protein

Protein

Unknown.

O33364

Mce-family related protein

Protein

Unknown.

I6X9D2

Mce-family protein Mce2B

Protein

Unknown.

O07788

Uncharacterized protein Rv0877

Protein

Unknown.

P9WKR3

Uncharacterized protein Rv0891c

Protein

Unknown.

P9WMV1

Uncharacterized protein Rv0814c

Protein

Unknown.

P0CG95

Uncharacterized membrane protein ArfC

Protein

Required for wild-type expression of ArfA and ammonia secretion, not however part of an ammonia transporter. {ECO:0000269|PubMed:21410778}..

P9WJG5

Uncharacterized protein Rv1109c

Protein

Unknown.

P9WM59

Uncharacterized protein Rv0883c

Protein

Unknown.

P9WKQ7

Uncharacterized protein Rv0966c

Protein

Unknown.

P9WKM1

Conserved serine rich protein

Protein

Unknown.

O05574

PE family protein PE7

Protein

Unknown.

I6Y936

PE family protein PE8

Protein

Unknown.

L7N667

Possible conserved exported protein

Protein

Unknown.

O86370

Uncharacterized protein Rv1498c

Protein

Unknown.

P9WLW9

Uncharacterized protein Rv1520

Protein

Unknown.

P9WLV5

Uncharacterized protein Rv1357c

Protein

Unknown.

P9WM07

Uncharacterized protein Rv1364c

Protein

Unknown.

P9WLZ7

Uncharacterized protein Rv1278

Protein

Unknown.

P9WM41

Uncharacterized protein Rv1332

Protein

Unknown.

P9WM25

Uncharacterized protein Rv1486c

Protein

Unknown.

P9WLX3

Uncharacterized protein Rv1290c

Protein

Unknown.

P9WM35

Uncharacterized protein Rv1545

Protein

Unknown.

P9WLU9

Uncharacterized protein Rv1502

Protein

Unknown.

P9WLW7

Nucleotide-binding protein Rv1421

Protein

Displays ATPase and GTPase activities. {ECO:0000255|HAMAP-Rule:MF_00636}..

P9WFQ3

Uncharacterized protein Rv1488

Protein

Unknown.

P9WPR9

Uncharacterized protein Rv1339

Protein

Unknown.

P9WGC1

Uncharacterized protein Rv1417

Protein

Unknown.

P9WLY1

Uncharacterized protein Rv1419

Protein

Unknown.

P9WLX9

Uncharacterized protein Rv1322

Protein

Unknown.

P9WM27

Probable transmembrane protein

Protein

Unknown.

O33223

Probable transcriptional regulatory protein

Protein

Unknown.

O53151

PE family protein PE12

Protein

Unknown.

L7N693

Possible membrane protein

Protein

Unknown.

O86313

Uncharacterized protein Rv1824

Protein

Unknown.

P9WLR7

UPF0749 protein Rv1823

Protein

Unknown.

P9WFG1

Probable transmembrane protein

Protein

Unknown.

O50451

Uncharacterized protein Rv1945

Protein

Unknown.

P9WLQ5

UPF0749 protein Rv1825

Protein

Unknown.

P9WFG3

Uncharacterized protein Rv1954c

Protein

Unknown.

P9WLQ3

Urease accessory protein UreG

Protein

Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG. {ECO:0000255|HAMAP-Rule:MF_01389}..

P9WFE3

Uncharacterized protein Rv1813c

Protein

Unknown.

P9WLS1

Uncharacterized protein Rv1734c

Protein

Unknown.

P9WLS7

Uncharacterized protein Rv1954A

Protein

Unknown.

P0CV86

Possible integral membrane protein

Protein

Unknown.

O65935

Probable hypothetical membrane protein

Protein

Unknown.

O06623

Conserved hypothetical membrane protein

Protein

Unknown.

O06625

Conserved hypothetical membrane protein

Protein

Unknown.

P94973

PE family protein PE18

Protein

Unknown.

L7N649

Probable PhiRv1 phage protein

Protein

Unknown.

O06608

Probable PhiRv1 phage protein

Protein

Unknown.

O06610

Possible Inv protein

Protein

Unknown.

O06624

Uncharacterized protein Rv2232

Protein

Unknown.

P9WPI9

Uncharacterized protein Rv2102

Protein

Unknown.

O53500

Uncharacterized protein Rv2248

Protein

Unknown.

P9WLG5

Uncharacterized protein Rv2229c

Protein

Unknown.

P9WLH3

Uncharacterized protein Rv2240c

Protein

Unknown.

P9WLG7

Uncharacterized protein Rv2012

Protein

Unknown.

P9WLM3

Uncharacterized protein Rv2227

Protein

Unknown.

P9WLH7

Uncharacterized protein Rv2313c

Protein

Unknown.

P9WLB7

Uncharacterized protein Rv2076c

Protein

Unknown.

P9WLL3

Uncharacterized protein Rv2082

Protein

Unknown.

Q10690

Uncharacterized protein Rv2085

Protein

Unknown.

P9WLJ9

Uncharacterized protein Rv2297

Protein

Unknown.

P9WLD9

30S ribosomal protein S14

Protein

Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. {ECO:0000255|HAMAP-Rule:MF_00537}..

P9WH59

Uncharacterized protein Rv2205c

Protein

Unknown.

P9WMT7

Uncharacterized protein Rv1998c

Protein

Unknown.

P9WLN9

Uncharacterized protein Rv2288

Protein

Unknown.

P9WLE5

Uncharacterized protein Rv2078

Protein

Unknown.

P9WLK9

Possible conserved transmembrane protein

Protein

Unknown.

O06230

Probable conserved membrane protein

Protein

Unknown.

O53975

Transcriptional regulatory protein

Protein

Unknown.

O53463

Conserved transmembrane protein

Protein

Unknown.

L0TB61

PE family protein PE22

Protein

Unknown.

L7N6B5

Probable transmembrane protein

Protein

Unknown.

O06231

Uncharacterized protein Rv2644c

Protein

Unknown.

P9WL53

Uncharacterized protein Rv2557

Protein

Unknown.

P9WLA5

Uncharacterized protein Rv2599

Protein

Unknown.

P9WL69

Uncharacterized protein Rv2411c

Protein

Unknown.

P9WLA9

Uncharacterized protein Rv2468c

Protein

Unknown.

P9WLA7

Uncharacterized membrane protein Rv2637

Protein

Unknown.

P9WP07

Possible conserved membrane protein

Protein

Unknown.

I6YA32

Possible conserved membrane protein

Protein

Unknown.

Q79FE4

Conserved transmembrane protein

Protein

Unknown.

P71912

Probable transmembrane protein

Protein

Unknown.

I6XER9

Hypothetical alanine rich protein

Protein

Unknown.

P95012

30S ribosomal protein S2

Protein

Unknown.

P9WH39

Uncharacterized protein Rv2927c

Protein

Unknown.

P9WL15

Uncharacterized protein Rv3073c

Protein

Unknown.

P9WL11

Uncharacterized protein Rv2891

Protein

Unknown.

P9WL33

Possible conserved secreted protein

Protein

Unknown.

P95115

PPE family protein PPE43

Protein

Unknown.

Q79FA9

30S ribosomal protein S9

Protein

Unknown.

P9WH25

Uncharacterized protein Rv3254

Protein

Unknown.

O05897

Uncharacterized membrane protein Rv3479

Protein

Unknown.

O06342

Uncharacterized protein Rv3118

Protein

Unknown.

P0CG96

30S ribosomal protein S11

Protein

Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. {ECO:0000255|HAMAP-Rule:MF_01310}..

P9WH65

Probable conserved transmembrane protein

Protein

Unknown.

P96882

Mce-family protein Mce4D

Protein

Unknown.

I6XHD6

Probable membrane protein

Protein

Unknown.

Q6MWX4

PE family protein PE31

Protein

Unknown.

I6YG87

Possible conserved transmembrane protein

Protein

Unknown.

O06320

Conserved protein TB9.4

Protein

Unknown.

Q6MWZ8

Uncharacterized protein Rv3786c

Protein

Unknown.

P9WKW9

Recombination protein RecR

Protein

May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. {ECO:0000255|HAMAP-Rule:MF_00017}..

P9WHI3

Possible conserved secreted protein

Protein

Unknown.

O53313

Nucleoid-associated protein Rv3716c

Protein

Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. {ECO:0000255|HAMAP-Rule:MF_00274}..

P9WNR9

Uncharacterized protein Rv3778c

Protein

Is essential for optimal growth..

P9WQ67

Possible conserved transmembrane protein

Protein

Unknown.

O69662

PE family protein PE36

Protein

Unknown.

L7N660

Probable conserved membrane protein

Protein

Unknown.

O69658

Probable conserved transmembrane protein

Protein

Unknown.

I6YCR8

Probable conserved membrane protein

Protein

Unknown.

I6X7J6

Phosphate-binding protein PstS 3 (PBP 3) (PstS-3) (Antigen Ag88)

Protein

Functions in inorganic phosphate uptake, is probably the main carrier for phosphate uptake, it is the most highly expressed of the 3 PstS proteins under phosphate starvation (PubMed:20933472). Binds phosphate; probably able to bind both H(2)PO(4)(-) and HPO(4)(2-) (PubMed:24615888). Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Probably plays a role in host phagosome maturation arrest (PubMed:20844580). {ECO:0000269|PubMed:20933472, ECO:0000269|PubMed:24615888, ECO:0000305, ECO:0000305|PubMed:20844580}..

P9WGT7

PE-PGRS family protein PE_PGRS33

Protein

Induces TNF-alpha release through human Toll-like receptor 2 (TLR2) signaling pathway, leading to macrophage apoptosis (PubMed:17095513, PubMed:17223373, PubMed:24106104). The signaling pathway involves TLR2-dependent activation of the mitogen-activated protein kinase kinase kinase 5 (ASK1), which activates the p38 and JNK MAPKs, leading to enhanced expression of TNF-alpha and tumor necrosis factor receptor superfamily member 1A (TNFRI) genes. Signals are amplified through classical caspase 8-dependent mitochondrial release of cytochrome c, leading to the activation of caspases 9 and 3 (PubMed:17095513). Mediates Ca(2+)-dependent up-regulation of the anti-inflammatory cytokine IL-10 (PubMed:27483162). Mediates entry into macrophages in a TLR2-dependent mechanism and activates the TLR2-dependent pro-adhesive pathway (PubMed:26978522). {ECO:0000269|PubMed:17095513, ECO:0000269|PubMed:17223373, ECO:0000269|PubMed:24106104, ECO:0000269|PubMed:26978522, ECO:0000269|PubMed:27483162}..

P9WIF5

PPE family protein PPE57

Protein

Plays a key role in regulating innate and adaptive immune responses through human Toll-like receptor 2 (TLR2). Interacts with TLR2, leading to the subsequent activation of the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappa-B) signaling pathways. Induces macrophage activation by augmenting the expression of several cell surface molecules (CD40, CD80, CD86 and MHC class II) and pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-12p40) within macrophages. Also participates in adaptive immunity by directing Th1-polarised immune responses (PubMed:25586105). Stimulates specific humoral and cellular immune responses in tuberculosis (TB) patients (PubMed:17328725, PubMed:19467342, PubMed:23136116). Induces a strong IgG(1) antibody response and an increased Th1/Th2 type immune response in mice (PubMed:18426397). {ECO:0000269|PubMed:17328725, ECO:0000269|PubMed:18426397, ECO:0000269|PubMed:19467342, ECO:0000269|PubMed:23136116, ECO:0000269|PubMed:25586105}..

Q50703

Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Glutamine synthetase I alpha) (GSI alpha)

Protein

Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes. {ECO:0000250|UniProtKB:P12425}..

P9WN37

Uncharacterized protein Rv0030

Protein

Unknown.

P9WM95

Uncharacterized protein Rv0104

Protein

Unknown.

P9WM61

Uncharacterized protein Rv0098

Protein

Unknown.

P9WM67

Isoniazid-induced protein IniC

Protein

Unknown.

P9WJ95

Uncharacterized protein Rv0010c

Protein

Unknown.

P9WMA3

PE family protein PE3

Protein

Plays significant roles in mycobacterial persistence during infection and modulates host immune response. {ECO:0000269|PubMed:23708146}..

Q79G04

UPF0301 protein Rv0038

Protein

Unknown.

P9WFK5

Uncharacterized protein Rv0027

Protein

Unknown.

P9WM99

Uncharacterized membrane protein Rv0364

Protein

Unknown.

P9WP09

Possible transcriptional regulatory protein

Protein

Unknown.

P96812

Conserved protein TB18.5

Protein

Unknown.

L7N657

Probable conserved transmembrane protein

Protein

Unknown.

I6Y748

Possible conserved transmembrane protein

Protein

Unknown.

O53651

Possible conserved secreted protein

Protein

Unknown.

O53718

Probable conserved membrane protein

Protein

Unknown.

O06311

Conserved secreted protein

Protein

Unknown.

Q79FZ8

Mce-family protein Mce1F

Protein

Unknown.

L0T2W6

Mce-family protein Mce1C

Protein

Unknown.

O07415

Uncharacterized protein Rv0501

Protein

Unknown.

P9WKT3

50S ribosomal protein L14

Protein

Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome. {ECO:0000255|HAMAP-Rule:MF_01367}..

P9WHD9

Uncharacterized protein Rv0647c

Protein

Unknown.

P9WQI1

50S ribosomal protein L10

Protein

Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. {ECO:0000250}..

P9WHE7

Uncharacterized protein Rv0569

Protein

Unknown.

P9WM83

Uncharacterized protein Rv0499

Protein

Unknown.

P9WKT9

Possible transcriptional regulatory protein

Protein

Unknown.

O53807

Possible protein ThiS

Protein

Unknown.

P96262

Possible conserved transmembrane protein

Protein

Unknown.

O53731

Possible conserved transmembrane protein

Protein

Unknown.

O33358

Probable conserved membrane protein

Protein

Unknown.

O53748

Uncharacterized protein (Fragment)

Protein

Unknown.

Q79FX1

Possible conserved transmembrane protein

Protein

Unknown.

O06410

Conserved threonine rich protein

Protein

Unknown.

I6WZ30

Probable conserved transmembrane protein

Protein

Unknown.

I6Y4F1

Beta lactamase like protein

Protein

Unknown.

O86336

Conserved hydrophobic protein

Protein

Unknown.

O53745

Mce-family protein Mce2D

Protein

Unknown.

I6WYT7

Possible membrane protein

Protein

Unknown.

I6X9F4

Uncharacterized protein Rv0940c

Protein

Unknown.

P9WKP1

Uncharacterized protein Rv0885

Protein

Unknown.

P9WKQ5

Uncharacterized membrane protein ArfB

Protein

Required for wild-type expression of ArfA and ammonia secretion, not however part of an ammonia transporter. {ECO:0000269|PubMed:21410778}..

P9WJG7

Transcriptional regulatory protein KdpE

Protein

Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. {ECO:0000250}..

P9WGN1

Uncharacterized protein Rv1128c

Protein

Unknown.

P9WM57

Uncharacterized protein Rv1155A

Protein

Unknown.

A0A089QKZ7

Uncharacterized protein Rv0959

Protein

Unknown.

P9WKN1

Uncharacterized protein Rv0961

Protein

Unknown.

P9WKM9

Uncharacterized protein Rv0964c

Protein

Unknown.

P9WKM5

Uncharacterized protein Rv0955

Protein

Unknown.

P9WKN3

Uncharacterized protein Rv0942

Protein

Unknown.

P9WKN9

Probable transcriptional regulatory protein

Protein

Unknown.

O06550

Probable membrane protein KdpF

Protein

Unknown.

Q79FT7

Probable conserved transmembrane protein

Protein

Unknown.

O53420

Conserved membrane protein

Protein

Unknown.

O06583

Uncharacterized protein Rv1268c

Protein

Unknown.

P9WM47

UPF0051 protein Rv1462

Protein

Unknown.

P9WFP5

Uncharacterized protein Rv1507c

Protein

Unknown.

P9WLW5

Uncharacterized protein Rv1518

Protein

Unknown.

P9WLV9

Transcriptional regulatory protein EmbR

Protein

Positively regulates the transcription of the embCAB operon. Exhibits ATPase and GTPase activities. {ECO:0000269|PubMed:16585755, ECO:0000269|PubMed:16817899}..

P9WGJ9

Uncharacterized protein Rv1360

Protein

Unknown.

P9WM03

Uncharacterized protein Rv1280c

Protein

Unknown.

P9WGU5

Uncharacterized protein Rv1526c

Protein

Unknown.

P9WLV1

Uncharacterized protein Rv1351

Protein

Unknown.

P9WM17

Uncharacterized protein Rv1375

Protein

Unknown.

P9WF27

Uncharacterized protein Rv1549

Protein

Unknown.

P9WLU5

Uncharacterized protein Rv1265

Protein

Unknown.

P9WM49

Uncharacterized protein Rv1342c

Protein

Unknown.

P9WM19

Uncharacterized protein Rv1354c

Protein

Unknown.

P9WM13

Uncharacterized protein Rv1403c

Protein

Unknown.

P9WLY9

Uncharacterized protein Rv1405c

Protein

Unknown.

P9WLY7

Uncharacterized protein Rv1288

Protein

Unknown.

P9WM39

Uncharacterized protein Rv1413

Protein

Unknown.

P9WLY5

Uncharacterized protein Rv1359

Protein

Unknown.

P9WM05

Uncharacterized protein Rv1318c

Protein

Unknown.

P9WQ33

Uncharacterized protein Rv1324

Protein

Unknown.

P9WG61

Probable transport protein MmpL12

Protein

Unknown.

P9WJT7

Probable membrane protein

Protein

Unknown.

P71787

Urease accessory protein UreF

Protein

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-Rule:MF_01385}..

P9WFE5

Uncharacterized protein Rv1738

Protein

Unknown.

P9WLS3

Uncharacterized protein Rv1829

Protein

Unknown.

P9WLR5

Uncharacterized protein Rv1591

Protein

Unknown.

P9WLT5

Uncharacterized protein Rv1708

Protein

May play a role in septum formation. {ECO:0000269|PubMed:16735741}..

P9WLT1

Uncharacterized membrane protein Rv1735c

Protein

Unknown.

P9WLS5

Possible transmembrane protein

Protein

Unknown.

O07744

Probable PhiRv1 phage protein

Protein

Unknown.

O06614

Possible phage PhiRv1 protein

Protein

Unknown.

O06605

Conserved membrane protein

Protein

Unknown.

O06136

Partial REP13E12 repeat protein

Protein

Unknown.

O06603

Possible PhiRv1 phage protein

Protein

Unknown.

O06606

Probable PhiRv1 phage protein

Protein

Unknown.

L0T9U5

Probable PhiRv1 phage protein

Protein

Unknown.

O06611

Uncharacterized protein Rv2081c

Protein

Unknown.

P9WLK5

Uncharacterized protein Rv2083

Protein

Unknown.

P9WLK3

UPF0098 protein Rv2140c

Protein

Unknown.

P9WFN1

Uncharacterized protein Rv2293c

Protein

Unknown.

P9WLE1

Uncharacterized protein Rv1993c

Protein

Unknown.

P9WLP5

Uncharacterized protein Rv2011c

Protein

Unknown.

P9WLM5

Uncharacterized protein Rv2206

Protein

Unknown.

P9WLI5

Uncharacterized protein Rv2312

Protein

Unknown.

P9WLB9

Uncharacterized protein Rv2305

Protein

Unknown.

P9WLD1

Uncharacterized protein Rv2212

Protein

Unknown.

P9WMU7

Uncharacterized protein Rv2075c

Protein

Unknown.

P9WLL5

Uncharacterized protein Rv2283

Protein

Unknown.

P9WLE9

Uncharacterized protein Rv2286c

Protein

Unknown.

P9WLE7

UPF0167 protein Rv2295

Protein

Probably plays a role in host phagosome maturation arrest (PubMed:20844580). {ECO:0000305|PubMed:20844580}..

P9WFL7

Uncharacterized protein Rv2308

Protein

Unknown.

P9WLC5

Uncharacterized protein Rv2030c

Protein

Unknown.

P9WLM1

Uncharacterized protein Rv2331

Protein

Unknown.

P9WLB3

Epimerase family protein Rv2216

Protein

Unknown.

P9WGP7

Uncharacterized protein Rv2197c

Protein

Unknown.

P9WLI9

Uncharacterized protein Rv2091c

Protein

Unknown.

P9WLJ5

Uncharacterized protein Rv2273

Protein

Unknown.

P9WLF3

Uncharacterized protein Rv2079

Protein

Unknown.

P9WLK7

Probable integral membrane protein

Protein

Unknown.

O53528

Mce-family protein Mce3B

Protein

Unknown.

O53968

Hypothetical glycine rich protein

Protein

Unknown.

L7N678

30S ribosomal protein S20

Protein

Binds directly to 16S ribosomal RNA. {ECO:0000255|HAMAP-Rule:MF_00500}..

P9WH41

Uncharacterized protein Rv2627c

Protein

Unknown.

P9WL67

Uncharacterized protein Rv2558

Protein

Unknown.

P9WLA3

Deoxyguanosinetriphosphate triphosphohydrolase-like protein

Protein

Unknown.

P9WNY7

Uncharacterized protein Rv2574

Protein

Unknown.

P9WL87

UPF0053 protein Rv2366c

Protein

Unknown.

P9WFP1

Uncharacterized protein Rv2577

Protein

Unknown.

P9WL81

Probable transport protein MmpL9

Protein

Unknown.

P9WJU3

Uncharacterized protein Rv2656c

Protein

Unknown.

P9WL49

Uncharacterized protein Rv2597

Protein

Unknown.

P9WL73

Uncharacterized protein Rv2598

Protein

Unknown.

P9WL71

Probable conserved transmembrane protein

Protein

Unknown.

I6YA25

Uncharacterized protein Rv2850c

Protein

Unknown.

P9WPR3

UPF0039 protein Rv2851c

Protein

Unknown.

P9WFQ5

UPF0109 protein Rv2908c

Protein

Unknown.

P9WFM7

Uncharacterized protein Rv2926c

Protein

Unknown.

P9WL17

Uncharacterized protein Rv2876

Protein

Unknown.

P9WL39

Cell division protein FtsX

Protein

Part of the ABC transporter FtsEX involved in cellular division. {ECO:0000250}..

P9WG19

Immunogenic protein MPT70

Protein

Unknown.

P9WNF5

Uncharacterized protein Rv3035

Protein

Unknown.

I6XFZ8

Probable membrane protein

Protein

Unknown.

I6XFB7

Possible membrane protein

Protein

Unknown.

I6YAA5

Probable transcriptional regulatory protein

Protein

Unknown.

I6X5M3

Possible conserved transmembrane protein

Protein

Unknown.

I6X5Z8

PE family protein PE27A

Protein

Unknown.

Q6MX19

Possible membrane protein

Protein

Unknown.

O33309

Uncharacterized protein Rv3395c

Protein

Unknown.

P9WKZ9

Mce-family protein Mce4C

Protein

Unknown.

I6YGB1

Uncharacterized protein Rv3633

Protein

Unknown.

P9WI89

Probable conserved membrane protein

Protein

Unknown.

I6YG92

Uncharacterized membrane protein Rv3760

Protein

Unknown.

O69726

Uncharacterized membrane protein Rv3691

Protein

Unknown.

O69659

Uncharacterized protein Rv3766

Protein

Unknown.

O69731

Possible membrane protein

Protein

Unknown.

P96226

PPE family protein PPE67

Protein

Unknown.

Q79FA2

GDT1 family protein

Protein

Unknown.

P96229

Probable conserved membrane protein

Protein

Unknown.

O53581

Probable conserved transmembrane protein

Protein

Unknown.

I6X7Z3

Probable conserved transmembrane protein

Protein

Unknown.

I6Y460

Possible conserved membrane protein

Protein

Unknown.

O69661

Possible membrane protein

Protein

Unknown.

O05444

Probable PHOH-like protein PhoH2 (Phosphate starvation-inducible protein PSIH)

Protein

Unknown.

O53443

ESAT-6-like protein EsxG (Conserved protein TB9.8)

Protein

EsxG, in complex with EsxH, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. EsxG stabilizes EsxH in the host cytosol. {ECO:0000269|PubMed:24204276}..

O53692

Penicillin-binding protein PbpB (Penicillin-binding protein 3) (PBP3)

Protein

Synthesis of cross-linked peptidoglycan from the lipid intermediates. {ECO:0000250, ECO:0000269|PubMed:19496931}..

L0T911

Trk system potassium uptake protein TrkA (K(+)-uptake protein TrkA)

Protein

Part of a potassium transport system. {ECO:0000250}..

P9WFZ3

Serine/threonine-protein kinase PknK (EC 2.7.11.1) (Protein kinase K)

Protein

Key microbial factor involved in regulation of early and late events in tuberculosis infection, and in host-pathogen interactions. Modulates host immunity during early infection. Slows mycobacterial growth during chronic infection in host and during a variety of stress conditions in vitro. Regulates the expression of a large subset of tRNA genes as a means to facilitate adaptation to changing growth environments. In vitro, directs the inhibition of transcription and translation processes in a phosphorylation-dependent manner. Phosphorylates the transcriptional regulator VirS, thereby increasing the affinity of VirS for the mycobacterial monooxygenase (mymA) promoter. In vitro, can also phosphorylate the mycobacterial monooxygenase operon products Rv3083 (MymA), Rv3084 (LipR), Rv3085 and Rv3088. {ECO:0000269|PubMed:19251699, ECO:0000269|PubMed:20522497, ECO:0000269|PubMed:22661693, ECO:0000269|PubMed:22740025}..

P9WI65

Nucleoid-associated protein EspR (ESX-1 transcriptional regulatory protein EspR)

Protein

Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression. {ECO:0000269|PubMed:18685700, ECO:0000269|PubMed:21883526, ECO:0000269|PubMed:22389481, ECO:0000269|PubMed:22479184, ECO:0000269|PubMed:23743602}..

P9WJB7

Elongation factor G-like protein

Protein

Unknown.

P9WNM9

PE-PGRS family protein PE_PGRS5

Protein

Involved in endoplasmic reticulum (ER) stress-mediated apoptosis through human Toll-like receptor 4 (TLR4) signaling pathway. Localizes to the host ER, leading to ER stress, disruption of intracellular Ca(2+) homeostasis and increase of nitric oxide (NO) and reactive oxygen species (ROS) levels. Stress response results in caspase-8 activation and apoptosis of macrophage cells. Apoptosis may lead to dissemination of the bacteria, thereby spreading the disease. {ECO:0000269|PubMed:29921671}..

Q6MX50

Probable conserved integral membrane protein

Protein

Unknown.

O07235

Conserved hypothetical glycine rich protein

Protein

Unknown.

O53713

Uncharacterized PPE family protein PPE12

Protein

Unknown.

P9WI37

Transcription termination/antitermination protein NusG

Protein

Participates in transcription elongation, termination and antitermination. {ECO:0000255|HAMAP-Rule:MF_00948}..

P9WIU9

Uncharacterized HIT-like protein Rv0759c

Protein

Unknown.

P9WML3

Siderophore export accessory protein MmpS5

Protein

Part of an export system, which is required for biosynthesis and secretion of siderophores. Essential for virulence. {ECO:0000269|PubMed:23431276}.; FUNCTION: Overexpression of the system confers non-target based resistance to azoles, clofazimine and bedaquiline, via an efflux mechanism. {ECO:0000269|PubMed:18851927, ECO:0000269|PubMed:25010492}..

P9WJS7

Probable conserved integral membrane protein

Protein

Unknown.

O06781

PE-PGRS family protein PE_PGRS9

Protein

Unknown.

Q79FW8

Probable conserved integral membrane protein

Protein

Unknown.

O53781

Uncharacterized PPE family protein PPE14

Protein

Unknown.

P9WI33

PE-PGRS family protein PE_PGRS16

Protein

Unknown.

Q79FU3

Uncharacterized NTE family protein Rv1063c

Protein

Unknown.

P9WIY9

Probable conserved integral membrane protein

Protein

Unknown.

O53854

PE-PGRS family protein PE_PGRS12

Protein

Unknown.

Q79FV8

Uncharacterized PPE family protein PPE19

Protein

Unknown.

P9WI25

Probable cell division protein WhiA

Protein

Involved in cell division and chromosome segregation. {ECO:0000255|HAMAP-Rule:MF_01420}..

P9WF45

Uncharacterized HIT-like protein Rv1262c

Protein

Unknown.

P9WML1

Putative OXPP cycle protein OpcA

Protein

Unknown.

O06813

Uncharacterized PPE family protein PPE25

Protein

Unknown.

P9WI13

Uncharacterized PPE family protein PPE32

Protein

Unknown.

P9WI05

Probable transcriptional regulatory protein MoxR1

Protein

Unknown.

Q79FN7

Probable transcriptional regulatory protein pdtaR

Protein

Member of the two-component regulatory system pdtaR/pdtaS. {ECO:0000269|PubMed:16026786}..

P9WGM3

PE-PGRS family protein PE_PGRS31

Protein

Unknown.

Q79FK9

Probable PhiRv1 phage related protein

Protein

Unknown.

L0TA08

PE-PGRS family protein PE_PGRS32

Protein

Unknown.

Q79FJ9

Uncharacterized PE family protein PE23

Protein

Unknown.

P9WIG9

Probable transport accessory protein MmpS3

Protein

Unknown.

P9WJT1

PE-PGRS family protein PE_PGRS37

Protein

Unknown.

L0TBL4

Probable conserved integral membrane protein

Protein

Unknown.

O53514

Uncharacterized NTE family protein Rv2565

Protein

Unknown.

P9WIY7

Uncharacterized PPE family protein PPE42

Protein

Elicits a high humoral and a low T-cell response. Could be involved in directing the host toward development of a more humoral type of immune response. {ECO:0000269|PubMed:15346333}..

P9WHZ5

Probable conserved integral membrane protein

Protein

Unknown.

O53173

Conserved hypothetical alanine rich protein

Protein

Unknown.

I6XF17

PE-PGRS family protein PE_PGRS42

Protein

Unknown.

I6XEF1

Possible molybdopterin biosynthesis protein MoeW

Protein

Unknown.

P95234

Conserved hypothetical alanine rich protein

Protein

Unknown.

I6Y1I1

Probable conserved integral membrane protein

Protein

Unknown.

I6Y2I9

Uncharacterized PPE family protein PPE59

Protein

Unknown.

P9WHY1

Probable conserved integral membrane protein

Protein

Unknown.

O05849

Probable ATP/GTP-binding protein

Protein

Unknown.

O50391

Possible SOJ/para-related protein

Protein

Unknown.

O05853

PE-PGRS family protein PE_PGRS52

Protein

Unknown.

Q6MWX5

Probable cold shock protein A

Protein

Unknown.

P9WP75

PE-PGRS family protein PE_PGRS61

Protein

Mediates Ca(2+)-dependent up-regulation of the anti-inflammatory cytokine IL-10. {ECO:0000269|PubMed:27483162}..

Q6MWV0

PE-PGRS family protein PE_PGRS55

Protein

Unknown.

Q6MWW8

Probable conserved integral membrane protein

Protein

Unknown.

O06378

Probable chromosome-partitioning protein ParB

Protein

Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity). {ECO:0000250}..

P9WIJ9

ATP synthase subunit b-delta [Includes: ATP synthase subunit b (ATP synthase F(0) sector subunit b 2) (ATPase subunit I 2) (F-type ATPase subunit b 2) (F-ATPase subunit b 2); ATP synthase subunit delta (ATP synthase F(1) sector subunit delta) (F-type ATPase subunit delta) (F-ATPase subunit delta)]

Protein

F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). {ECO:0000250}.; FUNCTION: This fusion protein includes a component of the F(0) channel (subunit b) and of the F(1) subunit (subunit delta). Two copies of subunit b and one of delta together form the peripheral "stator" stalk which links F(1) to F(0) (By similarity). {ECO:0000250}..

P9WPV3

Uncharacterized PPE family protein PPE2

Protein

Unknown.

P9WI47

Conserved integral membrane protein YrbE1B

Protein

Unknown.

L0T2Q9

Probable conserved integral membrane protein

Protein

Unknown.

Q6MX47

Conserved 13E12 repeat family protein

Protein

Unknown.

O33266

PE-PGRS family protein PE_PGRS4

Protein

Unknown.

L0T4W6

Uncharacterized PPE family protein PPE10

Protein

Unknown.

P9WI41

Conserved 13E12 repeat family protein

Protein

Unknown.

P95201

Multidrug resistance protein B homolog

Protein

Unknown.

P9WG89

PE-PGRS family protein PE_PGRS22

Protein

Unknown.

Q79FS5

PE-PGRS family protein PE_PGRS19

Protein

Unknown.

Q79FT3

Conserved ala-, pro-rich protein

Protein

Unknown.

O06555

PE-PGRS family protein PE_PGRS29

Protein

Unknown.

Q79FP0

Possible nitrogen fixation related protein

Protein

Unknown.

O53156

PE-PGRS family protein PE_PGRS27

Protein

Unknown.

Q79FP2

Uncharacterized PPE family protein PPE23

Protein

Unknown.

P9WI17

Uncharacterized PPE family protein PPE30

Protein

Unknown.

P9WI07

Segregation and condensation protein B

Protein

Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. {ECO:0000256|SAAS:SAAS00459874}..

I6XCB2

Possible molybdopterin biosynthesis protein MoeX

Protein

Unknown.

O33183

Uncharacterized SURF1-like protein Rv2235

Protein

Unknown.

P9WGA7

RNA polymerase-binding protein RbpA

Protein

Binds to RNA polymerase (RNAP), stimulating and stabilizing the formation of stable RNAP promoter complexes up to 2-fold from principal sigma factor SigA-dependent but not alternative sigma factor SigF-dependent promoters. Increases the affinity of core RNAP for SigA, increasing the transcriptional activity of RNAP. Unlike the case in M.smegmatis or S.coelicolor, has no effect on rifampicin inhibition of transcription. Has no effect on E.coli RNAP. {ECO:0000269|PubMed:22570422}..

P9WHJ5

Uncharacterized PPE family protein PPE36

Protein

Unknown.

P9WI01

DegV domain-containing protein Rv2417c

Protein

May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. {ECO:0000250}..

P9WP05

Conserved hypothetical proline rich protein

Protein

Unknown.

O53538

PE-PGRS family protein PE_PGRS38

Protein

Unknown.

L7N6A1

Probable transcriptional regulatory protein Rv2603c

Protein

Unknown.

P9WGA5

ESAT-6-like protein EsxO

Protein

Plays an important role in mycobacterial pathogenesis in the context of innate immunity. Aids host cell invasion and intracellular bacillary persistence. Increases host oxidative stress response, leading to genomic instability and decrease in macrophage viability. Also induces autophagy and modulates the immune function of macrophages. {ECO:0000269|PubMed:26786654}..

P9WNI7

Probable conserved integral membrane protein

Protein

Unknown.

P71749

Possible oxidase regulatory-related protein

Protein

Unknown.

I6Y9H2

PE-PGRS family protein PE_PGRS45

Protein

Unknown.

Q79FC3

Nitrogen regulatory protein P-II

Protein

In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed (By similarity). {ECO:0000250}..

P9WN31

Putative DNA processing protein DprA

Protein

May help load RecA onto ssDNA (By similarity). {ECO:0000250|UniProtKB:Q8DPI7}..

P9WL29

Uncharacterized PPE family protein PPE45

Protein

Unknown.

P9WHZ1

PE-PGRS family protein PE_PGRS47

Protein

Contributes to evasion of both innate and adaptive immunity. Inhibits autophagy in infected host phagocytes and inhibits major histocompatibility complex (MHC) class II antigen presentation by mycobacteria-infected dendritic cells. Has an important role in the growth and survival of M.tuberculosis, particularly during intracellular growth and in the later chronic phase of infection. {ECO:0000269|PubMed:27562263}..

Q79FB3

Uncharacterized PPE family protein PPE50

Protein

Unknown.

Q6MX07

Uncharacterized PPE family protein PPE58

Protein

Unknown.

Q50702

Probable conserved integral membrane protein

Protein

Unknown.

O06321

ESAT-6-like protein EsxW

Protein

Unknown.

P9WNI3

Uncharacterized PPE family protein PPE62

Protein

Unknown.

P9WHX7

Probable transcriptional regulatory protein TcrX

Protein

Member of the two-component regulatory system TcrY/TcrX. {ECO:0000269|PubMed:12595424, ECO:0000269|PubMed:19962420}..

O69730

Putative conjugal transfer protein Rv3659c

Protein

Unknown.

P9WMT3

Possible cell filamentation protein Fic

Protein

Unknown.

I6YCN3

Conserved hypothetical proline rich protein

Protein

Unknown.

I6YGY9

PE-PGRS family protein PE_PGRS53

Protein

Unknown.

Q6MWW9

PE-PGRS family protein PE_PGRS57

Protein

Unknown.

Q6MWW6

Probable chromosome partitioning protein ParA

Protein

Unknown.

Q1LVD4

Conserved hypothetical alanine rich protein

Protein

Unknown.

O05445

10 kDa chaperonin (10 kDa antigen) (BCG-A heat shock protein) (GroES protein) (Protein Cpn10)

Protein

Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter..

P9WPE5

DNA repair protein RadA (EC 3.6.4.-) (Branch migration protein RadA) (DNA repair protein Sms)

Protein

DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. {ECO:0000255|HAMAP-Rule:MF_01498}..

P9WHJ9

Proteasome-associated ATPase (AAA ATPase forming ring-shaped complexes) (ARC) (Mycobacterial proteasome ATPase)

Protein

ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Is required but not sufficient to confer resistance against the lethal effects of reactive nitrogen intermediates (RNI), antimicrobial molecules produced by activated macrophages and other cell types. {ECO:0000255|HAMAP-Rule:MF_02112, ECO:0000269|PubMed:14671303, ECO:0000269|PubMed:15659170, ECO:0000269|PubMed:17082771, ECO:0000269|PubMed:19836337, ECO:0000269|PubMed:20203624}..

P9WQN5

Phosphotyrosine protein phosphatase PTPB (Protein-tyrosine-phosphatase) (PTPase)

Protein

Unknown.

I6WXK4

UvrABC system protein B (Protein UvrB) (Excinuclease ABC subunit B)

Protein

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage. {ECO:0000255|HAMAP-Rule:MF_00204}..

P9WFC7

Probable PE family protein PE34 (PE family-related protein)

Protein

Unknown.

Q79FA1

DNA repair protein RecN (Recombination protein N)

Protein

May be involved in recombinational repair of damaged DNA. {ECO:0000250}..

P9WHI7

FHA domain-containing protein FhaA

Protein

Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis. {ECO:0000269|PubMed:22275220}..

P71590

Probable conserved integral membrane protein

Protein

Unknown.

O53668

PE-PGRS family protein PE_PGRS1

Protein

Unknown.

L0T2H7

PE-PGRS family protein PE_PGRS2

Protein

Unknown.

Q79G08

Probable transport accessory protein MmpS2

Protein

Unknown.

P9WJT3

Conserved 13E12 repeat family protein

Protein

Unknown.

O33360

Uncharacterized PPE family protein PPE16

Protein

Unknown.

P9WI29

ESAT-6-like protein EsxJ

Protein

Unknown.

P9WNJ9

34 kDa antigenic protein homolog

Protein

Unknown.

P9WIR9

Probable transcriptional regulatory protein NarL

Protein

Probable member of the two-component regulatory system NarS/NarL. {ECO:0000269|PubMed:12595424}..

P9WGM5

PE-PGRS family protein PE_PGRS18

Protein

Unknown.

Q79FU0

Probable fatty oxidation protein FadB

Protein

Unknown.

O53872

PE-PGRS family protein PE_PGRS14

Protein

Unknown.

Q79FV6

Possible conserved integral membrane protein

Protein

Unknown.

I6Y8Z3

Uncharacterized PPE family protein PPE17

Protein

Unknown.

P9WI27

ESAT-6-like protein EsxL

Protein

Induces apoptosis of host cells. {ECO:0000269|PubMed:25242740}..

P9WNJ5

ESAT-6-like protein EsxK

Protein

Unknown.

P9WNJ7

Uncharacterized PPE family protein PPE28

Protein

Unknown.

P9WI11

Possible sensor-transducer protein BlaR

Protein

Unknown.

P95164

Probable urease accessory protein UreD

Protein

Unknown.

P95161

Uncharacterized PPE family protein PPE38

Protein

Unknown.

P9WHZ9

Fluoroquinolones export permease protein Rv2687c

Protein

Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for the translocation of the substrate across the membrane. {ECO:0000269|PubMed:15273144}..

P9WJB1

Probable restriction system protein Mrr

Protein

Unknown.

I6Y9K2

PE-PGRS family protein PE_PGRS41

Protein

Unknown.

Q79FE6

PE-PGRS family protein PE_PGRS39

Protein

Unknown.

L7N659

Uncharacterized PPE family protein PPE46

Protein

Unknown.

P9WHY9

Probable conserved secreted protein TB22.2

Protein

Unknown.

I6YF08

Conserved hypothetical alanine rich protein

Protein

Unknown.

O33329

Probable conserved integral membrane protein

Protein

Unknown.

I6YEL8

Conserved hypothetical arginine rich protein

Protein

Unknown.

O33285

Uncharacterized SufE-like protein Rv3284

Protein

Unknown.

P9WGC3

Probable conserved transmembrane transport protein

Protein

Unknown.

O05884

Probable conserved integral membrane protein

Protein

Unknown.

O53385

Probable conserved integral membrane protein

Protein

Unknown.

P96876

Uncharacterized PPE family protein PPE61

Protein

Unknown.

P9WHX9

Uncharacterized PPE family protein PPE66

Protein

Unknown.

P9WHX1

Uncharacterized PPE family protein PPE65

Protein

Unknown.

P9WHX3

PE-PGRS family protein PE_PGRS62

Protein

Unknown.

L7N680

ESAT-6-like protein EsxE

Protein

Unknown.

P9WNH9

Possible histone-like protein Hns

Protein

Unknown.

I6YHB0

Beta sliding clamp (Beta clamp) (Sliding clamp) (Beta-clamp processivity factor) (DNA polymerase III beta sliding clamp subunit) (DNA polymerase III subunit beta) (Mtb beta-clamp)

Protein

Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication (By similarity). Binds ds-and ssDNA (PubMed:22545130). Binds the antibiotic griselimycin and its derivatives with high affinity (1.0 x 10(-10) to 2.0 x 10(-10) M s(-1)) (PubMed:26045430). Binding occurs in a hydrophobic cleft between domains 2 and 3, which have been shown to be responsible for binding DNA polymerases and other DNA-modifying proteins (PubMed:26045430). {ECO:0000250|UniProtKB:P0A988, ECO:0000269|PubMed:22545130, ECO:0000269|PubMed:26045430}..

P9WNU1

Oxygen sensor histidine kinase response regulator DosT (EC 2.7.13.3)

Protein

Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Required for full induction of the DevR (DosR) regulon; required during early adaptation to anaerobiosis, to start induction of the DevR regulon (PubMed:19487478). May act as a direct hypoxia/oxygen sensor (PubMed:17609369, PubMed:17600145, PubMed:28977726). O(2) acts as a switch, with the Fe(2+)-O(2)-bound protein inactive in autophosphorylation (PubMed:17600145). Autophosphorylates under anaerobic but not aerobic conditions, binding of NO or CO has no effect on autophosphorylation (PubMed:17600145). Binds a number of gases; O(2), NO, CO (PubMed:17609369, PubMed:17600145). May be a secondary sensor for CO (PubMed:18400743). Donates a phosphate group to transcriptional regulator DevR (DosR) (PubMed:15135056, PubMed:15033981, PubMed:28977726). {ECO:0000269|PubMed:15033981, ECO:0000269|PubMed:15135056, ECO:0000269|PubMed:17600145, ECO:0000269|PubMed:17609369, ECO:0000269|PubMed:18400743, ECO:0000269|PubMed:18474359, ECO:0000269|PubMed:19487478, ECO:0000269|PubMed:28977726}..

P9WGK1

UPF0678 fatty acid-binding protein-like protein Rv2717c

Protein

May play a role in the intracellular transport of hydrophobic ligands. {ECO:0000305}..

P9WFG7

50S ribosomal protein L28-1

Protein

Unknown.

P9WHB1

Uncharacterized PPE family protein PPE1

Protein

Unknown.

P9WI49

Uncharacterized PPE family protein PPE3

Protein

Unknown.

P9WI45

Probable conserved Mce associated protein

Protein

Unknown.

O07421

50S ribosomal protein L33 2

Protein

Unknown.

P9WH95

Probable conserved integral membrane protein

Protein

Unknown.

O06407

Uncharacterized PPE family protein PPE13

Protein

Unknown.

P9WI35

PE-PGRS family protein PE_PGRS17

Protein

Induces maturation and activation of human dendritic cells (DCs), via TLR2-dependent activation of ERK1/2, p38 MAPK, and NF-kappa-B signaling pathways, and enhances the ability of DCs to stimulate CD4(+) T cells. By activating DCs, could potentially contribute to the initiation of innate immune responses during tuberculosis infection and hence regulate the clinical course of tuberculosis. {ECO:0000269|PubMed:20176745}..

Q79FU2

PE-PGRS family protein PE_PGRS13

Protein

Unknown.

Q79FV7

Uncharacterized PPE family protein PPE20

Protein

Unknown.

P9WI23

Iron-sulfur cluster carrier protein

Protein

Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP. {ECO:0000255|HAMAP-Rule:MF_02040}..

P9WJN7

Probable export or membrane protein

Protein

Unknown.

P71810

PE-PGRS family protein PE_PGRS28

Protein

Unknown.

Q79FP1

PE-PGRS family protein PE_PGRS25

Protein

Unknown.

P71664

PE-PGRS family protein PE_PGRS30

Protein

Mediates suppression of proinflammatory immune response in macrophages via modulation of host cytokine response (PubMed:27129781). Required for full virulence. Involved in inhibition of phago-lysosome fusion (PubMed:22050772). {ECO:0000269|PubMed:22050772, ECO:0000269|PubMed:27129781}..

Q79FL8

Nitrate reductase-like protein NarX

Protein

Does not seem to have nitrate reductase activity. {ECO:0000269|PubMed:14645286}..

P9WJQ1

Uncharacterized PPE family protein PPE37

Protein

Unknown.

Q79FH3

Immunogenic protein MPT64 (Antigen MPT64)

Protein

Unknown.

P9WIN9

Probable conserved integral membrane protein

Protein

Unknown.

O33255

Possible conserved integral membrane protein

Protein

Unknown.

O86339

Uncharacterized PPE family protein PPE40

Protein

Unknown.

P9WHZ7

Fluoroquinolones export permease protein Rv2686c

Protein

Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for the translocation of the substrate across the membrane. {ECO:0000269|PubMed:15273144}..

P9WJB3

PE-PGRS family protein PE_PGRS43

Protein

Unknown.

Q79FD4

Probable lipid-transfer protein Ltp1

Protein

Unknown.

O33332

Probable conserved integral membrane protein

Protein

Unknown.

I6XG31

Conserved alanine valine rich protein

Protein

Unknown.

O05854

PE-PGRS family protein PE_PGRS50

Protein

Unknown.

Q6MWY0

PE-PGRS family protein PE_PGRS51

Protein

Unknown.

L0TCB8

Uncharacterized PPE family protein PPE63

Protein

Unknown.

P9WHX5

ESAT-6-like protein EsxF

Protein

Unknown.

P9WNH7

PE-PGRS family protein PE_PGRS58

Protein

Unknown.

I6XHM5

Uncharacterized protein Rv0250c

Protein

Unknown.

O53672

Uncharacterized protein Rv0083

Protein

Unknown.

P9WIW3

Uncharacterized protein Rv0085

Protein

Unknown.

P9WM75

Uncharacterized protein Rv0049

Protein

Unknown.

P9WM85

Uncharacterized protein Rv0088

Protein

Unknown.

P9WM73

Probable conserved transmembrane protein

Protein

Unknown.

P96820

PPE family protein PPE8

Protein

Unknown.

I6Y7L4

Probable conserved transmembrane protein

Protein

Unknown.

P96401

Possible conserved exported protein

Protein

Unknown.

O07246

PPE family protein PPE7

Protein

Unknown.

L0T545

Probable conserved transmembrane protein

Protein

Unknown.

P96805

Probable conserved membrane protein

Protein

Unknown.

L0T243

Probable conserved membrane protein

Protein

Unknown.

P96409

PE family protein PE6

Protein

Unknown.

L7N648

50S ribosomal protein L15

Protein

Binds to the 23S rRNA. {ECO:0000255|HAMAP-Rule:MF_01341}..

P9WHD7

50S ribosomal protein L30

Protein

Unknown.

P9WHA3

Sensory transduction protein regX3

Protein

Probably forms part of a two-component regulatory system regX3/senX3..

P9WGL9

Uncharacterized protein Rv0497

Protein

Unknown.

P9WKU3

30S ribosomal protein S5

Protein

With S4 and S12 plays an important role in translational accuracy. {ECO:0000255|HAMAP-Rule:MF_01307}.; FUNCTION: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. {ECO:0000255|HAMAP-Rule:MF_01307}..

P9WH33

UPF0336 protein Rv0635

Protein

Unknown.

P9WFK1

UPF0336 protein Rv0504c

Protein

Unknown.

P9WFK3

Uncharacterized protein Rv0560c

Protein

Unknown.

P9WKL5

Uncharacterized protein Rv0634A

Protein

Unknown.

P9WKS5

Uncharacterized protein Rv0493c

Protein

Unknown.

P9WKU7

Uncharacterized protein Rv0476

Protein

Unknown.

P9WKW1

Possible membrane protein

Protein

Unknown.

O06773

Possible conserved transmembrane protein

Protein

Unknown.

I6Y3V3

Possible transmembrane protein

Protein

Unknown.

P96272

Probable transmembrane protein

Protein

Unknown.

I6X961

Mce-family protein Mce2F

Protein

Unknown.

O07784

Possible conserved membrane protein

Protein

Unknown.

O06397

Possible membrane protein

Protein

Unknown.

P96912

Mce-family protein Mce2A

Protein

Unknown.

Q79FY7

Mce-family protein Mce2C

Protein

Unknown.

O07787

Uncharacterized protein Rv0965c

Protein

Unknown.

P9WKM3

Uncharacterized protein Rv0874c

Protein

Unknown.

P9WKR9

Uncharacterized protein Rv0879c

Protein

Unknown.

P9WKR1

Uncharacterized protein Rv0897c

Protein

Unknown.

P9WKP7

Uncharacterized protein Rv0968

Protein

Unknown.

P9WKL9

Uncharacterized protein Rv1148c

Protein

Unknown.

P9WM55

Uncharacterized protein Rv0970

Protein

Unknown.

P9WKL7

Uncharacterized protein Rv0882

Protein

Unknown.

P9WKQ9

Conserved hypothetical membrane protein

Protein

Unknown.

O06539

Possible conserved membrane protein

Protein

Unknown.

P96376

Transcriptional regulatory protein

Protein

Unknown.

O53830

PE family protein PE13

Protein

May play a pivotal role in the interaction between M.tuberculosis and host. Can enhance the survival within macrophages under stress conditions such as H(2)O(2), SDS and low pH. Increases the production of IL-6 and IL-1beta from macrophages, and decreases the secretion of suppressor of cytokine signaling 3 (SOCS-3). These changes probably involve the p38-ERK-NF-kappa-B signaling pathway. Also precipitates the macrophage death. {ECO:0000269|PubMed:27147522}..

Q79FR3

Possible conserved transmembrane protein

Protein

Unknown.

P71833

Probable conserved membrane protein

Protein

Unknown.

O53429

Uncharacterized protein Rv1271c

Protein

Unknown.

P9WM43

Uncharacterized protein Rv1519

Protein

Unknown.

P9WLV7

Uncharacterized protein Rv1525

Protein

Unknown.

P9WLV3

Uncharacterized protein Rv1352

Protein

Unknown.

P9WM15

Uncharacterized protein Rv1367c

Protein

Unknown.

P9WLZ3

Uncharacterized protein Rv1260

Protein

Unknown.

P9WM51

Uncharacterized protein Rv1320c

Protein

Unknown.

P9WQ29

UPF0353 protein Rv1481

Protein

Unknown.

P9WFJ7

Uncharacterized protein Rv1355c

Protein

Unknown.

P9WM11

Uncharacterized protein Rv1424c

Protein

Unknown.

P9WLX7

Uncharacterized protein Rv1289

Protein

Unknown.

P9WM37

Uncharacterized protein Rv1337

Protein

Unknown.

P9WM21

Probable transport protein MmpL6

Protein

Unknown.

P9WJU9

Probable transcriptional regulatory protein

Protein

Unknown.

O50423

Conserved membrane protein

Protein

Unknown.

O06827

Possible membrane protein

Protein

Unknown.

O53167

Probable transcriptional regulatory protein

Protein

Unknown.

P71672

PE family protein PE16

Protein

Unknown.

L7N697

50S ribosomal protein L35

Protein

Unknown.

P9WH91

Possible transcriptional regulatory protein

Protein

Unknown.

L7N691

Probable conserved membrane protein

Protein

Unknown.

P71799

UPF0053 protein Rv1842c

Protein

Unknown.

P9WFP3

Uncharacterized protein Rv1831

Protein

Unknown.

P9WLR3

PPE family protein PPE34

Protein

Facilitates a shift in the ensuing immunity toward the Th2 phenotype and could aid in immune evasion by mycobacteria. Interacts with human Toll-like receptor 2 (TLR2) and triggers functional maturation of human dendritic cells (DCs), leading to secretion of IL-4, IL-5 and IL-10 from CD4(+) T cells and induction of Th2 immune response. Maturation of DCs involves PI3K, ERK1/2, p38 MAPK and NF-kappa-B signaling pathways. {ECO:0000269|PubMed:20837474}..

Q79FI9

Uncharacterized protein Rv1702cMb1728c

Protein

Unknown.

P9WLT3

Uncharacterized protein Rv1590

Protein

Unknown.

P9WLT7

PPE family protein PPE35

Protein

Unknown.

Q79FI8

Transport permease protein

Protein

Unknown.

O33188

Possible integral membrane protein

Protein

Unknown.

O53930

Probable PhiRv1 phage protein

Protein

Unknown.

O06609

Probable transmembrane protein

Protein

Unknown.

P94983

Probable membrane protein

Protein

Unknown.

O06132

PE family protein PE17

Protein

Unknown.

L7N681

Possible transcriptional regulatory protein

Protein

Unknown.

O33179

Probable conserved transmembrane protein

Protein

Unknown.

P95154

Probable membrane protein

Protein

Unknown.

O53962

DNA-binding protein Rv2175c

Protein

Binds DNA at low salt concentrations. {ECO:0000269|PubMed:19457863}..

O53509

Uncharacterized protein Rv2242

Protein

Unknown.

P9WPH5

Uncharacterized protein Rv2077c

Protein

Unknown.

P9WLL1

Uncharacterized protein Rv1990c

Protein

Unknown.

P9WLP7

Uncharacterized protein Rv2269c

Protein

Unknown.

P9WLF9

Uncharacterized protein Rv2087

Protein

Unknown.

P9WLJ7

Uncharacterized protein Rv2310

Protein

Unknown.

P9WLC3

Uncharacterized protein Rv2047c

Protein

Unknown.

P9WIH5

Uncharacterized protein Rv2209

Protein

Unknown.

P9WLI3

Uncharacterized protein Rv2311

Protein

Unknown.

P9WLC1

Uncharacterized protein Rv1987

Protein

Unknown.

P9WLQ1

Uncharacterized protein Rv2001

Protein

Unknown.

P9WLN5

Uncharacterized protein Rv2271

Protein

Unknown.

P9WLF7

Outer membrane protein Rv1973

Protein

Unknown.

P9WJ77

Uncharacterized protein Rv2226

Protein

Unknown.

P9WLH9

Uncharacterized protein Rv2219

Protein

Unknown.

P9WLI1

Uncharacterized protein Rv2067c

Protein

Unknown.

P9WLL9

Uncharacterized protein Rv1995

Protein

Unknown.

P9WLP3

Uncharacterized protein Rv2086

Protein

Unknown.

P64937

Uncharacterized protein Rv2203

Protein

Unknown.

P9WLI7

Probable conserved membrane protein

Protein

Unknown.

Q79FG7

Mce-family protein Mce3F

Protein

Unknown.

O53972

Conserved protein TB16.3

Protein

Unknown.

O53519

Probable conserved transmembrane protein

Protein

Unknown.

O53503

Mce-family protein Mce3C

Protein

Unknown.

O53969

Mce-family protein Mce3D

Protein

Unknown.

O53970

UPF0603 protein Rv2345

Protein

May play a role in septum formation. {ECO:0000269|PubMed:16735741}..

P9WFJ5

50S ribosomal protein L27

Protein

Unknown.

P9WHB3

Uncharacterized protein Rv2715

Protein

Unknown.

P9WNH3

Uncharacterized protein Rv2570

Protein

Unknown.

P9WL91

Uncharacterized protein Rv2716

Protein

Unknown.

P9WL43

Uncharacterized protein Rv2569c

Protein

Unknown.

P9WL93

Uncharacterized protein Rv2571c

Protein

Unknown.

P9WL89

Cadmium-induced protein CadI

Protein

Unknown.

P9WIR5

Uncharacterized protein Rv2635

Protein

Unknown.

P9WL57

Uncharacterized protein Rv2575

Protein

Unknown.

P9WL85

Uncharacterized protein Rv2658c

Protein

Unknown.

P9WL47

Possible transcriptional regulatory protein

Protein

Unknown.

I6Y187

Possible conserved membrane protein

Protein

Unknown.

I6XEI0

Hypothetical arginine rich protein

Protein

Unknown.

I6Y1F9

Possible PhiRv2 prophage protein

Protein

Unknown.

P71947

Probable conserved transmembrane protein

Protein

Unknown.

P71915

Probable PhiRv2 prophage protein

Protein

Unknown.

I6YE30

Uncharacterized protein Rv2910c

Protein

Unknown.

P9WL25

Probable PhiRv2 prophage protein

Protein

Unknown.

P71949

Uncharacterized protein Rv2895c

Protein

Unknown.

P9WL31

Uncharacterized protein Rv2913c

Protein

Unknown.

P9WJH9

UPF0102 protein Rv2898c

Protein

Unknown.

P9WFM9

Probable conserved transmembrane protein

Protein

Unknown.

I6YA75

PE family protein PE29

Protein

Unknown.

Q6MX17

Possible conserved transmembrane protein

Protein

Unknown.

O05781

PE family protein PE27

Protein

Unknown.

Q79FA8

Uncharacterized protein Rv3400

Protein

Unknown.

P9WKZ7

Uncharacterized protein Rv3129

Protein

Unknown.

P9WL05

Uncharacterized protein Rv3292

Protein

Unknown.

P9WL01

Probable integral membrane protein

Protein

Unknown.

O50384

Mce-family protein Mce4A

Protein

Unknown.

I6YC99

PPE family protein PPE56

Protein

Unknown.

Q6MWX8

Possible conserved transmembrane protein

Protein

Unknown.

I6YG51

Mce-family protein Mce4F

Protein

Unknown.

I6YC95

PPE family protein PPE53

Protein

Unknown.

Q6MX04

Uncharacterized protein Rv3785

Protein

Unknown.

P9WKX1

Uncharacterized protein Rv3788

Protein

Unknown.

P9WKW7

Possible siderophore-binding protein

Protein

Unknown.

I6YCB9

Probable conserved transmembrane protein

Protein

Unknown.

I6Y479

Probable conserved transmembrane protein

Protein

Unknown.

O69704

Possible conserved membrane protein

Protein

Unknown.

I6YGT7

PE family protein PE32

Protein

Unknown.

I6YGS7

Phosphoserine phosphatase SerB2 (PSP) (PSPase) (EC 3.1.3.3) (O-phosphoserine phosphohydrolase) (Protein-serine/threonine phosphatase) (EC 3.1.3.16)

Protein

Catalyzes the dephosphorylation of O-phospho-L-serine into L-serine, a step in the L-serine biosynthetic pathway (PubMed:25037224, PubMed:25521849). Exhibits high specificity for L-phosphoserine compared to substrates like L-phosphothreonine (5% relative activity) and L-phosphotyrosine (1.7% relative activity) (PubMed:25521849). {ECO:0000269|PubMed:25037224, ECO:0000269|PubMed:25521849}.; FUNCTION: In the host, induces significant cytoskeleton rearrangements through cofilin dephosphorylation and its subsequent activation, and affects the expression of genes that regulate actin dynamics. It specifically interacts with HSP90, HSP70 and HSP27 that block apoptotic pathways but not with other HSPs. Also interacts with GAPDH. It actively dephosphorylates MAP kinase p38 and NF-kappa B p65 (specifically at Ser-536) that play crucial roles in inflammatory and immune responses. This in turn leads to down-regulation of Interleukin 8, a chemotactic and inflammatory cytokine. Thus might help the pathogen to evade the host's immune response (PubMed:26984196). Exogenous addition of purified SerB2 protein to human THP-1 cells (that can be differentiated into macrophage-like cells) induces microtubule rearrangements; the phosphatase activity is co-related to the elicited rearrangements, while addition of the ACT-domains alone elicits no rearrangements (PubMed:25521849). {ECO:0000269|PubMed:25521849, ECO:0000269|PubMed:26984196}..

O53289

ESX-3 secretion system protein EccD3 (ESX conserved component D3) (Type VII secretion system protein EccD3) (T7SS protein EccD3)

Protein

Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. {ECO:0000269|PubMed:19684129, ECO:0000269|PubMed:24155985}..

P9WNQ3

ESAT-6-like protein EsxH (10 kDa antigen CFP7) (CFP-7) (Low molecular weight protein antigen 7) (Protein TB10.4)

Protein

EsxH, in complex with EsxG, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. {ECO:0000269|PubMed:24204276}..

P9WNK3

ESX-2 secretion system protein EccA2 (ESX conserved component A2) (Type VII secretion system protein EccA2) (T7SS protein EccA2)

Protein

Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). {ECO:0000250}..

P9WPH7

ESX-3 secretion system protein EccE3 (ESX conserved component E3) (Type VII secretion system protein EccE3) (T7SS protein EccE3)

Protein

Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. {ECO:0000269|PubMed:19684129, ECO:0000269|PubMed:24155985}..

P9WJE5

Uncharacterized ABC transporter ATP-binding protein Rv0073

Protein

Probably part of an ABC transporter complex. Probably responsible for energy coupling to the transport system (By similarity). {ECO:0000250}..

P9WQK5

Possible transcriptional regulatory protein (Possibly ArsR-family)

Protein

Unknown.

O08446

Conserved hypothetical integral membrane protein YrbE2A

Protein

Unknown.

I6Y870

Probable transcriptional regulatory protein (Probably TetR-family)

Protein

Unknown.

P96381

Probable conserved transmembrane transport protein MmpL13a

Protein

Unknown.

O06545

Probable cold shock-like protein B CspB

Protein

Unknown.

I6WZM9

Serine/threonine-protein kinase PknH (EC 2.7.11.1)

Protein

May regulate bacterial growth in response to external signals to facilitate adaptation to the host environment. In vitro, phosphorylates several substrates such as EmbR, DevR (DosR), DacB1 and Rv0681. {ECO:0000269|PubMed:14690440, ECO:0000269|PubMed:15043876, ECO:0000269|PubMed:16077122, ECO:0000269|PubMed:16585755, ECO:0000269|PubMed:16817899, ECO:0000269|PubMed:17286964, ECO:0000269|PubMed:20630871}..

P9WI71

Uncharacterized ABC transporter ATP-binding protein Rv1281c

Protein

Unknown.

P9WQJ5

Protein PafC (Proteasome accessory factor C)

Protein

Part of the pafABC operon, but PafC does not seem to be involved in pupylation or substrate degradation. Appears to play at least a small role in resistance to reactive nitrogen intermediates (RNI) in vitro. {ECO:0000269|PubMed:17277063}..

P9WIL9

Probable cation efflux system protein Rv2025c

Protein

Unknown.

P9WGF5

Uncharacterized ABC transporter ATP-binding protein Rv2564

Protein

Unknown.

P9WQI5

Probable arsenic-transport integral membrane protein ArsC

Protein

Unknown.

I6X4W4

Possible conserved secreted alanine rich protein

Protein

Unknown.

I6Y1I5

Acid and phagosome regulated protein A AprA

Protein

Unknown.

V5QPR9

TRK system potassium uptake protein CeoB

Protein

Unknown.

I6XF25

Possible transcriptional regulatory protein (Probably ArsR-family)

Protein

Unknown.

I6Y1A7

Possible transcriptional regulatory protein (Probably ArsR-family)

Protein

Unknown.

P71941

Probable transcriptional regulatory protein (LuxR-family)

Protein

Unknown.

O53213

Possible exported alanine and valine rich protein

Protein

Unknown.

P71965

Doxorubicin resistance ABC transporter permease protein DrrB

Protein

Part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane. {ECO:0000269|PubMed:12057006}..

P9WG23

Probable transcriptional regulatory protein (Probably DeoR-family)

Protein

Unknown.

I6X658

Possible conserved membrane or secreted protein

Protein

Unknown.

O33272

Probable transcriptional regulatory protein (Probably AsnC-family)

Protein

Unknown.

I6XG13

Probable methanol dehydrogenase transcriptional regulatory protein MoxR3

Protein

Unknown.

O53314

SOS response-associated protein (EC 3.4.-.-)

Protein

Unknown.

O05872

Conserved hypothetical threonine and proline rich protein

Protein

Unknown.

O05857

Hypothetical alanine arginine proline rich protein

Protein

Unknown.

O05880

ESX-1 secretion system protein EccCa1 (ESX conserved component Ca1) (Snm1 secretory protein) (Type VII secretion system protein EccCa1) (T7SS protein EccCa1)

Protein

Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). {ECO:0000269|PubMed:14557536, ECO:0000269|PubMed:16368961}..

P9WNB3

ESX-1 secretion-associated protein EspI

Protein

Required to repress ESX-1-mediated secretion under low ATP conditions. This function requires the ATP-binding motif. {ECO:0000269|PubMed:25039394, ECO:0000305|PubMed:14557547}..

P9WJC5

Hypothetical arginine and proline rich protein

Protein

Unknown.

O06272

Possible arsenical pump integral membrane protein ArsB2

Protein

Unknown.

I6YCG9

Possible conserved alanine rich membrane protein

Protein

Unknown.

O69625

Diacylglycerol acyltransferase/mycolyltransferase Ag85A (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex A) (85A) (Ag85A) (Fibronectin-binding protein A) (Fbps A)

Protein

The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM. FbpA mediates triacylglycerol (TAG) formation with long-chain acyl-CoA as the acyl donor and 1,2-dipalmitoyl-sn-glycerol (1,2-dipalmitin) as the acyl acceptor. It has a preference for C26:0-CoA over C18:1-CoA. {ECO:0000269|PubMed:12010501, ECO:0000269|PubMed:21819455, ECO:0000269|PubMed:3141278, ECO:0000269|PubMed:9162010}..

P9WQP3

Enoyl-[acyl-carrier-protein] reductase [NADH] (ENR) (Enoyl-ACP reductase) (EC 1.3.1.9) (FAS-II enoyl-ACP reductase) (NADH-dependent 2-trans-enoyl-ACP reductase)

Protein

Enoyl-ACP reductase of the type II fatty acid syntase (FAS-II) system, which is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls (PubMed:25227413). Catalyzes the NADH-dependent reduction of the double bond of 2-trans-enoyl-[acyl-carrier protein], an essential step in the fatty acid elongation cycle of the FAS-II pathway (PubMed:7599116). Shows preference for long-chain fatty acyl thioester substrates (>C16), and can also use 2-trans-enoyl-CoAs as alternative substrates (PubMed:7599116). The mycobacterial FAS-II system utilizes the products of the FAS-I system as primers to extend fatty acyl chain lengths up to C56, forming the meromycolate chain that serves as the precursor for final mycolic acids (PubMed:25227413). {ECO:0000269|PubMed:7599116, ECO:0000303|PubMed:25227413}.; FUNCTION: Is the primary target of the first-line antitubercular drug isoniazid (INH) and of the second-line drug ethionamide (ETH) (PubMed:8284673, PubMed:12406221, PubMed:16906155, PubMed:17227913). Overexpressed inhA confers INH and ETH resistance to M.tuberculosis (PubMed:12406221). The mechanism of isoniazid action against InhA is covalent attachment of the activated form of the drug to the nicotinamide ring of NAD and binding of the INH-NAD adduct to the active site of InhA (PubMed:9417034, PubMed:16906155). Similarly, the ETH-NAD adduct binds InhA (PubMed:17227913). {ECO:0000269|PubMed:12406221, ECO:0000269|PubMed:16906155, ECO:0000269|PubMed:17227913, ECO:0000269|PubMed:9417034, ECO:0000305|PubMed:8284673}..

P9WGR1

Uncharacterized PE-PGRS family protein PE_PGRS3

Protein

Unknown.

P9WIG3

Possible transcriptional regulatory protein (Possibly TetR-family)

Protein

Unknown.

L7N6A2

Possible transcriptional regulatory protein (Probably TetR-family)

Protein

Unknown.

O53661

Siderophore export accessory protein MmpS4 (PGB14T-X)

Protein

Part of an export system, which is required for biosynthesis and secretion of siderophores. Essential for virulence. {ECO:0000269|PubMed:23431276}..

P9WJS9

Probable ribonucleotide transport ATP-binding protein mkl

Protein

Not known, could be involved in the transport of ribonucleotides..

P9WQL5

Possible cytochrome C-type biogenesis protein CcdA

Protein

Unknown.

L7N671

Serine/threonine-protein kinase PknD (EC 2.7.11.1)

Protein

Key microbial factor required for central nervous system tuberculosis. Required for invasion of host brain endothelia, but not macrophages, lung epithelia or other endothelia. Phosphorylates the anti-anti-sigma factor homolog Rv0516c, which inhibits binding of Rv0516c to Rv2638, another anti-anti-sigma factor. Can also phosphorylate the FHA domain of Rv1747. {ECO:0000269|PubMed:15987910, ECO:0000269|PubMed:17242402, ECO:0000269|PubMed:17411339}..

P9WI79

Phosphate transport system permease protein PstC 2

Protein

Part of the ABC transporter complex PstSACB involved in phosphate import; probably responsible for the translocation of the substrate across the membrane. {ECO:0000305|PubMed:20933472}..

P9WG05

Uncharacterized PE-PGRS family protein PE_PGRS20

Protein

Unknown.

P9WIF9

Uncharacterized ABC transporter ATP-binding protein Rv0986

Protein

Unknown.

P9WQK1

Putative peptide transport permease protein Rv1282c

Protein

Unknown.

P9WFZ9

Uncharacterized ABC transporter ATP-binding protein Rv1273c

Protein

Unknown.

P9WQJ1

Probable conserved ATP-binding protein ABC transporter

Protein

Unknown.

O53154

Probable serine protease HtrA (DEGP protein)

Protein

Unknown.

O06291

Putative lipoprotein LppC (UPF0098 protein Rv1911c)

Protein

Probably involved in bacterial recognition and uptake by its host (human) (PubMed:25041568). {ECO:0000269|PubMed:25041568}..

P9WFN3

Probable conserved integral membrane transport protein

Protein

Unknown.

O53919

Universal stress protein Rv2026c (USP Rv2026c)

Protein

Unknown.

P9WFD1

Universal stress protein Rv2319c (USP Rv2319c)

Protein

Unknown.

P9WLB5

Conserved hypothetical integral membrane protein YrbE3B

Protein

Unknown.

O53966

Uncharacterized PE-PGRS family protein PE_PGRS46

Protein

Unknown.

P9WIE7

Possible PE family-related protein PE24

Protein

Unknown.

Q79FE3

Hypothetical proline and serine rich protein

Protein

Unknown.

O53178

Probable C4-dicarboxylate-transport transmembrane protein DctA

Protein

Unknown.

P71906

Possible conserved proline rich membrane protein

Protein

Unknown.

O06170

Uncharacterized PPE family protein PPE47/PPE48

Protein

Unknown.

P9WHY7

Probable conserved transmembrane alanine rich protein

Protein

Unknown.

I6YAE2

Universal stress protein Rv3134c (USP Rv3134c)

Protein

Unknown.

P9WFD3

Insertion element IS6110 uncharacterized 12.0 kDa protein

Protein

Unknown.

P9WKH5

Probable conserved ATP-binding protein ABC transporter

Protein

Unknown.

O53343

Probable transcriptional regulatory protein (Probably MerR-family)

Protein

Unknown.

O53384

ESX-1 secretion-associated protein EspE

Protein

Unknown.

P9WJD3

Conserved hypothetical alanine and leucine rich protein

Protein

Unknown.

O06279

Transcriptional regulatory protein (Probably LacI-family)

Protein

Unknown.

P96857

PE-PGRS family protein PE_PGRS56 (Fragment)

Protein

Unknown.

Q6MWW7

Peptidoglycan-binding protein ArfA (Outer membrane porin A) (Outer membrane protein A) (OmpATb) (Outer membrane protein ArfA)

Protein

Probably plays a role in ammonia secretion that neutralizes the medium at pH 5.5, although it does not play a direct role in ammonia transport. The OmpA-like domain (196-326) binds M.tuberculosis peptidoglycan. Overexpression in M.bovis or M.smegmatis gives channels with average conductance value of 1,600 +/- 100 pS, but this may not be physiologically relevant. {ECO:0000269|PubMed:12366842, ECO:0000269|PubMed:17573469, ECO:0000269|PubMed:21410778}..

P9WIU5

Probable transcriptional regulatory protein (Possibly TetR-family)

Protein

Unknown.

O53641

Probable conserved Mce associated transmembrane protein

Protein

Unknown.

O07420

Possible transcriptional regulatory protein (Probably MarR-family)

Protein

Unknown.

P71699

Probable conserved Mce associated membrane protein

Protein

Unknown.

O07422

Probable transcriptional regulatory protein (Possibly TetR-family)

Protein

Unknown.

P96821

Uncharacterized PE-PGRS family protein PE_PGRS10

Protein

Unknown.

P9WIG1

Conserved hypothetical integral membrane protein YrbE2B

Protein

Unknown.

O07790

Probable monoacyl phosphatidylinositol tetramannoside-binding protein LpqW

Protein

May directly or indirectly regulate the accessibility of the key branch point intermediate, monoacyl phosphatidylinositol tetramannoside (AcPIM4), to the elongating alpha-1,6 mannosyltransferases which could regulate the lipoarabinomannans (LAMs) biosynthesis. {ECO:0000250}..

P9WGU7

Uncharacterized formamidopyrimidine-DNA glycosylase-like protein

Protein

Unknown.

L0T864

Conserved hypothetical ala-, pro-rich protein

Protein

Unknown.

O06556

Multidrug efflux system permease protein Rv1217c

Protein

Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs (PubMed:23143285). Probably responsible for the translocation of the substrate across the membrane (Probable). {ECO:0000269|PubMed:23143285, ECO:0000305}..

O05318

Probable conserved integral membrane transport protein

Protein

Unknown.

O05301

Probable conserved polyketide synthase associated protein PapA4

Protein

Unknown.

O53902

Serine/threonine-protein kinase PknE (EC 2.7.11.1)

Protein

Important for survival of the bacterium in the host during infection. Promotes the survival of infected macrophages by activating multiple signaling responses and suppressing apoptosis of macrophages during nitrate stress. May contribute to the adaptation of M.tuberculosis during stress conditions by maintaining the cellular integrity. Can phosphorylate the FHA domain of Rv1747. {ECO:0000269|PubMed:15987910, ECO:0000269|PubMed:17892498, ECO:0000269|PubMed:21945589, ECO:0000269|PubMed:23108860}..

P9WI77

NADH dehydrogenase-like protein Rv1812c (EC 1.6.-.-)

Protein

Unknown.

P9WJJ1

Probable conserved ATP-binding protein ABC transporter

Protein

Unknown.

O33189

Probable ionic transporter integral membrane protein ChaA

Protein

Unknown.

O53910

Universal stress protein Rv2005c (USP Rv2005c)

Protein

Unknown.

P9WLN1

Universal stress protein Rv1996 (USP Rv1996)

Protein

Unknown.

P9WLP1

Universal stress protein Rv2028c (USP Rv2028c)

Protein

Unknown.

P9WFD9

Serine/threonine-protein kinase PknJ (EC 2.7.11.1)

Protein

In vitro, phosphorylates various substrates such as EmbR, PepE, MmaA4, Pyk, LldD and GroEL2. {ECO:0000269|PubMed:20185505, ECO:0000269|PubMed:20520732}..

P9WI67

Uncharacterized PE-PGRS family protein PE_PGRS35

Protein

Unknown.

P9WIF1

Probable conserved Mce associated membrane protein

Protein

Unknown.

O53973

Conserved alanine and leucine rich protein

Protein

Unknown.

I6YA29

Sulfate transport system permease protein CysT

Protein

Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. {ECO:0000256|RuleBase:RU366001}..

P71745

Possible alanine and proline rich membrane protein

Protein

Unknown.

O53200

Cell division ATP-binding protein FtsE

Protein

Part of the ABC transporter FtsEX involved in cellular division. Has ATPase activity. {ECO:0000250|UniProtKB:A5U7B7, ECO:0000250|UniProtKB:P0A9R7}..

O05779

Possible transcriptional regulatory protein (Probably TetR-family)

Protein

Unknown.

P95103

Probable transcriptional regulatory protein (Probably GntR-family)

Protein

Unknown.

P95098

Possible transcriptional regulatory protein (Probably TetR-family)

Protein

Unknown.

O53310

Conserved hypothetical alanine and proline-rich protein

Protein

Unknown.

O53338

Probable conserved integral membrane transport protein

Protein

Unknown.

L7N665

PE-PGRS family protein PE_PGRS49 (Fragment)

Protein

Unknown.

L0TFC2

ESX-1 secretion system protein EccCb1 (ESX conserved component Cb1) (Snm2 secretory protein) (Type VII secretion system protein EccCb1) (T7SS protein EccCb1)

Protein

Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10) (PubMed:14557547, PubMed:14557536, PubMed:16368961, PubMed:16973880). EccCb1 may link the cytosolic components of the system with the membrane components (PubMed:16973880). {ECO:0000269|PubMed:14557536, ECO:0000269|PubMed:16368961, ECO:0000269|PubMed:16973880, ECO:0000305|PubMed:14557547}..

P9WNB1

ESX-1 secretion-associated protein EspJ (TB27.4)

Protein

Could be involved in regulation of growth and intracellular survival. {ECO:0000269|PubMed:26228622}..

P9WJC3

ESX-1 secretion-associated protein EspH

Protein

Unknown.

O69732

Transcriptional regulatory protein (Probably TetR-family)

Protein

Unknown.

P96248

UPF0678 fatty acid-binding protein-like protein Rv0813c

Protein

May play a role in the intracellular transport of hydrophobic ligands. {ECO:0000305}..

P9WFG9

UvrABC system protein C (Protein UvrC) (Excinuclease ABC subunit C)

Protein

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-Rule:MF_00203}..

P9WFC5

Immunogenic protein MPT63 (16 kDa immunoprotective extracellular protein) (Antigen MPT63)

Protein

Unknown.

P9WIP1

tRNA threonylcarbamoyladenosine biosynthesis protein TsaE (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE)

Protein

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity). {ECO:0000250}..

P9WFS7

Possible membrane-anchored thioredoxin-like protein (Thiol-disulfide interchange related protein)

Protein

Unknown.

I6YGW6

Chromosomal replication initiator protein DnaA

Protein

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). Binds its own promoter. {ECO:0000250}..

P9WNW3

Penicillin-binding protein A (PBPA)

Protein

Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation..

P9WKD1

Probable conserved integral membrane protein

Protein

Unknown.

O53632

Conserved integral membrane protein YrbE1A

Protein

Unknown.

O07412

50S ribosomal protein L7/L12

Protein

Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation. {ECO:0000255|HAMAP-Rule:MF_00368}..

P9WHE3

Uncharacterized PPE family protein PPE11

Protein

Unknown.

P9WI39

PE-PGRS family protein PE_PGRS8

Protein

Unknown.

I6Y8K5

Probable transport accessory protein MmpS1

Protein

Unknown.

P9WJT5

Putative DNA-binding protein Rv0500A

Protein

Unknown.

P9WKT7

Conserved 13E12 repeat family protein

Protein

Unknown.

P95205

PE-PGRS family protein PE_PGRS7

Protein

Unknown.

Q6MX28

PE family protein PE10 (Fragment)

Protein

Together with PE9, induces macrophage apoptosis through human Toll-like receptor 4 (TLR4) signaling pathway. Interaction with TLR4 leads to increased levels of phospho-IRF-3, increase in the transcript levels of IFN-beta and pro-apoptotic genes, up-regulation of IL-10, down-regulation of IL-1b and enhanced levels of macrophage apoptosis. {ECO:0000269|PubMed:26031846}..

L0T5T4

Probable molybdopterin biosynthesis Mog protein

Protein

Unknown.

I6Y8Y8

PE-PGRS family protein PE_PGRS21

Protein

Unknown.

Q79FT0

PE-PGRS family protein PE_PGRS15

Protein

Unknown.

Q79FV3

Uncharacterized PPE family protein PPE21

Protein

Unknown.

P9WI21

Uncharacterized protein Rv1276c (EC 3.1.3.-)

Protein

Unknown.

P9WGF9

PE-PGRS family protein PE_PGRS26

Protein

Unknown.

Q79FP3

Probable conserved integral membrane protein

Protein

Unknown.

O05317

PE-PGRS family protein PE_PGRS23

Protein

Unknown.

Q79FQ7

Uncharacterized PPE family protein PPE29

Protein

Could be required for host endothelial-cell invasion and/or intracellular survival. {ECO:0000269|PubMed:16586367}..

P9WI09

Uncharacterized PPE family protein PPE22

Protein

Unknown.

P9WI19

Uncharacterized PPE family protein PPE24

Protein

Unknown.

P9WI15

Uncharacterized PPE family protein PPE33

Protein

Unknown.

P9WI03

ESAT-6-like protein EsxN

Protein

Unknown.

P9WNJ3

Probable conserved integral membrane protein

Protein

Unknown.

P95152

PPE family protein PPE31 (Fragment)

Protein

Unknown.

L0T7Y7

Segregation and condensation protein A

Protein

Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. {ECO:0000256|SAAS:SAAS00952070}..

O33208

Probable coiled-coil structural protein

Protein

Unknown.

O33184

Probable nonspecific lipid-transfer protein

Protein

Unknown.

O06144

50S ribosomal protein L28-2

Protein

Unknown.

P9WHA9

50S ribosomal protein L33 1

Protein

Unknown.

P9WH97

ESAT-6-like protein EsxP

Protein

Unknown.

P9WNI5

Uncharacterized protein Rv2581c (EC 3.-.-.-)

Protein

Unknown.

P9WMW3

PE-PGRS family protein PE_PGRS40

Protein

Unknown.

Q79FE9

ESAT-6-like protein EsxQ

Protein

Unknown.

P9WNJ1

Transcription termination/antitermination protein NusA

Protein

Participates in both transcription termination and antitermination. {ECO:0000255|HAMAP-Rule:MF_00945}..

P9WIV3

ESAT-6-like protein EsxS

Protein

Unknown.

Q6MX18

Uncharacterized PPE family protein PPE44

Protein

Unknown.

P9WHZ3

Probable conserved integral membrane protein

Protein

Unknown.

I6X5W1

Conserved hypothetical cysteine rich protein

Protein

Unknown.

Q79FB4

Conserved hypothetical alanine rich protein

Protein

Unknown.

I6Y259

PE-PGRS family protein PE_PGRS48

Protein

Unknown.

Q6MX26

Uncharacterized response regulatory protein Rv3143

Protein

Unknown.

P9WGL7

ESAT-6-like protein EsxT

Protein

Induces apoptosis of host cells via activation of NF-kappa-B. {ECO:0000269|PubMed:25242740}..

I6YC53

ESAT-6-like protein EsxU

Protein

Unknown.

I6Y3I6

Uncharacterized PPE family protein PPE49

Protein

Unknown.

P9WHY5

Uncharacterized PPE family protein PPE54

Protein

Probably plays a role in host phagosome maturation arrest (PubMed:20844580). {ECO:0000305|PubMed:20844580}..

Q6MWY2

Uncharacterized PPE family protein PPE51

Protein

Unknown.

P9WHY3

Pentapeptide repeat protein MfpA (MfpAMt)

Protein

Might be involved in fluoroquinolone resistance (PubMed:15933203). Inhibits ATP-independent DNA relaxation, ATP-dependent DNA supercoiling and ATP-dependent decatenation by endogenous gyrase, 50% inhibition occurs at 2 uM; inhibition is abolished if GyrA is mutated (Asp-87 to Gly or His) (PubMed:19060136). Also inhibits fluoroquinolone-promoted dsDNA cleavage (PubMed:19060136). Increases fluoroquinolone (ciprofloxacin or moxifloxacin) inhibition of gyrase supercoiling activity in a concentration-dependent manner (PubMed:19060136). Inhibits DNA relaxation and supercoiling by E.coli gyrase (PubMed:15933203). Forms a structure that exhibits size, shape and electrostatic similarity to B-form DNA; it may bind to DNA gyrase which is postulated to protect it from fluoroquinolones (PubMed:15933203). {ECO:0000269|PubMed:15933203, ECO:0000269|PubMed:19060136}..

I6YBX3

Conserved hypothetical Mce associated protein

Protein

Unknown.

I6YGA5

ESAT-6-like protein EsxD

Protein

Unknown.

O05453

ESAT-6-like protein EsxC

Protein

Unknown.

P9WNI1

PE-PGRS family protein PE_PGRS60

Protein

Binds fibronectin. May contribute to pathogenicity. {ECO:0000269|PubMed:26158346}..

Q6MWV1

Uncharacterized PPE family protein PPE69

Protein

Unknown.

P9WHW7

Possible electron transfer protein FdxB

Protein

Unknown.

P71846

Conserved hypothetical proline rich protein

Protein

Unknown.

I6X849

PE-PGRS family protein PE_PGRS59

Protein

Unknown.

Q6MWV6

Probable peptidoglycan biosynthesis protein MviN

Protein

Essential for cell growth and peptidoglycan synthesis. {ECO:0000269|PubMed:22275220}..

P9WJK3

Probable enoyl-CoA hydratase 1 (EC 4.2.1.17) (N-related protein) (Nodulation protein)

Protein

May be involved in the hydration of fatty acids for production of polyhydroxylalkanoates. {ECO:0000269|PubMed:16963641}..

P9WNP3

Phosphate-specific transport system accessory protein PhoU homolog 2 (Pst system accessory protein PhoU homolog 2)

Protein

Plays a role in the regulation of phosphate uptake. In this role, it may bind, possibly as a chaperone, to PhoR, PhoP or a PhoR-PhoP complex to promote dephosphorylation of phospho-PhoP, or inhibit formation of the PhoR-PhoP transitory complex (By similarity). Important for tolerance to antibiotics. {ECO:0000250, ECO:0000269|PubMed:20360062}..

P9WI95

Possible GTP-binding translation elongation factor TypA (Tyrosine phosphorylated protein A) (GTP-binding protein)

Protein

Unknown.

O06563

CRISPR system Cms protein Csm5 (CRISPR type III A-associated protein Csm5)

Protein

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions (PubMed:29979631). {ECO:0000269|PubMed:29979631, ECO:0000305|PubMed:29979631}.; FUNCTION: This subunit might be involved in maturation of a crRNA intermediate to its mature form. {ECO:0000250|UniProtKB:A0A0A7HF79}..

P9WJF5

Phosphate-specific transport system accessory protein PhoU homolog 1 (Pst system accessory protein PhoU homolog 1)

Protein

Plays a role in the regulation of phosphate uptake. In this role, it may bind, possibly as a chaperone, to PhoR, PhoP or a PhoR-PhoP complex to promote dephosphorylation of phospho-PhoP, or inhibit formation of the PhoR-PhoP transitory complex (By similarity). {ECO:0000250}..

P9WI97

Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (Biotin--protein ligase)

Protein

Unknown.

I6YFP0

ESX-3 secretion system protein EccC3 (ESX conserved component C3) (Type VII secretion system protein EccC3) (T7SS protein EccC3)

Protein

Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. {ECO:0000269|PubMed:19684129, ECO:0000269|PubMed:24155985}..

P9WNA9

ESX-4 secretion system protein eccD4 (ESX conserved component D4) (Type VII secretion system protein eccD4) (T7SS protein eccD4)

Protein

Unknown.

P9WNQ1

Chaperone protein HtpG (Heat shock protein HtpG) (High temperature protein G)

Protein

Molecular chaperone. Has ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00505}..

P9WMJ7

Single-stranded DNA-binding protein (SSB)

Protein

Unknown.

P9WGD5

Possible transcriptional regulatory protein (Possibly TetR-family)

Protein

Unknown.

O53612

TVP38/TMEM64 family membrane protein Rv0625c

Protein

Unknown.

P9WFS5

PE-PGRS family protein PE_PGRS6 (PE_PGRS6)

Protein

Unknown.

L0T3X8

Possible cytochrome C-type biogenesis protein CcsA

Protein

Unknown.

O06393

Phosphate transport system permease protein PstC 1

Protein

Part of the ABC transporter complex PstSACB involved in phosphate import; probably responsible for the translocation of the substrate across the membrane. {ECO:0000305|PubMed:20933472}..

P9WG07

Probable conserved transmembrane transport protein MmpL13b

Protein

Unknown.

O06546

Putative peptide transport permease protein Rv1283c

Protein

Unknown.

P9WFZ7

Trehalose transport system permease protein SugA

Protein

Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Probably responsible for the translocation of the substrate across the membrane. {ECO:0000269|PubMed:21118978}..

P9WG03

Uncharacterized PE-PGRS family protein PE_PGRS24

Protein

Unknown.

P9WIF7

Universal stress protein Rv1636 (USP Rv1636)

Protein

Unknown.

P9WFC9

GTPase Der (GTP-binding protein EngA)

Protein

GTPase that plays an essential role in the late steps of ribosome biogenesis. {ECO:0000255|HAMAP-Rule:MF_00195}..

P9WNL3

Vitamin B12 transport ATP-binding protein BacA

Protein

ABC transporter involved in uptake of vitamin B12 and related corrinoids. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Contributes to maintenance of chronic infections. {ECO:0000269|PubMed:18996991, ECO:0000269|PubMed:23407640}..

P9WQI9

Glycogen operon protein GlgX homolog (EC 3.2.1.-)

Protein

Unknown.

P9WQ25

Uncharacterized ABC transporter ATP-binding protein Rv2326c

Protein

Unknown.

P9WQI7

Probable transcriptional regulatory protein (Probably AsnC-family)

Protein

Unknown.

P71888

Probable conserved proline rich membrane protein

Protein

Unknown.

O06213

Transcription antitermination protein NusB (Antitermination factor NusB)

Protein

Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. {ECO:0000255|HAMAP-Rule:MF_00073}..

P9WIV1

Uncharacterized PE-PGRS family protein PE_PGRS44

Protein

Unknown.

P9WIE9

Probable transcriptional regulatory protein (Probably TetR-family)

Protein

Unknown.

O06169

Serine/threonine-protein kinase PknI (EC 2.7.11.1)

Protein

Plays an important role in slowing down the growth of mycobacteria within the infected host. {ECO:0000269|PubMed:19341393}..

P9WI69

Hypothetical arginine and alanine rich protein

Protein

Unknown.

P71649

Possible DNA-damage-inducible protein F DinF

Protein

Unknown.

P71616

Possible conserved transmembrane alanine rich protein

Protein

Unknown.

I6YA50

Possible transcriptional regulatory protein (Probably TetR-family)

Protein

Unknown.

O05892

Probable transcriptional regulatory protein (Probably TetR-family)

Protein

Unknown.

P96900

Probable transcriptional regulatory protein (Probably TetR-family)

Protein

Unknown.

O05858

ESX-1 secretion-associated protein EspA

Protein

Required for secretion of EsxA (ESAT-6) and EsxB (CFP-10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm (PubMed:17604718). {ECO:0000269|PubMed:16030141, ECO:0000269|PubMed:17604718, ECO:0000269|PubMed:24078612}..

P9WJE1

ESX-1 secretion-associated protein EspD

Protein

Required for ESX-1 function (PubMed:16135231, PubMed:22155774). Required for the maintenance of adequate cellular levels of both EspA and EspC (PubMed:22155774). Facilitates EsxA secretion (PubMed:22155774). {ECO:0000269|PubMed:16135231, ECO:0000269|PubMed:22155774}..

P9WJD5

ESX-1 secretion-associated protein EspL

Protein

Probably plays a role in host phagosome maturation arrest (PubMed:20844580). {ECO:0000305|PubMed:20844580}..

P9WJB9

Uncharacterized PE-PGRS family protein PE_PGRS54

Protein

Unknown.

O53553

Probable methanol dehydrogenase transcriptional regulatory protein MoxR2

Protein

Unknown.

I6YGX9

Putative mutator protein MutT4 (EC 3.6.1.-)

Protein

May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool (By similarity). In vitro has dATPase rather than 8-oxo-dGTPase activity. {ECO:0000250}..

P9WIX7

Transcriptional regulatory protein (Probably AraC/XylS-family)

Protein

Unknown.

O69703

Heat shock protein Hsp (Heat-stress-induced ribosome-binding protein A)

Protein

Unknown.

O53673

Bifunctional protein PyrR [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase (UPRTase) (EC 2.4.2.9)]

Protein

Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. {ECO:0000255|HAMAP-Rule:MF_01219}.; FUNCTION: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. {ECO:0000255|HAMAP-Rule:MF_01219}..

P9WHK3

Acyl-[acyl-carrier-protein] dehydrogenase MbtN (Acyl-ACP dehydrogenase MbtN) (EC 1.3.99.-) (Mycobactin synthase protein N)

Protein

Catalyzes the dehydrogenation at the alpha-beta position of ACP-bound acyl chains. This results in the introduction of a double bond in the lipidic chain, which is further transferred to the epsilon-amino group of lysine residue in the mycobactin core by MbtK. {ECO:0000269|PubMed:16461464}..

P9WQF9

3-oxoacyl-[acyl-carrier-protein] reductase FabG1 (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) (Beta-ketoacyl-acyl carrier protein reductase)

Protein

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. MabA preferentially metabolizes long-chain substrates (C8-C20) and has a poor affinity for the C4 substrate. {ECO:0000269|PubMed:11932442, ECO:0000269|PubMed:19685079, ECO:0000269|PubMed:9802011}..

P9WGT3

Probable transcriptional regulatory protein (Probably LuxR/UhpA-family)

Protein

Unknown.

O53720

Sulfur carrier protein CysO (9.5 kDa culture filtrate antigen cfp10A)

Protein

In its thiocarboxylated form (CysO-COSH), is the sulfur donor in the CysM-dependent cysteine biosynthetic pathway. May be of particular importance for cysteine biosynthesis in the persistent phase of M.tuberculosis. {ECO:0000269|PubMed:16104727, ECO:0000269|PubMed:18799456, ECO:0000269|PubMed:18842002}..

P9WP33

Peptide transporter CstA (Carbon starvation protein A homolog)

Protein

Involved in peptide utilization. {ECO:0000250|UniProtKB:P15078}..

P9WP47

Probable doxorubicin resistance ABC transporter permease protein DrrC

Protein

Probably part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane..

P9WG21

Low molecular weight protein antigen 6 (CFP-6)

Protein

Unknown.

P9WIR1

Putative ATP-binding protein Rv3427c in insertion sequence

Protein

Unknown.

Q50701

Probable dipeptide-transport integral membrane protein ABC transporter DppC

Protein

Unknown.

L0TEV4

Conserved integral membrane protein YrbE4A. Possible ABC transporter

Protein

Unknown.

O53546

Probable transcriptional regulatory protein (Probably TetR/AcrR-family)

Protein

Unknown.

O07229

PPE family protein PPE15 (Mycobacterial perilipin-1) (MPER1)

Protein

May play a critical role in the homeostasis of triacylglycerol-containing lipid droplets in M.tuberculosis and influence the entry of the pathogen into a dormant state. {ECO:0000269|PubMed:27325376}..

P9WI31

Non-homologous end joining protein Ku (Mt-Ku)

Protein

With LigD forms a non-homologous end joining (NHEJ) repair enzyme. Binds linear dsDNA with 5'- and 3'-overhangs but not closed circular dsDNA nor ssDNA. One dimer binds for every 30 bp. Recruits and stimulates the ligase activity of LigD but not of T4 ligase or a human ligase complex (LIG4/XRCC4). Attenuates the 3'- to 5'-exonuclease activity of LigD. Stimulates the template-directed addition of dNTPs by LigD on 5'-overhangs and nuclease activity on 3'-overhangs. {ECO:0000269|PubMed:12215643, ECO:0000269|PubMed:15499016, ECO:0000269|PubMed:15778718, ECO:0000269|PubMed:16023671}..

P9WKD9

Multidrug efflux system ATP-binding protein Rv1218c (EC 7.6.2.-)

Protein

Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs (PubMed:20921309, PubMed:23143285). Could be involved in the efflux of substrates belonging to the diverse chemical classes of novobiocins, biarylpiperazines, pyridines, bisanilinopyrimidines, pyrroles and, to a smaller extent, pyrazolones (PubMed:20921309). Probably responsible for energy coupling to the transport system (Probable). {ECO:0000269|PubMed:20921309, ECO:0000269|PubMed:23143285, ECO:0000305}..

O86311

Probable sialic acid-transport integral membrane protein NanT

Protein

Unknown.

O07730

Malonyl CoA-acyl carrier protein transacylase (MCT) (EC 2.3.1.39)

Protein

Unknown.

P9WNG5

Multidrug resistance protein Stp (Spectinomycin tetracycline efflux pump)

Protein

Contributes to spectinomycin and tetracycline resistance. {ECO:0000269|PubMed:17242035}..

P9WG91

Putative bifunctional exonuclease/endonuclease protein Rv2191 (EC 3.1.-.-)

Protein

Unknown.

P9WLJ1

Probable sugar-transport integral membrane protein ABC transporter

Protein

Unknown.

O53483

Putative peroxiredoxin Rv2521 (EC 1.11.1.15) (Bacterioferritin comigratory protein) (Thioredoxin peroxidase)

Protein

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000250|UniProtKB:P0AE52}..

P9WIE1

GTPase Obg (EC 3.6.5.-) (GTP-binding protein Obg)

Protein

An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control (By similarity). GTPase activity is not inhibited by ATP or GDP. Overexpression decreases cell growth starting in late log phase and continuing into stationary phase (PubMed:21352546). {ECO:0000255|HAMAP-Rule:MF_01454, ECO:0000269|PubMed:21352546}..

P9WMT1

Phenyloxazoline synthase MbtB (EC 6.3.2.-) (Mycobactin synthetase protein B)

Protein

Involved in the initial steps of the mycobactin biosynthetic pathway. Putatively couples activated salicylic acid with serine or threonine and cyclizes this precursor to the hydroxyphenyloxazoline ring system present in this class of siderophores. Essential for growth in macrophages. {ECO:0000269|PubMed:10655517}..

P9WQ63

Probable conserved integral membrane leucine and alanine rich protein

Protein

Unknown.

O06171

Probable sulfate-transport integral membrane protein ABC transporter CysW

Protein

Unknown.

P71746

Doxorubicin resistance ATP-binding protein DrrA (EC 3.6.3.-)

Protein

Part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Responsible for energy coupling to the transport system. Binds ATP. {ECO:0000269|PubMed:12057006}..

P9WQL9

HTH-type transcriptional regulator VirS (Virulence-regulating protein VirS)

Protein

Regulates the expression of the mymA operon (Rv3083-Rv3089). {ECO:0000269|PubMed:14568148}..

P9WMJ3

Conserved integral membrane protein YrbE4B. Possible ABC transporter

Protein

Unknown.

I6Y3P5

Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family)

Protein

Unknown.

I6YBQ3

SL1278 acyltransferase Chp1 (EC 2.3.1.284) (Cutinase-like hydrolase protein)

Protein

Involved in the final steps of the cell wall sulfolipid-1 (SL-1) biosynthesis. Catalyzes two successive acylations of the precursor 2-palmitoyl-3-(C43)-phthioceranyl-alpha, alpha'-D-trehalose-2'-sulfate (SL1278) to yield the tetraacylated sulfolipid SL-1. {ECO:0000269|PubMed:22194604}..

O07801

ESX-1 secretion-associated protein EspB (Antigen MTB48)

Protein

Required for host-cell death and may support an EsxA-independent virulence function (PubMed:23869560). Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine (PubMed:23869560). Inhibits IFN-gamma-induced autophagy in murine macrophages (PubMed:25641595). {ECO:0000269|PubMed:23869560, ECO:0000269|PubMed:25641595}..

P9WJD9

ESX-3 secretion system protein EccA3 (ESX conserved component A3) (Type VII secretion system protein EccA3) (T7SS protein EccA3)

Protein

Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis (PubMed:19684129, PubMed:24155985). EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity). {ECO:0000250|UniProtKB:P9WPH9, ECO:0000269|PubMed:19684129, ECO:0000269|PubMed:24155985}..

P9WPI3

ESX-4 secretion system protein EccC4 (ESX conserved component C4) (Type VII secretion system protein EccC4) (T7SS protein EccC4)

Protein

Unknown.

P9WNA7

ESX-2 secretion system protein EccE2 (ESX conserved component E2) (Type VII secretion system protein EccE2) (T7SS protein EccE2)

Protein

Unknown.

P9WJE7

ESX-2 secretion system protein eccD2 (ESX conserved component D2) (Type VII secretion system protein eccD2) (T7SS protein eccD2)

Protein

Unknown.

P9WNQ5

Multidrug efflux ATP-binding/permease protein Rv0194 (EC 3.6.3.-)

Protein

Overexpression in M. smegmatis increases resistance to erythromycin, ampicillin, novobiocin and vancomycin. It also reduces accumulation of ethidium bromide in the cell. {ECO:0000269|PubMed:18458127}..

O53645

Probable transcriptional regulatory protein (Probably TetR/AcrR-family)

Protein

Unknown.

P96415

Probable adhesion component transport transmembrane protein ABC transporter

Protein

Unknown.

O53900

Probable macrolide-transport ATP-binding protein ABC transporter

Protein

Unknown.

O53164

Putative peroxiredoxin Rv1608c (EC 1.11.1.15) (Bacterioferritin comigratory protein) (Thioredoxin peroxidase)

Protein

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000250|UniProtKB:P0AE52}..

P9WID9

Uncharacterized protein SocB (Small ORF induced by copper B)

Protein

Unknown.

E2FZM5

Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II)

Protein

Unknown.

L7N669

Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein)

Protein

The glycine cleavage system catalyzes the degradation of glycine. {ECO:0000255|HAMAP-Rule:MF_00259}..

P9WN51

Probable sugar-transport integral membrane protein ABC transporter UspB

Protein

Unknown.

L7N652

Possible conserved transmembrane alanine and glycine rich protein

Protein

Unknown.

I6XF52

Probable conserved transmembrane alanine and leucine rich protein

Protein

Unknown.

I6YE67

Possible transcriptional regulatory protein (Probably Lrp/AsnC-family)

Protein

Unknown.

O33321

Probable conserved integral membrane alanine valine and leucine rich protein

Protein

Unknown.

O33234

Putative thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese-like protein)

Protein

May be a sulfotransferase involved in the formation of thiosulfate. {ECO:0000250}..

P9WHF9

Transcriptional regulatory protein MoaR1 (Molybdopterin biosynthesis positive regulator)

Protein

Acts as a positive transcriptional regulator of the molybdopterin biosynthesis moa1 locus, promoting the expression of the moaA1B1C1D1 genes. Binds directly to the moaA1 promoter. {ECO:0000269|PubMed:20378651}..

O05797

Possible cationic amino acid transport integral membrane protein

Protein

Unknown.

O05896

Conserved hypothetical Mce associated alanine and valine rich protein

Protein

Unknown.

I6X7G4

Sulfolipid-1 exporter Sap (Sulfolipid-1-addressing protein)

Protein

Required for the transport across the inner membrane of sulfolipid-1 (SL-1), which is a major cell wall lipid of pathogenic mycobacteria. Could also transport SL1278 (2-palmitoyl-3-(C43)-phthioceranyl-alpha, alpha'-D-trehalose-2'-sulfate), which is the precursor of SL-1. May potentiate SL-1 levels and confer specificity for sulfolipids over structurally similar glycolipids. {ECO:0000269|PubMed:22194604}..

O07802

Probable dipeptide-transport ATP-binding protein ABC transporter DppD

Protein

Unknown.

I6Y482

Probable dipeptide-transport integral membrane protein ABC transporter DppB

Protein

Unknown.

I6YGV9

Probable acyl carrier protein AcpA (ACP)

Protein

Unknown.

I6WX95

Oxidative stress response regulatory protein OxyS

Protein

Unknown.

L7N677

Probable conserved Mce associated membrane protein

Protein

Unknown.

O07419

Conserved hypothetical proline and threonine rich protein

Protein

Unknown.

O07239

Serine/threonine-protein kinase PknG (EC 2.7.11.1)

Protein

Phosphorylates GarA. May play a role in metabolic regulation via control of the phosphorylation status of GarA. Plays a crucial role in the survival of mycobacteria within host macrophages, by blocking the intracellular degradation of mycobacteria in lysosomes. Required for intrinsic antibiotic resistance. {ECO:0000269|PubMed:17616581, ECO:0000269|PubMed:19019160, ECO:0000269|PubMed:19528288, ECO:0000269|PubMed:19638631}..

P9WI73

30S ribosomal protein S14 type Z

Protein

Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. {ECO:0000255|HAMAP-Rule:MF_01364}..

P9WH57

Probable polyglutamine synthesis accessory protein Rv0574c

Protein

Could be involved in the biosynthesis, transport or localization of poly-alpha-L-glutamine (PLG), a cell wall component. Contributes to stress tolerance and virulence. {ECO:0000269|PubMed:25312955}..

P9WM79

Probable transcriptional regulatory protein (Possibly TetR-family)

Protein

Unknown.

O53789

Probable transcriptional regulatory protein (Possibly ArsR-family)

Protein

Unknown.

O53773

Possible transcriptional regulatory protein (Probably TetR-family)

Protein

Unknown.

P96941

ESAT-6-like protein EsxI (Antigen Mtb9.9B)

Protein

Unknown.

P0DOA6

Probable transcriptional regulatory protein (Probably GntR-family)

Protein

Unknown.

O86331

Probable membrane glycine and proline rich protein

Protein

Unknown.

O53445

TVP38/TMEM64 family membrane protein Rv1491c

Protein

Unknown.

P9WFS3

Trehalose transport system permease protein SugB

Protein

Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Probably responsible for the translocation of the substrate across the membrane. {ECO:0000269|PubMed:21118978}..

P9WG01

PE family protein. Possible lipase LipX

Protein

Unknown.

Q79FR5

Uncharacterized PE-PGRS family protein PE_PGRS34

Protein

Unknown.

P9WIF3

Probable mannosyltransferase. Probable conserved transmembrane protein

Protein

Unknown.

O06152

Protein PafB (Proteasome accessory factor B)

Protein

Part of the pafABC operon, however PafB does not seem to be involved in pupylation or substrate degradation. Appears to play at least a small role in resistance to reactive nitrogen intermediates (RNI) in vitro. {ECO:0000269|PubMed:17277063}..

P9WIM1

Cell wall synthesis protein Wag31 (Antigen 84)

Protein

Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress-induced cleavage. {ECO:0000269|PubMed:18310019, ECO:0000269|PubMed:19496931, ECO:0000269|PubMed:21190553}..

P9WMU1

Conserved hypothetical integral membrane protein YrbE3A

Protein

Unknown.

O53965

Universal stress protein Rv2624c (USP Rv2624c)

Protein

Unknown.

P9WFD5

Uncharacterized AAA domain-containing protein Rv2559c

Protein

Unknown.

P9WQN1

Acid and phagosome regulated protein B AprB

Protein

Unknown.

V5QRX2

Probable conserved alanine rich transmembrane protein

Protein

Unknown.

I6X552

ESAT-6-like protein EsxR (TB10.3)

Protein

Unknown.

P9WNI9

Conserved alanine and arginine rich protein

Protein

Unknown.

I6XF60

Possible conserved membrane or exported protein

Protein

Unknown.

I6X5W6

Possible transcriptional regulatory protein (Probably TetR-family)

Protein

Unknown.

P95100

Probable conserved ATP-binding protein ABC transporter

Protein

Unknown.

I6YF11

Peptidase M20 domain-containing protein 2

Protein

Unknown.

L7N690

Probable MoaD-MoaE fusion protein MoaX

Protein

Unknown.

Q6MWY3

Conserved hypothetical alanine and proline rich protein

Protein

Unknown.

I6YC49

Hypothetical alanine and valine rich protein

Protein

Unknown.

O06263

Probable sugar-transport integral membrane protein SugI

Protein

Unknown.

L0TDU1

Probable transcriptional regulatory protein (Probably TetR-family)

Protein

Unknown.

O53317

ESX-1 secretion-associated protein EspC

Protein

Required for ESX-1 function. Required for either stability or expression of EspA. {ECO:0000269|PubMed:16135231, ECO:0000269|PubMed:19682254}..

P9WJD7

ESX-1 secretion-associated protein EspK

Protein

May act as a chaperone that facilitates EspB secretion through an interaction with EccCb1. {ECO:0000269|PubMed:17676952}..

P9WJC1

ESX-1 secretion-associated protein EspF

Protein

Unknown.

P9WJD1

Transcriptional regulatory protein (Probably AraC-family)

Protein

Unknown.

P96245

Probable conserved two-domain membrane protein

Protein

Unknown.

O69695

CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (ssDNase Cas10) (EC 3.1.-.-) (Cyclic oligoadenylate synthase) (EC 2.7.7.-)

Protein

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions (PubMed:29979631). {ECO:0000269|PubMed:29979631, ECO:0000305|PubMed:29979631}.; FUNCTION: This subunit is a single-strand-specific deoxyribonuclease (ssDNase) which digests both linear and circular ssDNA; it has both exo- and endonuclease activity. {ECO:0000250|UniProtKB:B6YWB8}.; FUNCTION: ssDNase activity is stimulated in the ternary Csm effector complex; binding of cognate target RNA activates the ssDNase, as the target RNA is degraded ssDNA activity decreases. {ECO:0000250|UniProtKB:A0A0A7HFE1}.; FUNCTION: When associated with the ternary Csm effector complex (the crRNA, Cas proteins and a cognate target ssRNA) synthesizes cyclic oligoadenylates (cOA) from ATP. cOAs are second messengers that stimulate the ssRNase activity of Csm6, inducing an antiviral state important for defense against invading nucleic acids. {ECO:0000250|UniProtKB:A0A0A7HFE1}..

P71629

Possible two component transcriptional regulatory protein (Probably LuxR-family)

Protein

Unknown.

O53646

Probable integral membrane nitrite extrusion protein NarK3 (Nitrite facilitator)

Protein

Unknown.

P95218

Possible transcriptional regulatory protein NadR (Probably AsnC-family)

Protein

Unknown.

P96394

Probable primosomal protein N' (EC 3.6.4.-) (ATP-dependent helicase PriA)

Protein

Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. {ECO:0000255|HAMAP-Rule:MF_00983}..

P9WMQ9

Trehalose import ATP-binding protein SugC (EC 3.6.3.-)

Protein

Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Probably responsible for energy coupling to the transport system. {ECO:0000269|PubMed:21118978}..

P9WQI3

Probable conserved proline, glycine, valine-rich secreted protein

Protein

Unknown.

O06823

Uncharacterized protein SocA (Small ORF induced by copper A)

Protein

Unknown.

E2FZM4

Undecaprenyl-diphosphatase (EC 3.6.1.27) (Bacitracin resistance protein) (Undecaprenyl pyrophosphate phosphatase)

Protein

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin. {ECO:0000255|HAMAP-Rule:MF_01006}..

P9WFF9

L-asparagine permease 1 (L-asparagine transport protein 1)

Protein

Unknown.

P9WQM9

Probable nitrite extrusion protein 1 NarK1 (Nitrite facilitator 1)

Protein

Unknown.

P71883

Probable conserved integral membrane alanine and leucine rich protein

Protein

Unknown.

I6X548

Conserved alanine and valine and glycine rich protein

Protein

Unknown.

O07191

Conserved alanine and glycine and valine rich protein

Protein

Unknown.

I6XF31

Uncharacterized MFS-type transporter EfpA (Efflux protein A)

Protein

Unknown.

P9WJY5

Probable dicarboxylic acid transport integral membrane protein KgtP (Dicarboxylate transporter)

Protein

Unknown.

I6XHB8

Probable transcriptional regulatory protein (Probably TetR/AcrR-family)

Protein

Unknown.

O53323

Probable lipid transfer protein or keto acyl-CoA thiolase Ltp2

Protein

Unknown.

I6Y3T7

Cell wall synthesis protein CwsA (Cell wall synthesis and cell shape protein A)

Protein

Required for regulated cell division, cell wall synthesis and the maintenance of cell shape. {ECO:0000255|HAMAP-Rule:MF_00927, ECO:0000269|PubMed:23002219}..

P9WJF3

Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase)

Protein

Unknown.

I6Y778

Ribosomal-protein-alanine acetyltransferase RimJ (Acetylating enzyme for N-terminal of ribosomal protein S5)

Protein

Unknown.

O05578

CRISPR system Cms protein Csm2 (CRISPR type III A-associated protein Csm2)

Protein

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions (PubMed:29979631). {ECO:0000269|PubMed:29979631, ECO:0000305|PubMed:29979631}.; FUNCTION: This subunit may be involved in monitoring complementarity of crRNA and target RNA. {ECO:0000250|UniProtKB:A0A0A7HIX1}..

P9WJG1

CRISPR system Cms protein Csm4 (CRISPR type III-A associated RAMP protein Csm4)

Protein

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions (PubMed:29979631). {ECO:0000269|PubMed:29979631, ECO:0000305|PubMed:29979631}.; FUNCTION: The subunit probably binds to the 5' handle of the crRNA, helping in discrimination between self- and non-self. {ECO:0000250|UniProtKB:A0A0A7HGA1}..

P9WJF7

ESX conserved component EccC2. ESX-2 type VII secretion system protein. Possible membrane protein

Protein

Unknown.

O05450

Redox- and pH-responsive transcriptional regulator WhiB3

Protein

A redox-sensitive transcriptional regulator. Maintains intracellular redox homeostasis by regulating catabolic metabolism and polyketide biosynthesis (PubMed:17609386, PubMed:19680450). Regulates expression of the redox buffer ergothioneine (ERG) in a carbon-source-dependent manner; loss of ERG or mycothiol (MSH, the other major redox buffer in this bacteria) leads to respiratory alterations and bioenergetic deficiencies that negatively impact virulence (PubMed:26774486). In response to low external pH (like that found in host macrophage phagosomes) alters endogenous gene expression leading to acid resistance; MSH and WhiB3 are probably part of a regulatory circuit that mediates gene expression upon acid stress (PubMed:26637353). Regulates pathogenic lipid synthesis, coordinating proprionate flux (and other host-derived fatty acid oxidation intermediates) into methyl-branched fatty acids (polyacyltrehalose, phthiocerol dimycocerosates, sulfolipids) and the storage lipid triacylglycerol, functioning as reductive sink (PubMed:19680450). During intracellular growth M.tuberculosis uses host fatty acids as an energy source, generating large quantities of proprionate and NADH/NADPH, which are toxic and highly reducing respectively. WhiB3 is thought to help dissipate proprionate and NADH/NADPH by switching to the in vivo carbon source and via lipid anabolism (PubMed:19680450). Responds to NO and O(2) (PubMed:17609386). Regulates expression of genes encoding modular polyketide synthases such as pks2, pks3 and fbpA (PubMed:19680450). The oxidized apo-form of WhiB3 binds DNA (with 2 intramolecular disulfide bonds); holo-WhiB3 (with the 4Fe-4S cluster) binds DNA considerably less well (PubMed:19680450). Discriminates poorly between specific and non-specific DNA-binding. Plays a role in virulence and nutritional stress (PubMed:11880648, PubMed:17609386, PubMed:26637353). In its apo-form can act as a protein disulfide reductase (PubMed:18550384). {ECO:0000269|PubMed:11880648, ECO:0000269|PubMed:17609386, ECO:0000269|PubMed:18550384, ECO:0000269|PubMed:19016840, ECO:0000269|PubMed:19680450, ECO:0000269|PubMed:26637353, ECO:0000269|PubMed:26774486}.; FUNCTION: May respond to mycothiol (MSH) redox potential (E-MSH) which decreases at pH 4.5 for up to 72 hours, indicative of cellular reductive stress; deletion of whiB3 leads to a lesser E-MSH at 72 hours, indicative of cellular oxidative stress (PubMed:26637353). Probably via its effects on production of polyketide lipids, regulates host gene expression, leading to blockage of phagosome maturation (PubMed:26637353). Equilibration of extra- and intracytoplasmic pH kills bacteria (PubMed:26637353). {ECO:0000269|PubMed:26637353}..

P9WF41

ESX-4 secretion system ATPase EccB4 (EC 3.6.-.-) (ESX conserved component B4) (Type VII secretion system protein EccB4) (T7SS protein EccB4)

Protein

An ATPase (By similarity). {ECO:0000250|UniProtKB:P9WNR7}..

P9WNR1

tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD) (tRNA threonylcarbamoyladenosine biosynthesis protein TsaD)

Protein

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. {ECO:0000255|HAMAP-Rule:MF_01445}..

P9WHT7

Penicillin-binding protein 1A (PBP-1A) (Penicillin-binding protein 1*) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)]

Protein

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity). Has little peptidoglycan hydrolytic activity; however it inhibits the synergistic peptidoglycan hydrolysis of RipA plus RpfB. {ECO:0000250, ECO:0000269|PubMed:20686708}..

P71707

3-oxoacyl-[acyl-carrier-protein] synthase 3 (EC 2.3.1.180) (3-oxoacyl-[acyl-carrier-protein] synthase III) (Beta-ketoacyl-ACP synthase III) (KAS III) (MtFabH)

Protein

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for long chain acyl-CoA such as myristoyl-CoA. Does not use acyl-CoA as primer. Its substrate specificity determines the biosynthesis of mycolic acid fatty acid chain, which is characteristic of mycobacterial cell wall. {ECO:0000269|PubMed:10840036}..

P9WNG3

ESX-2 secretion system ATPase EccB2 (EC 3.6.-.-) (ESX conserved component B2) (Type VII secretion system protein EccB2) (T7SS protein EccB2)

Protein

An ATPase (By similarity). {ECO:0000250|UniProtKB:P9WNR7}..

P9WNR5

Alanine and proline-rich secreted protein Apa (45 kDa glycoprotein) (45/47 kDa antigen) (Antigen MPT-32) (FAP-B) (Fibronectin attachment protein) (Immunogenic protein MPT32)

Protein

A potent antigen in animals immunized with live bacteria, it induces a strong delayed-type hypersensitivity (DTH) in immunized animals (PubMed:10531201). Elicits a mostly Th1 type of T-cell response in healthy humans; induces IFN-gamma production from CD4(+) and CD8(+) cells (PubMed:12654810). Functions as an adhesin, binds to mouse macrophages via mannose residues (PubMed:10531201, PubMed:25359607). Might interact via host CD209 (PubMed:16092920). {ECO:0000269|PubMed:10531201, ECO:0000269|PubMed:12654810, ECO:0000269|PubMed:16092920, ECO:0000269|PubMed:25359607}..

P9WIR7

ESX-3 secretion system ATPase EccB3 (EC 3.6.-.-) (ESX conserved component B3) (Type VII secretion system protein EccB3) (T7SS protein EccB3)

Protein

An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. {ECO:0000250|UniProtKB:P9WNR7, ECO:0000269|PubMed:19684129, ECO:0000269|PubMed:24155985}..

P9WNR3

Peptidoglycan endopeptidase RipB (EC 3.4.-.-) (Macrophage invasion and intracellular persistence protein B) (Resuscitation-promoting factor interaction partner B) (Rpf-interacting protein B)

Protein

Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds high-molecular weight peptidoglycan, but does not degrade it. Required for normal separation of daughter cells after cell division and cell wall integrity. Required for host cell invasion. {ECO:0000269|PubMed:16495549}..

P9WHU5

L-asparagine permease 2 (L-asparagine transport protein 2)

Protein

Unknown.

P9WQM7

Probable heat shock protein transcriptional repressor HspR (MerR family)

Protein

Unknown.

O06302

Probable integral membrane nitrite extrusion protein NarU (Nitrite facilitator)

Protein

Unknown.

P95224

Possible transcriptional regulatory protein (Possibly TetR/AcrR-family)

Protein

Unknown.

O07252

Probable transcriptional regulatory protein Mce1R (Probably GntR-family)

Protein

Unknown.

Q79G00

Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT)

Protein

Unknown.

Q79FX5

Exopolysaccharide phosphotransferase CpsY (EC 2.7.-.-) (Stealth protein CpsY)

Protein

Unknown.

P9WGD1

Possible lipid carrier protein or keto acyl-CoA thiolase

Protein

Unknown.

I6XWJ8

Fatty acid ABC transporter ATP-binding/permease protein (EC 7.6.2.-)

Protein

ABC transporter involved in fatty acid import (PubMed:29360453). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable). {ECO:0000269|PubMed:29360453, ECO:0000305|PubMed:29360453}..

P9WQJ3

Probable unidentified antibiotic-transport ATP-binding protein ABC transporter

Protein

Unknown.

O53149

Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)

Protein

Unknown.

O53146

ABC transporter ATP-binding/permease protein Rv1747 (EC 3.6.3.-)

Protein

Involved in the translocation of an unknown substrate across the membrane. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for virulence. {ECO:0000269|PubMed:15135525, ECO:0000269|PubMed:16040957}..

O65934

Molybdenum import ATP-binding protein ModC (EC 7.3.2.5)

Protein

Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system. {ECO:0000255|HAMAP-Rule:MF_01705}..

P9WQL3

Probable D-serine/alanine/glycine transporter protein CycA

Protein

Unknown.

O33203

Probable sugar-transport integral membrane protein ABC transporter

Protein

Unknown.

O53484

Probable sugar-transport integral membrane protein ABC transporter UspA

Protein

Unknown.

P71896

Probable sugar-transport ATP-binding protein ABC transporter

Protein

Unknown.

O53482

Probable cationic amino acid transport integral membrane protein RocE

Protein

Unknown.

P71892

Energy-dependent translational throttle protein EttA (Translational regulatory factor EttA)

Protein

A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation (By similarity). {ECO:0000250}..

P9WQK3

Citrate lyase subunit beta-like protein (EC 4.1.-.-)

Protein

May play a role in fatty acid biosynthesis. {ECO:0000305}..

P9WPE1

Fluoroquinolones export ATP-binding protein Rv2688c (EC 3.6.3.-)

Protein

Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin and sparfloxacin. Probably responsible for energy coupling to the transport system. {ECO:0000269|PubMed:15273144}..

P9WQL7

Probable ATP-dependent helicase Lhr (Large helicase-related protein)

Protein

Unknown.

P96901

Probable conserved transmembrane protein alanine and leucine rich

Protein

Unknown.

P72045

Probable lipid carrier protein or keto acyl-CoA thiolase Ltp3

Protein

Unknown.

I6YGD8

Possible lipid transfer protein or keto acyl-CoA thiolase Ltp4

Protein

Unknown.

O53567

Putative quercetin 2,3-dioxygenase Rv0181c (Putative quercetinase) (EC 1.13.11.24) (Pirin-like protein Rv0181c)

Protein

Putative quercetin 2,3-dioxygenase. {ECO:0000250}..

P9WI85

Putative acyl-[acyl-carrier-protein] desaturase DesA1 (Putative acyl-ACP desaturase DesA1) (EC 1.14.19.-)

Protein

May be a desaturase involved in mycobacterial fatty acid biosynthesis. {ECO:0000305|PubMed:14559907}..

P9WNZ7

Putative acyl-[acyl-carrier-protein] desaturase DesA2 (Putative acyl-ACP desaturase DesA2) (EC 1.14.19.-)

Protein

May be a desaturase involved in mycobacterial fatty acid biosynthesis. {ECO:0000305|PubMed:14559907}..

P9WNZ5

HTH-type transcriptional regulatory protein RaaS (Regulator of antimicrobial-assisted survival)

Protein

Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and upstream of the Rv1218c gene (PubMed:24424575). Important for survival in prolonged stationary phase and during macrophage infection (PubMed:24590482). May be used to eliminate non-growing mycobacteria (PubMed:25012658). {ECO:0000269|PubMed:24424575, ECO:0000269|PubMed:24590482, ECO:0000269|PubMed:25012658}..

O86312

3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase 2) (KAS 2)

Protein

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. {ECO:0000250}..

P9WQD7

Heme chaperone HemW (Oxygen-independent coproporphyrinogen-III oxidase-like protein Rv2388c)

Protein

Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity). {ECO:0000250|UniProtKB:P32131, ECO:0000250|UniProtKB:P52062}..

P9WP73

Low molecular weight antigen MTB12 (CFP-2) (Low molecular weight protein antigen 2)

Protein

May play a role in the development of protective immune responses..

P9WIN7

Probable conserved integral membrane alanine and valine and leucine rich protein

Protein

Unknown.

I6Y1H7

Cyclic pyranopterin monophosphate synthase 1 (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C 1)

Protein

Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) (By similarity). Probably plays a role in host phagosome maturation arrest (PubMed:20844580). {ECO:0000255|HAMAP-Rule:MF_01224, ECO:0000305|PubMed:20844580}..

P9WJR9

Possible type I restriction/modification system specificity determinant HsdS (S protein)

Protein

Unknown.

I6YEB1

Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE

Protein

Unknown.

I6Y1U3

Bifunctional protein FolD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]

Protein

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. {ECO:0000255|HAMAP-Rule:MF_01576}..

P9WG81

Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (Epsilon chain) AccE5

Protein

Unknown.

P96886

Trehalose-2-sulfate acyltransferase papA2 (EC 2.3.1.-) (Polyketide synthase-associated protein A2)

Protein

Catalyzes the acylation of trehalose-2-sulfate by adding the palmitoyl group at the 2'-position to yield the intermediate trehalose-2-sulfate-2'-palmitate (SL659) during the cell wall sulfolipid-1 (SL-1) biosynthesis. {ECO:0000269|PubMed:17259623, ECO:0000269|PubMed:17592143}..

P9WIK7

Possible osmoprotectant (Glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProW

Protein

Unknown.

O69723

Possible osmoprotectant (Glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProZ

Protein

Unknown.

O69722

Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (Alpha chain) AccA3: biotin carboxylase + biotin carboxyl carrier protein (BCCP)

Protein

Unknown.

P96890

Probable bifunctional cobalamin biosynthesis protein CobU: cobinamide kinase + cobinamide phosphate guanylyltransferase

Protein

Unknown.

O53676

Acetyltransferase Pat (EC 2.3.1.-) (GCN5-like enzyme) (GCN5-related N-acetyltransferase) (GNAT) (Protein acetyltransferase) (Pat)

Protein

Catalyzes specifically the acetylation of the epsilon-amino group of a highly conserved lysine residue in acetyl-CoA synthetase (ACS). This acetylation results in the inactivation of ACS activity and could be important for mycobacteria to adjust to environmental changes. {ECO:0000269|PubMed:20507997, ECO:0000269|PubMed:21627103, ECO:0000269|PubMed:22773105}..

O05581

Lipoyl synthase (EC 2.8.1.8) (Lip-syn) (LS) (Lipoate synthase) (Lipoic acid synthase) (Sulfur insertion protein LipA)

Protein

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000255|HAMAP-Rule:MF_00206}..

P9WK91

Protein RecA (Recombinase A) [Cleaved into: Endonuclease PI-MtuI (EC 3.1.-.-) (Mtu RecA intein)]

Protein

Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.; FUNCTION: PI-MtuI is an endonuclease..

P9WHJ3

Possible type I restriction/modification system specificity determinant HsdS.1 (S protein)

Protein

Unknown.

I6XF84

Release factor glutamine methyltransferase (RF MTase) (EC 2.1.1.297) (M.MtuHHemKP) (N5-glutamine methyltransferase PrmC) (Protein-(glutamine-N5) MTase PrmC) (Protein-glutamine N-methyltransferase PrmC)

Protein

Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. {ECO:0000255|HAMAP-Rule:MF_02126}..

P9WHV3

Outer membrane channel protein CpnT (Channel protein with necrosis-inducing toxin) [Cleaved into: N-terminal channel domain; Tuberculosis necrotizing toxin (TNT) (NAD(+) glycohydrolase) (EC 3.2.2.5)]

Protein

Has a dual function in uptake of nutrients and induction of host cell death. The N-terminal domain (NTD) forms an outer membrane channel and is used for uptake of nutrients across the outer membrane. The secreted C-terminal toxic domain (TNT) acts as a glycohydrolase, which hydrolyzes the essential cellular coenzyme NAD(+) in the cytosol of infected macrophages, leading to necrotic host cell death. Both functions are required for survival, replication and cytotoxicity of M.tuberculosis in macrophages. {ECO:0000269|PubMed:24753609, ECO:0000269|PubMed:26237511}..

O05442

Probable exodeoxyribonuclease III protein XthA (Exonuclease III) (EXO III) (AP endonuclease VI)

Protein

Unknown.

P96273

GTP 3',8-cyclase 2 (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A 2)

Protein

Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. {ECO:0000255|HAMAP-Rule:MF_01225}..

P9WJS1

ATP-dependent RNA helicase DeaD (EC 3.6.4.13) (Cold-shock DEAD box protein A)

Protein

DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. {ECO:0000255|HAMAP-Rule:MF_00964}..

P9WH05

Iron import ATP-binding/permease protein IrtB (EC 3.6.3.-) (Iron-regulated transporter B)

Protein

Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for replication in human macrophages and in mouse lungs. {ECO:0000269|PubMed:16385031, ECO:0000269|PubMed:19948799}..

P9WQJ7

Group 2 truncated hemoglobin GlbO (Hemoglobin-like protein HbO) (Truncated hemoglobin) (trHbO)

Protein

When expressed in E.coli and M.smegmatis, HbO increases oxygen uptake. Membrane vesicles of E.coli carrying HbO show a respiration activity about twice that of membranes without HbO. HbO seems to interact with a terminal oxidase. Therefore, HbO could participate in oxygen/electron-transfer process, suggesting a function related to the facilitation of oxygen transfer during aerobic metabolism of M.tuberculosis..

P9WN23

Probable Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter UgpC

Protein

Unknown.

I6X5H3

Cyclic pyranopterin monophosphate synthase 3 (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C 3)

Protein

Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). {ECO:0000255|HAMAP-Rule:MF_01224}..

P9WJR5

Probable molybdenum cofactor biosynthesis protein MoeB2 (MPT-synthase sulfurylase) (Molybdopterin synthase sulphurylase)

Protein

Unknown.

L7N674

DNA topoisomerase 1 (EC 5.6.2.2) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme)

Protein

Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex (PubMed:8921893, PubMed:20724443). Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. {ECO:0000255|HAMAP-Rule:MF_00952, ECO:0000269|PubMed:20724443, ECO:0000269|PubMed:8921893}.; FUNCTION: The C-terminus (residues 622-934) inhibits RNA cleavage by MazF4. {ECO:0000269|PubMed:20724443}..

P9WG49

Probable conserved transmembrane protein rich in alanine and arginine and proline

Protein

Unknown.

O06278

HTH-type transcriptional regulator RamB (icl1 and ramB operon repressor protein)

Protein

Involved in the control of the glyoxylate cycle. RamB negatively controls the expression of icl expression during growth on acetate as the sole carbon source. Does not regulate the expression of other genes involved in acetate metabolism. {ECO:0000269|PubMed:19767422}..

P9WMI1

Cyclic pyranopterin monophosphate synthase 2 (EC 4.6.1.17) (Molybdenum cofactor biosynthesis protein C 2)

Protein

Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP). {ECO:0000255|HAMAP-Rule:MF_01224}..

P9WJR7

Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC

Protein

Unknown.

O06137

Bifunctional protein Rv2228c [Includes: Ribonuclease H (EC 3.1.26.4); Adenosylcobalamin/alpha-ribazole phosphatase (EC 3.1.3.73)]

Protein

Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as double-stranded RNase activity. As the only authenticated RNase HI in M.tuberculosis, probably plays an important role in the physiology of this organism, being likely involved in bacterial replication. {ECO:0000269|PubMed:20363939}.; FUNCTION: Catalyzes the hydrolysis of the phospho group from alpha-ribazole 5'-phosphate to form alpha-ribazole (PubMed:20363939). May also catalyze the conversion of adenosylcobalamin 5'-phosphate to adenosylcobalamin (vitamin B12) (By similarity). Has a possible role in B12 recycling, but the primary role of the C-terminal domain of this phosphatase enzyme could be phosphate generation to help bacterial survival within the macrophage, which is a phosphate-deprived environment (PubMed:20363939). {ECO:0000250|UniProtKB:P39701, ECO:0000269|PubMed:20363939}..

P9WLH5

Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA

Protein

Unknown.

I6XFF3

Phosphopantetheinyl transferase PptT (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase)

Protein

Unknown.

O33336

Probable glutaredoxin electron transport component of NRDEF (Glutaredoxin-like protein) NrdH

Protein

Unknown.

I6YB06

Probable succinate dehydrogenase (Iron-sulphur protein subunit) SdhB (Succinic dehydrogenase) (Fumarate reductase) (Fumarate dehydrogenase) (Fumaric hydrogenase)

Protein

Unknown.

O53371

Probable O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD

Protein

Unknown.

P72049

Possible osmoprotectant (Glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV

Protein

Unknown.

O69724

Probable bifunctional transcriptional activator/DNA repair enzyme AlkA (Regulatory protein AlkA) [Includes: Methylphosphotriester-DNA--protein-cysteine S-methyltransferase (EC 2.1.1.n11) (Methylphosphotriester-DNA methyltransferase); DNA-3-methyladenine glycosylase (EC 3.2.2.21) (DNA-3-methyladenine glycosidase)]

Protein

Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity). {ECO:0000250}.; FUNCTION: The methylation of Alka by methylphosphotriesters in DNA leads to its activation as a transcriptional regulator that activates the transcription of its own gene and other alkylation resistance genes. {ECO:0000250}..

P9WJW3

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (SEPHCHC synthase) (EC 2.2.1.9) (Menaquinone biosynthesis protein MenD)

Protein

Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). {ECO:0000255|HAMAP-Rule:MF_01659}..

P9WK11

Phosphate import ATP-binding protein PstB 1 (EC 7.3.2.1) (ABC phosphate transporter 1) (Phosphate-transporting ATPase 1)

Protein

Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. {ECO:0000255|HAMAP-Rule:MF_01702, ECO:0000305|PubMed:20933472}..

P9WQL1

Phosphate import ATP-binding protein PstB 2 (EC 7.3.2.1) (ABC phosphate transporter 2) (Phosphate-transporting ATPase 2)

Protein

Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport system. {ECO:0000255|HAMAP-Rule:MF_01702, ECO:0000305|PubMed:20933472}..

P9WQK9

Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)

Protein

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. {ECO:0000255|HAMAP-Rule:MF_00772}..

P9WJW5

Probable peptidoglycan glycosyltransferase FtsW (PGT) (EC 2.4.1.129) (Cell division protein FtsW) (Cell wall polymerase) (Peptidoglycan polymerase) (PG polymerase)

Protein

Peptidoglycan polymerase that is essential for cell division. {ECO:0000250|UniProtKB:P39604}..

P9WN97

Arginine biosynthesis bifunctional protein ArgJ [Cleaved into: Arginine biosynthesis bifunctional protein ArgJ alpha chain; Arginine biosynthesis bifunctional protein ArgJ beta chain] [Includes: Glutamate N-acetyltransferase (EC 2.3.1.35) (Ornithine acetyltransferase) (OATase) (Ornithine transacetylase); Amino-acid acetyltransferase (EC 2.3.1.1) (N-acetylglutamate synthase) (AGSase)]

Protein

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. {ECO:0000250}..

P9WPZ3

Peptidoglycan endopeptidase RipA (EC 3.4.-.-) (Macrophage invasion and intracellular persistence protein A) (Resuscitation-promoting factor interaction partner A) (Rpf-interacting protein A)

Protein

Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages. {ECO:0000269|PubMed:16495549, ECO:0000269|PubMed:17919286, ECO:0000269|PubMed:18463693, ECO:0000269|PubMed:20826344, ECO:0000269|PubMed:21864539}..

O53168

Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (Molybdopterin converting factor small subunit) (Molybdopterin [MPT] converting factor, subunit 1)

Protein

Unknown.

I6XWG2

Polyketide synthase-like Pks10 (EC 2.3.1.-) (Chalcone synthase-like protein) (CHS-like) (Polyketide synthase type III Pks10)

Protein

Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM). {ECO:0000269|PubMed:12730158}..

P9WPF5

Salicylate synthase (Chorismate mutase) (CM) (EC 5.4.99.5) (Isochorismate synthase/isochorismate lyase) (EC 4.2.99.21) (EC 5.4.4.2) (Mycobactin synthase protein)

Protein

Involved in the incorporation of salicylate into the virulence-conferring salicylate-based siderophore mycobactin. Catalyzes the initial conversion of chorismate to yield the intermediate isochorismate (isochorismate synthase activity), and the subsequent elimination of the enolpyruvyl side chain to give salicylate (isochorismate pyruvate-lyase activity). In the absence of magnesium, MbtI displays a chorismate mutase activity and converts chorismate to prephenate. {ECO:0000269|PubMed:16923875, ECO:0000269|PubMed:17240979, ECO:0000269|PubMed:20487026, ECO:0000269|PubMed:20512795, ECO:0000269|PubMed:9831524}..

P9WFX1

Phthiocerol/phthiodiolone dimycocerosyl transferase (EC 2.3.1.282) (Acyltransferase PapA5) (Phthiocerol/phthiodiolone O-acyltransferase) (Polyketide synthase-associated protein A5)

Protein

Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Is also able to catalyze acyl transfer using various nucleophiles as acceptors and several acyl-CoA thioesters as donors in vitro; preference is observed for saturated medium chain alcohols and long chain acyl-CoA thioesters. {ECO:0000269|PubMed:15070765, ECO:0000269|PubMed:15749014, ECO:0000269|PubMed:22361940}..

P9WIN5

Phosphomethylpyrimidine synthase (EC 4.1.99.17) (Hydroxymethylpyrimidine phosphate synthase) (HMP-P synthase) (HMP-phosphate synthase) (HMPP synthase) (Thiamine biosynthesis protein ThiC)

Protein

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. {ECO:0000255|HAMAP-Rule:MF_00089}..

P9WG79

Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (Alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrier protein (BCCP)

Protein

Unknown.

P71538

PE-PGRS family protein PE_PGRS11 (PE-PGRS phosphoglycerate mutase) (EC 5.4.2.12)

Protein

Induces maturation and activation of human dendritic cells (DCs), via TLR2-dependent activation of ERK1/2, p38 MAPK, and NF-kappa-B signaling pathways, and enhances the ability of DCs to stimulate CD4(+) T cells. By activating DCs, could potentially contribute to the initiation of innate immune responses during tuberculosis infection and hence regulate the clinical course of tuberculosis (PubMed:20176745). Involved in resistance to oxidative stress, via TLR2-dependent activation of the PI3K-ERK1/2-NF-kappa-B signaling pathway and expression of COX-2 and Bcl2. Also abolishes H(2)O(2)-triggered activation of p38 MAPK (PubMed:20558725). {ECO:0000269|PubMed:20176745, ECO:0000269|PubMed:20558725}..

Q79FW5

UPF0051 protein Rv1461 [Cleaved into: Endonuclease PI-MtuHIIP (EC 3.1.-.-) (Mtu pps1 intein)]

Protein

Unknown.

P9WFP7

Iron import ATP-binding/permease protein IrtA (EC 3.6.3.-) (Iron-regulated transporter A)

Protein

Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for replication in human macrophages and in mouse lungs. {ECO:0000269|PubMed:16385031, ECO:0000269|PubMed:19948799}..

P9WQJ9

Probable first part of macrolide-transport ATP-binding protein ABC transporter

Protein

Unknown.

O53916

Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD

Protein

Unknown.

O06138

Probable second part of macrolide-transport ATP-binding protein ABC transporter

Protein

Unknown.

O53915

3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase 1) (KAS 1)

Protein

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. {ECO:0000250}..

P9WQD9

Sulfate/thiosulfate import ATP-binding protein CysA (EC 7.3.2.3) (Sulfate-transporting ATPase)

Protein

Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system..

P9WQM1

CRISPR system Cms endoribonuclease Csm3 (EC 3.1.-.-) (CRISPR type III A-associated RAMP protein Csm3)

Protein

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions (PubMed:29979631). {ECO:0000269|PubMed:29979631, ECO:0000305|PubMed:29979631}.; FUNCTION: This subunit has the target ssRNA endonuclease activity; it cleaves multiple sites in the target RNA at 6 nucleotide intervals. {ECO:0000250|UniProtKB:A0A0A7HIF0}..

P9WJF9

CRISPR system endoribonuclease Csm6 (EC 3.1.-.-) (CRISPR type III-A associated protein Csm6)

Protein

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities (Probable). This CRISPR-Cas system protects bacteria against transformation with plasmids containing DNA homologous to its spacer regions (PubMed:29979631). This subunit is a single-strand-specific endoribonuclease (ssRNase) that is stimulated by cyclic oligoadenylates (cOA) produced by the Cas10 subunit of the Csm effector complex (By similarity). {ECO:0000250|UniProtKB:A0A0A7HIX6, ECO:0000269|PubMed:29979631, ECO:0000305|PubMed:29979631}..

P71635

GTP 3',8-cyclase 1 (EC 4.1.99.22) (Molybdenum cofactor biosynthesis protein A 1)

Protein

Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. {ECO:0000255|HAMAP-Rule:MF_01225}..

P9WJS3

Possible type I restriction/modification system DNA methylase HsdM (M protein) (DNA methyltransferase)

Protein

Unknown.

O33298

Probable pyruvate formate lyase activating protein PflA (Formate acetyltransferase activating enzyme) ([pyruvate formate-lyase] activating enzyme)

Protein

Unknown.

P95188

Probable O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter RfbE

Protein

Unknown.

P72047

Putative 8-oxo-dGTP diphosphatase 3 (8-oxo-dGTPase) (EC 3.6.1.55) (7,8-dihydro-8-oxoguanine-triphosphatase 3) (Mutator protein MutT3) (dGTP pyrophosphohydrolase 3)

Protein

May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate (By similarity). {ECO:0000250}..

P9WIX9

Trehalose-6-phosphate synthase (TPS) (EC 2.4.1.15) (EC 2.4.1.347) (Alpha,alpha-trehalose-phosphate synthase [UDP-forming]) (Osmoregulatory trehalose synthesis protein A) (OtsA)

Protein

Involved in the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1-phosphate (M1P), and probably in the osmoprotection via the biosynthesis of trehalose (PubMed:12473104, PubMed:27513637). Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate (PubMed:12473104). Is specific for the glucosyl acceptor (Glc-6-P cannot be replaced by either mannose-6-P, fructose-6-P or glucosamine-6-P), but any of the glucose sugar nucleotides can be used as glucosyl donors (PubMed:12473104). It is more active with the purine sugar nucleotides than with the pyrimidine sugar nucleotides (PubMed:12473104). {ECO:0000269|PubMed:12473104, ECO:0000269|PubMed:27513637}..

P9WN11

Ribosomal RNA small subunit methyltransferase G (EC 2.1.1.-) (16S rRNA 7-methylguanosine methyltransferase) (16S rRNA m7G methyltransferase) (Glucose-inhibited division protein B)

Protein

Specifically methylates the N7 position of guanine in position 518 of 16S rRNA. {ECO:0000255|HAMAP-Rule:MF_00074}..

P9WGW9

Probable NAD(P) transhydrogenase (Subunit alpha) PntAb [second part integral membrane protein] (Pyridine nucleotide transhydrogenase subunit alpha) (Nicotinamide nucleotide transhydrogenase subunit al...

Protein

Unknown.

P96833

Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)]

Protein

Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:19121323, ECO:0000269|PubMed:19237750}..

P9WMN3

ATP synthase subunit c (ATP synthase F(0) sector subunit c) (F-type ATPase subunit c) (F-ATPase subunit c) (Lipid-binding protein)

Protein

F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. {ECO:0000255|HAMAP-Rule:MF_01396}.; FUNCTION: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits. {ECO:0000255|HAMAP-Rule:MF_01396}..

P9WPS1

Alpha-pyrone synthesis polyketide synthase-like Pks18 (EC 2.3.1.-) (Alpha-pyrone synthesis polyketide synthase type III Pks18) (Chalcone synthase-like protein) (CHS-like)

Protein

Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. {ECO:0000269|PubMed:12941968}..

P9WPF1

Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX [Includes: Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS); Phosphatidylglycerol lysyltransferase (EC 2.3.2.3) (Lysylphosphatidylglycerol synthetase) (LPG synthetase)]

Protein

Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides. {ECO:0000269|PubMed:19649276}..

P9WFU7

L-lysine N6-monooxygenase MbtG (EC 1.14.13.59) (Lysine 6-N-hydroxylase) (Lysine N6-hydroxylase) (Lysine-N-oxygenase) (Mycobactin synthase protein G)

Protein

Flavoprotein monooxygenase required for N-hydroxylation of the two acylated lysine residues during mycobactin assembly, thus producing the hydroxamate groups necessary for iron sequestration. Is also able, but less efficiently, to hydroxylate L-lysine (non acylated) in vitro. {ECO:0000269|PubMed:16461464}..

P9WKF7

Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase (DRAP deaminase) (EC 3.5.4.26) (Riboflavin-specific deaminase); 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) (HTP reductase)]

Protein

Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate. {ECO:0000250}..

P9WPH1

Probable penicillin-binding protein DacB2 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (Serine-type D-ala-D-ala carboxypeptidase) (D-amino acid...

Protein

Unknown.

I6Y204

Probable penicillin-binding protein DacB1 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (Serine-type D-ala-D-ala carboxypeptidase) (D-amino acid...

Protein

Unknown.

O53380

Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase (HMG aldolase) (EC 4.1.3.17) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.112) (Regulator of ribonuclease activity homolog) (RraA-like protein)

Protein

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). {ECO:0000250}..

P9WGY3

Multifunctional non-homologous end joining DNA repair protein LigD (NHEJ DNA repair protein D) (Mt-Lig) (NHEJ DNA polymerase) [Includes: DNA repair polymerase (Pol) (Polymerase/primase); 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase) (PE); DNA ligase (Lig) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])]

Protein

With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs DNA double-strand breaks (DSB) with reduced fidelity. Recognizes, processes and reseals DSBs, including repairs on incompatible DSB which require 3'-resection, gap filling and ligation. Anneals the 3' overhanging strands from opposing breaks to form a gapped intermediate, which then can be extended in trans by using the termini as primers for extension of the annealed break. Binds to the recessed 5'-phosphate moiety of the downstream DNA strand forming a stable synaptic complex even when the 3'-protruding ends of the template DNA strands are not complementary. Has numerous activites; gap filling copies the template strand, and prefers a 5'-phosphate in the gap and rNTPS (PubMed:17174332, PubMed:17947582), DNA-directed DNA or RNA polymerase on 5'-overhangs, terminal transferase (extending ssDNA or blunt dsDNA in a non-templated fashion, preferentially with rNTPs), DNA-dependent RNA primase (synthesizes short RNAs on unprimed closed ssDNA) and 3'- to 5'-exonuclease on ssDNA (PubMed:15499016). Isolated Pol domain (and presumably the holoenzyme) is able to form complexes between 2 noncompatible protruding 3'-ends DNA ends via microhomologous DNA strands, in a end-bridging function to which it adds a templated nucleotide (PubMed:17947582). Minimal primer length is 2 nucleotides (PubMed:21255731). {ECO:0000269|PubMed:15499016, ECO:0000269|PubMed:17174332, ECO:0000269|PubMed:17947582, ECO:0000269|PubMed:21255731}.; FUNCTION: The preference of the polymerase domain for rNTPs over dNTPs may be advantageous in dormant cells, where the dNTP pool is limiting.; FUNCTION: In conjunction with endogenous or Mycobacterium phage Omega Ku (AC Q853W0) can reconstitute NHEJ in Saccharomyces cerevisiae..

P9WNV3

Bifunctional purine biosynthesis protein PurH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)]

Protein

Unknown.

P9WHM7

Putative threonylcarbamoyl-AMP synthase (TC-AMP synthase) (EC 2.7.7.87) (L-threonylcarbamoyladenylate synthase) (tRNA threonylcarbamoyladenosine biosynthesis protein Rv1301)

Protein

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. {ECO:0000250}..

P9WGC9

Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc...

Protein

Unknown.

P71968

Riboflavin biosynthesis protein [Includes: Riboflavin kinase (EC 2.7.1.26) (Flavokinase); FMN adenylyltransferase (EC 2.7.7.2) (FAD pyrophosphorylase) (FAD synthase)]

Protein

Unknown.

I6X5C9

DNA integrity scanning protein DisA (Cyclic-di-AMP synthase) (c-di-AMP synthase) (Diadenylate cyclase) (EC 2.7.7.85)

Protein

Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions. {ECO:0000255|HAMAP-Rule:MF_01438}.; FUNCTION: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. To a lesser extent, can also use ADP as substrate to produce c-di-AMP. Does not convert GTP to c-di-GMP. Also exhibits residual ATPase and ADPase activities in vitro. {ECO:0000255|HAMAP-Rule:MF_01438, ECO:0000269|PubMed:22529992}..

P9WNW5

Putative 8-oxo-dGTP diphosphatase 2 (8-oxo-dGTPase 2) (EC 3.6.1.55) (7,8-dihydro-8-oxoguanine-triphosphatase 2) (Mutator protein MutT2) (dGTP pyrophosphohydrolase 2)

Protein

May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate (By similarity). In vitro has 8-oxo-dGTPase activity. {ECO:0000250, ECO:0000269|PubMed:16585780}..

P9WIY1

Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)]

Protein

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. {ECO:0000255|HAMAP-Rule:MF_01283}.; FUNCTION: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. {ECO:0000255|HAMAP-Rule:MF_01283}..

P9WHF1

Alpha-pyrone synthesis polyketide synthase-like Pks11 (EC 2.3.1.-) (Alpha-pyrone synthesis polyketide synthase type III Pks11) (Chalcone synthase-like protein) (CHS-like)

Protein

Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. {ECO:0000269|PubMed:12941968}..

P9WPF3

Cytochrome bc1 complex Rieske iron-sulfur subunit (Cytochrome bc1 reductase complex subunit QcrA) (Rieske iron-sulfur protein) (Ubiquinol--cytochrome c reductase iron-sulfur subunit)

Protein

Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis. {ECO:0000305}..

P9WH23

Molybdopterin synthase catalytic subunit 1 (EC 2.8.1.12) (MPT synthase subunit 2 1) (Molybdenum cofactor biosynthesis protein E 1) (Molybdopterin-converting factor large subunit 1) (Molybdopterin-converting factor subunit 2 1)

Protein

Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity). {ECO:0000250}..

P9WJR3

Bifunctional (p)ppGpp synthase/hydrolase RelA [Includes: GTP pyrophosphokinase (EC 2.7.6.5) ((p)ppGpp synthase) (ATP:GTP 3'-pyrophosphotransferase) (Stringent response-like protein) (ppGpp synthase II); Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)]

Protein

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the formation of pppGpp, which is then hydrolyzed to form ppGpp, as well as the hydrolysis of ppGpp. RelA is probably a key factor in the pathogenesis of M.tuberculosis as it regulates the intracellular concentrations of (p)ppGpp. {ECO:0000269|PubMed:10375643, ECO:0000269|PubMed:10940033}..

P9WHG9

Bifunctional NAD(P)H-hydrate repair enzyme Nnr (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]

Protein

Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity). {ECO:0000250}..

P9WF11

Molybdopterin synthase catalytic subunit 2 (EC 2.8.1.12) (MPT synthase subunit 2 2) (Molybdenum cofactor biosynthesis protein E 2) (Molybdopterin-converting factor large subunit 2) (Molybdopterin-converting factor subunit 2 2)

Protein

Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity). {ECO:0000250}..

P9WJR1

Coenzyme A biosynthesis bifunctional protein CoaBC (DNA/pantothenate metabolism flavoprotein) [Includes: Phosphopantothenoylcysteine decarboxylase (PPCDC) (EC 4.1.1.36) (CoaC); Phosphopantothenate--cysteine ligase (EC 6.3.2.5) (CoaB) (PPC synthetase) (PPCS) (Phosphopantothenoylcysteine synthase)]

Protein

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine (By similarity). {ECO:0000250}..

P9WNZ1

Probable 8-oxo-dGTP diphosphatase 1 (8-oxo-dGTPase 1) (EC 3.6.1.55) (7,8-dihydro-8-oxoguanine-triphosphatase 1) (Mutator protein MutT1) (dGTP pyrophosphohydrolase 1)

Protein

May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate (By similarity). In vitro has 8-oxo-dGTPase activity. {ECO:0000250, ECO:0000269|PubMed:16585780}..

P9WIY3